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Retina April 2025

Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

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Kao-Jung Chang; Ching-Yun Wang; Hsin-Yu Wu; Pei-Yu Weng; Chia-Hsin Lu; Wei Chiu; Wei-Chieh Fang; Chong-En Kao; Cheng-Yi Li; Yi-Ting Chung; Yu-Chun Chen; Ai-Ru Hsieh; Shih-Hwa Chiou; Chih-Chien Hsu; Tai-Chi Lin; Shih-Jen Chen; De-Kuang Hwang
TAGS: biological markers, polygenic risk score, retinal detachment, screening, ultrasonography, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(4):16. https://doi.org/10.1167/tvst.14.4.16

Includes: Supplemental Content

Retinal Cell Biology March 2025

Dicer Loss in Müller Glia Leads to a Defined Sequence of Pathological Events Beginning With Cone Dysfunction

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Daniel Larbi; Alexander M. Rief; Seoyoung Kang; Shaoheng Chen; Khulan Batsuuri; Sabine Fuhrmann; Suresh Viswanathan; Stefanie G. Wohl
TAGS: embryonic lethal mutation, health, mice, micrornas, neuroglia, pathophysiology, retina, retinal cone, rod photoreceptors, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):7. https://doi.org/10.1167/iovs.66.3.7

Includes: Supplemental Content

Glaucoma February 2025

Characterization, Enrichment, and Computational Modeling of Cross-Linked Actin Networks in Transformed Trabecular Meshwork Cells

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Haiyan Li; Devon H. Harvey; Jiannong Dai; Steven P. Swingle; Anthony M. Compton; Chenna Kesavulu Sugali; Kamesh Dhamodaran; Jing Yao; Tsai-Yu Lin; Todd Sulchek; Taeyoon Kim; C. Ross Ethier; Weiming Mao
TAGS: actins, adhesions, computer simulation, trabecular meshwork, cell nucleus, green fluorescent proteins, diagnostic imaging, incidence
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):65. https://doi.org/10.1167/iovs.66.2.65

Includes: Multimedia, Supplemental Content

Glaucoma February 2025

Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response

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Raymond Fang; Pengpeng Zhang; Daniel Kim; Junghun Kweon; Cheng Sun; Alex S. Huang; Hao F. Zhang
TAGS: optical coherence tomography, pilocarpine, schlemm's canal, visible light, eye, diagnostic imaging, vaccine information sheets, language morphology, morphology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):47. https://doi.org/10.1167/iovs.66.2.47

Glaucoma January 2025

In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics

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Daniel Kim; Raymond Fang; Pengpeng Zhang; Zihang Yan; Cheng Sun; Guorong Li; Christa Montgomery; Simon W. M. John; W. Daniel Stamer; Hao F. Zhang; C. Ross Ethier
TAGS: anterior chamber of eye, aqueous humor, diagnostic imaging, eye, mice, vaccine information sheets, volume, x-ray microtomography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):18. https://doi.org/10.1167/iovs.66.1.18

Includes: Supplemental Content

Perspective December 2024

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

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Ted S. Acott; Michael P. Fautsch; Weiming Mao; C. Ross Ethier; Alex S. Huang; Mary J. Kelley; Mini Aga; Sanjoy K. Bhattacharya; Terete Borras; Diane Bovenkamp; Uttio Roy Chowdhury; Abbot F. Clark; Mohammed I. Dibas; Yiqin Du; Michael H. Elliott; Jennifer A. Faralli; Haiyan Gong; Samuel Herberg; Murray A. Johnstone; Paul L. Kaufman; Kate E. Keller; Ruth A. Kelly; David Krizaj; Markus H. Kuehn; Hoi Lam Li; Raquel Lieberman; Shan C. Lin; Yutao Liu; Fiona S. McDonnell; Colleen M. McDowell; Gillian J. McLellan; Philip Mzyk; Kayarat Saidas Nair; Darryl R. Overby; Donna M. Peters; VijayKrishna Raghunathan; Ponugoti Vasantha Rao; Gavin W. Roddy; Najam A. Sharif; Myoung Sup Shim; Yang Sun; Benjamin R. Thomson; Carol B. Toris; Colin E. Willoughby; Hao F. Zhang; Thomas F. Freddo; Rudolf Fuchshofer; Kamisha R. Hill; Alireza Karimi; Krishnakumar Kizhatil; Casey C. Kopcyznski; Paloma Liton; Gaurang Patel; Michael Peng; Padmanabhan P. Pattabiraman; Ganesh Prasanna; Ester Reina-Torres; E. Griffen Samples; John R. Samples; Cynthia L. Steel; Clemens A. Strohmaier; Preeti Subramanian; Chenna Kesavulu Sugali; Joseph van Batenburg-Sherwood; Cydney Wong; Hannah Youngblood; Gulab S. Zode; Elizabeth White; W. Daniel Stamer
TAGS: body tissue, eye, fluid flow, intraocular pressure, perfusion, regulation, organ culture techniques
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):32. https://doi.org/10.1167/iovs.65.14.32

Data Science December 2024

Development of an Open-Source Dataset of Flat-Mounted Images for the Murine Oxygen–Induced Retinopathy Model of Ischemic Retinopathy

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Kyle V. Marra; Jimmy S. Chen; Hailey K. Robles-Holmes; Kristine B. Ly; Joseph Miller; Guoqin Wei; Edith Aguilar; Felicitas Bucher; Yoichi Ideguchi; Fritz Gerald P. Kalaw; Andrew C. Lin; Napoleone Ferrara; J. Peter Campbell; Martin Friedlander; Eric Nudleman
TAGS: datasets, ischemia, mice, oxygen, retinal diseases
Trans. Vis. Sci. Tech.. 2024; 13(12):4. https://doi.org/10.1167/tvst.13.12.4

Includes: Supplemental Content

Cornea November 2024

Restoration of Corneal Stiffness in Rabbits Following Withdrawal of Travoprost

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XiaoBo Zheng; Chong Wang; YiWen Fan; YuXin Hong; Han Bao; ErChi Zhang; Yi Jin; Peng Yang; LingQiao Li; JunJie Wang; ShiHao Chen; Ahmed Elsheikh; FangJun Bao
TAGS: cornea, oryctolagus cuniculus, travoprost, cardiac ct, multiple wake test, eye
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):35. https://doi.org/10.1167/iovs.65.13.35

Retinal Cell Biology November 2024

Single-Cell Multiomics Profiling Reveals Heterogeneity of Müller Cells in the Oxygen-Induced Retinopathy Model

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Xueming Yao; Ziqi Li; Yi Lei; Qiangyun Liu; Siyue Chen; Haokun Zhang; Xue Dong; Kai He; Ju Guo; Mulin Jun Li; Xiaohong Wang; Hua Yan
TAGS: astrocytes, genes, heterogeneity, mice, multiomics, oxygen, retinal diseases, small nuclear rna, cell communication, retina
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):8. https://doi.org/10.1167/iovs.65.13.8

Includes: Supplemental Content

Retina October 2024

Optical Coherence Tomography Split-Spectrum Amplitude-Decorrelation Optoretinography Detects Early Central Cone Photoreceptor Dysfunction in Retinal Dystrophies

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Nida Wongchaisuwat; Alessia Amato; Paul Yang; Lesley Everett; Mark E. Pennesi; David Huang; Siyu Chen
TAGS: optical coherence tomography, pathophysiology, retinal cone, retinal dystrophies, diagnostic imaging, eye
Trans. Vis. Sci. Tech.. 2024; 13(10):5. https://doi.org/10.1167/tvst.13.10.5

Includes: Supplemental Content

Multidisciplinary Ophthalmic Imaging September 2024

Plexus-Specific Retinal Capillary Blood Flow Analysis Using Erythrocyte Mediated Angiography and Optical Coherence Tomography Angiography

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Victoria Y. Chen; Jessica A. Pottenburgh; Shih-En Chen; Sarah Kim; Lakyn Mayo; Aashka Damani; Marvin Cruz; Ashley Park; Lily Im; Laurence Magder; Osamah J. Saeedi
TAGS: angiogram, blood capillaries, erythrocytes, vascular flow, velocity, optical coherence tomography, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):33. https://doi.org/10.1167/iovs.65.11.33

Includes: Supplemental Content

Vision Sciences Society Annual Meeting Abstract September 2024

From attention capture to social coordination: “Abrupt onset” rallies joint planning

Shaozhe Cheng; Jingyin Zhu; Jifan Zhou; Mowei Shen; Tao Gao

Journal of Vision. 2024; 24(10):798. https://doi.org/10.1167/jov.24.10.798

Vision Sciences Society Annual Meeting Abstract September 2024

Possible Optimal Strategies for Orientation Coding in Macaque V1 Revealed with a Self-Attention Deep Neural Network (SA-DNN) Model

Xin Wang; Cai-Xia Chen; Sheng-Hui Zhang; Dan-Qing Jiang; Shu-Chen Guan; Shi-Ming Tang; Cong Yu

Journal of Vision. 2024; 24(10):433. https://doi.org/10.1167/jov.24.10.433

Vision Sciences Society Annual Meeting Abstract September 2024

Age-related differences in detecting facial emotion changes: unveiling the impact of dynamic stimuli on sensitivity

Su-Ling Yeh; Po-Cheng Huang; Yu-Shan Chen; Yi-Chuan Chen

Journal of Vision. 2024; 24(10):356. https://doi.org/10.1167/jov.24.10.356

Clinical and Epidemiologic Research August 2024

Long-Term Prediction and Risk Factors for Incident Visual Field Defect in Nonpathologic High Myopia

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Cong Li; Yanping Chen; Shaopeng Yang; Ruilin Xiong; Riqian Liu; Ziyu Zhu; Shida Chen; Mingguang He; Wei Wang
TAGS: myopia, visual field defects, risk factors
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):43. https://doi.org/10.1167/iovs.65.10.43

Includes: Supplemental Content

Retina August 2024

Optical Assessment of Photoreceptor Function Over the Macula

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Shuibin Ni; Shanjida Khan; Alfonso Jiménez-Villar; Mark E. Pennesi; David Huang; Yifan Jian; Siyu Chen
TAGS: diagnostic imaging, macula lutea, optics, photoreceptors, retinal cone
Trans. Vis. Sci. Tech.. 2024; 13(8):41. https://doi.org/10.1167/tvst.13.8.41

Includes: Supplemental Content

Lens August 2024

Biologically Relevant Laminin-511 Moderates the Derivation and Proliferation of Human Lens Epithelial Stem/Progenitor-Like Cells

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Jinyan Li; Jingyu Ma; Yijia Chen; Shuyi Chen; Lixia Luo; Hao Cheng
TAGS: epithelium, laminin, lens cell, lens, crystalline, pax6 transcription factor, crystallins, lens (device), genes, protein isoforms
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):12. https://doi.org/10.1167/iovs.65.10.12

Includes: Supplemental Content

Glaucoma August 2024

GSK3β Inhibitors Inhibit TGFβ Signaling in the Human Trabecular Meshwork

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Chenna Kesavulu Sugali; Naga Pradeep Rayana; Jiannong Dai; Devon H. Harvey; Kamesh Dhamodaran; Weiming Mao
TAGS: proteins, signal transduction, trabecular meshwork, perfusion, luciferases
Invest. Ophthalmol. Vis. Sci.. 2024; 65(10):3. https://doi.org/10.1167/iovs.65.10.3

Includes: Supplemental Content

Glaucoma July 2024

Pigment Dispersion Contributes to Ocular Immune Privilege in a DBA/2J Mouse Model of Pigmentary Glaucoma

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Qian Li; Liping Pu; Sijie Cheng; Shaoping Tang; Jingxue Zhang; Guoping Qing
TAGS: mice, pigment, immune privilege, glaucoma, pigmentary, particle, hypertension
Invest. Ophthalmol. Vis. Sci.. 2024; 65(8):51. https://doi.org/10.1167/iovs.65.8.51

ARVO Imaging in the Eye Conference Abstract July 2024

Method of Applying Deep Learning Model (DLM) Trained on OCT Images of Lower Axial Resolution to Images of Higher Axial Resolution without Model Retraining for Retinal Layer Segmentation

Yi-Zhong Wang; Mark E. Pennesi; Siyu Chen; David G. Birch

Invest. Ophthalmol. Vis. Sci.. 2024; 65(9):PB0013.

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Instrumenting Carotid Sonography Biomarkers and Polygenic Risk Score As a Novel Screening Approach for Retinal Detachment

Dicer Loss in Müller Glia Leads to a Defined Sequence of Pathological Events Beginning With Cone Dysfunction

Characterization, Enrichment, and Computational Modeling of Cross-Linked Actin Networks in Transformed Trabecular Meshwork Cells

Robotic Visible-Light Optical Coherence Tomography Visualizes Segmental Schlemm's Canal Anatomy and Segmental Pilocarpine Response

In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

Development of an Open-Source Dataset of Flat-Mounted Images for the Murine Oxygen–Induced Retinopathy Model of Ischemic Retinopathy

Restoration of Corneal Stiffness in Rabbits Following Withdrawal of Travoprost

Single-Cell Multiomics Profiling Reveals Heterogeneity of Müller Cells in the Oxygen-Induced Retinopathy Model

Optical Coherence Tomography Split-Spectrum Amplitude-Decorrelation Optoretinography Detects Early Central Cone Photoreceptor Dysfunction in Retinal Dystrophies

Plexus-Specific Retinal Capillary Blood Flow Analysis Using Erythrocyte Mediated Angiography and Optical Coherence Tomography Angiography

From attention capture to social coordination: “Abrupt onset” rallies joint planning

Possible Optimal Strategies for Orientation Coding in Macaque V1 Revealed with a Self-Attention Deep Neural Network (SA-DNN) Model

Age-related differences in detecting facial emotion changes: unveiling the impact of dynamic stimuli on sensitivity

Long-Term Prediction and Risk Factors for Incident Visual Field Defect in Nonpathologic High Myopia

Optical Assessment of Photoreceptor Function Over the Macula

Biologically Relevant Laminin-511 Moderates the Derivation and Proliferation of Human Lens Epithelial Stem/Progenitor-Like Cells

GSK3β Inhibitors Inhibit TGFβ Signaling in the Human Trabecular Meshwork

Pigment Dispersion Contributes to Ocular Immune Privilege in a DBA/2J Mouse Model of Pigmentary Glaucoma

Method of Applying Deep Learning Model (DLM) Trained on OCT Images of Lower Axial Resolution to Images of Higher Axial Resolution without Model Retraining for Retinal Layer Segmentation

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