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Physiology and Pharmacology June 2021

Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration

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John T. Demirs; Junzheng Yang; Maura A. Crowley; Michael Twarog; Omar Delgado; Yubin Qiu; Stephen Poor; Dennis S. Rice; Thaddeus P. Dryja; Karen Anderson; Sha-Mei Liao
TAGS: complement system proteins, eye, rna, messenger, age-related macular degeneration, choroid, neural retina, donors
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):26. doi: https://doi.org/10.1167/iovs.62.7.26

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Identification of a spontaneous mutation in Adiponectin receptor 1 in a complement factor H knockout mouse

JUNZHENG YANG; Angela Banks; Natasha M Buchanan; Sha-Mei Liao; Erika Lima; Nalini Rangaswamy; Ivana Arellano; Shawn Hanks; Joanna Vrouvlianis; Yubin Qiu; Dennis S Rice

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2948. doi:

ARVO Annual Meeting Abstract July 2019

Overexpression of HTRA1 in mice compromises the extracellular matrix integrity in Bruch’s membrane and choroidal/retinal vasculature

Omar Delgado; erika lima; Natasha Buchanan; Hui Li; Joanna Vrouvlianis; Barrett Leehy; Chad E Bigelow; Junzheng Yang; Jean-Rene Galarneau; Emily Meseck; Christopher Hayden; Stephen H Poor; Sha-Mei Liao

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1233. doi:

ARVO Annual Meeting Abstract July 2019

Complement factor B is necessary for sub-RPE deposit formation in Efemp1 R345W /R345W knock-in mice

Maura Crowley; Donita Garland; Rosario Fernandez-Godino; Tomas Rejtar; Natasha Buchanan; Karen Anderson; Holger Sellner; Muneto Mogi; Y. Karen Wang; Bruce Jaffee; Stephen H Poor; Thaddeus Dryja; Eric A Pierce; Sha-Mei Liao

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1241. doi:

ARVO Annual Meeting Abstract July 2019

Development of anti-drug antibodies following intravitreal administration of anti-C3b Fabs in cynomolgus monkeys and rabbits

Michael Twarog; Steve Louie; Mark Milton; Ana Carrion; Omar Delgado; Maura Crowley; Natasha Buchanan; Shawn Hanks; John T Demirs; Chad E Bigelow; Stephen H Poor; Yong-in Kim; Sha-Mei Liao

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4014. doi:

ARVO Annual Meeting Abstract July 2018

Retinal degeneration and subretinal Iba1 + accumulation in complement factor H-deficient mice are associated with increased gene expression of phagocytic markers

Natasha Buchanan; Erika Queiroz; John Demirs; Junzheng Yang; Barrett Leehy; Nalini Rangaswamy; Ivana Arellano; Maura Crowley; Chad E Bigelow; Karen Anderson; Sha-Mei Liao

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):990. doi:

Physiology and Pharmacology February 2018

Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

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Maura A. Crowley; Omar Delgado; Adrian Will-Orrego; Natasha M. Buchanan; Karen Anderson; Bruce D. Jaffee; Thaddeus P. Dryja; Sha-Mei Liao
TAGS: animal model, complement activation, complement factor d, complement system proteins, eye, mice, proteins, plasma, body tissue
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):940-951. doi: https://doi.org/10.1167/iovs.17-22605

ARVO Annual Meeting Abstract June 2017

Deletion of complement factor H is associated with accumulation of subretinal Iba-1-positive cells and retinal degeneration in aged mice

Sha-Mei Liao; Natasha Buchanan; John Demirs; Barrett Leehy; Casey Lewis; Junzheng Yang; Vanessa Davis; Nalini V Rangaswamy; Maura Crowley; Karen Anderson; Chad E Bigelow; Thaddeus P Dryja; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1625. doi:

ARVO Annual Meeting Abstract September 2016

AMD-associated SNPs in the ARMS2/HTRA1 locus influence local gene expression in multiple human tissues

Sha-Mei Liao; casey lewis; Omar Delgado; Maura Crowley; Natasha Buchanan; Wei Zheng; Thaddeus P Dryja; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2629. doi:

ARVO Annual Meeting Abstract September 2016

Ocular complement activation and inhibition in rodent models of endotoxin-induced uveitis

Maura Crowley; Omar Delgado; Karen Anderson; Wei Zheng; Holger Sellner; Nello Mainolfi; Muneto Mogi; Bruce D Jaffee; Sha-Mei Liao

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):482. doi:

ARVO Annual Meeting Abstract September 2016

Ocular inflammatory cell infiltrates and angiogenesis are augmented by administration of the toll-like receptor-2 (TLR-2) ligand in a mouse model of choroidal neovascularization (CNV)

Stephen H Poor; Yubin Qiu; Adrian Will-Orrego; Elizabeth Fassbender; Siyuan Shen; Maura Crowley; Sha-Mei Liao; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):484. doi:

ARVO Annual Meeting Abstract September 2016

Systemic VEGF Inhibition does not modulate ocular inflammatory cell infiltrate in the murine laser-induced choroidal neovascularization (CNV) Model

Adrian Will-Orrego; Sha-Mei Liao; Yubin Qiu; Elizabeth Fassbender; Siyuan Shen; Namrata Kotagiri; Bruce D Jaffee; Stephen H Poor

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3323. doi:

ARVO Annual Meeting Abstract September 2016

A novel oral small molecule Factor D inhibitor blocks complement activation in the blood and ocular tissues

Karen Anderson; Sha-Mei Liao; Juergen Maibaum; Frederic Cumin; Omar Delgado; Andrea De Erkenez; Fang Liu; Upendra Argikar; Ron Newton; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4440. doi:

ARVO Annual Meeting Abstract June 2015

Dynamic changes of M1 and M2 macrophages in a murine model of endotoxin-induced uveitis

Omar Delgado; Maura Crowley; Wei Zheng; Casey Lewis; Kathryn McAllister; Bruce D Jaffee; Sha-Mei Liao

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3093. doi:

ARVO Annual Meeting Abstract June 2015

Impaired alternative complement pathway function does not protect against light-induced retinopathy in mice

Shawn M Hanks; Joanna Vrouvlianis; Barrett Leehy; Maura Crowley; Michael Maker; Sha-Mei Liao; Bruce D Jaffee; Chad E Bigelow

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3553. doi:

ARVO Annual Meeting Abstract June 2015

Systemic Inhibition of the EGF Receptor Reduces Leukostasis and Retinal Vascular Leakage in Streptozotocin Induced-Diabetic Rats

Steve Louie; Karen Anderson; Hui Li; Debby Long; Sha-Mei Liao; Bruce D Jaffee; Michael Stefanidakis

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4700. doi:

ARVO Annual Meeting Abstract April 2014

Differential inflammatory stages in the eyes and kidneys of aged complement factor H-deficient mice

Sha-Mei Liao; Natasha M Buchanan; John T Demirs; Karen L Anderson; Shawn M Hanks; Chad E Bigelow; Melinda Hubbard; Wei Zheng; Kathryn H McAllister; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):71. doi:

ARVO Annual Meeting Abstract June 2013

Differential effects of a MyD88 knockout on ocular inflammation induced by the TLR2/3/4 ligands (PAM3CSK4, PolyI:C, and LPS)

Maura Crowley; Omar Delgado; Steve Louie; Michael Stefanidakis; Bruce Jaffee; Sha-Mei Liao

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):167. doi:

ARVO Annual Meeting Abstract June 2013

A comparison of the effects of subretinal injection of scAAV2-CMV-GFP on retinal structure, visual function, and GFP expression by two injectors

Hui Li; Stephen Poor; Chad Bigelow; Vivian Choi; Shawn Hanks; Joanna Vrouvlianis; Michael Maker; Steve Louie; Sha-Mei Liao; Bruce Jaffee

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2740. doi:

ARVO Annual Meeting Abstract June 2013

HtrA1 regulates the subretinal infiltration of microglia cells in response to bacterial lipopolysaccharides (LPS) and aging in mice

Sha-Mei Liao; Maura Crowley; Steve Louie; Omar Delgado; Natasha Buchanan; Michael Stefanidakis; Bruce Jaffee

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):3666. doi:

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Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration

Identification of a spontaneous mutation in Adiponectin receptor 1 in a complement factor H knockout mouse

Overexpression of HTRA1 in mice compromises the extracellular matrix integrity in Bruch’s membrane and choroidal/retinal vasculature

Complement factor B is necessary for sub-RPE deposit formation in Efemp1 R345W /R345W knock-in mice

Development of anti-drug antibodies following intravitreal administration of anti-C3b Fabs in cynomolgus monkeys and rabbits

Retinal degeneration and subretinal Iba1 + accumulation in complement factor H-deficient mice are associated with increased gene expression of phagocytic markers

Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

Deletion of complement factor H is associated with accumulation of subretinal Iba-1-positive cells and retinal degeneration in aged mice

AMD-associated SNPs in the ARMS2/HTRA1 locus influence local gene expression in multiple human tissues

Ocular complement activation and inhibition in rodent models of endotoxin-induced uveitis

Ocular inflammatory cell infiltrates and angiogenesis are augmented by administration of the toll-like receptor-2 (TLR-2) ligand in a mouse model of choroidal neovascularization (CNV)

Systemic VEGF Inhibition does not modulate ocular inflammatory cell infiltrate in the murine laser-induced choroidal neovascularization (CNV) Model

A novel oral small molecule Factor D inhibitor blocks complement activation in the blood and ocular tissues

Dynamic changes of M1 and M2 macrophages in a murine model of endotoxin-induced uveitis

Impaired alternative complement pathway function does not protect against light-induced retinopathy in mice

Systemic Inhibition of the EGF Receptor Reduces Leukostasis and Retinal Vascular Leakage in Streptozotocin Induced-Diabetic Rats

Differential inflammatory stages in the eyes and kidneys of aged complement factor H-deficient mice

Differential effects of a MyD88 knockout on ocular inflammation induced by the TLR2/3/4 ligands (PAM3CSK4, PolyI:C, and LPS)

A comparison of the effects of subretinal injection of scAAV2-CMV-GFP on retinal structure, visual function, and GFP expression by two injectors

HtrA1 regulates the subretinal infiltration of microglia cells in response to bacterial lipopolysaccharides (LPS) and aging in mice

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