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Biochemistry and Molecular Biology August 2018

Murine Retinal Citrullination Declines With Age and is Mainly Dependent on Peptidyl Arginine Deiminase 4 (PAD4)

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T. J. Hollingsworth; Marko Z. Radic; Sarka Beranova-Giorgianni; Francesco Giorgianni; Yanming Wang; Alessandro Iannaccone
TAGS: arginine, citrullination, mice, western blotting, retina, antibodies, peptides
Invest. Ophthalmol. Vis. Sci.. 2018; 59(10):3808-3815. https://doi.org/10.1167/iovs.18-24118

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Early events in oxLDL-induced transcriptome alteration in ARPE-19 cells

Francesco Giorgianni; Diwa Koirala; Sarka Beranova-Giorgianni

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4019.

ARVO Annual Meeting Abstract June 2017

Association between macular phenotype and serum auto-antibodies (AAbs) against macular antigens in age-related macular degeneration (AMD): Preliminary studies

Alessandro Iannaccone; TJ Hollingsworth; Natalia Lenchik; Sarka Beranova-Giorgianni; Ivan Gerling; Marko Z. Radic; Francesco Giorgianni

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5740.

ARVO Annual Meeting Abstract June 2017

The superoxide dismutase 1 knock out (SOD1 KO) mouse develops age-dependent auto reactivity to ocular antigens

Diwa Koirala; Alessandro Iannaccone; TJ Hollingsworth; Sarka Beranova-Giorgianni; Ivan Gerling; Marko Z. Radic; Francesco Giorgianni

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5759.

ARVO Annual Meeting Abstract June 2017

Peptidylarginine deiminase 4 (PAD4) is the primary mediator of retinal citrullination in mice

TJ Hollingsworth; Marko Z. Radic; Francesco Giorgianni; Sarka Beranova-Giorgianni; Diwa Koirala; Yanming Wang; Alessandro Iannaccone

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):616.

ARVO Annual Meeting Abstract September 2016

The CD5-like (CD5L) protein is expressed by retinal pigment epithelium (RPE) cells and is a key role player in the uptake of oxidized low-density lipoproteins (oxLDL).

Diwa Koirala; Alessandro Iannaccone; Marko Z. Radic; TJ Hollingsworth; Ivan Gerling; Sarka Beranova-Giorgianni; Francesco Giorgianni

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5014.

ARVO Annual Meeting Abstract September 2016

Circulating autoantibodies in age-related macular degeneration (AMD) recognize human macular tissue antigens implicated in immunomodulation, protection from oxidative stress and apoptosis, and autophagy

Alessandro Iannaccone; Marko Z. Radic; Sarka Beranova-Giorgianni; Nataliya Lenchik; TJ Hollingsworth; Ivan Gerling; Francesco Giorgianni

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6560.

ARVO Annual Meeting Abstract June 2015

The Cu/Zn+ superoxide dismutase knockout mouse (Sod1-/-) , a model of age-related macular degeneration (AMD), exhibits anti-retinal autoantibodies (AAbs) and marked signs of intraretinal inflammation prior to onset of an AMD-like phenotype

David New; TJ Hollingsworth; Francesco Giorgianni; Nataliya Lenchik; Ivan Gerling; Sarka Beranova-Giorgianni; Marko Radic; Alessandro Iannaccone

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3986.

ARVO Annual Meeting Abstract June 2015

Peptidylarginine deiminase (PAD4) expression and citrullination levels in normal human and mouse retinas and in murine models of late- (Sod1 -/- ) and early-onset (Tyro3 -/- , Axl -/- , Mertk -/- or TAM mice) retinal degeneration

TJ Hollingsworth; David New; Francesco Giorgianni; Nataliya Lenchik; Sarka Beranova-Giorgianni; Ivan Gerling; Qingxian Lu; Yanming Wang; Marko Radic; Alessandro Iannaccone

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4636.

ARVO Annual Meeting Abstract June 2015

Sera from subjects with age-related macular degeneration (AMD) exhibit strong autoreactivity against human macular Heat Shock Proteins (HSPs)

Alessandro Iannaccone; David New; Francesco Giorgianni; Nataliya Lenchik; Sarka Beranova-Giorgianni; Ivan Gerling; Marko Radic

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):815.

ARVO Annual Meeting Abstract April 2014

The Apolipoprotein E4 Targeted Replacement (APOE4 TR) Mouse Model of Age-Related Macular Degeneration (AMD) Exhibits Anti-Retinal Autoreactivity

Albert H. Alhatem; Nataliya Lenchik; Sarka Beranova-Giorgianni; Mikael Klingeborn; David D New; Francesco Giorgianni; Ivan Gerling; Marko Radic; Catherine Bowes Rickman; Alessandro Iannaccone

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1173.

ARVO Annual Meeting Abstract April 2014

Evidence for Anti-Retinal Auto-Antibodies (AAbs) in the Complement Factor H Chimeric Transgenic (Cfh-Tg) Mouse Model of Age-Related Macular Degeneration (AMD)

Alessandro Iannaccone; Albert H. Alhatem; Nataliya Lenchik; Francesco Giorgianni; David D New; Sarka Beranova-Giorgianni; Ivan Gerling; Rafael Ufret-Vincenty; Marko Radic

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1205.

ARVO Annual Meeting Abstract June 2013

Identification of Human Macular Tissue Antigens Recognized by Serum Auto-Antibodies (auto-Abs) in Patients with Age-Related Macular Degeneration (AMD)

Nataliya Lenchik; Francesco Giorgianni; Sarka Beranova-Giorgianni; Ivan Gerling; Marko Radic; Alessandro Iannaccone

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):4103.

Retinal Cell Biology May 2010

In Search of the Identity of the XAP-1 Antigen: A Protein Localized to Cone Outer Segments

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Suba Nookala; Rohit Gandrakota; Amira Wohabrebbi; XiaoFei Wang; Danielle Howell; Francesco Giorgianni; Sarka Beranova-Giorgianni; Dominic M. Desiderio; Monica M. Jablonski
TAGS: antigens, proteins, retinal cone, western blotting, antibodies
Invest. Ophthalmol. Vis. Sci.. 2010; 51(5):2736-2743. https://doi.org/10.1167/iovs.09-4286

ARVO Annual Meeting Abstract April 2009

In Search of the Identity of the XAP-1 Antigen

M. M. Jablonski; R. Gandrakota; F. Giorgianni; S. Beranova-Giorgianni; S. Nookala

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):5457.

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Murine Retinal Citrullination Declines With Age and is Mainly Dependent on Peptidyl Arginine Deiminase 4 (PAD4)

Early events in oxLDL-induced transcriptome alteration in ARPE-19 cells

Association between macular phenotype and serum auto-antibodies (AAbs) against macular antigens in age-related macular degeneration (AMD): Preliminary studies

The superoxide dismutase 1 knock out (SOD1 KO) mouse develops age-dependent auto reactivity to ocular antigens

Peptidylarginine deiminase 4 (PAD4) is the primary mediator of retinal citrullination in mice

The CD5-like (CD5L) protein is expressed by retinal pigment epithelium (RPE) cells and is a key role player in the uptake of oxidized low-density lipoproteins (oxLDL).

Circulating autoantibodies in age-related macular degeneration (AMD) recognize human macular tissue antigens implicated in immunomodulation, protection from oxidative stress and apoptosis, and autophagy

The Cu/Zn+ superoxide dismutase knockout mouse (Sod1-/-) , a model of age-related macular degeneration (AMD), exhibits anti-retinal autoantibodies (AAbs) and marked signs of intraretinal inflammation prior to onset of an AMD-like phenotype

Peptidylarginine deiminase (PAD4) expression and citrullination levels in normal human and mouse retinas and in murine models of late- (Sod1 -/- ) and early-onset (Tyro3 -/- , Axl -/- , Mertk -/- or TAM mice) retinal degeneration

Sera from subjects with age-related macular degeneration (AMD) exhibit strong autoreactivity against human macular Heat Shock Proteins (HSPs)

The Apolipoprotein E4 Targeted Replacement (APOE4 TR) Mouse Model of Age-Related Macular Degeneration (AMD) Exhibits Anti-Retinal Autoreactivity

Evidence for Anti-Retinal Auto-Antibodies (AAbs) in the Complement Factor H Chimeric Transgenic (Cfh-Tg) Mouse Model of Age-Related Macular Degeneration (AMD)

Identification of Human Macular Tissue Antigens Recognized by Serum Auto-Antibodies (auto-Abs) in Patients with Age-Related Macular Degeneration (AMD)

In Search of the Identity of the XAP-1 Antigen: A Protein Localized to Cone Outer Segments

In Search of the Identity of the XAP-1 Antigen

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