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ARVO Annual Meeting Abstract June 2025

Gene replacement therapy targeting photoreceptors improves visual behavior in Usher Syndrome Type 1C (USH1C) mice

Dongjoon Kim; Bhagwat V Alapure; Sanford L. Boye; Shannon Elizabeth Boye; Jennifer J Lentz

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):5958.

ARVO Annual Meeting Abstract June 2025

Retinal gene therapy rescues retinal structure and function in the BBS7 macaque model of macular photoreceptor degeneration

Martha Neuringer; Lauren Renner; Hannah Gray Woolard; Andreas K Lauer; Jonathan Stoddard; Junghyun Ryu; Jon Hennebold; Carol B Hanna; Fernanda C Burch; Emily Mishler; Samuel Peterson; David J Wilson; Mark Pennesi; Sanford L. Boye; Shannon Elizabeth Boye; Trevor J McGill

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):5948.

ARVO Annual Meeting Abstract June 2025

Antisense verses gene replacement therapy for USH1C

Jennifer J Lentz; Bhagwat V Alapure; Dongjoon Kim; Sanford L. Boye; Shannon Elizabeth Boye; Wadih M Zein; Michel Michaelides; Maria Reinoso; Robert K Koenekoop

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):5945.

ARVO Annual Meeting Abstract June 2025

Novel tools to identify ON and OFF midget ganglion cells in marmoset retina

Alex Gallego-Ortega; Menglin Li; Martin O Bohlen; William H Merigan; Jude F F Mitchell; Sanford L. Boye; Shannon Elizabeth Boye; Yi-Rong Peng; Greg Field

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4958.

ARVO Annual Meeting Abstract June 2025

Gene augmentation therapy imparts partial visual recovery in a large animal model of GUCY2D Leber congenital amaurosis (LCA1)

Billie Beckwith-Cohen; Paige A Winkler; Alexandra J Azarkevich; Kelian Sun; Geneive M. Carrion; Mariza Bortolini; Fabiano Montiani Ferreira; Shannon Elizabeth Boye; Sanford L. Boye; Simon M Petersen-Jones

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2699.

ARVO Annual Meeting Abstract June 2024

Gene-edited monkey model of Usher 1B: Assessment of gene therapy

Martha Neuringer; Jonathan Stoddard; Rene Reynaga; Junghyun Ryu; Jon D Hennebold; Carol B Hanna; John V Brigande; Hannah Woolard; Andreas K Lauer; David Wilson; Mark E Pennesi; Sanford L Boye; Shannon Elizabeth Boye; Renee Christine Ryals; Trevor J Mcgill; Lauren Renner

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4269.

ARVO Annual Meeting Abstract June 2024

Using cytokine profiling to characterize the immune response associated with AAV subretinal administration

Rene Stephen Reynaga; Jonathan Stoddard; Lauren Renner; Hannah Woolard; Andreas K Lauer; Sanford L Boye; Shannon Elizabeth Boye; Steven Grey; Alison Weiss; Will Liguore; Trevor J Mcgill; Paul Yang; Renee Christine Ryals; Martha Neuringer

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6088.

ARVO Annual Meeting Abstract June 2023

Nonhuman primate model of Usher Syndrome Type 1B: course of retinal degeneration and initial gene therapy results

Lauren Renner; Junghyun Ryu; Jon D Hennebold; Sanford L Boye; Carol Hanna; Fernanda Burch; Beth Kempton; Edward V Porsov; Rachel Spears; Benjamin Burwitz; Andreas K Lauer; David Wilson; Mark E Pennesi; Shannon Boye; John V Brigande; Martha Neuringer

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):475.

ARVO Annual Meeting Abstract June 2023

Modification of rAAV capsid to improve retinal vascular endothelial tropism

Ramesh Periasamy; Dwani Patel; Sanford L Boye; Shannon E Boye; Daniel M Lipinski

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):768.

ARVO Annual Meeting Abstract June 2023

Six-month safety and efficacy of ATSN-101 in patients with Leber congenital amaurosis caused by biallelic mutations in GUCY2D (LCA1)

Christine Nichols Kay; Paul Yang; Artur V Cideciyan; Allen Ho; Andreas K Lauer; Shannon E Boye; Sanford L Boye; Alejandro J Roman; Vivian Wu; Alexandra V Garafalo; Alexander Sumaroka; Laura P Pardon; Dan Yoon; Kenji P Fujita; Samuel Jacobson

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1914.

ARVO Annual Meeting Abstract June 2023

Rhesus macaque model of Bardet-Biedl syndrome: Progression and response to gene therapy

Martha Neuringer; Junghyun Ryu; Jon D Hennebold; Carol Hanna; Fernanda Burch; Emily Mishler; Samuel Peterson; Betsy Ferguson; Rachel Spears; Hannah Woolard; Andreas K Lauer; David Wilson; Mark E Pennesi; Sanford L Boye; Shannon Boye; Lauren Renner

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3854.

ARVO Annual Meeting Abstract June 2022

Improving retinal vascular endothelial cell tropism through rational rAAV capsid design.

Ramesh Periasamy; Dwani D Patel; Sanford L Boye; Shannon E Boye; Daniel M Lipinski

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):66 – A0039.

ARVO Annual Meeting Abstract June 2022

Long-term follow up of gene therapy for NPHP5 -LCA in a canine model shows restoration of photoreceptor function and vision for > 5 years

William A Beltran; Artur V Cideciyan; Ana Ripolles-Garcia; Valerie L Dufour; Yu Sato; Alexa Gray; Malgorzata Swider; Sanford L Boye; William W Hauswirth; Samuel G. Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):454.

ARVO Annual Meeting Abstract June 2021

Four-year follow up of intraocular pressure (IOP) control in a canine model of open-angle glaucoma (OAG) treated with adeno-associated virus (AAV)-mediated modification of gene expression within the aqueous humor outflow pathways (AHOP)

Andras M Komaromy; Christine Harman; Kristin Koehl; Amanda Anderson; Sanford L Boye; Juan Pedro Steibel; Leandro Teixeira; Carol B Toris; Sayoko E Moroi; Shannon E Boye

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2783.

ARVO Annual Meeting Abstract June 2021

Development of rAAV capsid mutant vectors with improved tropism for retinal vascular endothelial.

Ramesh Periasamy; Dwani Patel; Shannon E Boye; Sanford L Boye; Daniel M Lipinski

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1468.

ARVO Annual Meeting Abstract June 2021

Gene therapy and gene-editing approaches to treat vision loss in a murine model of Acadian Usher syndrome

Katelyn N Robillard; Bhagwat V Alapure; Sanford L Boye; Shannon E Boye; Nicolas G Bazan; Jennifer J Lentz

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1184.

ARVO Annual Meeting Abstract July 2019

Highly Efficient Foveal Cone Transduction by AAV44.9 and AAV2(4pMutΔHS) Mediated by Lateral Spread Following Extrafoveal Subretinal Injection

Ryan F. Boyd; Joshua T Bartoe; Thomas S Vihtelic; James J Peterson; Hangning Zhang; Sanford L Boye; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1330.

ARVO Annual Meeting Abstract July 2019

Long-term stable intraocular pressure (IOP) control and optic nerve head (ONH) preservation following AAV-mediated ocular gene therapy in a canine model of ADAMTS10 -open-angle glaucoma (OAG)

Andras M Komaromy; Kristin L Koehl; Christine Harman; Sanford L Boye; Juan P. Steibel; Leandro B C Teixeira; Carol B Toris; Sayoko Eileen Moroi; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6470.

ARVO Annual Meeting Abstract July 2018

Development of a drug-regulated, broad-spectrum neuroprotective gene therapy for retinal degeneration

John D Ash; Casey Keuthan; Aisha Imam; Sanford L Boye; Shannon Elizabeth Boye; Clayton Santiago

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3961.

ARVO Annual Meeting Abstract July 2018

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

Julia V Busik; Nermin Kady; Xuwen Liu; Todd Lydic; Sergey S Seregin; Andrea Amalfitano; Vince A Chiodo; Sanford L Boye; William W Hauswirth; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3002.

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Gene replacement therapy targeting photoreceptors improves visual behavior in Usher Syndrome Type 1C (USH1C) mice

Retinal gene therapy rescues retinal structure and function in the BBS7 macaque model of macular photoreceptor degeneration

Antisense verses gene replacement therapy for USH1C

Novel tools to identify ON and OFF midget ganglion cells in marmoset retina

Gene augmentation therapy imparts partial visual recovery in a large animal model of GUCY2D Leber congenital amaurosis (LCA1)

Gene-edited monkey model of Usher 1B: Assessment of gene therapy

Using cytokine profiling to characterize the immune response associated with AAV subretinal administration

Nonhuman primate model of Usher Syndrome Type 1B: course of retinal degeneration and initial gene therapy results

Modification of rAAV capsid to improve retinal vascular endothelial tropism

Six-month safety and efficacy of ATSN-101 in patients with Leber congenital amaurosis caused by biallelic mutations in GUCY2D (LCA1)

Rhesus macaque model of Bardet-Biedl syndrome: Progression and response to gene therapy

Improving retinal vascular endothelial cell tropism through rational rAAV capsid design.

Long-term follow up of gene therapy for NPHP5 -LCA in a canine model shows restoration of photoreceptor function and vision for > 5 years

Four-year follow up of intraocular pressure (IOP) control in a canine model of open-angle glaucoma (OAG) treated with adeno-associated virus (AAV)-mediated modification of gene expression within the aqueous humor outflow pathways (AHOP)

Development of rAAV capsid mutant vectors with improved tropism for retinal vascular endothelial.

Gene therapy and gene-editing approaches to treat vision loss in a murine model of Acadian Usher syndrome

Highly Efficient Foveal Cone Transduction by AAV44.9 and AAV2(4pMutΔHS) Mediated by Lateral Spread Following Extrafoveal Subretinal Injection

Long-term stable intraocular pressure (IOP) control and optic nerve head (ONH) preservation following AAV-mediated ocular gene therapy in a canine model of ADAMTS10 -open-angle glaucoma (OAG)

Development of a drug-regulated, broad-spectrum neuroprotective gene therapy for retinal degeneration

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

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