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ARVO Annual Meeting Abstract June 2023

Neuroprotection based on a gene therapy approach for long-term expression of PEDF in retinitis pigmentosa mutant retinas

Valeria Marigo; Andrea Bighinati; Elisa Adani; Maria Claudia Gargini; Ilaria Piano; S. Patricia Becerra

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3853.

ARVO Annual Meeting Abstract June 2022

Ablation of pigment epithelium-derived factor receptor, PEDF-R, causes photoreceptor degeneration Alexandra Bernardo-Colón 1 , Lijin Dong 2 , Mones Abu-Asab 3 , and S. Patricia Becerra 1 1. Section of Protein Structure and Function, LRCMB; 2. Genetic Engineering Core; 3. Section of Histopathology, NEI-NIH

Alexandra Bernardo- Colón; Ligin Dong; Mones Abu-Asab; S Patricia Becerra

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1787 – F0336.

ARVO Annual Meeting Abstract June 2021

Drusen proteins are released in association with exosomes

Miguel Flores-Bellver; Jason Mighty; Silvia Aparicio-Domingo; Kang Li; Cui Shi; Hannah Cobb; Jing Zhou; Patricia Lenhart; German Ariel Michelis; Andrew E Goodspeed; Søren Heissel; Christina Coughlan; S Patricia Becerra; Stephen M Redenti; Valeria Canto Soler

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2225.

ARVO Annual Meeting Abstract June 2021

PEDF protects photoreceptors via a CRX-dependent mechanism

Ivan Rebustini; S Patricia Becerra

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2966.

Biochemistry and Molecular Biology February 2021

Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R)

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Jeanee Bullock; Federica Polato; Mones Abu-Asab; Alexandra Bernardo-Colón; Elma Aflaki; Martin-Paul Agbaga; S. Patricia Becerra
TAGS: catabolism, epithelium, lipids, mice, phagocytosis, photoreceptors, pigment, proteins, retinal pigment epithelium, rhodopsin
Invest. Ophthalmol. Vis. Sci.. 2021; 62(2):30. https://doi.org/10.1167/iovs.62.2.30

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

PNPLA 2 is required for the degradation of Photoreceptor Outer Segments by the RPE

Federica Polato; Jeanee Bullock; S Patricia Becerra

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1505.

ARVO Annual Meeting Abstract June 2020

Peptides derived from Pigmented Epithelium-derived Factor (PEDF) prevent apoptosis and promote apical localization of rhodopsin in retinal photoreceptors

German Ariel Michelis; Olga Lorena German; Nora Rotstein; Luis Enrique Politi; S Patricia Becerra

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2488.

ARVO Annual Meeting Abstract July 2018

Neuroprotection of photoreceptors bearing the P23H mutation in Rhodopsin

Valeria Marigo; Antonella Comitato; Clara La Marca; Davide Schiroli; Preeti Subramanian; Manel Llado; S Patricia Becerra; Alberto Auricchio

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2488.

ARVO Annual Meeting Abstract June 2017

Novel therapeutic approaches for Retinitis Pigmentosa caused by mutations in Rhodopsin

Valeria Marigo; Antonella Comitato; Clara La Marca; Preeti Subramanian; Angelo Felline; Francesca Fanelli; S Patricia Becerra

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4552.

ARVO Annual Meeting Abstract June 2017

Effects of two SERPINS on ARPE-19 Cells after Acute Induced-NaIO 3 Damage

Francisco M Nadal-Nicolas; Sofia P Becerra

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5357.

ARVO Annual Meeting Abstract September 2016

Study of the neuroprotective effects of BDNF, bFGF, CNTF or several doses of PEDF in a focal Light-emission-diode (LED) - induced phototoxicity model in adult albino mice

F Javier Valiente-Soriano; Diego García-Ayuso; Arturo Ortin-Martinez; Manuel Jimenez-Lopez; Yolanda Caja-Matas; Antonio Cánovas-León; Jose Manuel Bernal-Garro; S Patricia Becerra; María Paz Villegas-Pérez; Manuel Vidal-Sanz

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):186.

ARVO Annual Meeting Abstract September 2016

Pigment epithelium-derived factor (PEDF) prevents apoptosis and promotes apical localization of opsin in retina photoreceptors

S Patricia Becerra; Germán Michelis; Lorena Germán; Nora Patricia Rotstein; Luis Politi

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):188.

ARVO Annual Meeting Abstract September 2016

Protease Nexin-1 (PN-1): A Novel Survival Factor for Retina Cells

Preeti Subramanian; Jeanee Bullock; Paige Winokur; Veronique Arocas; S. Patricia Becerra

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1738.

ARVO Annual Meeting Abstract September 2016

Expression, purification and characterization of a membrane-bound receptor for PEDF

Jeanee Bullock; Preeti Subramanian; S Patricia Becerra

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4806.

Biochemistry and Molecular Biology September 2016

A Novel Inhibitor of 5-Lipoxygenase (5-LOX) Prevents Oxidative Stress–Induced Cell Death of Retinal Pigment Epithelium (RPE) Cells

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Preeti Subramanian; Emily F. Mendez; S. Patricia Becerra
TAGS: arachidonate 5-lipoxygenase, cell death, oxidative stress, peptides, retinal pigment cell, leukotriene b4, retinal pigment epithelium, lipoxygenase, hydrogen peroxide
Invest. Ophthalmol. Vis. Sci.. 2016; 57(11):4581-4588. https://doi.org/10.1167/iovs.15-19039

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2013

A 34-amino acid region of PEDF protects the RPE barrier from VEGF-induced breakdown

Danielle Desjardins; Mohammad Dahrouj; Jason Kenealey; S Patricia Becerra; Yueying Liu; Kumar Sambamurti; Craig Crosson; Zsolt Ablonczy

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1187.

ARVO Annual Meeting Abstract June 2013

Mapping the Receptor-binding Site on PEDF: Implications for a Neurotrophic Role of PEDF-R

Jason Kenealey; Preeti Subramanian; David Hoover; S Patricia Becerra

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):700.

ARVO Annual Meeting Abstract March 2012

Pigment Epithelium-derived Factor Inhibits Neuroretinal Apoptosis in a Murine Model of Focal Retinal Degeneration

Yujuan Wang; Defen Shen; Jingsheng Tuo; Preeti Subramanian; S. Patricia Becerra; Chi-Chao Chan

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):4278.

Biochemistry and Molecular Biology March 2010

Effects of Human Recombinant PEDF Protein and PEDF-Derived Peptide 34-mer on Choroidal Neovascularization

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Juan Amaral; S. Patricia Becerra
TAGS: choroidal neovascularization, peptides, proteins, lasers
Invest. Ophthalmol. Vis. Sci.. 2010; 51(3):1318-1326. https://doi.org/10.1167/iovs.09-4455

Includes: Supplemental Content

Biochemistry and Molecular Biology November 2009

Doxycycline-Mediated Inhibition of Choroidal Neovascularization

PDF

Sonia Samtani; Juan Amaral; Maria M. Campos; Robert N. Fariss; S. Patricia Becerra
TAGS: choroidal neovascularization, doxycycline, gelatinase a, gelatinase b
Invest. Ophthalmol. Vis. Sci.. 2009; 50(11):5098-5106. https://doi.org/10.1167/iovs.08-3174

Includes: Supplemental Content

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Neuroprotection based on a gene therapy approach for long-term expression of PEDF in retinitis pigmentosa mutant retinas

Drusen proteins are released in association with exosomes

PEDF protects photoreceptors via a CRX-dependent mechanism

Degradation of Photoreceptor Outer Segments by the Retinal Pigment Epithelium Requires Pigment Epithelium-Derived Factor Receptor (PEDF-R)

PNPLA 2 is required for the degradation of Photoreceptor Outer Segments by the RPE

Peptides derived from Pigmented Epithelium-derived Factor (PEDF) prevent apoptosis and promote apical localization of rhodopsin in retinal photoreceptors

Neuroprotection of photoreceptors bearing the P23H mutation in Rhodopsin

Novel therapeutic approaches for Retinitis Pigmentosa caused by mutations in Rhodopsin

Effects of two SERPINS on ARPE-19 Cells after Acute Induced-NaIO 3 Damage

Study of the neuroprotective effects of BDNF, bFGF, CNTF or several doses of PEDF in a focal Light-emission-diode (LED) - induced phototoxicity model in adult albino mice

Pigment epithelium-derived factor (PEDF) prevents apoptosis and promotes apical localization of opsin in retina photoreceptors

Protease Nexin-1 (PN-1): A Novel Survival Factor for Retina Cells

Expression, purification and characterization of a membrane-bound receptor for PEDF

A Novel Inhibitor of 5-Lipoxygenase (5-LOX) Prevents Oxidative Stress–Induced Cell Death of Retinal Pigment Epithelium (RPE) Cells

A 34-amino acid region of PEDF protects the RPE barrier from VEGF-induced breakdown

Mapping the Receptor-binding Site on PEDF: Implications for a Neurotrophic Role of PEDF-R

Pigment Epithelium-derived Factor Inhibits Neuroretinal Apoptosis in a Murine Model of Focal Retinal Degeneration

Effects of Human Recombinant PEDF Protein and PEDF-Derived Peptide 34-mer on Choroidal Neovascularization

Doxycycline-Mediated Inhibition of Choroidal Neovascularization

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