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ARVO Annual Meeting Abstract June 2021

Single-cell RNA-seq analysis of human cornea and corneal organoid

George Maiti; Karl J Wahlin; James W Foster; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):952. doi:

ARVO Annual Meeting Abstract June 2021

Reduced WNT10A in keratoconus corneal epithelium and Bowman’s layer and upregulation of collagen I suggest Wnt signaling as a therapeutic target

Uri Soiberman; James W Foster; Michelle Lu; Shukti Chakravarti; Albert S Jun; Charles Eberhart

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2043. doi:

Cornea May 2021

Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer

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James W. Foster; Rupin N. Parikh; Jiangxia Wang; Kraig S. Bower; Mario Matthaei; Shukti Chakravarti; Albert S. Jun; Charles G. Eberhart; Uri S. Soiberman
TAGS: epithelium, keratoconus, wnt10a gene, bowman's layer
Invest. Ophthalmol. Vis. Sci.. 2021; 62(6):16. doi: https://doi.org/10.1167/iovs.62.6.16

Includes: Supplemental Content

Cornea August 2019

Small Molecule Modulation of the Integrated Stress Response Governs the Keratoconic Phenotype In Vitro

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Uri Simcha Soiberman; Ahmed Elsayed Mahmoud Shehata; Michelle Xiaoyi Lu; Tempest Young; Yassine J. Daoud; Shukti Chakravarti; Albert S. Jun; James William Foster
TAGS: keratoconus, phenotype, regulation, small molecule, stress response, fibroblasts, proteins, cell count, collagen synthesis, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3422-3431. doi: https://doi.org/10.1167/iovs.19-27151

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Transcriptomic analysis of corneas from Keratoconus patients in Saudi Arabia and the United States.

Nan Hu; Vishal Shinde; James W Foster; Uri Soiberman; Yassine Jamil Daoud; Alka Mahale; Samar A Al-Swailem; Albert Jun; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2922. doi:

ARVO Annual Meeting Abstract July 2018

Role of FOXO1 in the progression of Keratoconus.

Vishal Shinde; James W Foster; Yassine Jamil Daoud; Albert Jun; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2923. doi:

ARVO Annual Meeting Abstract July 2018

Development of cornea organoids from human induced pluripotent stem cells and their future use

Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2610. doi:

Cornea June 2018

Integrated Stress Response and Decreased ECM in Cultured Stromal Cells From Keratoconus Corneas

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James W. Foster; Vishal Shinde; Uri S. Soiberman; Gajanan Sathe; Sheng Liu; Julius Wan; Jiang Qian; Yassine Dauoud; Akhilesh Pandey; Albert S. Jun; Shukti Chakravarti
TAGS: collagen, cornea, keratoconus, keratocytes, proteins, stress response, stromal cells, peptides, cell culture techniques
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2977-2986. doi: https://doi.org/10.1167/iovs.18-24367

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

AKT and mTOR differential signaling in keratoconus compared to donor stromal cells.

Vishal Shinde; James W Foster; Yassine Jamil Daoud; Uri Soiberman; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3903. doi:

ARVO Annual Meeting Abstract June 2017

Molecular insights into ECM and collagen assembly disruptions in keratoconus

James William Foster; Vishal Shinde; Uri Soiberman; Yassine Jamil Daoud; Fares Alsaleh; Gajanan Sathe; Jun Wan; Jiang Qian; Albert S Jun; Akhilesh Pandey; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3904. doi:

ARVO Annual Meeting Abstract June 2017

Proteomic comparison of keratoconus with and without vernal keratoconjunctivitis in individuals from Saudi Arabia.

Shukti Chakravarti; Alka Mahale; Gajanan Sathe; James W Foster; Vishal Shinde; Akhilesh Pandey; Charles Eberhart; Albert S Jun; Samar A Al-Swailem; Donald U Stone; Azza Maktabi

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3902. doi:

ARVO Annual Meeting Abstract June 2017

Corneal proteoglycan lumican modulates lipid rafts and innate immunity

George Maiti; Jihane Frikeche; Ye Eun Jeong; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2064. doi:

Research Highlight April 2017

Fibrillin Microfibrils Keep the Cornea in Shape

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Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2117. doi: https://doi.org/10.1167/iovs.17-21840

ARVO Annual Meeting Abstract June 2015

Keratoconus transcriptome analysis by RNA-Seq of individual corneas identifies dysregulated cell survival and mesenchymal regulatory programs.

Shukti Chakravarti; Steven Salzberg; Stacey Gabriel; Yassine Daoud; James W Foster; Albert S Jun; Walter J. Stark; Phenotypic and Genotypic Analysis of Keratoconus

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1929. doi:

ARVO Annual Meeting Abstract June 2015

Cultured stromal cells from keratoconus corneas show reduced fibrillar collagen deposition with no changes in overall collagen production

James W Foster; Yassine Daoud; Walter J. Stark; Laura Kallay; John R Hassell; Albert S Jun; Shukti Chakravarti

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1931. doi:

ARVO Annual Meeting Abstract April 2014

Peptidoglycan recognition protein 2 (Pglyrp 2) exacerbates Pseudomonas aeruginosa keratitis in a mouse model.

Shukti Chakravarti; Ranjita N Gowda; Sudarshan Punglay; Wai-Hong Wu; Abdel R Hamad

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1463. doi:

ARVO Annual Meeting Abstract April 2014

Age Effect on Glaucoma Susceptibility: CD1 vs B6

Matthew Steinhart; Elizabeth Cone-Kimball; Cathy Nguyen; Thao D Nguyen; Mary Ellen Pease; Shukti Chakravarti; Ericka Oglesby; Harry Quigley; Glaucoma Center of Excellence

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3818. doi:

ARVO Annual Meeting Abstract April 2014

Down-Regulation of Fibromodulin Is Critical In Regulation of Stromal Matrix Assembly and Corneal Transparency

Shoujun Chen; Ake Oldberg; Shukti Chakravarti; David E Birk

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4607. doi:

ARVO Annual Meeting Abstract June 2013

Interclass Synergistic Effects of Small Leucine-Rich Proteoglycans in Regulating Collagen Fibrillogenesis During Corneal Development

Shoujun Chen; Shukti Chakravarti; David Birk

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):5255. doi:

Cornea March 2013

L450W and Q455K Col8a2 Knock-In Mouse Models of Fuchs Endothelial Corneal Dystrophy Show Distinct Phenotypes and Evidence for Altered Autophagy

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Huan Meng; Mario Matthaei; Narendrakumar Ramanan; Rhonda Grebe; Shukti Chakravarti; Caroline L. Speck; Martha Kimos; Neeraj Vij; Charles G. Eberhart; Albert S. Jun
TAGS: autophagy, endothelium, mice, polymerase chain reaction, hereditary corneal dystrophy, corneal endothelium, phenotype, cornea, proteins, up-regulation (physiology)
Invest. Ophthalmol. Vis. Sci.. 2013; 54(3):1887-1897. doi: https://doi.org/10.1167/iovs.12-11021

Includes: Supplemental Content

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Single-cell RNA-seq analysis of human cornea and corneal organoid

Reduced WNT10A in keratoconus corneal epithelium and Bowman’s layer and upregulation of collagen I suggest Wnt signaling as a therapeutic target

Transcriptomic and Immunohistochemical Analysis of Progressive Keratoconus Reveal Altered WNT10A in Epithelium and Bowman's Layer

Small Molecule Modulation of the Integrated Stress Response Governs the Keratoconic Phenotype In Vitro

Transcriptomic analysis of corneas from Keratoconus patients in Saudi Arabia and the United States.

Role of FOXO1 in the progression of Keratoconus.

Development of cornea organoids from human induced pluripotent stem cells and their future use

Integrated Stress Response and Decreased ECM in Cultured Stromal Cells From Keratoconus Corneas

AKT and mTOR differential signaling in keratoconus compared to donor stromal cells.

Molecular insights into ECM and collagen assembly disruptions in keratoconus

Proteomic comparison of keratoconus with and without vernal keratoconjunctivitis in individuals from Saudi Arabia.

Corneal proteoglycan lumican modulates lipid rafts and innate immunity

Fibrillin Microfibrils Keep the Cornea in Shape

Keratoconus transcriptome analysis by RNA-Seq of individual corneas identifies dysregulated cell survival and mesenchymal regulatory programs.

Cultured stromal cells from keratoconus corneas show reduced fibrillar collagen deposition with no changes in overall collagen production

Peptidoglycan recognition protein 2 (Pglyrp 2) exacerbates Pseudomonas aeruginosa keratitis in a mouse model.

Age Effect on Glaucoma Susceptibility: CD1 vs B6

Down-Regulation of Fibromodulin Is Critical In Regulation of Stromal Matrix Assembly and Corneal Transparency

Interclass Synergistic Effects of Small Leucine-Rich Proteoglycans in Regulating Collagen Fibrillogenesis During Corneal Development

L450W and Q455K Col8a2 Knock-In Mouse Models of Fuchs Endothelial Corneal Dystrophy Show Distinct Phenotypes and Evidence for Altered Autophagy

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