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Cornea July 2021

Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus

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Jin-Miao Li; Sangbae Kim; Yun Zhang; Fang Bian; Jiaoyue Hu; Rong Lu; Stephen C. Pflugfelder; Rui Chen; De-Quan Li
TAGS: teller acuity cards, trigeminal autonomic cephalalgias, genes, epithelium
Invest. Ophthalmol. Vis. Sci.. 2021; 62(9):36. doi: https://doi.org/10.1167/iovs.62.9.36

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Retinoid X receptor alpha (RXRa) mutant Pinkie and vitamin A deficient B6 mice develop similar spectrum of corneal inflammation

Jehan Alam; Zhiyuan Yu; Rinki Ratnapriya; Cintia S De Paiva; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):912. doi:

ARVO Annual Meeting Abstract June 2021

Single-Cell Transcriptomics Identifies Limbal Stem Cell Population, Differentiation Trajectory and Signature Markers in Human Corneal Limbus

De-Quan Li; Jinmiao Li; Sangbae Kim; Jongsu Choi; Fang Bian; Stephen C Pflugfelder; Rui Chen

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):861. doi:

ARVO Annual Meeting Abstract June 2021

Gut microbiota from Sjögren Syndrome patients causes decreased T regulatory cells in the lymphoid organs and ocular barrier disruption in mice.

Laura Schaefer; Claudia Trujillo-Vargas; Stephen C Pflugfelder; Robert Britton; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1329. doi:

ARVO Annual Meeting Abstract June 2021

Activation of NFkB and NLRP3 Inflammasome in the corneal epithelium following short-term desiccating stress

Zhiyuan Yu; Stephen C Pflugfelder; Jehan Alam; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1299. doi:

ARVO Annual Meeting Abstract June 2021

Ectoine protects corneal barrier funtion via promoting IL-37 that suppresses TNF-α-induced Cathepsin S in primary human corneal epithelial cells under hyperosmotic stress

Jinmiao Li; Yun zhang; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1293. doi:

ARVO Annual Meeting Abstract June 2021

Dry Eye Disease Flares: A Ten-Year Literature Review

Christopher Starr; Desiree V Owen; Sara Lucas; Stephen C Pflugfelder; Reza Dana; Edward Holland; Kim Brazzell; Steven Zhang

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1257. doi:

Cornea August 2020

Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress

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Zhao Liu; Ding Chen; Xin Chen; Fang Bian; Wenjuan Qin; Ning Gao; Yangyan Xiao; Jinmiao Li; Stephen C. Pflugfelder; De-Quan Li
TAGS: autophagy, inflammation, stress, trehalose, corneal epithelial cells, signal pathway, signal transduction pathways
Invest. Ophthalmol. Vis. Sci.. 2020; 61(10):26. doi: https://doi.org/10.1167/iovs.61.10.26

ARVO Annual Meeting Abstract June 2020

Attenuated RXRa mediated suppression of innate IFN-γ production by conjunctival monocytes promotes conjunctiva goblet cell loss - implications for xerophthalmia of vitamin A deficiency

Jahan Alam; Stephen C Pflugfelder; Cintia De Paiva; Rodrigo de Souza; Zhiyuan Yu

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):138. doi:

Cornea October 2019

Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide

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Changjun Wang; Laura Schaefer; Fang Bian; Zhiyuan Yu; Stephen C. Pflugfelder; Robert A. Britton; Cintia S. de Paiva
TAGS: antibiotics, dysbiosis, inflammatory response, mice, microbiome, conjunctiva, cornea
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4224-4233. doi: https://doi.org/10.1167/iovs.19-27939

ARVO Annual Meeting Abstract July 2019

Short Ragweed Pollen Primes Macrophage Polarization toward an Alternatively Activated Phenotype via TSLP/TSLPR Signaling Pathway in Allergic Conjunctivitis

De-Quan Li; Ruzhi Deng; Xin Chen; Ning Gao; Jiaoyue Hu; Yun Zhang; Fang Bian; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1348. doi:

ARVO Annual Meeting Abstract July 2019

Increased conjunctival monocyte/macrophage antigen presenting cells in Pinkie RXRα deficient mice with accelerated dry eye

Stephen C Pflugfelder; Rodrigo Guimaraes de Souza; Jehan Alam; Zhiyuan Yu; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1413. doi:

ARVO Annual Meeting Abstract July 2019

Decrease in blink rate during video display viewing is lost in certain types of tear dysfunction

Travis Mitchell; Michael Murri; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2763. doi:

ARVO Annual Meeting Abstract July 2019

Sjögren-Syndrome Microbiota Colonization in Germ-Free Mice induces Antigen-Presenting Cell Activation and Production of IL-12

Laura Schaefer; Claudia M Trujillo-Vargas; Stephen C Pflugfelder; Robert A Britton; Cintia S De Paiva

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):272. doi:

ARVO Annual Meeting Abstract July 2019

Low humidity plus anti-cholinergic-induced dry eye skews toward a Th1 response

Zhiyuan Yu; Jehan Alam; Rodrigo G. de Souza; Cintia S De Paiva; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):275. doi:

ARVO Annual Meeting Abstract July 2019

IL-27 Signaling Deficiency Develops Th17-enhanced Allergic Inflammation

Yun Zhang; Xin Chen; Ruzhi Deng; Wei Chi; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6722. doi:

ARVO Annual Meeting Abstract July 2018

Trehalose Protects Human Corneal Epithelial Cells from Inflammation by Promoting Autophagic Flux via TFEB Activation

Ning Gao; Zhao Liu; XIN Chen; Ding Chen; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3277. doi:

ARVO Annual Meeting Abstract July 2018

Loss of RXRα signaling leads to increased antigen presenting cells and reduced goblet cells in conjunctiva

Rodrigo Guimaraes de Souza; Yangyan Xiao; Cintia S De Paiva; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3291. doi:

ARVO Annual Meeting Abstract July 2018

IL-12 depletion Ameliorates Autoimmunity in the Germ-Free CD25KO Model of Sjögren Syndrome by Decreasing Generation of Th-1 cells

Cintia S De Paiva; Mahira Zaheer; Zhiyuan Yu; Alton G Swennes; Robert Britton; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4953. doi:

ARVO Annual Meeting Abstract July 2018

Suppressed Interleukin-27 Signaling Aggravates Pollen-induced Allergic Inflammation via T Cell Dysregulation by Imbalanced STAT1/STAT6 Activation

De-Quan Li; XIN Chen; Stephen C Pflugfelder; Ruzhi Deng; Xia Hua; Wenjuan Qin; Ning Gao

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3314. doi:

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Single-Cell Transcriptomics Identifies a Unique Entity and Signature Markers of Transit-Amplifying Cells in Human Corneal Limbus

Retinoid X receptor alpha (RXRa) mutant Pinkie and vitamin A deficient B6 mice develop similar spectrum of corneal inflammation

Single-Cell Transcriptomics Identifies Limbal Stem Cell Population, Differentiation Trajectory and Signature Markers in Human Corneal Limbus

Gut microbiota from Sjögren Syndrome patients causes decreased T regulatory cells in the lymphoid organs and ocular barrier disruption in mice.

Activation of NFkB and NLRP3 Inflammasome in the corneal epithelium following short-term desiccating stress

Ectoine protects corneal barrier funtion via promoting IL-37 that suppresses TNF-α-induced Cathepsin S in primary human corneal epithelial cells under hyperosmotic stress

Dry Eye Disease Flares: A Ten-Year Literature Review

Trehalose Induces Autophagy Against Inflammation by Activating TFEB Signaling Pathway in Human Corneal Epithelial Cells Exposed to Hyperosmotic Stress

Attenuated RXRa mediated suppression of innate IFN-γ production by conjunctival monocytes promotes conjunctiva goblet cell loss - implications for xerophthalmia of vitamin A deficiency

Dysbiosis Modulates Ocular Surface Inflammatory Response to Liposaccharide

Short Ragweed Pollen Primes Macrophage Polarization toward an Alternatively Activated Phenotype via TSLP/TSLPR Signaling Pathway in Allergic Conjunctivitis

Increased conjunctival monocyte/macrophage antigen presenting cells in Pinkie RXRα deficient mice with accelerated dry eye

Decrease in blink rate during video display viewing is lost in certain types of tear dysfunction

Sjögren-Syndrome Microbiota Colonization in Germ-Free Mice induces Antigen-Presenting Cell Activation and Production of IL-12

Low humidity plus anti-cholinergic-induced dry eye skews toward a Th1 response

IL-27 Signaling Deficiency Develops Th17-enhanced Allergic Inflammation

Trehalose Protects Human Corneal Epithelial Cells from Inflammation by Promoting Autophagic Flux via TFEB Activation

Loss of RXRα signaling leads to increased antigen presenting cells and reduced goblet cells in conjunctiva

IL-12 depletion Ameliorates Autoimmunity in the Germ-Free CD25KO Model of Sjögren Syndrome by Decreasing Generation of Th-1 cells

Suppressed Interleukin-27 Signaling Aggravates Pollen-induced Allergic Inflammation via T Cell Dysregulation by Imbalanced STAT1/STAT6 Activation

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