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ARVO Annual Meeting Abstract June 2022

Differentially expressed tear proteins in Sjögren syndrome keratoconjunctivitis sicca

Stephen Paul Yoon; Eduardo Serrano; Zhiyuan Yu; Stephen C Pflugfelder; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1537 – A0262. doi:

ARVO Annual Meeting Abstract June 2022

Single cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes.

Jahan Alam; Ghasem Yazdanpanah; Nicholas Borcherding; Rinki Ratnapriya; Cintia S De Paiva; De-Quan Li; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):857. doi:

ARVO Annual Meeting Abstract June 2022

Evaluation of novel YP-P10 Peptide in animal models of inflammatory dry eye disease

Larry Chong Park; Laxmikant Gharat; Kyungho Park; Jahan Alam; Zhiyuan Yu; Yelin Hu; Cintia S De Paiva; Gary D Novack; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1984 – A0314. doi:

ARVO Annual Meeting Abstract June 2022

IL-37 prevents corneal barrier disruption by inhibiting TNF-α/CTSS signaling in primary human corneal epithelial cells under hyperosmotic stress

De-Quan Li; Yun Zhang; Jinmiao Li; Xin Chen; Stephen C Pflugfelder; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1977 – A0307. doi:

ARVO Annual Meeting Abstract June 2022

Reduced RXRα signaling increases dry eye disease inducing γδT17 cells in the conjunctiva

Stephen C Pflugfelder; Jahan Alam; Ghasem Yazdanpanah; Rinki Ratnapriya; Nicholas Borcherding; Cintia S De Paiva; De-Quan Li; Rodrigo Guimaraes de Souza; Zhiyuan Yu

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2276. doi:

ARVO Annual Meeting Abstract June 2022

Results of a Phase 1b clinical trial of KPI-012, a novel secretome therapy, in patients with Persistent Corneal Epithelial Defect (PCED)

Valeria Sanchez-Huerta; Enrique O Graue-Hernandez; Alejandro Navas; Hugo Quiroz-Mercado; Spencer Alford; Darius Kharabi; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3232 – A0267. doi:

ARVO Annual Meeting Abstract June 2022

Nasal Paracentral Corneal Melt Associated with Bacterial Dacryocystitis

ERIN ONG; Andres Serrano; David T Tse; Eduardo C Alfonso; Stephen C Pflugfelder; Carol L. Karp

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3978 – A0258. doi:

ARVO Annual Meeting Abstract June 2022

Metagenomic sequencing of Sjögren syndrome and healthy gut microbiota reveals differential bacterial species that correlate with disease severity

Laura Schaefer; Firas S Midani; Claudia M Trujillo-Vargas; Stephen C Pflugfelder; Robert A Britton; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3833. doi:

ARVO Annual Meeting Abstract June 2022

Change in Blink Rate Following Botulinum Toxin Injection in Benign Essential Blepharospasm

Ghasem Yazdanpanah; Michael Tze-Chien Yen; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):607 – A0308. doi:

Cornea July 2021

Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus

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Jin-Miao Li; Sangbae Kim; Yun Zhang; Fang Bian; Jiaoyue Hu; Rong Lu; Stephen C. Pflugfelder; Rui Chen; De-Quan Li
TAGS: teller acuity cards, trigeminal autonomic cephalalgias, genes, epithelium
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):36. doi: https://doi.org/10.1167/iovs.62.9.36

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Retinoid X receptor alpha (RXRa) mutant Pinkie and vitamin A deficient B6 mice develop similar spectrum of corneal inflammation

Jehan Alam; Zhiyuan Yu; Rinki Ratnapriya; Cintia S De Paiva; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):912. doi:

ARVO Annual Meeting Abstract June 2021

Single-Cell Transcriptomics Identifies Limbal Stem Cell Population, Differentiation Trajectory and Signature Markers in Human Corneal Limbus

De-Quan Li; Jinmiao Li; Sangbae Kim; Jongsu Choi; Fang Bian; Stephen C Pflugfelder; Rui Chen

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):861. doi:

ARVO Annual Meeting Abstract June 2021

Gut microbiota from Sjögren Syndrome patients causes decreased T regulatory cells in the lymphoid organs and ocular barrier disruption in mice.

Laura Schaefer; Claudia Trujillo-Vargas; Stephen C Pflugfelder; Robert Britton; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1329. doi:

ARVO Annual Meeting Abstract June 2021

Activation of NFkB and NLRP3 Inflammasome in the corneal epithelium following short-term desiccating stress

Zhiyuan Yu; Stephen C Pflugfelder; Jehan Alam; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1299. doi:

ARVO Annual Meeting Abstract June 2021

Ectoine protects corneal barrier funtion via promoting IL-37 that suppresses TNF-α-induced Cathepsin S in primary human corneal epithelial cells under hyperosmotic stress

Jinmiao Li; Yun zhang; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1293. doi:

ARVO Annual Meeting Abstract June 2021

Dry Eye Disease Flares: A Ten-Year Literature Review

Christopher Starr; Desiree V Owen; Sara Lucas; Stephen C Pflugfelder; Reza Dana; Edward Holland; Kim Brazzell; Steven Zhang

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1257. doi:

Cornea August 2020

Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress

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Zhao Liu; Ding Chen; Xin Chen; Fang Bian; Wenjuan Qin; Ning Gao; Yangyan Xiao; Jinmiao Li; Stephen C. Pflugfelder; De-Quan Li
TAGS: autophagy, inflammation, stress, trehalose, corneal epithelial cells, signal pathway, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2020; 61(10):26. doi: https://doi.org/10.1167/iovs.61.10.26

ARVO Annual Meeting Abstract June 2020

Attenuated RXRa mediated suppression of innate IFN-γ production by conjunctival monocytes promotes conjunctiva goblet cell loss - implications for xerophthalmia of vitamin A deficiency

Jahan Alam; Stephen C Pflugfelder; Cintia De Paiva; Rodrigo de Souza; Zhiyuan Yu

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):138. doi:

Cornea October 2019

Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide

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Changjun Wang; Laura Schaefer; Fang Bian; Zhiyuan Yu; Stephen C. Pflugfelder; Robert A. Britton; Cintia S. de Paiva
TAGS: antibiotics, dysbiosis, inflammatory response, mice, microbiome, conjunctiva, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4224-4233. doi: https://doi.org/10.1167/iovs.19-27939

ARVO Annual Meeting Abstract July 2019

Sjögren-Syndrome Microbiota Colonization in Germ-Free Mice induces Antigen-Presenting Cell Activation and Production of IL-12

Laura Schaefer; Claudia M Trujillo-Vargas; Stephen C Pflugfelder; Robert A Britton; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):272. doi:

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Differentially expressed tear proteins in Sjögren syndrome keratoconjunctivitis sicca

Single cell transcriptional profiling of murine conjunctival immune cells reveals distinct populations expressing homeostatic and regulatory genes.

Evaluation of novel YP-P10 Peptide in animal models of inflammatory dry eye disease

IL-37 prevents corneal barrier disruption by inhibiting TNF-α/CTSS signaling in primary human corneal epithelial cells under hyperosmotic stress

Reduced RXRα signaling increases dry eye disease inducing γδT17 cells in the conjunctiva

Results of a Phase 1b clinical trial of KPI-012, a novel secretome therapy, in patients with Persistent Corneal Epithelial Defect (PCED)

Nasal Paracentral Corneal Melt Associated with Bacterial Dacryocystitis

Metagenomic sequencing of Sjögren syndrome and healthy gut microbiota reveals differential bacterial species that correlate with disease severity

Change in Blink Rate Following Botulinum Toxin Injection in Benign Essential Blepharospasm

Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus

Retinoid X receptor alpha (RXRa) mutant Pinkie and vitamin A deficient B6 mice develop similar spectrum of corneal inflammation

Single-Cell Transcriptomics Identifies Limbal Stem Cell Population, Differentiation Trajectory and Signature Markers in Human Corneal Limbus

Gut microbiota from Sjögren Syndrome patients causes decreased T regulatory cells in the lymphoid organs and ocular barrier disruption in mice.

Activation of NFkB and NLRP3 Inflammasome in the corneal epithelium following short-term desiccating stress

Ectoine protects corneal barrier funtion via promoting IL-37 that suppresses TNF-α-induced Cathepsin S in primary human corneal epithelial cells under hyperosmotic stress

Dry Eye Disease Flares: A Ten-Year Literature Review

Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress

Attenuated RXRa mediated suppression of innate IFN-γ production by conjunctival monocytes promotes conjunctiva goblet cell loss - implications for xerophthalmia of vitamin A deficiency

Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide

Sjögren-Syndrome Microbiota Colonization in Germ-Free Mice induces Antigen-Presenting Cell Activation and Production of IL-12

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