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Retinal Cell Biology August 2019

Highly Differentiated Human Fetal RPE Cultures Are Resistant to the Accumulation and Toxicity of Lipofuscin-Like Material

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Qitao Zhang; Feriel Presswalla; Melissa Calton; Carol Charniga; Jeffrey Stern; Sally Temple; Douglas Vollrath; David N. Zacks; Robin R. Ali; Debra A. Thompson; Jason M. L. Miller
TAGS: fetus, lipofuscin, toxic effect
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3468-3479. doi: 10.1167/iovs.19-26690

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Primary fetal RPE cultures resist accumulation and toxicity of lipofuscin-like material, and accumulated material can be further reduced by autophagy induction.

Qitao Zhang; Feriel Presswalla; Anne McCusker; Carol Charniga; Melissa A Calton; Douglas Vollrath; sally Temple; Jeffrey Stern; David N Zacks; Debra A Thompson; Jason Miller

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1718. doi:

ARVO Annual Meeting Abstract July 2019

The optic nerve lamina region (ONLR) contains a neural progenitor/stem cell (NPC/NSC) niche

Steven L Bernstein; Yan Guo; Zara Mehrabyan; Candace Kerr; Rebecca J Fawcett; sally Temple; Jeffrey Stern

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6387. doi:

ARVO Annual Meeting Abstract July 2018

Nicotinamide protects against PVR by preventing RPE cells to undergo EMT

Marie Fernandes; Lauren Schiff; Tomasz Swigut; Nathan Boles; Rajini Srinivasan; Alvaro Rada-Iglesias; Qingjie Wang; Janmeet Saini; Tom Kiehl; Jeffrey Stern; Joanna Wysocka; Sally Temple; Timothy A Blenkinsop

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2477. doi:

ARVO Annual Meeting Abstract September 2016

A primary retinal pigment epithelial culture model for evaluating therapeutic targets in dry macular degeneration

Qitao Zhang; Feriel Presswalla; Carol Charniga; Jeffrey Stern; Sally Temple; David N Zacks; Debra A Thompson; Jason Miller

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5015. doi:

ARVO Annual Meeting Abstract September 2016

FOXS1 drives EMT in retinal pigment, mammary and hepatic epithelial cells through p38 activation by TGFΒ1 and TNFa

Timothy A Blenkinsop; Tomasz Swigut; Nathan Boles; Rajini Srinivasan; Qingjie Wang; Jeffrey Stern; Joanna Wysocka; Sally Temple

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5363. doi:

Retinal Cell Biology November 2015

Human Adult Retinal Pigment Epithelial Stem Cell–Derived RPE Monolayers Exhibit Key Physiological Characteristics of Native Tissue

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Timothy A. Blenkinsop; Janmeet S. Saini; Arvydas Maminishkis; Kapil Bharti; Qin Wan; Tina Banzon; Mostafa Lotfi; Janine Davis; Deepti Singh; Lawrence J. Rizzolo; Sheldon Miller; Sally Temple; Jeffrey H. Stern
TAGS: gene expression, immunohistochemistry, adult, pigment, body tissue, physiology, proteins, epithelial stem cells
Invest. Ophthalmol. Vis. Sci.. 2015; 56(12):7085-7099. doi: 10.1167/iovs.14-16246

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Modeling Age-related Macular Degeneration (AMD) using Patient-Specific induced Pluripotent Stem Cells

Janmeet S Saini; Barbara Corneo; Jeffrey Stern; Sally Temple

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2346. doi:

ARVO Annual Meeting Abstract June 2015

Human Adult Retinal Pigment Epithelial Cultures Exhibit Key Physiological Characteristics of Native RPE Tissue

Timothy A Blenkinsop; Janmeet S Saini; Arvydas Maminishkis; Kapil Bharti; Qin Wan; Janine Davis; Sheldon S Miller; Sally Temple; Jeffrey Stern

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2330. doi:

ARVO Annual Meeting Abstract April 2014

In pursuit of authenticity: Comprehensive analysis of iPSC derived RPE offer a benchmark and insight for clinical applications

Qin Wan; Kiyoharu j Miyagishima; Mostafa R Lotfi; Arvydas Maminishkis; Ruchi Sharma; Barbara Corneo; Fang Hua; Sally Temple; Sheldon S Miller; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6310. doi:

ARVO Annual Meeting Abstract April 2014

The optic nerve lamina is a neural progenitor cell niche

Steven L Bernstein; Zara Mehrabyan; Candace Kerr; Sally Temple; Jeffrey Stern; Yan Guo

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1385. doi:

ARVO Annual Meeting Abstract June 2013

Primary Culture and Characterization of Mouse Laminar Cells

Yan Guo; Zara Mehrabyan; Carol Charniga; Sally Temple; Steven Bernstein

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):5162. doi:

ARVO Annual Meeting Abstract June 2013

Generation Of iPSCs From Adult Proliferating RPE Stem Cells

Barbara Corneo; Timothy Blenkinsop; Patricia Lederman; Nathan Boles; Janmeet Saini; Gretchen Kusek; Sunita L D'Souza; Christoph Schaniel; Jeffrey Stern; Sally Temple

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2225. doi:

ARVO Annual Meeting Abstract June 2013

A Multiplex High Content High Throughput Screening Platform Using iPS Cells Derived RPE

FNU RUCHI; Barbara Corneo; Janine Davis; Becky King; Qin Wan; Kiyoharu Miyagishima; Sally Temple; Sheldon Miller; Marc Ferrer; Kapil Bharti

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2230. doi:

ARVO Annual Meeting Abstract June 2013

Histone marks predict cell plasticity of the adult human retinal pigment epithelium

Timothy Blenkinsop; Alvaro Rada-Iglesias; Joanna Wysocka; Sally Temple

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2616. doi:

ARVO Annual Meeting Abstract June 2013

Improving Human RPE Differentiation from iPS Cells: Lessons from Mouse Eye Development

Kapil Bharti; Janine Davis; Barbara Corneo; Qin Wan; Kiyoharu Miyagishima; Sally Temple; Sheldon Miller

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):4051. doi:

ARVO Annual Meeting Abstract March 2012

Use of an iPS Reporter Cell Line Expressing RPE-Specific GFP For Improving iPS Cell to RPE Differentiation

Kapil Bharti; Janine Davis; Barbara Corneo; Sally Temple; Sheldon Miller

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):2691. doi:

ARVO Annual Meeting Abstract March 2012

Physiological Differences Between iPSC-RPE and Human Fetal RPE

Tarun Bansal; Qin Wan; Rong Li; Patricia Lederman; Barbara Corneo; Sally Temple; Sunita D'Souza; Kapil Bharti; Sheldon S. Miller

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):2697. doi:

ARVO Annual Meeting Abstract March 2012

Amyloid-β42 Oligomers Induce Drusen-related Protein Expression and Cytotoxicity in Human RPE Cells: A Mechanism for Drusen Formation and Progression of Age-Related Macular Degeneration

David M. Rabin; Ali Reza Ladiwala; Timothy A. Blenkinsop; Richard L. Rabin; Peter M. Tessier; Sheldon Miller; Sally Temple; Jeffrey H. Stern

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):5296. doi:

ARVO Annual Meeting Abstract March 2012

Adult Human RPE Can Be Activated Into Multipotent Stem Cell That Produces Mesenchymal Derivates

Enrique Salero; Timothy A. Blenkinsop; Barbara Corneo; Ashley Harris; David Rabin; Jeffrey Stern; Sally Temple

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1126. doi:

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Highly Differentiated Human Fetal RPE Cultures Are Resistant to the Accumulation and Toxicity of Lipofuscin-Like Material

Primary fetal RPE cultures resist accumulation and toxicity of lipofuscin-like material, and accumulated material can be further reduced by autophagy induction.

The optic nerve lamina region (ONLR) contains a neural progenitor/stem cell (NPC/NSC) niche

Nicotinamide protects against PVR by preventing RPE cells to undergo EMT

A primary retinal pigment epithelial culture model for evaluating therapeutic targets in dry macular degeneration

FOXS1 drives EMT in retinal pigment, mammary and hepatic epithelial cells through p38 activation by TGFΒ1 and TNFa

Human Adult Retinal Pigment Epithelial Stem Cell–Derived RPE Monolayers Exhibit Key Physiological Characteristics of Native Tissue

Modeling Age-related Macular Degeneration (AMD) using Patient-Specific induced Pluripotent Stem Cells

Human Adult Retinal Pigment Epithelial Cultures Exhibit Key Physiological Characteristics of Native RPE Tissue

In pursuit of authenticity: Comprehensive analysis of iPSC derived RPE offer a benchmark and insight for clinical applications

The optic nerve lamina is a neural progenitor cell niche

Primary Culture and Characterization of Mouse Laminar Cells

Generation Of iPSCs From Adult Proliferating RPE Stem Cells

A Multiplex High Content High Throughput Screening Platform Using iPS Cells Derived RPE

Histone marks predict cell plasticity of the adult human retinal pigment epithelium

Improving Human RPE Differentiation from iPS Cells: Lessons from Mouse Eye Development

Use of an iPS Reporter Cell Line Expressing RPE-Specific GFP For Improving iPS Cell to RPE Differentiation

Physiological Differences Between iPSC-RPE and Human Fetal RPE

Amyloid-β42 Oligomers Induce Drusen-related Protein Expression and Cytotoxicity in Human RPE Cells: A Mechanism for Drusen Formation and Progression of Age-Related Macular Degeneration

Adult Human RPE Can Be Activated Into Multipotent Stem Cell That Produces Mesenchymal Derivates

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