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Glaucoma January 2025

In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics

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Daniel Kim; Raymond Fang; Pengpeng Zhang; Zihang Yan; Cheng Sun; Guorong Li; Christa Montgomery; Simon W. M. John; W. Daniel Stamer; Hao F. Zhang; C. Ross Ethier
TAGS: anterior chamber of eye, aqueous humor, diagnostic imaging, eye, mice, vaccine information sheets, volume, x-ray microtomography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):18. https://doi.org/10.1167/iovs.66.1.18

Includes: Supplemental Content

Perspective February 2022

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

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Colleen M. McDowell; Krishnakumar Kizhatil; Michael H. Elliott; Darryl R. Overby; Joseph van Batenburg-Sherwood; J. Cameron Millar; Markus H. Kuehn; Gulab Zode; Ted S. Acott; Michael G. Anderson; Sanjoy K. Bhattacharya; Jacques A. Bertrand; Terete Borras; Diane E. Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A. Faralli; Rudolf Fuchshofer; Preethi S. Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W. M. John; Paul L. Kaufman; Kate E. Keller; Mary J. Kelley; Ruth A. Kelly; David Krizaj; Ajay Kumar; Brian C. Leonard; Raquel L. Lieberman; Paloma Liton; Yutao Liu; Katy C. Liu; Navita N. Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J. McLellan; Philip Mzyk; Andrews Nartey; Louis R. Pasquale; Gaurang C. Patel; Padmanabhan P. Pattabiraman; Donna M. Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R. Samples; E. Griffen Samples; Najam Sharif; Joel S. Schuman; Val C. Sheffield; Cooper H. Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B. Toris; Karen Y. Torrejon; Amir Vahabikashi; Janice A. Vranka; Ting Wang; Colin E. Willoughby; Chen Xin; Hongmin Yun; Hao F. Zhang; Michael P. Fautsch; Ernst R. Tamm; Abbot F. Clark; C. Ross Ethier; W. Daniel Stamer
TAGS: eye, mice, ocular hypertension, intraocular pressure, perfusion
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):12. https://doi.org/10.1167/iovs.63.2.12

Glaucoma August 2019

Meox2 Haploinsufficiency Accelerates Axonal Degeneration in DBA/2J Glaucoma

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Rebecca A. Buchanan; Kate E. Foley; Keating W. Pepper; Alaina M. Reagan; Kelly J. Keezer; Amanda A. Hewes; Cory A. Diemler; Christoph Preuss; Ileana Soto; Simon W. M. John; Gareth R. Howell
TAGS: glaucoma, haploinsufficiency, mice, retrograde degeneration, optic disk, retina, axon, eye, myeloid cells, genes
Invest. Ophthalmol. Vis. Sci.. 2019; 60(10):3283-3296. https://doi.org/10.1167/iovs.18-26126

Includes: Supplemental Content

Glaucoma October 2016

An In Vitro Perfusion System to Enhance Outflow Studies in Mouse Eyes

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Krishnakumar Kizhatil; Arthur Chlebowski; Nicholas G. Tolman; Nelson F. Freeburg; Margaret M. Ryan; Nicholas N. Shaw; Alexander D. M. Kokini; Jeffrey K. Marchant; Simon W. M. John
TAGS: eye, mice, perfusion
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5207-5215. https://doi.org/10.1167/iovs.16-19481

Includes: Supplemental Content

Glaucoma October 2015

Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma in Col4a1 Mutant Mice

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Mao Mao; Richard S. Smith; Marcel V. Alavi; Jeffrey K. Marchant; Mihai Cosma; Richard T. Libby; Simon W. M. John; Douglas B. Gould
TAGS: congenital abnormality, glaucoma, mice, genetics, phenotype
Invest. Ophthalmol. Vis. Sci.. 2015; 56(11):6823-6831. https://doi.org/10.1167/iovs.15-17527

Includes: Supplemental Content

Glaucoma August 2011

Missing Optomotor Head-Turning Reflex in the DBA/2J Mouse

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Peter Barabas; Wei Huang; Hui Chen; Christopher L. Koehler; Gareth Howell; Simon W. M. John; Ning Tian; René C. Rentería; David Križaj
TAGS: mice, reflex, glaucoma
Invest. Ophthalmol. Vis. Sci.. 2011; 52(9):6766-6773. https://doi.org/10.1167/iovs.10-7147

Includes: Multimedia, Supplemental Content

Glaucoma April 2011

Anterior Segment Dysgenesis and Early-Onset Glaucoma in nee Mice with Mutation of Sh3pxd2b

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Mao Mao; Adam Hedberg-Buenz; Demelza Koehn; Simon W. M. John; Michael G. Anderson
TAGS: congenital abnormality, glaucoma, mice, mutation
Invest. Ophthalmol. Vis. Sci.. 2011; 52(5):2679-2688. https://doi.org/10.1167/iovs.10-5993

Includes: Supplemental Content

Anatomy and Pathology/Oncology April 2009

The Aqueous Humor Outflow Pathway of Zebrafish

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Matthew P. Gray; Richard S. Smith; Kelly A. Soules; Simon W. M. John; Brian A. Link
TAGS: aqueous humor, zebrafish, eye, mammals, body tissue, injections
Invest. Ophthalmol. Vis. Sci.. 2009; 50(4):1515-1521. https://doi.org/10.1167/iovs.08-3010

Anatomy and Pathology/Oncology September 2007

Analysis of Ocular Hypopigmentation in Rab38 cht/cht Mice

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Brian P. Brooks; Denise M. Larson; Chi-Chao Chan; Sten Kjellstrom; Richard S. Smith; Mary A. Crawford; Lynn Lamoreux; Marjan Huizing; Richard Hess; Xiaodong Jiao; J. Fielding Hejtmancik; Arvydas Maminishkis; Simon W. M. John; Ronald Bush; William J. Pavan
TAGS: hypopigmentation disorder, mice, proteins, eye, melanosomes, immune reconstitution inflammatory syndrome
Invest. Ophthalmol. Vis. Sci.. 2007; 48(9):3905-3913. https://doi.org/10.1167/iovs.06-1464

Lecture August 2005

Mechanistic Insights into Glaucoma Provided by Experimental Genetics The Cogan Lecture

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Simon W. M. John
TAGS: glaucoma, mice, genetics, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2005; 46(8):2650-2661. https://doi.org/10.1167/iovs.05-0205

Physiology and Pharmacology December 2004

Intraocular Pressure in Zebrafish: Comparison of Inbred Strains and Identification of a Reduced Melanin Mutant with Raised IOP

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Brian A. Link; Matthew P. Gray; Richard S. Smith; Simon W. M. John
TAGS: intraocular pressure, melanins, raised intraocular pressure, zebrafish, mammals, glaucoma, phenotype
Invest. Ophthalmol. Vis. Sci.. 2004; 45(12):4415-4422. https://doi.org/10.1167/iovs.04-0557

Glaucoma June 2003

Novel Anterior Segment Phenotypes Resulting from Forkhead Gene Alterations: Evidence for Cross-Species Conservation of Function

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Ordan J. Lehmann; Stephen Tuft; Glen Brice; Richard Smith; Åsa Blixt; Rachel Bell; Bengt Johansson; Tim Jordan; Roger A. Hitchings; Peng T. Khaw; Simon W. M. John; Peter Carlsson; Shomi S. Bhattacharya
TAGS: genes, phenotype, mutation, glaucoma, foxc2 gene, cornea
Invest. Ophthalmol. Vis. Sci.. 2003; 44(6):2627-2633. https://doi.org/10.1167/iovs.02-0609

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In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Meox2 Haploinsufficiency Accelerates Axonal Degeneration in DBA/2J Glaucoma

An In Vitro Perfusion System to Enhance Outflow Studies in Mouse Eyes

Strain-Dependent Anterior Segment Dysgenesis and Progression to Glaucoma in Col4a1 Mutant Mice

Missing Optomotor Head-Turning Reflex in the DBA/2J Mouse

Anterior Segment Dysgenesis and Early-Onset Glaucoma in nee Mice with Mutation of Sh3pxd2b

The Aqueous Humor Outflow Pathway of Zebrafish

Analysis of Ocular Hypopigmentation in Rab38 cht/cht Mice

Mechanistic Insights into Glaucoma Provided by Experimental Genetics The Cogan Lecture

Intraocular Pressure in Zebrafish: Comparison of Inbred Strains and Identification of a Reduced Melanin Mutant with Raised IOP

Novel Anterior Segment Phenotypes Resulting from Forkhead Gene Alterations: Evidence for Cross-Species Conservation of Function

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