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ARVO Annual Meeting Abstract June 2021

Chronic Oxidative Stress in Primary Retinal Pigmented Epithelium Monolayers Increases Basolateral Exosome Release and Changes Both Exosome and Extracellular Matrix Proteomes

Belinda Hernandez; Mikael Klingeborn; Nikolai Skiba; Daniel Grigsby; Una Kelly; Martha Caday; Arvydas Maminishkis; TeddiJo Watkins; Sheldon S Miller; W. Daniel Stamer; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):256.

ARVO Annual Meeting Abstract June 2020

Hypoxia-induced Alterations of miR-204 Regulates Autophagy Activity in Human Retinal Pigment Epithelium (hRPE)

Congxiao Zhang; Kiyoharu J Miyagishima; Ruchi Sharma; Malika Nimmagadda; Genqing Liang; Arvydas Maminishkis; Kapil Bharti; Sheldon S Miller

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3110.

ARVO Annual Meeting Abstract July 2019

Regional transcriptome map of the adult rhesus macaque retina and RPE-choroid

Ameera Mungale; Temesgen D Fufa; David McGaughey; Congxiao Zhang; Arvydas Maminishkis; Sheldon S Miller; Brian Patrick Brooks; Robert Hufnagel

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):998.

ARVO Annual Meeting Abstract July 2019

Fibulin-3 mutation induces loss of polarity in RPE cells and alters the protein and micro RNA content of exosomes

Mi Zhou; Sarah Weber; Yuanjun Zhao; Yuka Imamura; Arvydas Maminishkis; Sheldon S Miller; Jeffrey M. Sundstrom

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1917.

ARVO Annual Meeting Abstract July 2019

Elevation of miR-155 induces a non-canonical inflammasome activation pathway in human retinal pigment epithelium (hRPE)

Congxiao Zhang; Arvydas Maminishkis; Kiyoharu miyagishima; Genqing Liang; Fnu Ruchi; Sheldon S Miller

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):766.

ARVO Annual Meeting Abstract July 2019

Altered electrical responses in iPSC-RPE derived from distinct genetic eye diseases

Qin Wan; Mitra Farnoodian; Nathan Hotaling; Aman George; Kiyoharu miyagishima; Roba Dejene; Tyler Pfister; Arvydas Maminishkis; Brian Patrick Brooks; Sheldon S Miller; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6396.

ARVO Annual Meeting Abstract July 2018

Efficacy of clinical-grade iPSC-RPE cells and patch in rodent and swine models of retinal degeneration

Aaron Rising; Vladimir Khristov; Yichao Li; Maria M Campos; Haohua Qian; Jonathan Stoddard; Arvydas Maminishkis; Juan Amaral; Trevor J McGill; Sheldon S Miller; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):546.

ARVO Annual Meeting Abstract July 2018

ABCA4 in Human Retinal Pigment Epithelium: a New Link to Stargardt Pathogenesis

Mitra Farnoodian-Tedrick; Praveen Joseph Susaimanickam; Vladimir Khristov; Qin Wan; Karla Y Barbosa-Sabanero; Sheldon S Miller; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1985.

ARVO Annual Meeting Abstract July 2018

Elovanoid profiling of iPSC-RPE derived from a family affected by Late-Onset Retinal Degeneration reveals attenuated neuroprotective signaling in patients

Bokkyoo Jun; Kiyoharu Joshua Miyagishima; Ruchi Sharma; Catherine A Cukras; Paul Sieving; Sheldon S Miller; Kapil Bharti; Nicolas G Bazan

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3051.

ARVO Annual Meeting Abstract June 2017

CEP290 or IFT88 Loss of Function in RPE Suggest a Role for Primary Cilia in Human iPSC-RPE Maturation and Provide Insights into the Mechanism of Ciliopathy-Induced Retinal Degeneration

Qin Wan; Ruchi Sharma; Justin Chang; Vladimir Khristov; Kiyoharu Miyagishima; Roba Dejene; Quanlong Lu; Christopher Westlake; Meral Gunay-Aygun; Sheldon S Miller; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1056.

ARVO Annual Meeting Abstract June 2017

Endothelial cell-derived Indian Hedgehog targets multipotent perivascular cells in the adult choroid and prevents retinal damage

Guillermo Lehmann-Mantaras; Ignacio Benedicto; Michael Ginsberg; Daniel J Nolan; Olivier Elemento; Arvydas Maminishkis; Sheldon S Miller; Alexandre Wojcinski; Alexandra L Joyner; Shahin Rafii; Enrique J. Rodriguez-Boulan

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1103.

ARVO Annual Meeting Abstract June 2017

Human iPSC-RPE cell transplant in a swine laser-injury model mitigates progressive visual functionality decline.

Aaron Rising; Yichao Li; Vladimir Khristov; Balendu Jha; Haohua Qian; Maria M Campos; Arvydas Maminishkis; Juan Amaral; Sheldon S Miller; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1992.

ARVO Annual Meeting Abstract June 2017

Tissue-specific expression of alpha-2-macroglobulin by choroid endothelial cells in response to RPE-secreted factors: implications for AMD

Ignacio Benedicto; Guillermo Lehmann-Mantaras; Olivier Elemento; Arvydas Maminishkis; Sheldon S Miller; Shahin Rafii; Enrique J. Rodriguez-Boulan

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2261.

ARVO Annual Meeting Abstract June 2017

Analysis of Secretory Lipidomics and Proteomics of Late-Onset Retinal Degeneration iPSC-derived RPE

Kiyoharu J Miyagishima; Ruchi Sharma; Katharina Clore-Gronenborn; Zoya Qureshy; Bokkyoo Jun; William C Gordon; Nathan Hotaling; Congxiao Zhang; Catherine A Cukras; Paul A Sieving; Nicolas Guillermo Bazan; Sheldon S Miller; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3019.

ARVO Annual Meeting Abstract June 2017

RPE miR-204 or -211 KNOCK OUT ALTERS CELL MORPHOLOGY AND FUNCTION

Congxiao Zhang; Helen Zhao; Nathan Hotaling; Kiyoharu Miyagishima; Raymond Zhou; Lijing Dong; Arvydas Maminishkis; Kapil Bharti; Sheldon S Miller

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3568.

ARVO Annual Meeting Abstract June 2017

IND-enabling preclinical toxicity and tumorigenicity studies for AMD-patient’s iPSC-derived RPE in immunocompromised rats

Vladimir Khristov; Arvydas Maminishkis; Balendu Jha; Sheldon S Miller; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1991.

ARVO Annual Meeting Abstract September 2016

Choroid endothelial cells regulate RPE tight junctions through modulation of Bruch′s membrane assembly

Ignacio Benedicto; Guillermo Lehmann-Mantaras; Michael Ginsberg; Daniel J. Nolan; Olivier Elemento; Nazia M Alam; Glen T. Prusky; Arvydas Maminishkis; Sheldon S Miller; Shahin Rafii; Enrique J Rodriguez-Boulan

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):241.

ARVO Annual Meeting Abstract September 2016

Primary Cilia Regulates Human iPSC-RPE Maturation via Regulation of WNT Signaling

Qin Wan; Balendu Jha; Helen May-Simera; Ruchi Sharma; Juliet Hartford; Vladimir Khristov; Kiyoharu Miyagishima; Mostafa Reza Lotfi; Sheldon S Miller; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):252.

ARVO Annual Meeting Abstract September 2016

A Porcine Model of Retinal Pigment Epithelium (RPE) Injury to Test the Efficacy of Human Induced Pluripotent Stem Cell– derived RPE (hiPSC-RPE) Transplants.

Juan Amaral; Maria Mercedes Campos; Arvydas Maminishkis; Vladimir Khristov; Raymond Zhou; Steve T Charles; Boris Stanzel; Balendu Jha; Irina Bunea; Sheldon S Miller; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):258.

ARVO Annual Meeting Abstract September 2016

Developing Autologous Cell Therapy for Age-related Macular Degeneration using Patient-specific Induced Pluripotent Stem Cell derived Retinal Pigment Epithelium

Kapil Bharti; Vladimir Khristov; Balendu Jha; Maria Mercedes Campos; Zhu Raymond; Yichao Li; Haohua Qian; Arvydas Maminishkis; Steve T Charles; Juan Amaral; Sheldon S Miller

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12)

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Chronic Oxidative Stress in Primary Retinal Pigmented Epithelium Monolayers Increases Basolateral Exosome Release and Changes Both Exosome and Extracellular Matrix Proteomes

Hypoxia-induced Alterations of miR-204 Regulates Autophagy Activity in Human Retinal Pigment Epithelium (hRPE)

Regional transcriptome map of the adult rhesus macaque retina and RPE-choroid

Fibulin-3 mutation induces loss of polarity in RPE cells and alters the protein and micro RNA content of exosomes

Elevation of miR-155 induces a non-canonical inflammasome activation pathway in human retinal pigment epithelium (hRPE)

Altered electrical responses in iPSC-RPE derived from distinct genetic eye diseases

Efficacy of clinical-grade iPSC-RPE cells and patch in rodent and swine models of retinal degeneration

ABCA4 in Human Retinal Pigment Epithelium: a New Link to Stargardt Pathogenesis

Elovanoid profiling of iPSC-RPE derived from a family affected by Late-Onset Retinal Degeneration reveals attenuated neuroprotective signaling in patients

CEP290 or IFT88 Loss of Function in RPE Suggest a Role for Primary Cilia in Human iPSC-RPE Maturation and Provide Insights into the Mechanism of Ciliopathy-Induced Retinal Degeneration

Endothelial cell-derived Indian Hedgehog targets multipotent perivascular cells in the adult choroid and prevents retinal damage

Human iPSC-RPE cell transplant in a swine laser-injury model mitigates progressive visual functionality decline.

Tissue-specific expression of alpha-2-macroglobulin by choroid endothelial cells in response to RPE-secreted factors: implications for AMD

Analysis of Secretory Lipidomics and Proteomics of Late-Onset Retinal Degeneration iPSC-derived RPE

RPE miR-204 or -211 KNOCK OUT ALTERS CELL MORPHOLOGY AND FUNCTION

IND-enabling preclinical toxicity and tumorigenicity studies for AMD-patient’s iPSC-derived RPE in immunocompromised rats

Choroid endothelial cells regulate RPE tight junctions through modulation of Bruch′s membrane assembly

Primary Cilia Regulates Human iPSC-RPE Maturation via Regulation of WNT Signaling

A Porcine Model of Retinal Pigment Epithelium (RPE) Injury to Test the Efficacy of Human Induced Pluripotent Stem Cell– derived RPE (hiPSC-RPE) Transplants.

Developing Autologous Cell Therapy for Age-related Macular Degeneration using Patient-specific Induced Pluripotent Stem Cell derived Retinal Pigment Epithelium

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