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ARVO Annual Meeting Abstract September 2016

Interrelationship of primary virus replication in the eye, level of latency and time to reactivate in the trigeminal ganglia (TG) of latently infected mice

Homayon Ghiasi; Kevin Mott; Sariah Allen; Yasamin Ghiasi; Terrence Town; Steven Wechsler; Harry Matundan

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2334.

ARVO Annual Meeting Abstract September 2016

The Herpes Simplex Virus LAT Gene is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8 + T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits

Lbachir BenMohamed; Arif Khan; Ruchi Srivastava; Steven Wechsler; Anthony B Nesburn

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3293.

ARVO Annual Meeting Abstract September 2016

Increased Frequency of Herpes Simplex Virus-Specific Effector Memory CD26+CD8+ T Cells in HSV-Seropositive Ocular Herpes Asymptomatic Patients

Anthony B Nesburn; Ruchi Srivastava; Arif Khan; Steven Wechsler; Lbachir BenMohamed

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3318.

Immunology and Microbiology June 2015

A Herpes Simplex Virus Type 1 Human Asymptomatic CD8 + T-Cell Epitopes-Based Vaccine Protects Against Ocular Herpes in a “Humanized” HLA Transgenic Rabbit Model

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Ruchi Srivastava; Arif A. Khan; Jiawei Huang; Anthony B. Nesburn; Steven L. Wechsler; Lbachir BenMohamed
TAGS: epitopes, human herpesvirus 1, human leukocyte antigens, keratitis, herpetic, oryctolagus cuniculus, peptides, t-lymphocytes, vaccines, hla-a2 antigen, immunization
Invest. Ophthalmol. Vis. Sci.. 2015; 56(6):4013-4028. https://doi.org/10.1167/iovs.15-17074

ARVO Annual Meeting Abstract June 2015

Phenotypic and Functional Characterization of Herpes Simplex Virus Glycoprotein B Epitope-specific Effector and Memory CD8 + T Cells from Ocular Herpes Symptomatic and Asymptomatic Individuals

Lbachir BenMohamed; Arif A Khan; Ruchi Srivastava; Doran Spencer; Sumit Garg; Steven Wechsler; Anthony B Nesburn

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4402.

ARVO Annual Meeting Abstract June 2015

Therapeutic Immunization with Herpes Simplex Virus Type 1 Glycoprotein D Derived “Asymptomatic” Human CD8 + T-cell Epitopes Protects Against Recurrent Ocular Herpetic in Latently Infected HLA Transgenic Rabbits: Correlation with low Frequency of Exhausted PD-1 + TIM-3 + CD8 + T Cells

Anthony Nesburn; Arif A Khan; Ruchi Srivastava; Steven Wechsler; Lbachir BenMohamed

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1855.

ARVO Annual Meeting Abstract June 2015

HLA-A02:01-Restricted Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP11/12 Preferentially Recall Polyfunctional Effector Memory CD8 + T Cells from Seropositive Asymptomatic Individuals and Protect “Humanized” HLA-A*02:01 Transgenic Mice Against Ocular Herpes

Ruchi Srivastava; Arif A Khan; Doran Spencer; Sumit Garg; Anthony B Nesburn; Steven Wechsler; Lbachir BenMohamed

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1858.

ARVO Annual Meeting Abstract April 2014

Identification of Herpes Simplex Virus Glycoprotein B Human Epitopes That Preferentially Recall Polyfunctional CD8+ T Cells from Seropositive Asymptomatic Individuals and Protect HLA Transgenic Mice Against Ocular Herpes

Anthony B Nesburn; Arif Khan; Ruchi Srivastava; Steven L Wechsler1; Lbachir BenMohamed

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6255.

ARVO Annual Meeting Abstract June 2013

The Herpes Simplex Virus-1 Latency-Associated Transcript Promotes Functional Exhaustion of Virus-Specific CD8+ T Cells in Trigeminal Ganglia of Latently Infected “humanized” HLA-transgenic rabbits

Lbachir BenMohamed; Xavier Dervillez; Huma Qureshi; Aziz Chentoufi; Chelsea Nguyen; Oscar Diaz; Anthony Nesburn; Steven Wechsler

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2043.

ARVO Annual Meeting Abstract June 2013

Two Human Leukocyte Antigen (HLA)-A*0201-Restricted Epitopes Identified from Herpes Simplex Virus Glycoprotein B are Recognized Exclusively by CD8+ T cells from Asymptomatic Individuals and Protect Against Ocular Herpes

Anthony Nesburn; Xavier Dervillez; Huma Qureshi; Aziz Chentoufi; Oscar Diaz; John Sidney; Alessandro Sette; Maria Villacres; Steven Wechsler; Lbachir BenMohamed

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2044.

ARVO Annual Meeting Abstract March 2012

Interplay of LAT and HVEM affect HSV-1 Latency and CD8+ T Cell Exhaustion

Homayon Ghiasi; Sariah Allen; Kevin Mott; Antje Rhode-Kurnow; Xianzhi Jiang; Dale Carpenter; Clinton Jones; Steven WEchsler; Carl Ware

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):2232.

ARVO Annual Meeting Abstract March 2012

The Herpes Simplex Virus Type 1 Latency Associated Transcript Inhibits Phenotypic and Functional Maturation of Dendritic Cells

Lbachir BenMohamed; Aziz A. Chentoufi; Xavier Dervillez; Gargi Dasgupta; Chelsea Nguyen; Khaled K. Kabbara; Steven L. Wechsler; Anthony B. Nesburn

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6147.

ARVO Annual Meeting Abstract March 2012

Protective Asymptomatic Human Leukocyte Antigen (HLA)-A*0201-Restricted CD8+ Cytotoxic T-Lymphocyte Epitopes Identified from Herpes Simplex Virus Glycoprotein B

Anthony B. Nesburn; Xavier Dervillez; Aziz A. Chentoufi; Gargi Dasgupta; Khaled W. Kabbara; Maria C. Villacres; Chelsea Nguyen; Steven L. Wechsler; Lbachir BenMohamed

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6152.

ARVO Annual Meeting Abstract April 2011

The Role Of HSV-1 LAT In Enhancement Of Latency And Increase Of CD8+ T Cell Exhaustion In Trigeminal Ganglia Of Infected Mice

Homayon Ghiasi; Pedram Hamrah; Kevin Mott; Arlene Sharpe; Lbachir BenMohamed; Rafi Ahmed; Steven Wechsler; Carl Ware; Sariah Allen

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2967.

ARVO Annual Meeting Abstract April 2011

The Herpes Simplex Virus-1 Encoded Latency-Associated Transcript Promotes Dysfunctional Virus-Specific CD8+ T Cells in Latently Infected Trigeminal Ganglia: A Novel Immune Evasion Mechanism

Lbachir BenMohamed; Aziz A. Chentoufi; Michael V. Tran; Elizabeth Krizer; Rash E. Afifi; Nelson Osorio; Xianzhi Jiang; Dale Carpenter; Anthony B. Nesburn; Steven L. Wechsler

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2909.

Immunology and Microbiology June 2009

The Role of a Glycoprotein K (gK) CD8 + T-Cell Epitope of Herpes Simplex Virus on Virus Replication and Pathogenicity

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Kevin R. Mott; Aziz A. Chentoufi; Dale Carpenter; Lbachir BenMohamed; Steven L. Wechsler; Homayon Ghiasi
TAGS: glycoproteins, human herpesvirus 1, mice, peptides, t-lymphocyte epitopes, virus replication, oryctolagus cuniculus, immunization, infections, pathogenicity
Invest. Ophthalmol. Vis. Sci.. 2009; 50(6):2903-2912. https://doi.org/10.1167/iovs.08-2957

Immunology and Microbiology October 2007

Protective Immunity against Ocular Herpes Infection and Disease Induced by Highly Immunogenic Self-Adjuvanting Glycoprotein D Lipopeptide Vaccines

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Ilham Bettahi; Anthony B. Nesburn; Susan Yoon; Xiuli Zhang; Amir Mohebbi; Valerie Sue; Aaron Vanderberg; Steven L. Wechsler; Lbachir BenMohamed
TAGS: eye infection herpes simplex, gadolinium, grenada, human herpesvirus 1, lipopeptides, vaccines, t-lymphocytes, glycoproteins, immunization, immunity
Invest. Ophthalmol. Vis. Sci.. 2007; 48(10):4643-4653. https://doi.org/10.1167/iovs.07-0356

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Interrelationship of primary virus replication in the eye, level of latency and time to reactivate in the trigeminal ganglia (TG) of latently infected mice

The Herpes Simplex Virus LAT Gene is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8 + T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits

Increased Frequency of Herpes Simplex Virus-Specific Effector Memory CD26+CD8+ T Cells in HSV-Seropositive Ocular Herpes Asymptomatic Patients

A Herpes Simplex Virus Type 1 Human Asymptomatic CD8 + T-Cell Epitopes-Based Vaccine Protects Against Ocular Herpes in a “Humanized” HLA Transgenic Rabbit Model

Phenotypic and Functional Characterization of Herpes Simplex Virus Glycoprotein B Epitope-specific Effector and Memory CD8 + T Cells from Ocular Herpes Symptomatic and Asymptomatic Individuals

Therapeutic Immunization with Herpes Simplex Virus Type 1 Glycoprotein D Derived “Asymptomatic” Human CD8 + T-cell Epitopes Protects Against Recurrent Ocular Herpetic in Latently Infected HLA Transgenic Rabbits: Correlation with low Frequency of Exhausted PD-1 + TIM-3 + CD8 + T Cells

HLA-A02:01-Restricted Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP11/12 Preferentially Recall Polyfunctional Effector Memory CD8 + T Cells from Seropositive Asymptomatic Individuals and Protect “Humanized” HLA-A*02:01 Transgenic Mice Against Ocular Herpes

Identification of Herpes Simplex Virus Glycoprotein B Human Epitopes That Preferentially Recall Polyfunctional CD8+ T Cells from Seropositive Asymptomatic Individuals and Protect HLA Transgenic Mice Against Ocular Herpes

The Herpes Simplex Virus-1 Latency-Associated Transcript Promotes Functional Exhaustion of Virus-Specific CD8+ T Cells in Trigeminal Ganglia of Latently Infected “humanized” HLA-transgenic rabbits

Two Human Leukocyte Antigen (HLA)-A*0201-Restricted Epitopes Identified from Herpes Simplex Virus Glycoprotein B are Recognized Exclusively by CD8+ T cells from Asymptomatic Individuals and Protect Against Ocular Herpes

Interplay of LAT and HVEM affect HSV-1 Latency and CD8+ T Cell Exhaustion

The Herpes Simplex Virus Type 1 Latency Associated Transcript Inhibits Phenotypic and Functional Maturation of Dendritic Cells

Protective Asymptomatic Human Leukocyte Antigen (HLA)-A*0201-Restricted CD8+ Cytotoxic T-Lymphocyte Epitopes Identified from Herpes Simplex Virus Glycoprotein B

The Role Of HSV-1 LAT In Enhancement Of Latency And Increase Of CD8+ T Cell Exhaustion In Trigeminal Ganglia Of Infected Mice

The Herpes Simplex Virus-1 Encoded Latency-Associated Transcript Promotes Dysfunctional Virus-Specific CD8+ T Cells in Latently Infected Trigeminal Ganglia: A Novel Immune Evasion Mechanism

The Role of a Glycoprotein K (gK) CD8 + T-Cell Epitope of Herpes Simplex Virus on Virus Replication and Pathogenicity

Protective Immunity against Ocular Herpes Infection and Disease Induced by Highly Immunogenic Self-Adjuvanting Glycoprotein D Lipopeptide Vaccines

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