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ARVO Annual Meeting Abstract July 2018

An AAV-CRISPR/Cas9 gene editing approach for GUCY2D -associated cone rod dystrophy (CORD6)

Kevin Mccullough; Sanford L Boye; Diego Fajardo; Christianne E Strang; Douglas C. Witherspoon; Sebastian Gloskowski; Abhishek Dass; Paul D Gamlin; Morgan Maeder; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6020. doi:

ARVO Annual Meeting Abstract July 2018

Development of a drug-regulated, broad-spectrum neuroprotective gene therapy for retinal degeneration

John D Ash; Casey Keuthan; Aisha Imam; Sanford L Boye; Shannon Elizabeth Boye; Clayton Santiago

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3961. doi:

ARVO Annual Meeting Abstract July 2018

Investigating tolerability of subretinally delivered dual AAV-MYO7A vectors in non-human primate (NHP)

Kaitlyn Calabro; Sanford L Boye; Kevin Mccullough; Diego Fajardo; W Clay Smith; Christianne E Strang; Douglas C. Witherspoon; Dibyendu Chakraborty; Paul D Gamlin; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4535. doi:

ARVO Annual Meeting Abstract July 2018

AAV 44.9- a novel capsid that efficiently transduces photoreceptors and retinal pigment epithelium

Shreyasi Choudhury; Russell Mellen; Kevin Mccullough; James Peterson; Diego Fajardo; John Chiorini; Sanford L Boye; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4536. doi:

ARVO Annual Meeting Abstract July 2018

Subfoveal Injections in Non-Human Primates: Safety and Efficacy Following Administration of a Photoreceptor-Targeted AAV5

Ryan F. Boyd; Joshua T. Bartoe; Thomas S Vihtelic; Sanford L Boye; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5662. doi:

ARVO Annual Meeting Abstract June 2017

Novel AAV variants isolated by directed evolution in primate display enhanced retinal transduction following intravitreal injection

Shreyasi Choudhury; Damien Marsic; James Peterson; Diego Fajardo; Antonette Bennett; Paul D Gamlin; Mavis Agbandje-McKenna; Sergei Zolotukhin; Sanford L Boye; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4507. doi:

ARVO Annual Meeting Abstract June 2017

AAV5 made by rHSV complementation displays increased retinal transduction relative to AAV5 made by plasmid transfection.

Kevin Tyler Mccullough; Laura Adamson-Small; James Peterson; Sanford Boye; Nathalie Clément; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4084. doi:

ARVO Annual Meeting Abstract June 2017

Directed Evolution of Enhanced AAV Capsid Variants Following Intravitreal Injection in Macaque

Sanford L Boye; Shreyasi Choudhury; Damien Marsic; Christianne E Strang; John J Alexander; C. Douglas Witherspoon; Sergei Zolotukhin; Paul D Gamlin; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4087. doi:

ARVO Annual Meeting Abstract June 2017

Investigating the utility of mice as a model for developing clinically relevant dual AAV vectors to treat USH1B

Kaitlyn Calabro; Sanford Boye; Kevin Tyler Mccullough; Shreyasi Choudhury; Paul D Gamlin; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4098. doi:

ARVO Annual Meeting Abstract June 2017

Optimization of transgene expression in the trabecular meshwork (TM) by comparing capsid mutant AAV2 vectors

Christine Harman; Kristin Koehl; Annie Oh; Vince A Chiodo; Sanford L Boye; William W Hauswirth; Shannon Elizabeth Boye; Andras M Komaromy

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4611. doi:

ARVO Annual Meeting Abstract September 2016

Novel Methodology for Creating Primate Retina with Sortable Cell Populations

Shreyasi Choudhury; Christianne E Strang; Sanford L. Boye; Julie Lynch Hill; Douglas C Witherspoon; Daniel T Kasuga; Paul D Gamlin; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):766. doi:

ARVO Annual Meeting Abstract September 2016

Towards a clinical trial to treat GUCY2D Leber congenital amaurosis (LCA1)

Shannon Elizabeth Boye; Sanford L. Boye; William Hauswirth; James Peterson; Seok-Hong Min; Qing Ruan; Catherine O'Riordan; Michael Lukason; Rena Baek; Abraham Scaria

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Transgenic expression of human photoreceptor guanylyl cyclase GUCY2D with LCA1 mutations: diversity of physiological effects and localization in photoreceptors.

Elena V Olshevskaya; Sanford L. Boye; Kevin Tyler McCullough; Igor V Peshenko; Shannon Elizabeth Boye; Alexander M Dizhoor

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3180. doi:

ARVO Annual Meeting Abstract September 2016

Induction of Endogenous Nrf2 Activation in the Retina Partially Protects from Oxidative Stress and Inflammation

Cristhian J Ildefonso; Emily E Brown; Ryo Iwata; Chulbul M Ahmed; Michael Massengill; Manas Biswal; Shannon Elizabeth Boye; William W Hauswirth; John Ash; Qiuhong Li; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5399. doi:

Biochemistry and Molecular Biology February 2016

Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide

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Cristhian J. Ildefonso; Henrique Jaime; Emily E. Brown; Ryo L. Iwata; Chulbul M. Ahmed; Michael T. Massengill; Manas R. Biswal; Shannon E. Boye; William W. Hauswirth; John D. Ash; Qiuhong Li; Alfred S. Lewin
TAGS: oxidative stress, polymerase chain reaction, disease vectors, electroretinography, fluorescent antibody technique, genes, peptides, uveitis, eye, mice, proteins, retina, signal pathway, signal transduction pathways, spatial vectors
Invest. Ophthalmol. Vis. Sci.. 2016; 57(2):372-386. doi: 10.1167/iovs.15-17703

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Rational Design of AAV Vectors For Efficient Transduction of Müller Cells

Shreyasi Choudhury; Rachna Manek; Miranda White; Jinfeng Sun; Georgiy Aslanidi; Arun Svrivistava; Sanford L Boye; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3641. doi:

ARVO Annual Meeting Abstract June 2015

In Vivo Gene Augmentation in the ADAMTS10 -Mutant Canine Trabecular Meshwork (TM) with Y444F-Capsid Mutant, Single-Stranded AAV2

Christine Harman; Annie Oh; Kristin L Koehl; Sanford L Boye; Vince Chiodo; Jiayan Huang; Gui-Shuang Ying; Shannon Elizabeth Boye; William W Hauswirth; Andras M Komaromy

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3648. doi:

ARVO Annual Meeting Abstract June 2015

AAV-mediated Long Term Rescue of Cone Function in the CNGA3 -/- Nrl -/- Mice Following Intravitreal Injection

Yuxin Zhang; Wei Du; Ping Zhu; Jie Li; Wen-Tao Deng; Sanford L Boye; Xi-Qin Ding; Shannon Elizabeth Boye; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5468. doi:

ARVO Annual Meeting Abstract June 2015

Gene therapy for a mouse model of Achromatopsia

Shanta Sarfare; Seok-Hong Min; Sanford L Boye; Shannon Elizabeth Boye; William W Hauswirth; Christine Nichols Kay

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5469. doi:

ARVO Annual Meeting Abstract June 2015

AAV-mediated rescue of a mouse model of X-linked Congenital Stationary Night Blindness

Miranda White; Sanford L Boye; Frank M Dyka; Kathryn MH Fransen; Charles N de Leeuw; Elizabeth M. Simpson; Ronald G Gregg; Maureen A McCall; Neal S Peachey; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2036. doi:

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An AAV-CRISPR/Cas9 gene editing approach for GUCY2D -associated cone rod dystrophy (CORD6)

Development of a drug-regulated, broad-spectrum neuroprotective gene therapy for retinal degeneration

Investigating tolerability of subretinally delivered dual AAV-MYO7A vectors in non-human primate (NHP)

AAV 44.9- a novel capsid that efficiently transduces photoreceptors and retinal pigment epithelium

Subfoveal Injections in Non-Human Primates: Safety and Efficacy Following Administration of a Photoreceptor-Targeted AAV5

Novel AAV variants isolated by directed evolution in primate display enhanced retinal transduction following intravitreal injection

AAV5 made by rHSV complementation displays increased retinal transduction relative to AAV5 made by plasmid transfection.

Directed Evolution of Enhanced AAV Capsid Variants Following Intravitreal Injection in Macaque

Investigating the utility of mice as a model for developing clinically relevant dual AAV vectors to treat USH1B

Optimization of transgene expression in the trabecular meshwork (TM) by comparing capsid mutant AAV2 vectors

Novel Methodology for Creating Primate Retina with Sortable Cell Populations

Towards a clinical trial to treat GUCY2D Leber congenital amaurosis (LCA1)

Transgenic expression of human photoreceptor guanylyl cyclase GUCY2D with LCA1 mutations: diversity of physiological effects and localization in photoreceptors.

Induction of Endogenous Nrf2 Activation in the Retina Partially Protects from Oxidative Stress and Inflammation

Targeting the Nrf2 Signaling Pathway in the Retina With a Gene-Delivered Secretable and Cell-Penetrating Peptide

Rational Design of AAV Vectors For Efficient Transduction of Müller Cells

In Vivo Gene Augmentation in the ADAMTS10 -Mutant Canine Trabecular Meshwork (TM) with Y444F-Capsid Mutant, Single-Stranded AAV2

AAV-mediated Long Term Rescue of Cone Function in the CNGA3 -/- Nrl -/- Mice Following Intravitreal Injection

Gene therapy for a mouse model of Achromatopsia

AAV-mediated rescue of a mouse model of X-linked Congenital Stationary Night Blindness

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