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Articles January 2021

Retinal Pigment Epithelium Atrophy in Recessive Stargardt Disease as Measured by Short-Wavelength and Near-Infrared Autofluorescence

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Ruben Jauregui; Yan Nuzbrokh; Pei-Yin Su; Jana Zernant; Rando Allikmets; Stephen H. Tsang; Janet R. Sparrow
TAGS: autofluorescence, chorioretinal atrophy, hypertrophy, retinal pigment epithelium atrophy, stargardt's disease, atrophy, diagnostic imaging, phenotype
Trans. Vis. Sci. Tech.. 2021; 10(1):3. doi: https://doi.org/10.1167/tvst.10.1.3

Includes: Supplemental Content

Genetics October 2020

Retinal Manifestations of Mitochondrial Oxidative Phosphorylation Disorders

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Jin Kyun Oh; Jose Ronaldo Lima de Carvalho, Jr; Yan Nuzbrokh; Joseph Ryu; Teja Chemudupati; Vinit B. Mahajan; Janet R. Sparrow; Stephen H. Tsang
TAGS: atrophy, diabetes mellitus, type 2, hearing loss, kearns-sayre syndrome, mitochondria, oxidative phosphorylation defect, spectral domain-optical coherence tomography, maternal inheritance, diabetes mellitus, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2020; 61(12):12. doi: https://doi.org/10.1167/iovs.61.12.12

Includes: Supplemental Content

Retina September 2020

Quantitative Fundus Autofluorescence in HCQ Retinopathy

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Vivienne C. Greenstein; Jose Ronaldo Lima de Carvalho, Jr.; Rait Parmann; Luz Amaro-Quireza; Winston Lee; Donald C. Hood; Stephen H. Tsang; Janet R. Sparrow
TAGS: fundus autofluorescence imaging, retinal diseases, spectral domain-optical coherence tomography, visual fields, eye
Invest. Ophthalmol. Vis. Sci.. 2020; 61(11):41. doi: https://doi.org/10.1167/iovs.61.11.41

Articles August 2020

Spectral-Domain Optical Coherence Tomography Is More Sensitive for Hydroxychloroquine-Related Structural Abnormalities Than Short-Wavelength and Near-Infrared Autofluorescence

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Ruben Jauregui; Rait Parmann; Yan Nuzbrokh; Stephen H. Tsang; Janet R. Sparrow
TAGS: autofluorescence, diagnostic imaging, hydroxychloroquine, screening, spectral domain-optical coherence tomography, toxic effect
Trans. Vis. Sci. Tech.. 2020; 9(9):8. doi: https://doi.org/10.1167/tvst.9.9.8

Retina April 2020

Progressive Choriocapillaris Impairment in ABCA4 Maculopathy Is Secondary to Retinal Pigment Epithelium Atrophy

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Ruben Jauregui; Ahra Cho; Winston Lee; Jana Zernant; Rando Allikmets; Janet R. Sparrow; Stephen H. Tsang
TAGS: abca4 gene, atrophy, chief complaint, impairment, macular disorders, retinal pigment epithelium atrophy, diagnostic imaging
Invest. Ophthalmol. Vis. Sci.. 2020; 61(4):13. doi: https://doi.org/10.1167/iovs.61.4.13

Includes: Supplemental Content

Perspective February 2020

Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations

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Ian M. MacDonald; Christopher Moen; Jacque L. Duncan; Stephen H. Tsang; Jasmina Cehajic-Kapetanovic; Tomas S. Aleman
TAGS: choroideremia, gene therapy, retinal degeneration, spatial vectors
Trans. Vis. Sci. Tech.. 2020; 9(3):17. doi: https://doi.org/10.1167/tvst.9.3.17

Retina September 2019

Patterns and Intensities of Near-Infrared and Short-Wavelength Fundus Autofluorescence in Choroideremia Probands and Carriers

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Maarjaliis Paavo; Jose R. L. Carvalho, Jr; Winston Lee; Jesse D. Sengillo; Stephen H. Tsang; Janet R. Sparrow
TAGS: choroideremia, eye, fundus autofluorescence imaging, multimodal imaging, proband, spectral domain-optical coherence tomography, diagnostic imaging, visual acuity, choroid, retina
Invest. Ophthalmol. Vis. Sci.. 2019; 60(12):3752-3761. doi: https://doi.org/10.1167/iovs.19-27366

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Mice with RPE-specific CLIC4 deficiency exhibit AMD-like changes in the retina-RPE-choroid complex

Wataru Otsu; Kuo-Shun Hsu; Joshua L Dunaief; Yao Li; Stephen H. Tsang; Jen-Zen Chuang; Ching-Hwa Sung

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1229. doi:

ARVO Annual Meeting Abstract July 2019

THE USE OF ARTIFICIAL INTELLIGENCE FOR THE DETECTION OF STARGARDT’S DISEASE FROM FUNDUS IMAGES

Saad Y Al-Kadhi; Loai Skouti; April Ellis; Qun Zeng; Tarun Sharma; Stephen H Tsang; Tongalp H Tezel

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1501. doi:

ARVO Annual Meeting Abstract July 2019

LACK OF VERTICAL STABILITY RESULTS IN EPITELIal-MESENCHYMAL TRANSITION OF THE IPS-DERIVED RETINAL PIGMENT EPITHELIAL CELL

Qun Zeng; Yao Li; Eyup Karahan; Stephen H Tsang; Tongalp H Tezel

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3935. doi:

ARVO Annual Meeting Abstract July 2019

Multimodal structural disease progression of retinitis pigmentosa according to mode of inheritance

Ruben Jauregui; Vitor K. L. Takahashi; Karen Sophia Park; Julia Takiuti; Stephen H Tsang

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4528. doi:

ARVO Annual Meeting Abstract July 2019

Choriocapillaris atrophy in ABCA4 retinopathy is secondary to retinal pigment epithelium impairment

Karen Sophia Park; Ruben Jauregui; Janet Sparrow; Rando Allikmets; Stephen H. Tsang

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4569. doi:

ARVO Annual Meeting Abstract July 2019

Multimodal imaging and electroretinography analysis of end-stage presentations of X-linked retinoschisis

Jesse D Sengillo; Winston Lee; Ruben Jauregui; Stephen H Tsang

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5422. doi:

ARVO Annual Meeting Abstract July 2019

CAPN5 genetic inactivation phenotype supports therapeutic inhibition trials

Katherine Wert; Susanne F. Koch; Gabriel Velez; Chun-Wei Hsu; MaryAnn Mahajan; Alexander G. Bassuk; Stephen H. Tsang; Vinit B Mahajan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):396. doi:

ARVO Annual Meeting Abstract July 2019

Stargardt disease ALK-001 phase 2 clinical trial: 12-month interim data

Hendrik P Scholl; Stephen H Tsang; Christine Nichols Kay; Thomas B. Connor; Michael B Gorin; Paul S Bernstein; Byron L Lam; Zach Strecker; Justin Tyler Zaremba; Gabrielle DeBartolomeo; Ilyas Washington; Leonide Saad

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1336. doi:

ARVO Annual Meeting Abstract July 2019

Anatomical and fixation parameters as predictors of reading speed (RS) in Stargardt Disease

Gabrielle DeBartolomeo; Justin Tyler Zaremba; Zach Strecker; Christine Nichols Kay; Stephen H Tsang; Thomas B. Connor; Michael B Gorin; Paul S Bernstein; Byron L Lam; Ilyas Washington; Hendrik P Scholl; Leonide Saad

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1063. doi:

ARVO Annual Meeting Abstract July 2019

The Visual Function Index (VF-14) reflects a notable loss in Vision-Related Quality of Life (VRQOL) in Stargardt Disease

Justin Tyler Zaremba; Zach Strecker; Gabrielle DeBartolomeo; Stephen H Tsang; Christine Nichols Kay; Thomas B. Connor; Michael B Gorin; Paul S Bernstein; Byron L Lam; Ilyas Washington; Hendrik P Scholl; Leonide Saad

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4970. doi:

Retina June 2019

Characterization of Retinal Structure in ATF6 -Associated Achromatopsia

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Rebecca R. Mastey; Michalis Georgiou; Christopher S. Langlo; Angelos Kalitzeos; Emily J. Patterson; Thomas Kane; Navjit Singh; Ajoy Vincent; Anthony T. Moore; Stephen H. Tsang; Jonathan H. Lin; Marielle P. Young; M. Elizabeth Hartnett; Elise Héon; Susanne Kohl; Michel Michaelides; Joseph Carroll
TAGS: achromatopsia, diagnostic imaging, mosaicism, retina, retinal cone, rod photoreceptors, parafoveal region, photoreceptors, genetics, fovea centralis
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2631-2640. doi: https://doi.org/10.1167/iovs.19-27047

Retina May 2019

Multimodal Imaging in Best Vitelliform Macular Dystrophy

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Jose Ronaldo Lima de Carvalho, Jr; Maarjaliis Paavo; Lijuan Chen; John Chiang; Stephen H. Tsang; Janet R. Sparrow
TAGS: autofluorescence, eye, multimodal imaging, spectral domain-optical coherence tomography, vitelliform dystrophy
Invest. Ophthalmol. Vis. Sci.. 2019; 60(6):2012-2022. doi: https://doi.org/10.1167/iovs.19-26571

Retina January 2019

VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site

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Peter H. Tang; Gabriel Velez; Stephen H. Tsang; Alexander G. Bassuk; Vinit B. Mahajan
TAGS: histopathology tests, mutation, proteins, proteolysis, splice-site mutation, surgical procedures, operative, tissue degeneration, vitreous body, cytokinesis, eye
Invest. Ophthalmol. Vis. Sci.. 2019; 60(1):282-293. doi: https://doi.org/10.1167/iovs.18-25624

Includes: Supplemental Content

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Retinal Pigment Epithelium Atrophy in Recessive Stargardt Disease as Measured by Short-Wavelength and Near-Infrared Autofluorescence

Retinal Manifestations of Mitochondrial Oxidative Phosphorylation Disorders

Quantitative Fundus Autofluorescence in HCQ Retinopathy

Spectral-Domain Optical Coherence Tomography Is More Sensitive for Hydroxychloroquine-Related Structural Abnormalities Than Short-Wavelength and Near-Infrared Autofluorescence

Progressive Choriocapillaris Impairment in ABCA4 Maculopathy Is Secondary to Retinal Pigment Epithelium Atrophy

Perspectives on Gene Therapy: Choroideremia Represents a Challenging Model for the Treatment of Other Inherited Retinal Degenerations

Patterns and Intensities of Near-Infrared and Short-Wavelength Fundus Autofluorescence in Choroideremia Probands and Carriers

Mice with RPE-specific CLIC4 deficiency exhibit AMD-like changes in the retina-RPE-choroid complex

THE USE OF ARTIFICIAL INTELLIGENCE FOR THE DETECTION OF STARGARDT’S DISEASE FROM FUNDUS IMAGES

LACK OF VERTICAL STABILITY RESULTS IN EPITELIal-MESENCHYMAL TRANSITION OF THE IPS-DERIVED RETINAL PIGMENT EPITHELIAL CELL

Multimodal structural disease progression of retinitis pigmentosa according to mode of inheritance

Choriocapillaris atrophy in ABCA4 retinopathy is secondary to retinal pigment epithelium impairment

Multimodal imaging and electroretinography analysis of end-stage presentations of X-linked retinoschisis

CAPN5 genetic inactivation phenotype supports therapeutic inhibition trials

Stargardt disease ALK-001 phase 2 clinical trial: 12-month interim data

Anatomical and fixation parameters as predictors of reading speed (RS) in Stargardt Disease

The Visual Function Index (VF-14) reflects a notable loss in Vision-Related Quality of Life (VRQOL) in Stargardt Disease

Characterization of Retinal Structure in ATF6 -Associated Achromatopsia

Multimodal Imaging in Best Vitelliform Macular Dystrophy

VCAN Canonical Splice Site Mutation is Associated With Vitreoretinal Degeneration and Disrupts an MMP Proteolytic Site

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