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Glaucoma April 2019

Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation

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Yan Hu; Arturo O. Barron; Sofya Gindina; Sandeep Kumar; Shravan Chintala; Ashima Nayyar; John Danias
TAGS: alteplase, urokinase, gelatinase b, platelet count measurement, mice, regulation, fibrinolysis pathway
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1571-1580. doi: 10.1167/iovs.18-25698

ARVO Annual Meeting Abstract July 2018

The pathogenesis of polypoidal choroidal vasculopathy proceeds via a two-stage process

Yingbin Fu; Sandeep Kumar; Hiroyuki Nakashizuka; Alex Jones; Alyssia Lambert; Xuchen Zhao; Megan Shen; Mackenzie Parker; Mark O M Tso; Jon Rainier

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):346. doi:

ARVO Annual Meeting Abstract July 2018

Elevated Intracranial Pressure in Mice Causes Retinal Ganglion Cell Loss, Dysfunction, and Hypoxia

Benjamin J Frankfort; Guofu Shen; Schuyler Link; Sandeep Kumar; Derek Nusbaum; Dennis Tse; Yingbin Fu; Samuel M Wu

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2193. doi:

ARVO Annual Meeting Abstract July 2018

Delayed blockade of retinal gap junctions still promotes neuroprotection in a mouse model of glaucoma

Abram Akopian; Sandeep Kumar; Hari Ramakrishnan; Stewart A Bloomfield

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6141. doi:

ARVO Annual Meeting Abstract June 2017

Up-regulation of connexin36 in retinal neurons amplifies gap junction-mediated neurodegeneration in glaucoma.

Sandeep Kumar; Hari Ramakrishnan; Kaushambi Roy; Abram Akopian; Stewart A Bloomfield

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2551. doi:

ARVO Annual Meeting Abstract September 2016

CRISPR/dCas9 to treat neovascular age-related macular degeneration

Katie L Pennington; Sandeep Kumar; Alex Jones; Margaret M DeAngelis; Yingbin Fu

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4436. doi:

ARVO Annual Meeting Abstract September 2016

Ablation of neuronal gap junctions prevents the changes in bipolar cell structure and function seen in a mouse model of glaucoma

Abram Akopian; Sandeep Kumar; Hari Ramakrishnan; Suresh Viswanathan; Stewart A Bloomfield

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2569. doi:

ARVO Annual Meeting Abstract September 2016

Blockade of neuronal gap junctions preserves the structural and functional integrity of the retina and optic nerve in a mouse model of glaucoma

Hari Ramakrishnan; Sandeep Kumar; Suresh Viswanathan; Abram Akopian; Stewart A Bloomfield

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2571. doi:

ARVO Annual Meeting Abstract September 2016

Focal ERG analysis on the impact of PCV lesions on retinal function

Sandeep Kumar; Stephanie VanBeuge; Zachary Berriochoa; Amrita .; Yingbin Fu

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract June 2015

Inflammation plays an important role in the pathogenesis of Polypoidal Choroidal Vasculopathy

Sandeep Kumar; Alex Jones; Shixian Wang; Zachary Berriochoa; Yingbin Fu

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4196. doi:

ARVO Annual Meeting Abstract June 2015

Secondary cell death via gap junctions mediates the loss of amacrine cells in a mouse model of experimental glaucoma

Sandeep Kumar; Abram Akopian; Stewart A Bloomfield

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4253. doi:

ARVO Annual Meeting Abstract June 2015

Efficient deletion of the IGFBP domain of multifunctional serine protease HTRA1 by CRISPR/Cas9

HUI XU; Sandeep Kumar; Yingbin Fu

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2363. doi:

ARVO Annual Meeting Abstract June 2015

Blockade of Retinal Gap Junctions Offers Significant Neuroprotection in an Experimental Mouse Model of Glaucoma

Stewart A Bloomfield; Sandeep Kumar; Abram Akopian

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2589. doi:

Multidisciplinary Ophthalmic Imaging June 2014

Angiographic Features of Transgenic Mice With Increased Expression of Human Serine Protease HTRA1 in Retinal Pigment Epithelium

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Sandeep Kumar; Zachary Berriochoa; Balamurali K Ambati; Yingbin Fu
TAGS: angiogram, phenotype, mice, transgenic, animal model, ophthalmoscopy, polyps, serine endopeptidases, mice, htra1 gene, retinal pigment epithelium
Invest. Ophthalmol. Vis. Sci.. 2014; 55(6):3842-3850. doi: 10.1167/iovs.13-13111

ARVO Annual Meeting Abstract April 2014

Histopathological characterization of different lesion types of polypoidal choroidal vasculopathy in HTRA1 transgenic mice

Alex Jones; Sandeep Kumar; Shixian Wang; Zachary Berriochoa; Yingbin Fu

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1184. doi:

ARVO Annual Meeting Abstract April 2014

Decreased PLAT expression and PLAT Promoter Activity after Steroid Treatment

Alina Genis; Sandeep Kumar; John Danias

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5657. doi:

ARVO Annual Meeting Abstract April 2014

Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium

Sandeep Kumar; Zachary Berriochoa; Alex Jones; Yingbin Fu

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5237. doi:

Glaucoma December 2013

Reduction of Steroid-Induced Intraocular Pressure Elevation in Sheep by Tissue Plasminogen Activator

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Rosana Gerometta; Sandeep Kumar; Shaily Shah; Larry Alvarez; Oscar Candia; John Danias
TAGS: alteplase, sheep, steroids, eye, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2013; 54(13):7903-7909. doi: 10.1167/iovs.13-12801

ARVO Annual Meeting Abstract June 2013

The proteolytic activity of HTRA1 is responsible for its pathological role in polypoidal choroidal vasculopathy

Sandeep Kumar; Alex Jones; Zach Berriochoa; Shixian Wang Wang; Yingbin Fu

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):4991. doi:

ARVO Annual Meeting Abstract June 2013

Effect of anecortave acetate (AA) on outflow facility in a mouse model of steroid-induced glaucoma

Sandeep Kumar; Shaily Shah; Emily Deutsch; Hai Tang; John Danias

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):782. doi:

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Investigations on the Role of the Fibrinolytic Pathway on Outflow Facility Regulation

The pathogenesis of polypoidal choroidal vasculopathy proceeds via a two-stage process

Elevated Intracranial Pressure in Mice Causes Retinal Ganglion Cell Loss, Dysfunction, and Hypoxia

Delayed blockade of retinal gap junctions still promotes neuroprotection in a mouse model of glaucoma

Up-regulation of connexin36 in retinal neurons amplifies gap junction-mediated neurodegeneration in glaucoma.

CRISPR/dCas9 to treat neovascular age-related macular degeneration

Ablation of neuronal gap junctions prevents the changes in bipolar cell structure and function seen in a mouse model of glaucoma

Blockade of neuronal gap junctions preserves the structural and functional integrity of the retina and optic nerve in a mouse model of glaucoma

Focal ERG analysis on the impact of PCV lesions on retinal function

Inflammation plays an important role in the pathogenesis of Polypoidal Choroidal Vasculopathy

Secondary cell death via gap junctions mediates the loss of amacrine cells in a mouse model of experimental glaucoma

Efficient deletion of the IGFBP domain of multifunctional serine protease HTRA1 by CRISPR/Cas9

Blockade of Retinal Gap Junctions Offers Significant Neuroprotection in an Experimental Mouse Model of Glaucoma

Angiographic Features of Transgenic Mice With Increased Expression of Human Serine Protease HTRA1 in Retinal Pigment Epithelium

Histopathological characterization of different lesion types of polypoidal choroidal vasculopathy in HTRA1 transgenic mice

Decreased PLAT expression and PLAT Promoter Activity after Steroid Treatment

Angiographic features of transgenic mice with increased expression of human serine protease HTRA1 in retinal pigment epithelium

Reduction of Steroid-Induced Intraocular Pressure Elevation in Sheep by Tissue Plasminogen Activator

The proteolytic activity of HTRA1 is responsible for its pathological role in polypoidal choroidal vasculopathy

Effect of anecortave acetate (AA) on outflow facility in a mouse model of steroid-induced glaucoma

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