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ARVO Annual Meeting Abstract July 2018

Intravitreal HC-HA/PTX3: A potential novel therapy for proliferative vitreoretinopathy

Ajay E. Kuriyan; Hua He; Esdras Arrieta; Nidhi Relhan; Jeffrey Peterson; Chen-Wei Su; Megha Mahabole; Sander R Dubovy; Harry W Flynn; Jean-Marie A Parel; Scheffer C G Tseng

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1157. doi:

ARVO Annual Meeting Abstract June 2017

Deactivation of CD44-mediated Endocytosis by Heavy Chain-Hyaluronic Acid/Pentrixin3 in Human Retinal Pigment Epithelium

Hua He; Yuan Zhang; Megha Mahabole; Chen-Wei Su; Scheffer C G Tseng

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):252. doi:

Cornea March 2017

Topical Cryopreserved Amniotic Membrane and Umbilical Cord Eye Drops Promote Re-Epithelialization in a Murine Corneal Abrasion Model

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Sean Tighe; Hamid-Reza Moein; Lorraine Chua; Anny Cheng; Pedram Hamrah; Scheffer C. G. Tseng
TAGS: corneal abrasions, epithelium, amnion, cryopreservation, umbilical cord, cornea, mice, eyedrops, epithelialization, abrasion
Invest. Ophthalmol. Vis. Sci.. 2017; 58(3):1586-1593. doi: 10.1167/iovs.16-20834

ARVO Annual Meeting Abstract September 2016

A potential novel therapy for PVR: HC-HA/PTX3, an active matrix component of amniotic membrane, inhibits proliferation of rabbit RPE cells and is non-toxic intravitreally

Ajay E. Kuriyan; Hua He; Esdras A. Quintero; Nidhi Rehlan; Harry W Flynn; Chen-Wei Su; Sander R Dubovy; Jean-Marie A Parel; Scheffer C G Tseng

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1126. doi:

ARVO Annual Meeting Abstract September 2016

Senescence Mediated by p16 INK4a Impedes Reprogramming of Human Corneal Endothelial Cells into Neural Crest Progenitors

Yingting Zhu; Wen-Juan Lu; Shuangling Chen; Sean Tighe; Yuan Zhang; Chen-Wei Su; Hua He; Scheffer C G Tseng

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5277. doi:

ARVO Annual Meeting Abstract September 2016

Inhibition of Proliferation and Epithelial Mesenchymal Transition via Wnt and TGF-β Signaling Pathway in an in vitro Cell Culture Based-PVR Model by HC-HA/PTX3 Purified from Amniotic Membrane

Hua He; Ajay E. Kuriyan; Chen-Wei Su; Yuan Zhang; Megha Mahabole; Ying-Ting Zhu; Esdras A. Quintero; Nidhi Rehlan; Harry W Flynn; Jean-Marie A Parel; Scheffer C G Tseng

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5384. doi:

Articles May 2016

Morselized Amniotic Membrane Tissue for Refractory Corneal Epithelial Defects in Cicatricial Ocular Surface Diseases

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Anny M. S. Cheng; Lorraine Chua; Victoria Casas; Scheffer C. G. Tseng
TAGS: amnion, body tissue, corneal epithelial defect
Trans. Vis. Sci. Tech.. 2016; 5(3):9. doi: 10.1167/tvst.5.3.9

Articles April 2016

HC-HA/PTX3 Purified From Amniotic Membrane as Novel Regenerative Matrix: Insight Into Relationship Between Inflammation and Regeneration

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Scheffer C. G. Tseng
TAGS: inflammation, stem cells, amnion, cornea, regulation, ptx3 protein
Invest. Ophthalmol. Vis. Sci.. 2016; 57(5):ORSFh1-ORSFh8. doi: 10.1167/iovs.15-17637

ARVO Annual Meeting Abstract June 2015

Activation of RhoA-ROCK-BMP-miR302 Network Reprograms Human Corneal Endothelial Cells to Neural Crest Progenitors

Yingting Zhu; Xin Liu; Wenjuan Lu; Szu-Yu Chen; Scheffer C G Tseng

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1143. doi:

ARVO Annual Meeting Abstract June 2015

HC-HA/PTX3 from Amniotic Membrane Promotes BMP Signaling in Limbal Niche Cells to Maintain Quiescence and Self Renewal of Limbal Epithelial Progenitor/Stem Cells

Szu-Yu Chen; Bo Han; Yingting Zhu; Megha Mahabole; Huang Jie; David C Beebe; Scheffer C G Tseng

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3472. doi:

ARVO Annual Meeting Abstract June 2015

HC-HA/PTX3, an active matrix component of amniotic membrane, inhibits proliferation and epithelial mesenchymal transition of RPE cells: a potential novel therapy for PVR

Ajay E Kuriyan; Hua He; Esdras Arrieta; Varona Sargent; Ying-Ting Zhu; Chen-Wei Su; Nidhi Batra; Harry W Flynn; Jean-Marie A Parel; Scheffer C G Tseng

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2287. doi:

Nantotechnology and Regenerative Medicine August 2014

Isolation and Characterization of Mesenchymal Progenitor Cells From Human Orbital Adipose Tissue

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Szu-Yu Chen; Megha Mahabole; Elan Horesh; Sara Wester; Jeffrey L. Goldberg; Scheffer C. G. Tseng
TAGS: phenotype, stem cells, cd31 antigens, cd34 antigens, collagenase, digestion, patient isolation, social isolation, adipose tissue, stem cell, mesenchymal, orbital fat
Invest. Ophthalmol. Vis. Sci.. 2014; 55(8):4842-4852. doi: 10.1167/iovs.14-14441

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

Human limbal niche cell support epithelial stem cell through Stem Cell Factor pathway

Gui-Gang Li; Juan Wang; Xinyu Li; Scheffer C G Tseng; Limbal stem cell niche group

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):501. doi:

Cornea March 2014

In Vivo Downregulation of Innate and Adaptive Immune Responses in Corneal Allograft Rejection by HC-HA/PTX3 Complex Purified From Amniotic Membrane

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Hua He; Yaohong Tan; Stephanie Duffort; Victor L. Perez; Scheffer C. G. Tseng
TAGS: immune response, amnion, macrophage, rejection (psychology), t-lymphocyte, cornea, allografting, ptx3 protein
Invest. Ophthalmol. Vis. Sci.. 2014; 55(3):1647-1656. doi: 10.1167/iovs.13-13094

Cornea March 2014

Knockdown of Both p120 Catenin and Kaiso Promotes Expansion of Human Corneal Endothelial Monolayers via RhoA-ROCK-Noncanonical BMP-NFκB Pathway

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Ying-Ting Zhu; Bo Han; Fu Li; Szu-Yu Chen; Sean Tighe; Suzhen Zhang; Scheffer C. G. Tseng
TAGS: signal transduction, bromodeoxyuridine, endothelium, rhoa gtp-binding protein, cornea, rna, small interfering
Invest. Ophthalmol. Vis. Sci.. 2014; 55(3):1509-1518. doi: 10.1167/iovs.13-13633

Articles November 2013

Terpinen-4-ol is the Most Active Ingredient of Tea Tree Oil to Kill Demodex Mites

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Sean Tighe; Ying-Ying Gao; Scheffer C. G. Tseng
TAGS: tea tree oil, mites, killing
Trans. Vis. Sci. Tech.. 2013; 2(7):2. doi: 10.1167/tvst.2.7.2

Articles November 2013

Optimization of Ex Vivo Expansion of Limbal Epithelial Progenitors by Maintaining Native Niche Cells on Denuded Amniotic Membrane

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Szu-Yu Chen; Megha Mahabole; Scheffer C. G. Tseng
TAGS: epithelium, amnion, collagenase, zinostatin
Trans. Vis. Sci. Tech.. 2013; 2(7):1. doi: 10.1167/tvst.2.7.1

Includes: Supplemental Content

Cornea August 2012

Mesenchymal Stem Cells Derived from Human Limbal Niche Cells

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Gui-Gang Li; Ying-Ting Zhu; Hua-Tao Xie; Szu-Yu Chen; Scheffer C. G. Tseng
TAGS: angiogenesis, stem cells, epithelium, fibroblasts, collagenase, pericytes, serial passage, stromal cells, cornea, stem cell, mesenchymal, epithelial cells
Invest. Ophthalmol. Vis. Sci.. 2012; 53(9):5686-5697. doi: 10.1167/iovs.12-10300

Includes: Supplemental Content

Immunology and Microbiology June 2012

PTX3 Controls Activation of Matrix Metalloproteinase 1 and Apoptosis in Conjunctivochalasis Fibroblasts

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Ping Guo; Su-Zhen Zhang; Hua He; Ying-Ting Zhu; Scheffer C. G. Tseng
TAGS: apoptosis, tumor necrosis factors, fibroblasts, culture media, interstitial collagenase, stromelysin 1, conjunctiva, proteins, ptx3 protein, conjunctivochalasis
Invest. Ophthalmol. Vis. Sci.. 2012; 53(7):3414-3423. doi: 10.1167/iovs.11-9103

Cornea June 2012

Angiogenesis Potential of Human Limbal Stromal Niche Cells

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Gui-Gang Li; Szu-Yu Chen; Hua-Tao Xie; Ying-Ting Zhu; Scheffer C. G. Tseng
TAGS: angiogenesis, endothelial cells, epithelium, pericytes, serial passage, zinostatin
Invest. Ophthalmol. Vis. Sci.. 2012; 53(7):3357-3367. doi: 10.1167/iovs.11-9414

Includes: Supplemental Content

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Intravitreal HC-HA/PTX3: A potential novel therapy for proliferative vitreoretinopathy

Deactivation of CD44-mediated Endocytosis by Heavy Chain-Hyaluronic Acid/Pentrixin3 in Human Retinal Pigment Epithelium

Topical Cryopreserved Amniotic Membrane and Umbilical Cord Eye Drops Promote Re-Epithelialization in a Murine Corneal Abrasion Model

A potential novel therapy for PVR: HC-HA/PTX3, an active matrix component of amniotic membrane, inhibits proliferation of rabbit RPE cells and is non-toxic intravitreally

Senescence Mediated by p16 INK4a Impedes Reprogramming of Human Corneal Endothelial Cells into Neural Crest Progenitors

Inhibition of Proliferation and Epithelial Mesenchymal Transition via Wnt and TGF-β Signaling Pathway in an in vitro Cell Culture Based-PVR Model by HC-HA/PTX3 Purified from Amniotic Membrane

Morselized Amniotic Membrane Tissue for Refractory Corneal Epithelial Defects in Cicatricial Ocular Surface Diseases

HC-HA/PTX3 Purified From Amniotic Membrane as Novel Regenerative Matrix: Insight Into Relationship Between Inflammation and Regeneration

Activation of RhoA-ROCK-BMP-miR302 Network Reprograms Human Corneal Endothelial Cells to Neural Crest Progenitors

HC-HA/PTX3 from Amniotic Membrane Promotes BMP Signaling in Limbal Niche Cells to Maintain Quiescence and Self Renewal of Limbal Epithelial Progenitor/Stem Cells

HC-HA/PTX3, an active matrix component of amniotic membrane, inhibits proliferation and epithelial mesenchymal transition of RPE cells: a potential novel therapy for PVR

Isolation and Characterization of Mesenchymal Progenitor Cells From Human Orbital Adipose Tissue

Human limbal niche cell support epithelial stem cell through Stem Cell Factor pathway

In Vivo Downregulation of Innate and Adaptive Immune Responses in Corneal Allograft Rejection by HC-HA/PTX3 Complex Purified From Amniotic Membrane

Knockdown of Both p120 Catenin and Kaiso Promotes Expansion of Human Corneal Endothelial Monolayers via RhoA-ROCK-Noncanonical BMP-NFκB Pathway

Terpinen-4-ol is the Most Active Ingredient of Tea Tree Oil to Kill Demodex Mites

Optimization of Ex Vivo Expansion of Limbal Epithelial Progenitors by Maintaining Native Niche Cells on Denuded Amniotic Membrane

Mesenchymal Stem Cells Derived from Human Limbal Niche Cells

PTX3 Controls Activation of Matrix Metalloproteinase 1 and Apoptosis in Conjunctivochalasis Fibroblasts

Angiogenesis Potential of Human Limbal Stromal Niche Cells

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