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Retina June 2024

Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia

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Tatiana E. Getz; Micah A. Chrenek; Jack T. Papania; Debresha A. Shelton; Shanu Markand; P. Michael Iuvone; Zbynek Kozmik; Jeffrey H. Boatright; John M. Nickerson
TAGS: eye, mice, myopia, prescriptions, drug, retinal degeneration, retinol binding proteins, spectral domain-optical coherence tomography, retina, diagnostic imaging, photoreceptors
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):32. https://doi.org/10.1167/iovs.65.6.32

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Cytotoxic Effects of Elevated Homocysteine on Human Retinal Cells and Potential Treatment

Brynn K Schubert; shanu Markand

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4982.

ARVO Annual Meeting Abstract June 2024

Morphological analysis of retina from cone and rod conditional IRBP knockout mice

Micah A Chrenek; Chloe Reid; Manuela Garcia; Tatiana Getz; Shanu Markand; Jeffrey H Boatright; John M Nickerson

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4652.

ARVO Annual Meeting Abstract June 2021

Age-Related Ocular Changes in the RPE of C57/BL6J Mice

Vivian Summers; Salma Ferdous; Kristie Liao; Kevin Donaldson; Isabelle Gefke; Yong-Kyu Kim; Debresha Shelton; Jana T Sellers; Shanu Markand; Jeffrey H Boatright; John M Nickerson

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2977.

Biochemistry and Molecular Biology June 2021

Age-Related Retinal Changes in Wild-Type C57BL/6J Mice Between 2 and 32 Months

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Salma Ferdous; Kristie L. Liao; Isabelle D. Gefke; Vivian R. Summers; Wenfei Wu; Kevin J. Donaldson; Yong-Kyu Kim; Jana T. Sellers; Jendayi A. Dixon; Debresha A. Shelton; Shanu Markand; Somin M. Kim; Nan Zhang; Jeffrey H. Boatright; John M. Nickerson
TAGS: eye, mice, mice, inbred c57bl, body weight, photoreceptors, aging, retina
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):9. https://doi.org/10.1167/iovs.62.7.9

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Age-related Ocular Changes in C57BL/6J mice from P30 – P930

Vivian Persons; Salma Ferdous; Kristie L Liao; Wenfei Wu; Kevin J. Donaldson; Isabelle Gefke; Yong-Kyu Kim; Debresha Shelton; Jana T Sellers; Shanu Markand; Jeffrey H Boatright; John M Nickerson

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4011.

ARVO Annual Meeting Abstract July 2019

The effects of old age on RD and myopia in IRBP KO mice

Kristie Ling Liao; Shanu Markand; Salma Ferdous; Kevin Joseph Donaldson; Jeffrey H Boatright; John M Nickerson

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2335.

ARVO Annual Meeting Abstract July 2019

Interphotoreceptor Retinoid-Binding Protein (IRBP) prevents myopia, independent of mouse genetic backgrounds

Shanu Markand; Somin Kim; Micah A Chrenek; Jeffrey H Boatright; John M Nickerson

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2367.

ARVO Annual Meeting Abstract July 2018

Characterization of magnetofection transfection reagent, a novel transfection method for gene therapy in a mouse model

Priyanka Priyadarshani; Salma Ferdous; Shanu Markand; Kevin Joseph Donaldson; Jeffrey H Boatright; J M Nickerson

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4550.

ARVO Annual Meeting Abstract July 2018

Interaction between underlying pathways in IRBP induced myopia.

Shanu Markand; Paul Wong; Jeffrey H Boatright; J M Nickerson

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3071.

ARVO Annual Meeting Abstract June 2017

Assessment of efficacy of Magnetofection transfection system in delivering genes to RPE cells, a novel transfection method for gene therapy in mouse model.

Priyanka Priyadarshani; Shanu Markand; Jana T Sellers; Jeffrey H Boatright; J M Nickerson

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):621.

ARVO Annual Meeting Abstract June 2017

Upregulation of myopia-related genes in the Interphotoreceptor retinoid-binding protein (IRBP) knockout (KO) mouse model

Shanu Markand; Micah A Chrenek; Priyanka Priyadarshani; Jeffrey H Boatright; J M Nickerson

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2054.

ARVO Annual Meeting Abstract September 2016

Pupillary responses in the C57BL/6J and congenic IRBP knockout mouse

Kevin Joseph Donaldson; Shanu Markand; Jana T Sellers; Micah A Chrenek; Machelle T Pardue; P. Michael Iuvone; Jeffrey H Boatright; J M Nickerson

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):641.

ARVO Annual Meeting Abstract September 2016

Ocular parameters changes in the IRBP knockout mouse eye.

Shanu Markand; Sara A Wetzstein; Natecia Williams; Ranjay Chakraborty; priyanka priyadarshani; Kevin Donaldson; Jeffrey H Boatright; Machelle T Pardue; J M Nickerson

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1744.

ARVO Annual Meeting Abstract September 2016

Intravitreal injection vs. topical eye drop application of nanoparticles using a mouse model

Sara Wetzstein; Jana T Sellers; Kevin Donaldson; Gretchen Unger; Shanu Markand; priyanka priyadarshani; Jeffrey H Boatright; J M Nickerson

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1748.

ARVO Annual Meeting Abstract September 2016

Alternative splicing in the retina in a large family of genes is regulated by a single trans locus

J M Nickerson; Felix L Struebing; Shanu Markand; Kevin Donaldson; Salma Ferdous; Jeffrey H Boatright; Eldon E Geisert

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12)

ARVO Annual Meeting Abstract June 2015

Mild hyperhomocysteinemia (Hhcy) leads to modest retinal ganglion cell (RGC) dysfunction and focal vascular leakiness in rd8-free methylenetetrahydrofolate reductase ( Mthfr ) deficient mice.

Shanu Markand; Alan Saul; Rima Rozen; Arul Shanmugam; Vadivel Ganapathy; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4262.

Retinal Cell Biology April 2015

Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia

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Shanu Markand; Alan Saul; Penny Roon; Puttur Prasad; Pamela Martin; Rima Rozen; Vadivel Ganapathy; Sylvia B. Smith
TAGS: methylenetetrahydrofolate reductase (nadph2), mice, retina, vascular diseases, hyperhomocysteinemia
Invest. Ophthalmol. Vis. Sci.. 2015; 56(4):2684-2695. https://doi.org/10.1167/iovs.14-16190

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

Alterations of retinal vasculature in cystathionine-beta-synthase heterozygous mice, a model of mild-moderate hyperhomocysteinemia (HHcy).

Amany M Tawfik; Sally Elshafey; Arul Shanmugam; Shanu Markand; Kartik Angara; Mohamed Al-Shabrawey; Vadivel Ganapathy; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2250.

ARVO Annual Meeting Abstract April 2014

Comprehensive characterization of retinal phenotypic changes in methylene tetrahydrofolate reductase (MTHFR) deficient mice: a model of hyperhomocysteinemia (HHcy)

Shanu Markand; Arul Shanmugam; Amany Tawfik; Penny Roon; Alan Saul; Rima Rozen; Vadivel Ganapathy; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):353.

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Conditional Knockouts of Interphotoreceptor Retinoid Binding Protein Suggest Two Independent Mechanisms for Retinal Degeneration and Myopia

Cytotoxic Effects of Elevated Homocysteine on Human Retinal Cells and Potential Treatment

Morphological analysis of retina from cone and rod conditional IRBP knockout mice

Age-Related Ocular Changes in the RPE of C57/BL6J Mice

Age-Related Retinal Changes in Wild-Type C57BL/6J Mice Between 2 and 32 Months

Age-related Ocular Changes in C57BL/6J mice from P30 – P930

The effects of old age on RD and myopia in IRBP KO mice

Interphotoreceptor Retinoid-Binding Protein (IRBP) prevents myopia, independent of mouse genetic backgrounds

Characterization of magnetofection transfection reagent, a novel transfection method for gene therapy in a mouse model

Interaction between underlying pathways in IRBP induced myopia.

Assessment of efficacy of Magnetofection transfection system in delivering genes to RPE cells, a novel transfection method for gene therapy in mouse model.

Upregulation of myopia-related genes in the Interphotoreceptor retinoid-binding protein (IRBP) knockout (KO) mouse model

Pupillary responses in the C57BL/6J and congenic IRBP knockout mouse

Ocular parameters changes in the IRBP knockout mouse eye.

Intravitreal injection vs. topical eye drop application of nanoparticles using a mouse model

Alternative splicing in the retina in a large family of genes is regulated by a single trans locus

Mild hyperhomocysteinemia (Hhcy) leads to modest retinal ganglion cell (RGC) dysfunction and focal vascular leakiness in rd8-free methylenetetrahydrofolate reductase ( Mthfr ) deficient mice.

Retinal Ganglion Cell Loss and Mild Vasculopathy in Methylene Tetrahydrofolate Reductase (Mthfr)-Deficient Mice: A Model of Mild Hyperhomocysteinemia

Alterations of retinal vasculature in cystathionine-beta-synthase heterozygous mice, a model of mild-moderate hyperhomocysteinemia (HHcy).

Comprehensive characterization of retinal phenotypic changes in methylene tetrahydrofolate reductase (MTHFR) deficient mice: a model of hyperhomocysteinemia (HHcy)

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