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Meeting Abstract (246)
Journal Articles (53)

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Investigative Ophthalmology & Visual Science (298)
Translational Vision Science & Technology (1)

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ARVO Annual Meeting Abstract (246)
Cornea (41)
Immunology and Microbiology (6)
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Eye Anatomy and Disorders (51)
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cornea (25)
mice (23)
dry eye syndromes (21)
conjunctiva (17)
stress (12)
gelatinase b (10)
epithelium (9)
corneal epithelial cells (8)
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ARVO Annual Meeting Abstract June 2025

Investigating IL-2 Epithelial Signaling Pathways in Human Corneal Epithelial Cells

Fairouz Elsaeidi; Sonali Pal-Ghosh; Zhiyuan Yu; Stephen C Pflugfelder; Sumitra Khandelwal; Mitchell Weikert; Mary Ann Stepp; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4413.

ARVO Annual Meeting Abstract June 2025

NEt-3IB promotes resident regulatory macrophage differentiation and improves the ocular surface in desiccation-induced dry eye

Stephen C Pflugfelder; Ebru Yaman; Karen Zheng; Nicole Heyer; Hiroki Kakuta; Jahan Alam

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4626.

ARVO Annual Meeting Abstract June 2025

Investigating the ocular surface microbiome using a culturomics approach

Claire Bason; Taylor Robinson; Alfredo Calderon-Macedo; José Cantu; Samantha Venables; Karolina Szenkiel; Astrid Baeza Arana; Kristi Hoffman; Eric L Brown; Stephen C Pflugfelder; Cintia S De Paiva; Robert Britton; Laura Schaefer

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1789.

ARVO Annual Meeting Abstract June 2025

Aging and dry eye alter corneal sensitivity to mechanical and chemical stimulation

Ebru Yaman; Yangluowa Qu; Kaylin Christine Arpaia; Fairouz Elsaeidi; Rui Chen; Mary Ann Stepp; Cintia S De Paiva; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1574.

Cornea October 2024

Mouse Corneal Immune Cell Heterogeneity Revealed by Single-Cell RNA Sequencing

PDF

Ebru Yaman; Nicole Heyer; Cintia S. de Paiva; Mary Ann Stepp; Stephen C. Pflugfelder; Jehan Alam
TAGS: cornea, mice, rna, small cytoplasmic, heterogeneity, sequence analysis, rna, rna-seq, genes, gene expression
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):29. https://doi.org/10.1167/iovs.65.12.29

Includes: Supplemental Content

Cornea June 2024

Ectoine Enhances Mucin Production Via Restoring IL-13/IFN-γ Balance in a Murine Dry Eye Model

PDF

Na Lin; Xin Chen; Haixia Liu; Ning Gao; Zhao Liu; Jin Li; Stephen C. Pflugfelder; De-Quan Li
TAGS: dry eye syndromes, interleukin-13, mice, mucins, ocular surfaces, conjunctiva, balance, device, equilibrium
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):39. https://doi.org/10.1167/iovs.65.6.39

ARVO Annual Meeting Abstract June 2024

Conjunctival transcriptome changes in Sjögren Syndrome and non-Sjögren Syndrome aqueous-tear-deficient dry eye

Cintia S De Paiva; Stephen C Pflugfelder; Zhiyuan Yu; Robert Britton; Laura Schaefer; Kaitlin Scholand

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):412.

ARVO Annual Meeting Abstract June 2024

A Novel Dual Anti-Angiogenic and Anti-Opacity Therapy of Corneal Injury

Remya Ammassam Veettil; Hong Tian; Stephen C Pflugfelder; Wei Li; Douglas Donald Koch

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2920.

ARVO Annual Meeting Abstract June 2024

Single cell analysis of desiccation induced changes in cornea immune cell populations

Jahan Alam; Ebru Yaman; Gerda Cristal Villalba Silva; Rui Chen; Cintia S De Paiva; Mary Ann Stepp; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2908.

ARVO Annual Meeting Abstract June 2024

Novel Protective Effects of Ectoine on Ocular Surface Inflammation in a Murine Dry Eye Model

XIN CHEN; Na Lin; Jinmiao Li; Haixia Liu; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3608.

ARVO Annual Meeting Abstract June 2024

Spatially Resolved Single-Cell Atlas of Mouse Trigeminal Ganglion by MERFISH

Soo Hwan Oh; Gerda Cristal Villalba Silva; Jongsu Choi; Fairouz Elsaeidi; Ebru Yaman; Stephen C Pflugfelder; Rui Chen

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5820.

ARVO Annual Meeting Abstract June 2024

Severe dry eye and ocular surface inflammation in vitamin A deficient Lrat -/- Rpb -/- mice

Stephen C Pflugfelder; Ebru Yaman; Jahan Alam

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5742.

ARVO Annual Meeting Abstract June 2024

Novel role and regulatory mechanism of IL-36 family cytokines in dry eye models in vitro and in vivo

De-Quan Li; Jinmiao Li; XIN CHEN; Na Lin; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5737.

ARVO Annual Meeting Abstract June 2024

Ectoine Preserves Corneal Barrier via Suppressing IL-36α signaling pathway in Experimental Dry Eye Model

Na Lin; XIN CHEN; Haixia Liu; Cintia S De Paiva; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5720.

Cornea & External Disease June 2023

Differentially Expressed Tear Proteins in Sjögren's Syndrome Keratoconjunctivitis Sicca

PDF

Stephen P. Yoon; Zhiyuan Yu; Stephen C. Pflugfelder; Cintia S. de Paiva
TAGS: proteins, sjogren's syndrome, keratoconjunctivitis sicca
Trans. Vis. Sci. Tech.. 2023; 12(6):8. https://doi.org/10.1167/tvst.12.6.8

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

A Pooled Analysis Evaluating Visual Acuity in Patients with Neurotrophic Keratitis on Cenegermin (rhNGF) Treatment versus Vehicle

Yureeda Qazi; Stephen C Pflugfelder; Mina Massaro-Giordano; Natalie A Afshari; Flavio Mantelli

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5131.

ARVO Annual Meeting Abstract June 2023

Desiccation induced changes in cell number, gene expression profiles and transcriptional trajectories in conjunctival myeloid cells

Stephen C Pflugfelder; Jahan Alam; Cintia S. De Paiva; De-Quan Li; Ghasem Yasdanpanah; Kaitlyn Xiong; Zhen Zhong

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):681.

ARVO Annual Meeting Abstract June 2023

Retinoic acid receptor X alpha mutant strain develops meibomian gland disease with aging

Ebru Yaman; Igor A Butovich; Jahan Alam; Amber Wilkerson; Ghasem Yasdanpanah; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):171.

ARVO Annual Meeting Abstract June 2023

Characterization of transit-amplifying cells in human corneal limbus using single cell transcriptomics

De-Quan Li; Jin-Miao Li; Fang Bian; Xin Chen; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):971.

ARVO Annual Meeting Abstract June 2023

Probiotic Limosilactobacillus reuteri DSM 17938 suppresses corneal barrier dysfunction and conjunctival goblet cell reduction in mice subjected to desiccating stress

Laura Schaefer; Stephen C Pflugfelder; Robert Britton; Cintia S. De Paiva

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):697.

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