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Cornea October 2024

Mouse Corneal Immune Cell Heterogeneity Revealed by Single-Cell RNA Sequencing

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Ebru Yaman; Nicole Heyer; Cintia S. de Paiva; Mary Ann Stepp; Stephen C. Pflugfelder; Jehan Alam
TAGS: cornea, mice, rna, small cytoplasmic, heterogeneity, sequence analysis, rna, rna-seq, genes, gene expression
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):29. https://doi.org/10.1167/iovs.65.12.29

Includes: Supplemental Content

Cornea June 2024

Ectoine Enhances Mucin Production Via Restoring IL-13/IFN-γ Balance in a Murine Dry Eye Model

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Na Lin; Xin Chen; Haixia Liu; Ning Gao; Zhao Liu; Jin Li; Stephen C. Pflugfelder; De-Quan Li
TAGS: dry eye syndromes, interleukin-13, mice, mucins, ocular surfaces, conjunctiva, balance, device, equilibrium
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):39. https://doi.org/10.1167/iovs.65.6.39

ARVO Annual Meeting Abstract June 2024

Conjunctival transcriptome changes in Sjögren Syndrome and non-Sjögren Syndrome aqueous-tear-deficient dry eye

Cintia S De Paiva; Stephen C Pflugfelder; Zhiyuan Yu; Robert Britton; Laura Schaefer; Kaitlin Scholand

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):412.

ARVO Annual Meeting Abstract June 2024

A Novel Dual Anti-Angiogenic and Anti-Opacity Therapy of Corneal Injury

Remya Ammassam Veettil; Hong Tian; Stephen C Pflugfelder; Wei Li; Douglas Donald Koch

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2920.

ARVO Annual Meeting Abstract June 2024

Single cell analysis of desiccation induced changes in cornea immune cell populations

Jahan Alam; Ebru Yaman; Gerda Cristal Villalba Silva; Rui Chen; Cintia S De Paiva; Mary Ann Stepp; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2908.

ARVO Annual Meeting Abstract June 2024

Novel Protective Effects of Ectoine on Ocular Surface Inflammation in a Murine Dry Eye Model

XIN CHEN; Na Lin; Jinmiao Li; Haixia Liu; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3608.

ARVO Annual Meeting Abstract June 2024

Spatially Resolved Single-Cell Atlas of Mouse Trigeminal Ganglion by MERFISH

Soo Hwan Oh; Gerda Cristal Villalba Silva; Jongsu Choi; Fairouz Elsaeidi; Ebru Yaman; Stephen C Pflugfelder; Rui Chen

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5820.

ARVO Annual Meeting Abstract June 2024

Severe dry eye and ocular surface inflammation in vitamin A deficient Lrat -/- Rpb -/- mice

Stephen C Pflugfelder; Ebru Yaman; Jahan Alam

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5742.

ARVO Annual Meeting Abstract June 2024

Novel role and regulatory mechanism of IL-36 family cytokines in dry eye models in vitro and in vivo

De-Quan Li; Jinmiao Li; XIN CHEN; Na Lin; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5737.

ARVO Annual Meeting Abstract June 2024

Ectoine Preserves Corneal Barrier via Suppressing IL-36α signaling pathway in Experimental Dry Eye Model

Na Lin; XIN CHEN; Haixia Liu; Cintia S De Paiva; Stephen C Pflugfelder; De-Quan Li

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5720.

Cornea & External Disease June 2023

Differentially Expressed Tear Proteins in Sjögren's Syndrome Keratoconjunctivitis Sicca

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Stephen P. Yoon; Zhiyuan Yu; Stephen C. Pflugfelder; Cintia S. de Paiva
TAGS: proteins, sjogren's syndrome, keratoconjunctivitis sicca
Trans. Vis. Sci. Tech.. 2023; 12(6):8. https://doi.org/10.1167/tvst.12.6.8

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

A Pooled Analysis Evaluating Visual Acuity in Patients with Neurotrophic Keratitis on Cenegermin (rhNGF) Treatment versus Vehicle

Yureeda Qazi; Stephen C Pflugfelder; Mina Massaro-Giordano; Natalie A Afshari; Flavio Mantelli

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5131.

ARVO Annual Meeting Abstract June 2023

Desiccation induced changes in cell number, gene expression profiles and transcriptional trajectories in conjunctival myeloid cells

Stephen C Pflugfelder; Jahan Alam; Cintia S. De Paiva; De-Quan Li; Ghasem Yasdanpanah; Kaitlyn Xiong; Zhen Zhong

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):681.

ARVO Annual Meeting Abstract June 2023

Retinoic acid receptor X alpha mutant strain develops meibomian gland disease with aging

Ebru Yaman; Igor A Butovich; Jahan Alam; Amber Wilkerson; Ghasem Yasdanpanah; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):171.

ARVO Annual Meeting Abstract June 2023

Characterization of transit-amplifying cells in human corneal limbus using single cell transcriptomics

De-Quan Li; Jin-Miao Li; Fang Bian; Xin Chen; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):971.

ARVO Annual Meeting Abstract June 2023

Probiotic Limosilactobacillus reuteri DSM 17938 suppresses corneal barrier dysfunction and conjunctival goblet cell reduction in mice subjected to desiccating stress

Laura Schaefer; Stephen C Pflugfelder; Robert Britton; Cintia S. De Paiva

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):697.

ARVO Annual Meeting Abstract June 2023

Comparison of Immune Cell Phenotype, Gene Expression Profiles, and Cornea Wound Healing Response between RXR Mutant Pinkie Mouse Strain and Wild-Type C57BL/6 Mice

Jahan Alam; Ebru Yaman; Remya Ammassam Veettil; Wei Li; Stephen C Pflugfelder

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1731.

ARVO Annual Meeting Abstract June 2023

Anti-Scg3 Therapy for Corneal Neovascularization

Remya Ammassam Veettil; Hong Tian; Stephen C Pflugfelder; Wei Li; Douglas Koch

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1730.

ARVO Annual Meeting Abstract June 2023

A Phase 1/2a Study of ALY688 Ophthalmic Solution in Dry Eye Subjects

Kenneth Sall; Gary Foulks; Stephen C Pflugfelder; David Evans; Philip Shettle; Jeanette Stewart; Henry Hsu

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3959.

Immunology and Microbiology April 2023

Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model

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Zhiyuan Yu; Ghasem Yazdanpanah; Jehan Alam; Cintia S. de Paiva; Stephen Pflugfelder
TAGS: corneal epithelium, dry eye syndromes, nf-kappa b, stress, nlr family, pyrin domain-containing 3 protein, inflammasomes
Invest. Ophthalmol. Vis. Sci.. 2023; 64(4):8. https://doi.org/10.1167/iovs.64.4.8

Includes: Supplemental Content

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Mouse Corneal Immune Cell Heterogeneity Revealed by Single-Cell RNA Sequencing

Ectoine Enhances Mucin Production Via Restoring IL-13/IFN-γ Balance in a Murine Dry Eye Model

Conjunctival transcriptome changes in Sjögren Syndrome and non-Sjögren Syndrome aqueous-tear-deficient dry eye

A Novel Dual Anti-Angiogenic and Anti-Opacity Therapy of Corneal Injury

Single cell analysis of desiccation induced changes in cornea immune cell populations

Novel Protective Effects of Ectoine on Ocular Surface Inflammation in a Murine Dry Eye Model

Spatially Resolved Single-Cell Atlas of Mouse Trigeminal Ganglion by MERFISH

Severe dry eye and ocular surface inflammation in vitamin A deficient Lrat -/- Rpb -/- mice

Novel role and regulatory mechanism of IL-36 family cytokines in dry eye models in vitro and in vivo

Ectoine Preserves Corneal Barrier via Suppressing IL-36α signaling pathway in Experimental Dry Eye Model

Differentially Expressed Tear Proteins in Sjögren's Syndrome Keratoconjunctivitis Sicca

A Pooled Analysis Evaluating Visual Acuity in Patients with Neurotrophic Keratitis on Cenegermin (rhNGF) Treatment versus Vehicle

Desiccation induced changes in cell number, gene expression profiles and transcriptional trajectories in conjunctival myeloid cells

Retinoic acid receptor X alpha mutant strain develops meibomian gland disease with aging

Characterization of transit-amplifying cells in human corneal limbus using single cell transcriptomics

Probiotic Limosilactobacillus reuteri DSM 17938 suppresses corneal barrier dysfunction and conjunctival goblet cell reduction in mice subjected to desiccating stress

Comparison of Immune Cell Phenotype, Gene Expression Profiles, and Cornea Wound Healing Response between RXR Mutant Pinkie Mouse Strain and Wild-Type C57BL/6 Mice

Anti-Scg3 Therapy for Corneal Neovascularization

A Phase 1/2a Study of ALY688 Ophthalmic Solution in Dry Eye Subjects

Induction of Innate Inflammatory Pathways in the Corneal Epithelium in the Desiccating Stress Dry Eye Model

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