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Cornea August 2020

Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress

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Zhao Liu; Ding Chen; Xin Chen; Fang Bian; Wenjuan Qin; Ning Gao; Yangyan Xiao; Jinmiao Li; Stephen C. Pflugfelder; De-Quan Li
TAGS: autophagy, inflammation, stress, trehalose, corneal epithelial cells, signal pathway, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2020; 61(10):26. doi: https://doi.org/10.1167/iovs.61.10.26

ARVO Annual Meeting Abstract June 2020

Attenuated RXRa mediated suppression of innate IFN-γ production by conjunctival monocytes promotes conjunctiva goblet cell loss - implications for xerophthalmia of vitamin A deficiency

Jahan Alam; Stephen C Pflugfelder; Cintia De Paiva; Rodrigo de Souza; Zhiyuan Yu

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):138. doi:

Cornea October 2019

Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide

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Changjun Wang; Laura Schaefer; Fang Bian; Zhiyuan Yu; Stephen C. Pflugfelder; Robert A. Britton; Cintia S. de Paiva
TAGS: antibiotics, dysbiosis, inflammatory response, mice, microbiome, conjunctiva, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4224-4233. doi: https://doi.org/10.1167/iovs.19-27939

ARVO Annual Meeting Abstract July 2019

Short Ragweed Pollen Primes Macrophage Polarization toward an Alternatively Activated Phenotype via TSLP/TSLPR Signaling Pathway in Allergic Conjunctivitis

De-Quan Li; Ruzhi Deng; Xin Chen; Ning Gao; Jiaoyue Hu; Yun Zhang; Fang Bian; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1348. doi:

ARVO Annual Meeting Abstract July 2019

Increased conjunctival monocyte/macrophage antigen presenting cells in Pinkie RXRα deficient mice with accelerated dry eye

Stephen C Pflugfelder; Rodrigo Guimaraes de Souza; Jehan Alam; Zhiyuan Yu; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1413. doi:

ARVO Annual Meeting Abstract July 2019

Decrease in blink rate during video display viewing is lost in certain types of tear dysfunction

Travis Mitchell; Michael Murri; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2763. doi:

ARVO Annual Meeting Abstract July 2019

IL-27 Signaling Deficiency Develops Th17-enhanced Allergic Inflammation

Yun Zhang; Xin Chen; Ruzhi Deng; Wei Chi; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6722. doi:

ARVO Annual Meeting Abstract July 2019

Sjögren-Syndrome Microbiota Colonization in Germ-Free Mice induces Antigen-Presenting Cell Activation and Production of IL-12

Laura Schaefer; Claudia M Trujillo-Vargas; Stephen C Pflugfelder; Robert A Britton; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):272. doi:

ARVO Annual Meeting Abstract July 2019

Low humidity plus anti-cholinergic-induced dry eye skews toward a Th1 response

Zhiyuan Yu; Jehan Alam; Rodrigo G. de Souza; Cintia S De Paiva; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):275. doi:

ARVO Annual Meeting Abstract July 2018

IL-12 depletion Ameliorates Autoimmunity in the Germ-Free CD25KO Model of Sjögren Syndrome by Decreasing Generation of Th-1 cells

Cintia S De Paiva; Mahira Zaheer; Zhiyuan Yu; Alton G Swennes; Robert Britton; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4953. doi:

ARVO Annual Meeting Abstract July 2018

Trehalose Protects Human Corneal Epithelial Cells from Inflammation by Promoting Autophagic Flux via TFEB Activation

Ning Gao; Zhao Liu; XIN Chen; Ding Chen; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3277. doi:

ARVO Annual Meeting Abstract July 2018

Loss of RXRα signaling leads to increased antigen presenting cells and reduced goblet cells in conjunctiva

Rodrigo Guimaraes de Souza; Yangyan Xiao; Cintia S De Paiva; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3291. doi:

ARVO Annual Meeting Abstract July 2018

Suppressed Interleukin-27 Signaling Aggravates Pollen-induced Allergic Inflammation via T Cell Dysregulation by Imbalanced STAT1/STAT6 Activation

De-Quan Li; XIN Chen; Stephen C Pflugfelder; Ruzhi Deng; Xia Hua; Wenjuan Qin; Ning Gao

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3314. doi:

ARVO Annual Meeting Abstract July 2018

Limbal Stem Cells Promote Corneal Epithelial Regeneration by GDNF/Survivin/CRM1 Signaling Pathway

Wenjuan Qin; Yangluowa Qu; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3871. doi:

ARVO Annual Meeting Abstract July 2018

Reduced intraepithelial corneal nerve density and sensitivity accompany acute and chronic dry eye in C57BL/6 mice

Mary Ann Stepp; Sonali Pal-Ghosh; Gauri Tadvalkar; Alexa R. Williams; Stephen C Pflugfelder; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3875. doi:

ARVO Annual Meeting Abstract June 2017

Conjunctival goblet cells produce bioactive retinoic acid that modulates dendritic cell cytokine signaling

Yangyan Xiao; Cintia S De Paiva; Terry G Coursey; Fang Bian; De-Quan Li; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):461. doi:

ARVO Annual Meeting Abstract June 2017

Lack of Goblet Cells in SPDEF KO Mice Increases Retention of IL-12 Producing Dendritic Cells in Conjunctiva

Byung Yi Ko; Yangyan Xiao; Fang Bian; Jeffrey Whitsett; Hans Clever; Flavia L Barbosa; Cintia S De Paiva; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):463. doi:

ARVO Annual Meeting Abstract June 2017

Osmolarity-dependently Protective Effects of Trehalose on Inflammatory Markers in Primary Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress

Zhao Liu; XIN CHEN; DING CHEN; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):492. doi:

ARVO Annual Meeting Abstract June 2017

Commensal Bacteria Reconstitution Delays Autoimmunity in the Germ-Free CD25KO Model of Sjögren Syndrome

Cintia S De Paiva; Mahira Zaheer; Changjun Wang; Fang Bian; Alton Swennes; Robert A Britton; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):795. doi:

ARVO Annual Meeting Abstract June 2017

A Novel Innate Immunity Pathway in Dry Eye: ROS Dysregulates Activity of NLRP3/NLRP6 Inflammasomes via BRCC36 and Caspase-8 Signaling

De-Quan Li; Wei Chi; XIN CHEN; Xia Hua; Fang Bian; Cintia S De Paiva; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):798. doi:

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Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress

Attenuated RXRa mediated suppression of innate IFN-γ production by conjunctival monocytes promotes conjunctiva goblet cell loss - implications for xerophthalmia of vitamin A deficiency

Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide

Short Ragweed Pollen Primes Macrophage Polarization toward an Alternatively Activated Phenotype via TSLP/TSLPR Signaling Pathway in Allergic Conjunctivitis

Increased conjunctival monocyte/macrophage antigen presenting cells in Pinkie RXRα deficient mice with accelerated dry eye

Decrease in blink rate during video display viewing is lost in certain types of tear dysfunction

IL-27 Signaling Deficiency Develops Th17-enhanced Allergic Inflammation

Sjögren-Syndrome Microbiota Colonization in Germ-Free Mice induces Antigen-Presenting Cell Activation and Production of IL-12

Low humidity plus anti-cholinergic-induced dry eye skews toward a Th1 response

IL-12 depletion Ameliorates Autoimmunity in the Germ-Free CD25KO Model of Sjögren Syndrome by Decreasing Generation of Th-1 cells

Trehalose Protects Human Corneal Epithelial Cells from Inflammation by Promoting Autophagic Flux via TFEB Activation

Loss of RXRα signaling leads to increased antigen presenting cells and reduced goblet cells in conjunctiva

Suppressed Interleukin-27 Signaling Aggravates Pollen-induced Allergic Inflammation via T Cell Dysregulation by Imbalanced STAT1/STAT6 Activation

Limbal Stem Cells Promote Corneal Epithelial Regeneration by GDNF/Survivin/CRM1 Signaling Pathway

Reduced intraepithelial corneal nerve density and sensitivity accompany acute and chronic dry eye in C57BL/6 mice

Conjunctival goblet cells produce bioactive retinoic acid that modulates dendritic cell cytokine signaling

Lack of Goblet Cells in SPDEF KO Mice Increases Retention of IL-12 Producing Dendritic Cells in Conjunctiva

Osmolarity-dependently Protective Effects of Trehalose on Inflammatory Markers in Primary Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress

Commensal Bacteria Reconstitution Delays Autoimmunity in the Germ-Free CD25KO Model of Sjögren Syndrome

A Novel Innate Immunity Pathway in Dry Eye: ROS Dysregulates Activity of NLRP3/NLRP6 Inflammasomes via BRCC36 and Caspase-8 Signaling

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