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ARVO Annual Meeting Abstract June 2017

MCP-1 disrupts morphologic and functional barrier properties of polarized retinal pigment epithelium

Hidetaka Noma; Kevin McDonald; Masahiko Shimura; Shigeo Tamiya

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):598. doi:

ARVO Annual Meeting Abstract June 2017

Production and characterization of a sustained release system of dasatinib to prevent proliferative vitreoretinopathy

Shigeo Tamiya; Rajat Chauhan; Rayeanne Balgemann; Hidetaka Noma; Kevin McDonald; Henry J Kaplan; Martin O'Toole

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4759. doi:

ARVO Annual Meeting Abstract June 2017

The effect of Dasatinib in PVR model

Kazuhiko Umazume; Ryousuke Matsushima; Rintaro Tsukahara; Naoyuki Yamakawa; Shigeo Tamiya; Hiroshi Goto

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5975. doi:

ARVO Annual Meeting Abstract September 2016

The role of FAK in fibrotic matrix contraction by dedifferentiated Müller cells

Rintaro Tsukahara; Kazuhiko Umazume; Naoyuki Yamakawa; Takuya Iwasaki; Henry J Kaplan; Hiroshi Goto; Shigeo Tamiya

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4195. doi:

ARVO Annual Meeting Abstract September 2016

PYK2 plays a role in matrix contraction by RPE-derived cells

Shigeo Tamiya; Kevin McDonald; Henry J Kaplan

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):246. doi:

ARVO Annual Meeting Abstract June 2015

Molecular mechanism of dasatinib inhibition of matrix contraction

Rintaro Tsukahara; Kevin McDonald; Hiroshi Goto; Henry J Kaplan; Shigeo Tamiya

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):410. doi:

ARVO Annual Meeting Abstract April 2014

Dasatinib inhibits contraction of Müller and RPE cells on type I collagen gel assay

Rintaro Tsukahara; Kazuhiko Umazume; Kevin McDonald; Hiroshi Goto; Henry J Kaplan; Shigeo Tamiya

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1081. doi:

ARVO Annual Meeting Abstract June 2013

β-catenin signaling in RPE in experimental PVR

Kazuhiko Umazume; LanHsin Liu; Kevin McDonald; Hiroshi Goto; Henry Kaplan; Shigeo Tamiya

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):6252. doi:

Retinal Cell Biology February 2013

Inhibition of PVR with a Tyrosine Kinase Inhibitor, Dasatinib, in the Swine

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Kazuhiko Umazume; LanHsin Liu; Patrick A. Scott; Juan P. Fernandez de Castro; Kevin McDonald; Henry J. Kaplan; Shigeo Tamiya
TAGS: suidae, protein-tyrosine kinase inhibitor, dasatinib, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2013; 54(2):1150-1159. doi: 10.1167/iovs.12-10418

Retina July 2012

Proliferative Vitreoretinopathy in the Swine–A New Model

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Kazuhiko Umazume; Yoreh Barak; Kevin McDonald; LanHsin Liu; Henry J. Kaplan; Shigeo Tamiya
TAGS: epiretinal membrane, retinal detachment, surgical procedures, operative, suidae, vitreoretinopathy, proliferative, eye, retina, traction retinal detachment, intravitreal injections, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2012; 53(8):4910-4916. doi: 10.1167/iovs.12-9768

ARVO Annual Meeting Abstract March 2012

Development of a Swine Model of Proliferative Vitreoretinopathy Using RPE Cells

Kazuhiko Umazume; Yoreh Barak; Kevin L. Mcdonald; Lan Hsin Liu; Henry J. Kaplan; Shigeo Tamiya

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):890. doi:

ARVO Annual Meeting Abstract March 2012

Curcumin as Adjunctive Therapy for Proliferative Vitreoretinopathy

Shigeo Tamiya; Yoreh Barak; Kazuhiko Umazume; LanHsin Liu; Kevin L. McDonald; Henry J. Kaplan

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):898. doi:

ARVO Annual Meeting Abstract April 2011

Tyrosine Kinase Inhibitors Prevent Retinal Pigment Epithelial Cell EMT and Growth

Shigeo Tamiya; LanHsin Liu; Henry J. Kaplan

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):6593. doi:

Retinal Cell Biology May 2010

Epithelial-Mesenchymal Transition and Proliferation of Retinal Pigment Epithelial Cells Initiated upon Loss of Cell-Cell Contact

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Shigeo Tamiya; LanHsin Liu; Henry J. Kaplan
TAGS: cadherins, epithelial to mesenchymal transition, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2010; 51(5):2755-2763. doi: 10.1167/iovs.09-4725

Biochemistry and Molecular Biology November 2009

Zeb1 Represses Mitf and Regulates Pigment Synthesis, Cell Proliferation, and Epithelial Morphology

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Yongqing Liu; Fei Ye; Qiutang Li; Shigeo Tamiya; Douglas S. Darling; Henry J. Kaplan; Douglas C. Dean
TAGS: polymerase chain reaction, cell proliferation, epithelium, anaplasia, pigment, rna, messenger, morphology, mitf protein, language morphology, retinal pigment cell
Invest. Ophthalmol. Vis. Sci.. 2009; 50(11):5080-5088. doi: 10.1167/iovs.08-2911

Includes: Supplemental Content

Lens June 2005

Studies of Tyrosine Phosphorylation and Src Family Tyrosine Kinases in the Lens Epithelium

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Shigeo Tamiya; Nicholas A. Delamere
TAGS: western blotting, epithelium, lens (device), phosphorylation, phosphotransferases, src-family kinases, proteins, tyrosine, lens epithelium
Invest. Ophthalmol. Vis. Sci.. 2005; 46(6):2076-2081. doi: 10.1167/iovs.04-1199

Lens May 2004

Regional Differences in Tyrosine Kinase Receptor Signaling Components Determine Differential Growth Patterns in the Human Lens

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Jill M. Maidment; George Duncan; Shigeo Tamiya; David J. Collison; Lixin Wang; I. Michael Wormstone
TAGS: signal transduction, epithelium, lens (device), protein tyrosine kinase, epidermal growth factor receptors, geographic difference
Invest. Ophthalmol. Vis. Sci.. 2004; 45(5):1427-1435. doi: 10.1167/iovs.03-1187

Lens October 2003

Regional Distribution of Na,K-ATPase Activity in Porcine Lens Epithelium

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Shigeo Tamiya; William L. Dean; Christopher A. Paterson; Nicholas A. Delamere
TAGS: adenosine triphosphatases, suidae, proteins, lens epithelium
Invest. Ophthalmol. Vis. Sci.. 2003; 44(10):4395-4399. doi: 10.1167/iovs.03-0287

Lens July 2002

TGF-β2–Induced Matrix Modification and Cell Transdifferentiation in the Human Lens Capsular Bag

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I. Michael Wormstone; Shigeo Tamiya; Ian Anderson; George Duncan
TAGS: computed tomography, fibronectins, cataract, cats, chloramphenicol o-acetyltransferase, lens, crystalline, surgical procedures, operative, antibodies, eye, proteins, cell transdifferentiation, adaptive testing, copd assessment test
Invest. Ophthalmol. Vis. Sci.. 2002; 43(7):2301-2308. doi:

Lens May 2001

FGF: An Autocrine Regulator of Human Lens Cell Growth Independent of Added Stimuli

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I. Michael Wormstone; Katia Del Rio–Tsonis; Gerald McMahon; Shigeo Tamiya; Peter D. Davies; Julia M. Marcantonio; George Duncan
TAGS: methionine, enzyme-linked immunosorbent assay, cell growth, fibroblast growth factor 2, lens, crystalline, fibroblast growth factor receptors, reverse transcriptase polymerase chain reaction, proteins, protein biosynthesis, autocrine, donors
Invest. Ophthalmol. Vis. Sci.. 2001; 42(6):1305-1311. doi:

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MCP-1 disrupts morphologic and functional barrier properties of polarized retinal pigment epithelium

Production and characterization of a sustained release system of dasatinib to prevent proliferative vitreoretinopathy

The effect of Dasatinib in PVR model

The role of FAK in fibrotic matrix contraction by dedifferentiated Müller cells

PYK2 plays a role in matrix contraction by RPE-derived cells

Molecular mechanism of dasatinib inhibition of matrix contraction

Dasatinib inhibits contraction of Müller and RPE cells on type I collagen gel assay

β-catenin signaling in RPE in experimental PVR

Inhibition of PVR with a Tyrosine Kinase Inhibitor, Dasatinib, in the Swine

Proliferative Vitreoretinopathy in the Swine–A New Model

Development of a Swine Model of Proliferative Vitreoretinopathy Using RPE Cells

Curcumin as Adjunctive Therapy for Proliferative Vitreoretinopathy

Tyrosine Kinase Inhibitors Prevent Retinal Pigment Epithelial Cell EMT and Growth

Epithelial-Mesenchymal Transition and Proliferation of Retinal Pigment Epithelial Cells Initiated upon Loss of Cell-Cell Contact

Zeb1 Represses Mitf and Regulates Pigment Synthesis, Cell Proliferation, and Epithelial Morphology

Studies of Tyrosine Phosphorylation and Src Family Tyrosine Kinases in the Lens Epithelium

Regional Differences in Tyrosine Kinase Receptor Signaling Components Determine Differential Growth Patterns in the Human Lens

Regional Distribution of Na,K-ATPase Activity in Porcine Lens Epithelium

TGF-β2–Induced Matrix Modification and Cell Transdifferentiation in the Human Lens Capsular Bag

FGF: An Autocrine Regulator of Human Lens Cell Growth Independent of Added Stimuli

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