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ARVO Annual Meeting Abstract June 2020

Evaluation of a gene augmentation strategy for treating CRX -linked retinopathies

CHI SUN; Shiming Chen

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2743. doi:

ARVO Annual Meeting Abstract July 2019

Generation of a transgenic mouse for inducible ectopic CRX expression

CHI SUN; Shiming Chen

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2374. doi:

ARVO Annual Meeting Abstract July 2019

Rhodopsin enhancers mediate distinct temporal control of gene expression

Philip Ruzycki; Xiaodong Zhang; Shiming Chen

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1735. doi:

ARVO Annual Meeting Abstract July 2019

Global RNA metabolic changes associated with a dominant-negative Crx mutation

Inez Oh; Shiming Chen

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1003. doi:

Biochemistry and Molecular Biology September 2017

Crx-L253X Mutation Produces Dominant Photoreceptor Defects in TVRM65 Mice

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Philip A. Ruzycki; Courtney D. Linne; Anne K. Hennig; Shiming Chen
TAGS: mice, mutation, photoreceptors, retina, proteins, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4644-4653. doi: https://doi.org/10.1167/iovs.17-22075

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Long Range Genomic Interactions Regulate Photoreceptor Gene Expression

Philip Andrew Ruzycki; Courtney Danielle Linne; Shiming Chen

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4774. doi:

ARVO Annual Meeting Abstract June 2017

Crx-L253X mutation produces dominant photoreceptor defects in TVRM65 mice

Courtney Danielle Linne; Philip Andrew Ruzycki; Anne Hennig; Shiming Chen

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3588. doi:

ARVO Annual Meeting Abstract June 2017

TFIIH-ERCC2 Is Essential For Photoreceptor Gene Expression and Development

Xiaodong Zhang; Philip Andrew Ruzycki; Anne Hennig; Mingyan Yang; Shiming Chen

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3589. doi:

ARVO Annual Meeting Abstract June 2017

Hyper-stability of mutant mRNA causes pathogenic overexpression of mutant CRX in autosomal dominant retinopathies

Inez Oh; Xiaodong Zhang; Nicholas Tran; Shiming Chen

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3590. doi:

ARVO Annual Meeting Abstract September 2016

ChIPseq profiling of histone modification changes reveals gene misregulation mechanisms in mouse models of photoreceptor disease.

Philip Andrew Ruzycki; Xiaodong Zhang; Shiming Chen

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4816. doi:

Retinal Cell Biology July 2016

Crx Rdy Cat: A Large Animal Model for CRX -Associated Leber Congenital Amaurosis

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Laurence M. Occelli; Nicholas M. Tran; Kristina Narfström; Shiming Chen; Simon M. Petersen-Jones
TAGS: adaptive testing, animal model, cats, electroretinography, leber's amaurosis, photoreceptors, retina, retinal cone, rod photoreceptors, proteins
Invest. Ophthalmol. Vis. Sci.. 2016; 57(8):3780-3792. doi: https://doi.org/10.1167/iovs.16-19444

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Phenotypic characterization of cats homozygous for a frameshift mutation in Crx ( Crx Rdy/Rdy )

Laurence Mireille Occelli; Nicholas Minh Tran; Kristina Narfstrom; Shiming Chen; Simon M Petersen-Jones

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5395. doi:

ARVO Annual Meeting Abstract June 2015

Circularized Chromatin Conformation Capture (4C-seq) Identified Differences in Genome Organization Between Rod and Cone Photoreceptors

Philip Andrew Ruzycki; Shiming Chen

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1320. doi:

ARVO Annual Meeting Abstract June 2013

Distinct molecular mechanisms responsible for different retinopathies caused by CRX mutations DNH and LFH

Alan Zhang; Nicholas Tran; Xiaodong Zhang; Shiming Chen

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1580. doi:

ARVO Annual Meeting Abstract June 2013

GTF2IRD1 is a Dual-FunctionTranscription Factor that Promotes M Opsin Gene Expression and Suppresses S Opsin Gene Expression in M Cones

Donald Zack; Anitha Yerrabelli; Xiaodong Zhang; Elizabeth Conner; Snorri Thorgeirsson; Anand Swaroop; Shiming Chen; Tomohiro Masuda

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2613. doi:

ARVO Annual Meeting Abstract June 2013

The MLL1 Histone Methyltransferease is Essential for Development of Photoreceptor Function

Diana Brightman; Ray Suzuki; Shiming Chen

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2617. doi:

ARVO Annual Meeting Abstract March 2012

Crx Overexpression Identified in a Knock-IN Mouse Model for Severe Forms of Crx-Associated Disease

Nicholas M. Tran; Shiming Chen

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1636. doi:

ARVO Annual Meeting Abstract March 2012

CrxRdy Cat: An Excellent Large Animal Model For Severe Dominant Retinopathies Associated With CRX Mutations Based On Its Functional And Structural Characterization

Laurence M. Occelli; Nicholas M. Tran; Freya M. Mowat; Kara R. Gornik; Joshua T. Bartoe; Andrea L. Minella; Ashlee R. Bruewer; Kristina Narfstrom; Shiming Chen; Simon M. Petersen-Jones

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1638. doi:

ARVO Annual Meeting Abstract March 2012

TFIIH-XPD Co-Activator Protein in Photoreceptor and Retinal Pigment Epithelial Gene Transcription and Disease

Shiming Chen; Xiaodong Zhang

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1224. doi:

ARVO Annual Meeting Abstract April 2011

Crx E168d2, an Autosomal Dominant Mouse Model for Cone-Rod Dystrophy, Exhibits a Genetic Interaction with Otx2 in Mature Photoreceptors

Nicholas M. Tran; Shiming Chen

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5390. doi:

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Evaluation of a gene augmentation strategy for treating CRX -linked retinopathies

Generation of a transgenic mouse for inducible ectopic CRX expression

Rhodopsin enhancers mediate distinct temporal control of gene expression

Global RNA metabolic changes associated with a dominant-negative Crx mutation

Crx-L253X Mutation Produces Dominant Photoreceptor Defects in TVRM65 Mice

Long Range Genomic Interactions Regulate Photoreceptor Gene Expression

Crx-L253X mutation produces dominant photoreceptor defects in TVRM65 mice

TFIIH-ERCC2 Is Essential For Photoreceptor Gene Expression and Development

Hyper-stability of mutant mRNA causes pathogenic overexpression of mutant CRX in autosomal dominant retinopathies

ChIPseq profiling of histone modification changes reveals gene misregulation mechanisms in mouse models of photoreceptor disease.

Crx Rdy Cat: A Large Animal Model for CRX -Associated Leber Congenital Amaurosis

Phenotypic characterization of cats homozygous for a frameshift mutation in Crx ( Crx Rdy/Rdy )

Circularized Chromatin Conformation Capture (4C-seq) Identified Differences in Genome Organization Between Rod and Cone Photoreceptors

Distinct molecular mechanisms responsible for different retinopathies caused by CRX mutations DNH and LFH

GTF2IRD1 is a Dual-FunctionTranscription Factor that Promotes M Opsin Gene Expression and Suppresses S Opsin Gene Expression in M Cones

The MLL1 Histone Methyltransferease is Essential for Development of Photoreceptor Function

Crx Overexpression Identified in a Knock-IN Mouse Model for Severe Forms of Crx-Associated Disease

CrxRdy Cat: An Excellent Large Animal Model For Severe Dominant Retinopathies Associated With CRX Mutations Based On Its Functional And Structural Characterization

TFIIH-XPD Co-Activator Protein in Photoreceptor and Retinal Pigment Epithelial Gene Transcription and Disease

Crx E168d2, an Autosomal Dominant Mouse Model for Cone-Rod Dystrophy, Exhibits a Genetic Interaction with Otx2 in Mature Photoreceptors

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