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ARVO Annual Meeting Abstract July 2019

Highly Efficient Foveal Cone Transduction by AAV44.9 and AAV2(4pMutΔHS) Mediated by Lateral Spread Following Extrafoveal Subretinal Injection

Ryan F. Boyd; Joshua T Bartoe; Thomas S Vihtelic; James J Peterson; Hangning Zhang; Sanford L Boye; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1330. doi:

ARVO Annual Meeting Abstract July 2019

Long-term stable intraocular pressure (IOP) control and optic nerve head (ONH) preservation following AAV-mediated ocular gene therapy in a canine model of ADAMTS10 -open-angle glaucoma (OAG)

Andras M Komaromy; Kristin L Koehl; Christine Harman; Sanford L Boye; Juan P. Steibel; Leandro B C Teixeira; Carol B Toris; Sayoko Eileen Moroi; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6470. doi:

ARVO Annual Meeting Abstract July 2018

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

Julia V Busik; Nermin Kady; Xuwen Liu; Todd Lydic; Sergey S Seregin; Andrea Amalfitano; Vince A Chiodo; Sanford L Boye; William W Hauswirth; David A Antonetti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3002. doi:

ARVO Annual Meeting Abstract July 2018

Development of a drug-regulated, broad-spectrum neuroprotective gene therapy for retinal degeneration

John D Ash; Casey Keuthan; Aisha Imam; Sanford L Boye; Shannon Elizabeth Boye; Clayton Santiago

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3961. doi:

ARVO Annual Meeting Abstract July 2018

Investigating tolerability of subretinally delivered dual AAV-MYO7A vectors in non-human primate (NHP)

Kaitlyn Calabro; Sanford L Boye; Kevin Mccullough; Diego Fajardo; W Clay Smith; Christianne E Strang; Douglas C. Witherspoon; Dibyendu Chakraborty; Paul D Gamlin; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4535. doi:

ARVO Annual Meeting Abstract July 2018

AAV 44.9- a novel capsid that efficiently transduces photoreceptors and retinal pigment epithelium

Shreyasi Choudhury; Russell Mellen; Kevin Mccullough; James Peterson; Diego Fajardo; John Chiorini; Sanford L Boye; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4536. doi:

ARVO Annual Meeting Abstract July 2018

Subfoveal Injections in Non-Human Primates: Safety and Efficacy Following Administration of a Photoreceptor-Targeted AAV5

Ryan F. Boyd; Joshua T. Bartoe; Thomas S Vihtelic; Sanford L Boye; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5662. doi:

ARVO Annual Meeting Abstract July 2018

Long-term preservation of photoreceptor function and structure following early-stage treatment by AAV-mediated gene augmentation in canine model of NPHP5 Leber congenital amaurosis

Gustavo D Aguirre; Artur V Cideciyan; Sanford L Boye; Simone Iwabe; Valerie Dufour; Malgorzata Swider; Karolina Roszak; William W Hauswirth; Samuel G Jacobson; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6006. doi:

ARVO Annual Meeting Abstract July 2018

An AAV-CRISPR/Cas9 gene editing approach for GUCY2D -associated cone rod dystrophy (CORD6)

Kevin Mccullough; Sanford L Boye; Diego Fajardo; Christianne E Strang; Douglas C. Witherspoon; Sebastian Gloskowski; Abhishek Dass; Paul D Gamlin; Morgan Maeder; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6020. doi:

ARVO Annual Meeting Abstract June 2017

Inhibiting complement C3 activation by gene therapy reduces glaucoma progression

Alejandra Bosco; Sarah Anderson; Kevin T Breen; Cesar O Romero; Michael R Steele; Vince A Chiodo; Sanford L Boye; William W Hauswirth; Stephen Tomlinson; Monica L Vetter

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2957. doi:

ARVO Annual Meeting Abstract June 2017

Novel AAV variants isolated by directed evolution in primate display enhanced retinal transduction following intravitreal injection

Shreyasi Choudhury; Damien Marsic; James Peterson; Diego Fajardo; Antonette Bennett; Paul D Gamlin; Mavis Agbandje-McKenna; Sergei Zolotukhin; Sanford L Boye; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4507. doi:

ARVO Annual Meeting Abstract June 2017

Overexpression of ELOVL4 stabilizes tight junctions and prevents VEGF-induced vascular permeability in diabetic retina and retinal cells.

Nermin Kady; Xuwen Liu; Todd Lydic; Segey Seregin; Andrea Amalfitano; Vince A Chiodo; Sanford L Boye; William Hauswirth; Maria B Grant; David Antonetti; Julia V Busik

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4034. doi:

ARVO Annual Meeting Abstract June 2017

Directed Evolution of Enhanced AAV Capsid Variants Following Intravitreal Injection in Macaque

Sanford L Boye; Shreyasi Choudhury; Damien Marsic; Christianne E Strang; John J Alexander; C. Douglas Witherspoon; Sergei Zolotukhin; Paul D Gamlin; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4087. doi:

ARVO Annual Meeting Abstract June 2017

Gene augmentation therapy improves inner and outer segment morphology and preserves retinal structure in a large animal model of CNGB1 -retinitis pigmentosa

Laurence Mireille Occelli; Paige A Winkler; Vince A Chiodo; Sanford L Boye; William W Hauswirth; Simon M Petersen-Jones

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4508. doi:

ARVO Annual Meeting Abstract June 2017

Optimization of transgene expression in the trabecular meshwork (TM) by comparing capsid mutant AAV2 vectors

Christine Harman; Kristin Koehl; Annie Oh; Vince A Chiodo; Sanford L Boye; William W Hauswirth; Shannon Elizabeth Boye; Andras M Komaromy

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4611. doi:

ARVO Annual Meeting Abstract September 2016

Transgenic expression of human photoreceptor guanylyl cyclase GUCY2D with LCA1 mutations: diversity of physiological effects and localization in photoreceptors.

Elena V Olshevskaya; Sanford L. Boye; Kevin Tyler McCullough; Igor V Peshenko; Shannon Elizabeth Boye; Alexander M Dizhoor

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3180. doi:

ARVO Annual Meeting Abstract September 2016

Novel Methodology for Creating Primate Retina with Sortable Cell Populations

Shreyasi Choudhury; Christianne E Strang; Sanford L. Boye; Julie Lynch Hill; Douglas C Witherspoon; Daniel T Kasuga; Paul D Gamlin; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):766. doi:

ARVO Annual Meeting Abstract September 2016

Long-term preservation of retinal function in the rd6 mouse model of retinitis pigmentosa following AAV-mediated gene therapy

Rachel Michelle Stupay; Astra Dinculescu; Seok-Hong Min; Sanford L. Boye; Vince Chiodo Chiodo; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1167. doi:

ARVO Annual Meeting Abstract September 2016

Ocular Inhibition of Thyroid Hormone Signaling Protects Cone Photoreceptors in Mouse Models of Retinal Degeneration

Hongwei Ma; Fan Yang; Josh Belcher; Michael Butler; T. Michael Redmond; Thomas S Scanlan; Sanford L. Boye; William W Hauswirth; Xi-Qin Ding

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Towards a clinical trial to treat GUCY2D Leber congenital amaurosis (LCA1)

Shannon Elizabeth Boye; Sanford L. Boye; William Hauswirth; James Peterson; Seok-Hong Min; Qing Ruan; Catherine O'Riordan; Michael Lukason; Rena Baek; Abraham Scaria

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

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Highly Efficient Foveal Cone Transduction by AAV44.9 and AAV2(4pMutΔHS) Mediated by Lateral Spread Following Extrafoveal Subretinal Injection

Long-term stable intraocular pressure (IOP) control and optic nerve head (ONH) preservation following AAV-mediated ocular gene therapy in a canine model of ADAMTS10 -open-angle glaucoma (OAG)

Very long chain ceramides production mediated by ELOVL4 stabilizes tight junctions and prevents diabetes-induced retinal vascular permeability

Development of a drug-regulated, broad-spectrum neuroprotective gene therapy for retinal degeneration

Investigating tolerability of subretinally delivered dual AAV-MYO7A vectors in non-human primate (NHP)

AAV 44.9- a novel capsid that efficiently transduces photoreceptors and retinal pigment epithelium

Subfoveal Injections in Non-Human Primates: Safety and Efficacy Following Administration of a Photoreceptor-Targeted AAV5

Long-term preservation of photoreceptor function and structure following early-stage treatment by AAV-mediated gene augmentation in canine model of NPHP5 Leber congenital amaurosis

An AAV-CRISPR/Cas9 gene editing approach for GUCY2D -associated cone rod dystrophy (CORD6)

Inhibiting complement C3 activation by gene therapy reduces glaucoma progression

Novel AAV variants isolated by directed evolution in primate display enhanced retinal transduction following intravitreal injection

Overexpression of ELOVL4 stabilizes tight junctions and prevents VEGF-induced vascular permeability in diabetic retina and retinal cells.

Directed Evolution of Enhanced AAV Capsid Variants Following Intravitreal Injection in Macaque

Gene augmentation therapy improves inner and outer segment morphology and preserves retinal structure in a large animal model of CNGB1 -retinitis pigmentosa

Optimization of transgene expression in the trabecular meshwork (TM) by comparing capsid mutant AAV2 vectors

Transgenic expression of human photoreceptor guanylyl cyclase GUCY2D with LCA1 mutations: diversity of physiological effects and localization in photoreceptors.

Novel Methodology for Creating Primate Retina with Sortable Cell Populations

Long-term preservation of retinal function in the rd6 mouse model of retinitis pigmentosa following AAV-mediated gene therapy

Ocular Inhibition of Thyroid Hormone Signaling Protects Cone Photoreceptors in Mouse Models of Retinal Degeneration

Towards a clinical trial to treat GUCY2D Leber congenital amaurosis (LCA1)

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