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ARVO Annual Meeting Abstract June 2024

Deciphering NRF2- Dysregulations and Oxidative Stress in Keratoconus Corneal Degeneration

Madhuri Amulya Koduri; Dzhalil Abizgildin; Elias H Kahan; Andrea L Blitzer; Evan R Shapiro; Laurence T. D. Sperber; Ilyse D Haberman; Douglas R Lazzaro; Rose Mandel; Christina R Prescott; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4550.

ARVO Annual Meeting Abstract June 2023

Small Leucine-rich repeat proteoglycans regulate CD4 + T lymphocytes - implications in the eye

Shukti Chakravarti; George Maiti

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2868.

ARVO Annual Meeting Abstract June 2023

B Lymphocyte-Induced Maturation Protein-1 Regulates Corneal Epithelial Cell Phenotype

Sean Ashworth; Jessica E. Treisman; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):970.

ARVO Annual Meeting Abstract June 2022

Single cell transcriptomic analyses of human cornea organoids reveal cell lineages of a developing cornea

George Maiti; Maithe Rocha Monteiro de Barros; Karl J Wahlin; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):102 – A0200.

ARVO Annual Meeting Abstract June 2021

Reduced WNT10A in keratoconus corneal epithelium and Bowman’s layer and upregulation of collagen I suggest Wnt signaling as a therapeutic target

Uri Soiberman; James W Foster; Michelle Lu; Shukti Chakravarti; Albert S Jun; Charles Eberhart

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2043.

ARVO Annual Meeting Abstract June 2021

Single-cell RNA-seq analysis of human cornea and corneal organoid

George Maiti; Karl J Wahlin; James W Foster; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):952.

Cornea May 2021

Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer

PDF

James W. Foster; Rupin N. Parikh; Jiangxia Wang; Kraig S. Bower; Mario Matthaei; Shukti Chakravarti; Albert S. Jun; Charles G. Eberhart; Uri S. Soiberman
TAGS: epithelium, keratoconus, wnt10a gene, bowman's layer
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):16. https://doi.org/10.1167/iovs.62.6.16

Includes: Supplemental Content

Cornea August 2019

Small Molecule Modulation of the Integrated Stress Response Governs the Keratoconic Phenotype In Vitro

PDF

Uri Simcha Soiberman; Ahmed Elsayed Mahmoud Shehata; Michelle Xiaoyi Lu; Tempest Young; Yassine J. Daoud; Shukti Chakravarti; Albert S. Jun; James William Foster
TAGS: keratoconus, phenotype, regulation, small molecule, stress response, fibroblasts, proteins, cell count, collagen synthesis, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3422-3431. https://doi.org/10.1167/iovs.19-27151

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Development of cornea organoids from human induced pluripotent stem cells and their future use

Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2610.

ARVO Annual Meeting Abstract July 2018

Transcriptomic analysis of corneas from Keratoconus patients in Saudi Arabia and the United States.

Nan Hu; Vishal Shinde; James W Foster; Uri Soiberman; Yassine Jamil Daoud; Alka Mahale; Samar A Al-Swailem; Albert Jun; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2922.

ARVO Annual Meeting Abstract July 2018

Role of FOXO1 in the progression of Keratoconus.

Vishal Shinde; James W Foster; Yassine Jamil Daoud; Albert Jun; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2923.

Cornea June 2018

Integrated Stress Response and Decreased ECM in Cultured Stromal Cells From Keratoconus Corneas

PDF

James W. Foster; Vishal Shinde; Uri S. Soiberman; Gajanan Sathe; Sheng Liu; Julius Wan; Jiang Qian; Yassine Dauoud; Akhilesh Pandey; Albert S. Jun; Shukti Chakravarti
TAGS: collagen, cornea, keratoconus, keratocytes, proteins, stress response, stromal cells, peptides, cell culture techniques
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2977-2986. https://doi.org/10.1167/iovs.18-24367

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Corneal proteoglycan lumican modulates lipid rafts and innate immunity

George Maiti; Jihane Frikeche; Ye Eun Jeong; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2064.

ARVO Annual Meeting Abstract June 2017

Proteomic comparison of keratoconus with and without vernal keratoconjunctivitis in individuals from Saudi Arabia.

Shukti Chakravarti; Alka Mahale; Gajanan Sathe; James W Foster; Vishal Shinde; Akhilesh Pandey; Charles Eberhart; Albert S Jun; Samar A Al-Swailem; Donald U Stone; Azza Maktabi

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3902.

ARVO Annual Meeting Abstract June 2017

AKT and mTOR differential signaling in keratoconus compared to donor stromal cells.

Vishal Shinde; James W Foster; Yassine Jamil Daoud; Uri Soiberman; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3903.

ARVO Annual Meeting Abstract June 2017

Molecular insights into ECM and collagen assembly disruptions in keratoconus

James William Foster; Vishal Shinde; Uri Soiberman; Yassine Jamil Daoud; Fares Alsaleh; Gajanan Sathe; Jun Wan; Jiang Qian; Albert S Jun; Akhilesh Pandey; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3904.

Research Highlight April 2017

Fibrillin Microfibrils Keep the Cornea in Shape

PDF

Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2117. https://doi.org/10.1167/iovs.17-21840

ARVO Annual Meeting Abstract June 2015

Keratoconus transcriptome analysis by RNA-Seq of individual corneas identifies dysregulated cell survival and mesenchymal regulatory programs.

Shukti Chakravarti; Steven Salzberg; Stacey Gabriel; Yassine Daoud; James W Foster; Albert S Jun; Walter J. Stark; Phenotypic and Genotypic Analysis of Keratoconus

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1929.

ARVO Annual Meeting Abstract June 2015

Cultured stromal cells from keratoconus corneas show reduced fibrillar collagen deposition with no changes in overall collagen production

James W Foster; Yassine Daoud; Walter J. Stark; Laura Kallay; John R Hassell; Albert S Jun; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1931.

ARVO Annual Meeting Abstract April 2014

Peptidoglycan recognition protein 2 (Pglyrp 2) exacerbates Pseudomonas aeruginosa keratitis in a mouse model.

Shukti Chakravarti; Ranjita N Gowda; Sudarshan Punglay; Wai-Hong Wu; Abdel R Hamad

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1463.

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Deciphering NRF2- Dysregulations and Oxidative Stress in Keratoconus Corneal Degeneration

Small Leucine-rich repeat proteoglycans regulate CD4 + T lymphocytes - implications in the eye

B Lymphocyte-Induced Maturation Protein-1 Regulates Corneal Epithelial Cell Phenotype

Single cell transcriptomic analyses of human cornea organoids reveal cell lineages of a developing cornea

Reduced WNT10A in keratoconus corneal epithelium and Bowman’s layer and upregulation of collagen I suggest Wnt signaling as a therapeutic target

Single-cell RNA-seq analysis of human cornea and corneal organoid

Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer

Small Molecule Modulation of the Integrated Stress Response Governs the Keratoconic Phenotype In Vitro

Development of cornea organoids from human induced pluripotent stem cells and their future use

Transcriptomic analysis of corneas from Keratoconus patients in Saudi Arabia and the United States.

Role of FOXO1 in the progression of Keratoconus.

Integrated Stress Response and Decreased ECM in Cultured Stromal Cells From Keratoconus Corneas

Corneal proteoglycan lumican modulates lipid rafts and innate immunity

Proteomic comparison of keratoconus with and without vernal keratoconjunctivitis in individuals from Saudi Arabia.

AKT and mTOR differential signaling in keratoconus compared to donor stromal cells.

Molecular insights into ECM and collagen assembly disruptions in keratoconus

Fibrillin Microfibrils Keep the Cornea in Shape

Keratoconus transcriptome analysis by RNA-Seq of individual corneas identifies dysregulated cell survival and mesenchymal regulatory programs.

Cultured stromal cells from keratoconus corneas show reduced fibrillar collagen deposition with no changes in overall collagen production

Peptidoglycan recognition protein 2 (Pglyrp 2) exacerbates Pseudomonas aeruginosa keratitis in a mouse model.

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