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Retinal Cell Biology August 2019

Highly Differentiated Human Fetal RPE Cultures Are Resistant to the Accumulation and Toxicity of Lipofuscin-Like Material

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Qitao Zhang; Feriel Presswalla; Melissa Calton; Carol Charniga; Jeffrey Stern; Sally Temple; Douglas Vollrath; David N. Zacks; Robin R. Ali; Debra A. Thompson; Jason M. L. Miller
TAGS: fetus, lipofuscin, toxic effect
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3468-3479. doi: 10.1167/iovs.19-26690

Includes: Supplemental Content

Cornea July 2019

Modulation of Contact Inhibition by ZO-1/ZONAB Gene Transfer—A New Strategy to Increase the Endothelial Cell Density of Corneal Grafts

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Daniel Kampik; Mark Basche; Anastasios Georgiadis; Ulrich F. O. Luhmann; D. Frank Larkin; Alexander J. Smith; Robin R. Ali
TAGS: contact inhibition, cornea, endothelial cells, endothelium, keratoplasty, gene therapy, gene transfer techniques
Invest. Ophthalmol. Vis. Sci.. 2019; 60(8):3170-3177. doi: 10.1167/iovs.18-26260

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Development and efficacy assessment of AAV2/8-hG1.7p.coCNGA3, a CNGA3 gene therapy vector

Tassos Georgiadis; Takaaki Matsuki; Justin Hoke; Matteo Rizzi; Anai Gonzalez-Cordero; Robert Sampson; James WB Bainbridge; Alexander Smith; Robin R Ali

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3426. doi:

ARVO Annual Meeting Abstract July 2019

Gene therapy for Glaucoma by CRISPR-Cas9 mediated disruption of Aquaporin 1 in the Ciliary Body

Colin J Chu; Jiahui Wu; Oliver Hugh Bell; David Copland; Ryea Maswood; Alison Young; John Pooley; Peng Tee Khaw; Robin R Ali; Andrew D Dick

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5120. doi:

Articles October 2017

Augmenting Endogenous Levels of Retinal Annexin A1 Suppresses Uveitis in Mice

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Peter J. Gardner; Samia Yazid; Joana Ribeiro; Robin R. Ali; Andrew D. Dick
TAGS: annexin a1, uveitis, eye, mice, retina
Trans. Vis. Sci. Tech.. 2017; 6(5):10. doi: 10.1167/tvst.6.5.10

Includes: Supplemental Content

Retina June 2017

Early-Onset Progressive Degeneration of the Area Centralis in RPE65-Deficient Dogs

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Freya M. Mowat; Kristen J. Gervais; Laurence M. Occelli; Matthew J. Annear; Janice Querubin; James W. Bainbridge; Alexander J. Smith; Robin R. Ali; Simon M. Petersen-Jones
TAGS: retinal cone, dog, domestic, opsin, photoreceptors, rod photoreceptors, eye, retina, tissue degeneration
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):3268-3277. doi: 10.1167/iovs.17-21930

ARVO Annual Meeting Abstract September 2016

Myeloid-derived VEGF and HIF are dispensable for ocular neovascularisation

Sidath Liyanage; Alessandro Fantin; Pilar Villacampa; Clemens Lange; Laura Denti; Enrico Cristante; Alexander J Smith; Robin R Ali; Ulrich F O Luhmann; James W B Bainbridge; Christiana Ruhrberg

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Lentiviral gene transfer of E2F2 induces regeneration of retinal pigment epithelium in situ

Daniel Kampik; Ulrich F O Luhmann; Koji Miura Nishiguchi; Mark Basche; Alexander J Smith; Hong Han; Jennifer Williams; John Greenwood; Stephen E Moss; Frank Larkin; Robin R Ali

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2128. doi:

Article November 2015

Spectral sensitivity measurements reveal partial success in restoring missing rod function with gene therapy

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Caterina Ripamonti; G. Bruce Henning; Scott J. Robbie; Venki Sundaram; L. Ingeborgh van den Born; Ingele Casteels; Thomy J. L. de Ravel; Anthony T. Moore; Alexander J. Smith; James W. Bainbridge; Robin R. Ali; Andrew Stockman
TAGS: gene therapy, retinal cone, rod photoreceptors, photopsia, bleach
Journal of Vision. 2015; 15(15):20. doi: 10.1167/15.15.20

ARVO Annual Meeting Abstract June 2015

Residual Foveal Cone Structure in CNGB3 Achromatopsia: Factors for gene therapy candidate selection

Adam M Dubis; Christopher S Langlo; Alfredo Dubra; Andrew Webster; Jonathan Aboshiha; Anthony T Moore; Robin R Ali; James W B Bainbridge; Joseph Carroll; Michel Michaelides

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4264. doi:

ARVO Annual Meeting Abstract June 2015

Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179

Livia S Carvalho; Koji Nishiguchi; Matteo Rizzi; Kate Powell; Sophia Kleine Holthaus; Yanai Duran; Ulrich F. O. Luhmann; James W B Bainbridge; Alexander J Smith; Robin R Ali

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):248. doi:

ARVO Annual Meeting Abstract June 2015

Dose-response effect of RPE65 gene therapy on retinoid levels and correlation with clinical rescue in Rpe65-deficient dogs.

Freya Mowat; Kecia L Feathers; Alexander J Smith; Debra A Thompson; Simon M Petersen-Jones; James W B Bainbridge; Robin R Ali

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2064. doi:

Review February 2015

Advancing Therapeutic Strategies for Inherited Retinal Degeneration: Recommendations From the Monaciano Symposium

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Debra A. Thompson; Robin R. Ali; Eyal Banin; Kari E. Branham; John G. Flannery; David M. Gamm; William W. Hauswirth; John R. Heckenlively; Alessandro Iannaccone; K. Thiran Jayasundera; Naheed W. Khan; Robert S. Molday; Mark E. Pennesi; Thomas A. Reh; Richard G. Weleber; David N. Zacks; for the Monaciano Consortium
TAGS: gene therapy, retinal degeneration, universities, transplantation, comprehension, retinal dystrophies
Invest. Ophthalmol. Vis. Sci.. 2015; 56(2):918-931. doi: 10.1167/iovs.14-16049

Visual Psychophysics and Physiological Optics October 2014

Nature of the Visual Loss in Observers With Leber's Congenital Amaurosis Caused by Specific Mutations in RPE65

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Caterina Ripamonti; G. Bruce Henning; Robin R. Ali; James W. Bainbridge; Scott J. Robbie; Venki Sundaram; Vy A. Luong; L. Ingeborgh van den Born; Ingele Casteels; Thomy J. L. de Ravel; Anthony T. Moore; Andrew Stockman
TAGS: mutation, blindness, calibration, retinal cone, contrast sensitivity, flicker fusion, visual impairment, eye, photopsia, leber's amaurosis, filters, luminance
Invest. Ophthalmol. Vis. Sci.. 2014; 55(10):6817-6828. doi: 10.1167/iovs.14-14923

Visual Psychophysics and Physiological Optics October 2014

Dark-Adaptation Functions in Molecularly Confirmed Achromatopsia and the Implications for Assessment in Retinal Therapy Trials

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Jonathan Aboshiha; Vy Luong; Jill Cowing; Adam M. Dubis; James W. Bainbridge; Robin R. Ali; Andrew R. Webster; Anthony T. Moore; Frederick W. Fitzke; Michel Michaelides
TAGS: dark adaptation, achromatopsia
Invest. Ophthalmol. Vis. Sci.. 2014; 55(10):6340-6349. doi: 10.1167/iovs.14-14910

Retina September 2014

A Prospective Longitudinal Study of Retinal Structure and Function in Achromatopsia

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Jonathan Aboshiha; Adam M. Dubis; Jill Cowing; Rachel T. A. Fahy; Venki Sundaram; James W. Bainbridge; Robin R. Ali; Alfredo Dubra; Marko Nardini; Andrew R. Webster; Anthony T. Moore; Gary Rubin; Joseph Carroll; Michel Michaelides
TAGS: contrast sensitivity, follow-up, genotype, natural history, prospective studies, visual acuity, retina, achromatopsia, significance, fundus autofluorescence imaging
Invest. Ophthalmol. Vis. Sci.. 2014; 55(9):5733-5743. doi: 10.1167/iovs.14-14937

ARVO Annual Meeting Abstract April 2014

Sustained elevated light exposure in mice leads to strain dependent dysregulation of the complement system in the eye

Philipp Herrmann; Jill Cowing; Sidath E Liyanage; Koji Miura Nishiguchi; Ulrich F O Luhmann; Robin R Ali

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6329. doi:

ARVO Annual Meeting Abstract April 2014

Retinal phenotype in Cln6nclf mice, a mouse model of neuronal ceroid lipofuscinoses, amenable to AAV mediated gene therapy

Sophia Kleine Holthaus; Ulrich F O Luhmann; Alexander J Smith; Sara E Mole; Robin R Ali

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3314. doi:

ARVO Annual Meeting Abstract June 2013

Promoting CD200R signalling inhibits laser-induced choroidal neovascularisation due to altered proangiogenic macrophage gene expression

David Copland; Scott Robbie; Jian Liu; Wei-Kang Wu; Robin Ali; James Bainbridge; Andrew Dick

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):3179. doi:

ARVO Annual Meeting Abstract June 2013

Neuroglobin in the developing retina

Ranjan Rajendram; Harry Bradshaw; Philip Luthert; Robin Ali; James Bainbridge

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):3742. doi:

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Highly Differentiated Human Fetal RPE Cultures Are Resistant to the Accumulation and Toxicity of Lipofuscin-Like Material

Modulation of Contact Inhibition by ZO-1/ZONAB Gene Transfer—A New Strategy to Increase the Endothelial Cell Density of Corneal Grafts

Development and efficacy assessment of AAV2/8-hG1.7p.coCNGA3, a CNGA3 gene therapy vector

Gene therapy for Glaucoma by CRISPR-Cas9 mediated disruption of Aquaporin 1 in the Ciliary Body

Augmenting Endogenous Levels of Retinal Annexin A1 Suppresses Uveitis in Mice

Early-Onset Progressive Degeneration of the Area Centralis in RPE65-Deficient Dogs

Myeloid-derived VEGF and HIF are dispensable for ocular neovascularisation

Lentiviral gene transfer of E2F2 induces regeneration of retinal pigment epithelium in situ

Spectral sensitivity measurements reveal partial success in restoring missing rod function with gene therapy

Residual Foveal Cone Structure in CNGB3 Achromatopsia: Factors for gene therapy candidate selection

Gene therapy restores vision in rd1 mice after removal of a confounding mutation in Gpr179

Dose-response effect of RPE65 gene therapy on retinoid levels and correlation with clinical rescue in Rpe65-deficient dogs.

Advancing Therapeutic Strategies for Inherited Retinal Degeneration: Recommendations From the Monaciano Symposium

Nature of the Visual Loss in Observers With Leber's Congenital Amaurosis Caused by Specific Mutations in RPE65

Dark-Adaptation Functions in Molecularly Confirmed Achromatopsia and the Implications for Assessment in Retinal Therapy Trials

A Prospective Longitudinal Study of Retinal Structure and Function in Achromatopsia

Sustained elevated light exposure in mice leads to strain dependent dysregulation of the complement system in the eye

Retinal phenotype in Cln6nclf mice, a mouse model of neuronal ceroid lipofuscinoses, amenable to AAV mediated gene therapy

Promoting CD200R signalling inhibits laser-induced choroidal neovascularisation due to altered proangiogenic macrophage gene expression

Neuroglobin in the developing retina

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