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ARVO Annual Meeting Abstract June 2025

Lysophosphatidic acid signaling promotes orbital fibroblast activation and extracellular matrix production in Thyroid Eye Disease

Kevin Shan; Eric Zhu; Elisa Roztocil; Steven E Feldon; Collynn Woeller

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4300.

ARVO Annual Meeting Abstract June 2025

Transcriptomic analysis of orbital fibroblasts identifies differentially regulated genes, pathways and potential therapeutic targets in thyroid eye disease

Kyle Yuan; Alexander Baloga; Steven E Feldon; Collynn Woeller

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1323.

ARVO Annual Meeting Abstract June 2025

LX-101, a novel payload bearing IGF1-methotrexate conjugate, shows anti-inflammatory and anti-fibrotic effects in thyroid eye disease

Collynn Woeller; Farha Husain; Charkira Patrick; Elisa Roztocil; Steven E Feldon; Matt Hoberman; Peter McDonald

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4297.

Biochemistry and Molecular Biology November 2024

Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy

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Charkira C. Patrick; Elisa Roztocil; Farha Husain; Steven E. Feldon; Collynn F. Woeller
TAGS: aryl hydrocarbon receptor, fibroblasts, graves' ophthalmopathy, ligands, signal transduction, tapinarof, platelet-derived growth factor, thymidylate synthase, proto-oncogene proteins c-akt
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):40. https://doi.org/10.1167/iovs.65.13.40

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Elucidating the role of the aryl hydrocarbon receptor in controlling inflammation and epithelial-mesenchymal transition of retinal pigment epithelial cells: Implications for proliferative vitreoretinopathy

Farha Husain; Elisa Roztocil; Charkira Patrick; Steven E Feldon; Collynn Woeller

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1319.

ARVO Annual Meeting Abstract June 2024

Activating the aryl hydrocarbon receptor with naturally occurring compounds to mitigate thyroid eye disease orbital fibroblast activation

Charkira Patrick; Elisa Roztocil; Farha Husain; Steven E Feldon; Collynn Woeller

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3052.

Low Vision April 2024

Training in Cortically Blinded Fields Appears to Confer Patient-Specific Benefit Against Retinal Thinning

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Berkeley K. Fahrenthold; Matthew R. Cavanaugh; Madhura Tamhankar; Byron L. Lam; Steven E. Feldon; Brent A. Johnson; Krystel R. Huxlin
TAGS: retinal thinning, training, visual training, retinal nerve fiber layer, cerebrovascular accident, ganglia
Invest. Ophthalmol. Vis. Sci.. 2024; 65(4):29. https://doi.org/10.1167/iovs.65.4.29

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Retinal Vessel Tortuosity Index as a Potential Biomarker of Idiopathic Intracranial Hypertension: Analysis of the IIH Treatment Trial

David Buickians; Sylvia Elizabeth Villarreal Navarro; Heather Moss; Steven E Feldon; Mahnaz Shahidi

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4101.

ARVO Annual Meeting Abstract June 2022

Retinal Vessel Tortuosity Indices (VTIs) as a potential biomarker of idiopathic intracranial hypertension(IIH): Baseline analysis of the IIH treatment trial

David Buickians; Deena Dahshan; Mahnaz Shahidi; Amir Nankali; Steven E Feldon; Heather Moss

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):129 – A0291.

ARVO Annual Meeting Abstract June 2022

Activation of the aryl hydrocarbon receptor inhibits IGF1R and TSHR-mediated signaling in thyroid eye disease

Collynn Woeller; Steven E Feldon; Elisa Roztocil

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3999 – A0341.

Articles December 2021

Variability of Retinal Vessel Tortuosity Measurements Using a Semiautomated Method Applied to Fundus Images in Subjects With Papilledema

PDF

Heather E. Moss; Jing Cao; Munam Wasi; Steven E. Feldon; Mahnaz Shahidi
TAGS: eye, papilledema, retinal vessel tortuosity
Trans. Vis. Sci. Tech.. 2021; 10(14):32. https://doi.org/10.1167/tvst.10.14.32

ARVO Annual Meeting Abstract June 2021

Inhibition of TNF-α and NF-κB decreases epithelial-mesenchymal transition in cigarette smoke-induced proliferative vitreoretinopathy

Victor Wang; Alison Heffer; Elisa Roztocil; Steven E Feldon; Collynn Woeller; Ajay E. Kuriyan

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3644.

ARVO Annual Meeting Abstract June 2021

Investigating the role of circulating microRNAs as potential biomarkers for Thyroid Eye Disease

Christina Elise Douglas; Elisa Roztocil; Christine Hammond; Mithra Gonzalez; Steven E Feldon; Collynn Woeller

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3349.

ARVO Annual Meeting Abstract June 2021

Elucidating the role of the aryl hydrocarbon receptor and the insulin-like growth factor 1 receptor in Thyroid Eye Disease orbital fibroblasts.

Collynn Woeller; Elisa Roztocil; Christine Hammond; Mithra Gonzalez; Steven E Feldon

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3341.

ARVO Annual Meeting Abstract June 2021

Intravitreal HC-HA/PTX3, a soluble matrix component of amniotic membrane, inhibits proliferative vitreoretinopathy (PVR) in a mouse model of PVR

Ajay E. Kuriyan; Alison Heffer; Victor Wang; Hua He; Megha Mahabole; Steven E Feldon; Richard T Libby; Scheffer C G Tseng; Collynn Woeller

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3095.

Biochemistry and Molecular Biology January 2021

MicroRNA-130a Is Elevated in Thyroid Eye Disease and Increases Lipid Accumulation in Fibroblasts Through the Suppression of AMPK

PDF

Christine L. Hammond; Elisa Roztocil; Mithra O. Gonzalez; Steven E. Feldon; Collynn F. Woeller

Invest. Ophthalmol. Vis. Sci.. 2021; 62(1):29. https://doi.org/10.1167/iovs.62.1.29

ARVO Annual Meeting Abstract June 2020

A novel mouse model of proliferative vitreoretinopathy induced by intravitreal injection of gas and RPE cells.

Ajay E. Kuriyan; Alison Heffer; Victor Wang; Jayanth Sridhar; Steven E Feldon; Richard T Libby; Collynn Woeller

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1410.

ARVO Annual Meeting Abstract June 2020

TNF-α plays a critical role in cigarette smoke-induced epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy

Victor Wang; Alison Heffer; Steven E Feldon; Richard T Libby; Collynn Woeller; Ajay E. Kuriyan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1412.

ARVO Annual Meeting Abstract June 2020

Activation of the aryl hydrocarbon receptor induces matrix metalloproteinase-1 in thyroid eye disease orbital fibroblasts: implications for anti-scarring therapies

Collynn Woeller; Elisa Roztocil; Christine Hammond; Steven E Feldon

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2935.

Articles June 2020

A Mouse Model of Proliferative Vitreoretinopathy Induced by Intravitreal Injection of Gas and RPE Cells

PDF

Alison Heffer; Victor Wang; Jayanth Sridhar; Steven E. Feldon; Richard T. Libby; Collynn F. Woeller; Ajay E. Kuriyan
TAGS: injections, intravitreal injections, mice, retinal pigment cell, vitreoretinopathy, proliferative, eye, vitreous body, retina, tissue membrane
Trans. Vis. Sci. Tech.. 2020; 9(7):9. https://doi.org/10.1167/tvst.9.7.9

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Lysophosphatidic acid signaling promotes orbital fibroblast activation and extracellular matrix production in Thyroid Eye Disease

Transcriptomic analysis of orbital fibroblasts identifies differentially regulated genes, pathways and potential therapeutic targets in thyroid eye disease

LX-101, a novel payload bearing IGF1-methotrexate conjugate, shows anti-inflammatory and anti-fibrotic effects in thyroid eye disease

Tapinarof, an Aryl Hydrocarbon Receptor Ligand, Mitigates Fibroblast Activation in Thyroid Eye Disease: Implications for Novel Therapy

Elucidating the role of the aryl hydrocarbon receptor in controlling inflammation and epithelial-mesenchymal transition of retinal pigment epithelial cells: Implications for proliferative vitreoretinopathy

Activating the aryl hydrocarbon receptor with naturally occurring compounds to mitigate thyroid eye disease orbital fibroblast activation

Training in Cortically Blinded Fields Appears to Confer Patient-Specific Benefit Against Retinal Thinning

Retinal Vessel Tortuosity Index as a Potential Biomarker of Idiopathic Intracranial Hypertension: Analysis of the IIH Treatment Trial

Retinal Vessel Tortuosity Indices (VTIs) as a potential biomarker of idiopathic intracranial hypertension(IIH): Baseline analysis of the IIH treatment trial

Activation of the aryl hydrocarbon receptor inhibits IGF1R and TSHR-mediated signaling in thyroid eye disease

Variability of Retinal Vessel Tortuosity Measurements Using a Semiautomated Method Applied to Fundus Images in Subjects With Papilledema

Inhibition of TNF-α and NF-κB decreases epithelial-mesenchymal transition in cigarette smoke-induced proliferative vitreoretinopathy

Investigating the role of circulating microRNAs as potential biomarkers for Thyroid Eye Disease

Elucidating the role of the aryl hydrocarbon receptor and the insulin-like growth factor 1 receptor in Thyroid Eye Disease orbital fibroblasts.

Intravitreal HC-HA/PTX3, a soluble matrix component of amniotic membrane, inhibits proliferative vitreoretinopathy (PVR) in a mouse model of PVR

MicroRNA-130a Is Elevated in Thyroid Eye Disease and Increases Lipid Accumulation in Fibroblasts Through the Suppression of AMPK

A novel mouse model of proliferative vitreoretinopathy induced by intravitreal injection of gas and RPE cells.

TNF-α plays a critical role in cigarette smoke-induced epithelial-mesenchymal transition of retinal pigment epithelial cells in proliferative vitreoretinopathy

Activation of the aryl hydrocarbon receptor induces matrix metalloproteinase-1 in thyroid eye disease orbital fibroblasts: implications for anti-scarring therapies

A Mouse Model of Proliferative Vitreoretinopathy Induced by Intravitreal Injection of Gas and RPE Cells

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