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Lens May 2025

LncRNA HOTAIR Interaction With WTAP Promotes m 6 A Methyltransferase Complex Assembly and Posterior Capsule Opacification Formation by Increasing THBS1

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Xi Chen; Chenshuang Li; Jiankui Li; Zaoxia Guo; Siqi Zhang; Chenjun Guo; Hong Yan
TAGS: after-cataract, epithelial to mesenchymal transition, methyltransferase, proteins, rna, thrombospondin 1, western blotting, protein overexpression, polymerase chain reaction, cataract surgery
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):20. https://doi.org/10.1167/iovs.66.5.20

Includes: Supplemental Content

Retina April 2025

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

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Xing Wei; Sisi Ma; Yunyu Zhou; Haoliang Cui; Shan Zhang; Duanyang Wang; Yingying Fu; Wei Li; Huihui Han; Yamei Li; Wuyi Li; Huixin Liu; Zixi Sun; Xiaoxu Han; Xuan Zou; Hui Li; Cheng Wang; Ruifang Sui
TAGS: electroretinography, mice, gene therapy, capsid
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):37. https://doi.org/10.1167/iovs.66.4.37

Includes: Supplemental Content

Cornea March 2025

The Spatial Transcriptomic Atlas of Human Limbus and Vital Niche Microenvironment Regulating the Fate of Limbal Epithelial Stem Cells

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Shiding Li; Hao Sun; Fei Fang; Siyi Zhang; Junzhao Chen; Chunyi Shao; Yao Fu; Liangbo Chen
TAGS: body tissue, cell communication, cornea, epithelial stem cells, epithelium, fluorescent antibody technique, genes, rna, small cytoplasmic, transcriptomics, melanocytes
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):52. https://doi.org/10.1167/iovs.66.3.52

Includes: Supplemental Content

Retina February 2025

Metabolomic Characteristics of Aqueous Humor in Wet Age-Related Macular Degeneration and the Impact of Anti-VEGF Treatment

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Yijing Chen; Xiaoya Zhang; Yanli Zhang; Shian Zhang; Yu Huo; Yubo Wu; Lijun Shen; Jianbo Mao
TAGS: anti-vascular endothelial growth factor therapy, aqueous humor, exudative age-related macular degeneration, metabolites, metabolomics
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):37. https://doi.org/10.1167/iovs.66.2.37

Includes: Supplemental Content

Retina February 2025

Relationship of OCT-Based Diabetic Retinal Neurodegeneration to the Development and Progression of Diabetic Retinopathy: A Cohort Study

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Ziqi Tang; Dawei Yang; Truong X. Nguyen; Shuyi Zhang; Danqi Fang; Victor T. T. Chan; Clement C. Tham; Elliott H. Sohn; Ken K. Tsang; Cherie Y. K. Wong; Vivian W. K. Hui; Amy H. Y. Yu; Julia T. W. Lam; Carmen K. M. Chan; Timothy Y. Y. Lai; Simon K. H. Szeto; Carol Y. Cheung
TAGS: cohort studies, diabetes mellitus, diabetic retinopathy, dorsal raphe nucleus, nerve degeneration, eye, retinal nerve fiber layer
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):32. https://doi.org/10.1167/iovs.66.2.32

Includes: Supplemental Content

Vision Sciences Society Annual Meeting Abstract September 2024

Farewell to the explore-exploit trade-off in large-scale datasets

Tomas Knapen; Nick Hedger; Thomas Naselaris; Shufan Zhang; Martin Hebart

Journal of Vision. 2024; 24(10):150. https://doi.org/10.1167/jov.24.10.150

Vision Sciences Society Annual Meeting Abstract September 2024

Surviving Continuous Flash Suppression: A Two-Photon Calcium Imaging Study in Macaque V1

Cai-Xia Chen; Dan-Qing Jiang; Xin Wang; Sheng-Hui Zhang; Shi-Ming Tang; Cong Yu

Journal of Vision. 2024; 24(10):527. https://doi.org/10.1167/jov.24.10.527

Vision Sciences Society Annual Meeting Abstract September 2024

Possible Optimal Strategies for Orientation Coding in Macaque V1 Revealed with a Self-Attention Deep Neural Network (SA-DNN) Model

Xin Wang; Cai-Xia Chen; Sheng-Hui Zhang; Dan-Qing Jiang; Shu-Chen Guan; Shi-Ming Tang; Cong Yu

Journal of Vision. 2024; 24(10):433. https://doi.org/10.1167/jov.24.10.433

Biochemistry and Molecular Biology September 2024

The Effects of STRA6 Regulation of the Circadian Rhythm on Choroidal Neovascularization

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Ying Yang; Shenglai Zhang; Shu Su; Xiaowei Yang; Jia Chen; Aimin Sang
TAGS: choroidal neovascularization, circadian rhythms, mice, circadian rhythm disorders, proteins, vascular endothelial growth factor a
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):21. https://doi.org/10.1167/iovs.65.11.21

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Characteristics of design and statistical analysis of randomized clinical trials for dry eye disease: A review of primary result papers from dry eye treatment trials

Sifan Zhang; Anny Zhong; Gui-Shuang Ying

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2964.

ARVO Annual Meeting Abstract June 2024

Using a Deep Learning-based OCT Image Analysis for Diabetic Macular Edema Identification to Support Triage Screening: a Prospective Study

Shuyi Zhang; Anran Ran; Dawei Yang; Truong Xuan Nguyen; Ziqi Tang; Anni Ling; Kaiser Sham; Carman Chan; Simon Szeto; Carol Cheung

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4924.

ARVO Annual Meeting Abstract June 2024

Inhibition of rapamycin-insensitive mTORC1 /4E-BP1 axis attenuates TGF-β1-induced Fibrotic Response in Human Tenon's Fibroblasts

shaodan Zhang; Jiayu Zou; Binrong Wu; Yan Tao; Zuimeng Liu; Yuanbo Liang

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5132.

ARVO Annual Meeting Abstract June 2024

In vivo Imaging and Quantification of Retinal and Choroidal Vasculature in Cynomolgus Monkeys using Optical Coherence Tomography Angiography

Jin Cai; Qin Liao; Yanlin Zhang; Sucai Zhang; Wankun Xie

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5576.

ARVO Annual Meeting Abstract June 2024

Simultaneous Assessment of Vascular Responses and Oxygen Saturation Changes to Hypercapnia in Diabetic Mouse Retinas Using Dual-Color Optical Coherence Tomography

Chao Ren; Marcello Magri Amaral; Sheng Zhang; Aaron Adkins; Senyue Hao; Hongwu Liang; Rithwick Rajagopal; Chao Zhou

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5577.

ARVO Annual Meeting Abstract June 2024

A laser-induced retinal atrophy model in cynomolgus monkeys

FEGN GAO; Zhaohui Yan; Qin Liao; Yanlin Zhang; Sucai Zhang; Wankun Xie

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):757.

ARVO Annual Meeting Abstract June 2024

HG004 Gene Therapy for Patients with Leber Congenital Amaurosis

Alvin Luk; Ping Fei; Yuan Yang; Jie Peng; Xiang Zhang; Yanfei Wang; Shuaishuai Zhang; Xuan Yao; Yiqun Yuan; Peiquan Zhao

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3286.

ARVO Annual Meeting Abstract June 2024

World's First CRISPR/RNA-Targeting Therapy (HG202) for Patients with Neovascular Age-Related Macular Degeneration

Alvin Luk; Dongjun Xing; Boshi Liu; Weiwei Liu; Shuaishuai Zhang; Yuhan Jiang; Xuan Yao; Linyu Shi; Hui Yang; Yiqun Yuan; Xiaorong Li

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4357.

ARVO Annual Meeting Abstract June 2024

Perivascular Neurons Instruct Three-Dimensional Retinal Vascular Lattice Formation via Direct Neurovascular Contact

Kenichi Toma; Mengya Zhao; Shaobo Zhang; Shweta Modgil; Wenhao Shang; Yaping Joyce Liao; Tyson Kim; Xin Duan

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4348.

ARVO Annual Meeting Abstract June 2024

Changes in retinal and optic microglia and astrocytes in mice of different ages after optic nerve crush

Zongyi Zhan; Yiru Huang; Zijing Li; Difang Sun; Kaili Wu; Yuqing Lan; Minbin Yu; Shaochong Zhang

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6765.

ARVO Annual Meeting Abstract June 2024

Inhibition of BAX/BAK-mediated apoptosis promotes retinal ganglion cell maintenance in human retinal organoids

Jingliang Simon Zhang; Robert Johnston

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):951.

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LncRNA HOTAIR Interaction With WTAP Promotes m 6 A Methyltransferase Complex Assembly and Posterior Capsule Opacification Formation by Increasing THBS1

A Novel AAV Capsid-Mediated RS1 Gene Therapy Restored Retinal Function to Wild-Type Levels in Rs1 R213W Mouse Model

The Spatial Transcriptomic Atlas of Human Limbus and Vital Niche Microenvironment Regulating the Fate of Limbal Epithelial Stem Cells

Metabolomic Characteristics of Aqueous Humor in Wet Age-Related Macular Degeneration and the Impact of Anti-VEGF Treatment

Relationship of OCT-Based Diabetic Retinal Neurodegeneration to the Development and Progression of Diabetic Retinopathy: A Cohort Study

Farewell to the explore-exploit trade-off in large-scale datasets

Surviving Continuous Flash Suppression: A Two-Photon Calcium Imaging Study in Macaque V1

Possible Optimal Strategies for Orientation Coding in Macaque V1 Revealed with a Self-Attention Deep Neural Network (SA-DNN) Model

The Effects of STRA6 Regulation of the Circadian Rhythm on Choroidal Neovascularization

Characteristics of design and statistical analysis of randomized clinical trials for dry eye disease: A review of primary result papers from dry eye treatment trials

Using a Deep Learning-based OCT Image Analysis for Diabetic Macular Edema Identification to Support Triage Screening: a Prospective Study

Inhibition of rapamycin-insensitive mTORC1 /4E-BP1 axis attenuates TGF-β1-induced Fibrotic Response in Human Tenon's Fibroblasts

In vivo Imaging and Quantification of Retinal and Choroidal Vasculature in Cynomolgus Monkeys using Optical Coherence Tomography Angiography

Simultaneous Assessment of Vascular Responses and Oxygen Saturation Changes to Hypercapnia in Diabetic Mouse Retinas Using Dual-Color Optical Coherence Tomography

A laser-induced retinal atrophy model in cynomolgus monkeys

HG004 Gene Therapy for Patients with Leber Congenital Amaurosis

World's First CRISPR/RNA-Targeting Therapy (HG202) for Patients with Neovascular Age-Related Macular Degeneration

Perivascular Neurons Instruct Three-Dimensional Retinal Vascular Lattice Formation via Direct Neurovascular Contact

Changes in retinal and optic microglia and astrocytes in mice of different ages after optic nerve crush

Inhibition of BAX/BAK-mediated apoptosis promotes retinal ganglion cell maintenance in human retinal organoids

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