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ARVO Annual Meeting Abstract July 2018

An AAV-CRISPR/Cas9 gene editing approach for GUCY2D -associated cone rod dystrophy (CORD6)

Kevin Mccullough; Sanford L Boye; Diego Fajardo; Christianne E Strang; Douglas C. Witherspoon; Sebastian Gloskowski; Abhishek Dass; Paul D Gamlin; Morgan Maeder; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6020. doi:

ARVO Annual Meeting Abstract July 2018

Development of a drug-regulated, broad-spectrum neuroprotective gene therapy for retinal degeneration

John D Ash; Casey Keuthan; Aisha Imam; Sanford L Boye; Shannon Elizabeth Boye; Clayton Santiago

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3961. doi:

ARVO Annual Meeting Abstract July 2018

Investigating tolerability of subretinally delivered dual AAV-MYO7A vectors in non-human primate (NHP)

Kaitlyn Calabro; Sanford L Boye; Kevin Mccullough; Diego Fajardo; W Clay Smith; Christianne E Strang; Douglas C. Witherspoon; Dibyendu Chakraborty; Paul D Gamlin; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4535. doi:

ARVO Annual Meeting Abstract July 2018

AAV 44.9- a novel capsid that efficiently transduces photoreceptors and retinal pigment epithelium

Shreyasi Choudhury; Russell Mellen; Kevin Mccullough; James Peterson; Diego Fajardo; John Chiorini; Sanford L Boye; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4536. doi:

ARVO Annual Meeting Abstract July 2018

Subfoveal Injections in Non-Human Primates: Safety and Efficacy Following Administration of a Photoreceptor-Targeted AAV5

Ryan F. Boyd; Joshua T. Bartoe; Thomas S Vihtelic; Sanford L Boye; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5662. doi:

ARVO Annual Meeting Abstract June 2017

Novel AAV variants isolated by directed evolution in primate display enhanced retinal transduction following intravitreal injection

Shreyasi Choudhury; Damien Marsic; James Peterson; Diego Fajardo; Antonette Bennett; Paul D Gamlin; Mavis Agbandje-McKenna; Sergei Zolotukhin; Sanford L Boye; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4507. doi:

ARVO Annual Meeting Abstract June 2017

AAV5 made by rHSV complementation displays increased retinal transduction relative to AAV5 made by plasmid transfection.

Kevin Tyler Mccullough; Laura Adamson-Small; James Peterson; Sanford Boye; Nathalie Clément; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4084. doi:

ARVO Annual Meeting Abstract June 2017

Directed Evolution of Enhanced AAV Capsid Variants Following Intravitreal Injection in Macaque

Sanford L Boye; Shreyasi Choudhury; Damien Marsic; Christianne E Strang; John J Alexander; C. Douglas Witherspoon; Sergei Zolotukhin; Paul D Gamlin; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4087. doi:

ARVO Annual Meeting Abstract June 2017

Investigating the utility of mice as a model for developing clinically relevant dual AAV vectors to treat USH1B

Kaitlyn Calabro; Sanford Boye; Kevin Tyler Mccullough; Shreyasi Choudhury; Paul D Gamlin; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4098. doi:

ARVO Annual Meeting Abstract June 2017

Optimization of transgene expression in the trabecular meshwork (TM) by comparing capsid mutant AAV2 vectors

Christine Harman; Kristin Koehl; Annie Oh; Vince A Chiodo; Sanford L Boye; William W Hauswirth; Shannon Elizabeth Boye; Andras M Komaromy

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4611. doi:

ARVO Annual Meeting Abstract September 2016

Novel Methodology for Creating Primate Retina with Sortable Cell Populations

Shreyasi Choudhury; Christianne E Strang; Sanford L. Boye; Julie Lynch Hill; Douglas C Witherspoon; Daniel T Kasuga; Paul D Gamlin; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):766. doi:

ARVO Annual Meeting Abstract September 2016

Towards a clinical trial to treat GUCY2D Leber congenital amaurosis (LCA1)

Shannon Elizabeth Boye; Sanford L. Boye; William Hauswirth; James Peterson; Seok-Hong Min; Qing Ruan; Catherine O'Riordan; Michael Lukason; Rena Baek; Abraham Scaria

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Transgenic expression of human photoreceptor guanylyl cyclase GUCY2D with LCA1 mutations: diversity of physiological effects and localization in photoreceptors.

Elena V Olshevskaya; Sanford L. Boye; Kevin Tyler McCullough; Igor V Peshenko; Shannon Elizabeth Boye; Alexander M Dizhoor

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3180. doi:

ARVO Annual Meeting Abstract September 2016

Induction of Endogenous Nrf2 Activation in the Retina Partially Protects from Oxidative Stress and Inflammation

Cristhian J Ildefonso; Emily E Brown; Ryo Iwata; Chulbul M Ahmed; Michael Massengill; Manas Biswal; Shannon Elizabeth Boye; William W Hauswirth; John Ash; Qiuhong Li; Alfred S Lewin

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5399. doi:

ARVO Annual Meeting Abstract June 2015

Rational Design of AAV Vectors For Efficient Transduction of Müller Cells

Shreyasi Choudhury; Rachna Manek; Miranda White; Jinfeng Sun; Georgiy Aslanidi; Arun Svrivistava; Sanford L Boye; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3641. doi:

ARVO Annual Meeting Abstract June 2015

In Vivo Gene Augmentation in the ADAMTS10 -Mutant Canine Trabecular Meshwork (TM) with Y444F-Capsid Mutant, Single-Stranded AAV2

Christine Harman; Annie Oh; Kristin L Koehl; Sanford L Boye; Vince Chiodo; Jiayan Huang; Gui-Shuang Ying; Shannon Elizabeth Boye; William W Hauswirth; Andras M Komaromy

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3648. doi:

ARVO Annual Meeting Abstract June 2015

AAV-mediated Long Term Rescue of Cone Function in the CNGA3 -/- Nrl -/- Mice Following Intravitreal Injection

Yuxin Zhang; Wei Du; Ping Zhu; Jie Li; Wen-Tao Deng; Sanford L Boye; Xi-Qin Ding; Shannon Elizabeth Boye; William W Hauswirth

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5468. doi:

ARVO Annual Meeting Abstract June 2015

Gene therapy for a mouse model of Achromatopsia

Shanta Sarfare; Seok-Hong Min; Sanford L Boye; Shannon Elizabeth Boye; William W Hauswirth; Christine Nichols Kay

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5469. doi:

ARVO Annual Meeting Abstract June 2015

AAV-mediated rescue of a mouse model of X-linked Congenital Stationary Night Blindness

Miranda White; Sanford L Boye; Frank M Dyka; Kathryn MH Fransen; Charles N de Leeuw; Elizabeth M. Simpson; Ronald G Gregg; Maureen A McCall; Neal S Peachey; Shannon Elizabeth Boye

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2036. doi:

ARVO Annual Meeting Abstract June 2015

Gene therapy restores useful vision to a model of the GUCY2D -LCA1 patient fovea, the all-cone Nrl -/- GC1 -/- mouse

Shannon Elizabeth Boye; james peterson; Shreyasi Choudhury; Seok-Hong Min; Qing Ruan; Kevin T. McCullough; Alexander M Dizhoor; William W Hauswirth; Xi-Qin Ding; Sanford L Boye

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2065. doi:

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