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ARVO Annual Meeting Abstract June 2024

Engineered AAV capsid variants allow efficient in vivo and ex vivo gene transfer into the porcine retina

Knut Stieger; Maria Weller; Katerina Nemesh; Sabrina Babutzka; Yaroslav Nemesh; Ruslan Nyshchuk; Brigitte Müller; Taras Ardan; Stefan Juhas; Jana Juhasova; Ivona Valenkova; Jana Čízková; Zdenka Ellederova; Jan Motlik; Lyubomyr Lytvynchuk; Stylianos Michalakis

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2217.

ARVO Annual Meeting Abstract June 2024

The impact of photoreceptor-specific miRNAs in health and disease

Julia Pawlick; Sarah Kunze; Stylianos Michalakis; Rouhollah Habibey; Volker Busskamp

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4767.

ARVO Annual Meeting Abstract June 2024

Host cell protein impurities are not a relevant driver of gene therapy-associated immune response

Immanuel Philipp Seitz; Eduardo Bocanegra; Felix Reichel; Stylianos Michalakis; Martin Biel; Karl Ulrich Bartz-Schmidt; Tobias Peters; M Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5345.

ARVO Annual Meeting Abstract June 2023

Safety and Vision Outcomes of subretinal gene supplementation therapy in PDE6A -associated Retinitis pigmentosa

Felix Friedrich Lambert Reichel; Stylianos Michalakis; Dominik M Fischer; laura kuehlewein; Tobias Peters; Susanne Kohl; Karl-Ulrich Bartz-Schmidt; Marius Ueffing; Eberhart Zrenner; Martin Biel; Katarina Stingl; Bernd Wissinger

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):782.

ARVO Annual Meeting Abstract June 2023

Applying photoreceptor-specific miRNAs to prevent cone photoreceptor degeneration

Julia Pawlick; Sarah Kunze; Stylianos Michalakis; Volker Busskamp

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3210.

ARVO Annual Meeting Abstract June 2023

Evidence of potential early-stage ocular tertiary lymphoid tissue formation following high dose retinal AAV8 gene therapy

Kirsten Bucher; Daniela Süsskind; Martin Biel; Stylianos Michalakis; Karl-Ulrich Bartz-Schmidt; Tobias Peters; M Dominik Fischer; Simon J Clark

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3911.

ARVO Annual Meeting Abstract June 2023

Preclinical human model for retinal cell therapy: Pathology dependent integration of photoreceptor transplants into human retina organoid hosts

Felix Wagner; Roberto Carrera; Thomas Kurth; Stylianos Michalakis; Deniz Dalkara; Mike O. Karl

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3858.

ARVO Annual Meeting Abstract June 2022

The role of Tet3 in retinal development and function

Grazia Giorgio; Silke Haverkamp; Elisa Murenu; Stylianos Michalakis

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4283.

ARVO Annual Meeting Abstract June 2022

Multimodal retina examination of patients with CNGA1 retinitis pigmentosa

Milda Reith; Friederike Charlotte Kortuem; Saskia Ott; Pohl Lisa; Melanie Kempf; Stylianos Michalakis; Susanne Kohl; Katarina Stingl; Krunoslav Stingl

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4486 – F0273.

ARVO Annual Meeting Abstract June 2021

Gene Therapy Successfully Restores Retinal Function and Delays Degeneration in a Mouse Model of CNGB1-linked Retinitis Pigmentosa

Lena Zobel; Johanna E Wagner; Catherine R O'Riordan; Amy M Frederick; Martin Biel; Stylianos Michalakis

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3069.

ARVO Annual Meeting Abstract June 2020

Testing of a therapeutic vector for CNGB1 retinitis pigmentosa

Simon M Petersen-Jones; Laurence Mireille Occelli; Johanna Wagner; Luis Marinho; Amy Frederick; Catherine O'Riordan; Stylianos Michalakis

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):793.

ARVO Annual Meeting Abstract June 2020

Gene augmentation therapy in a large animal model of PDE6A -Retinitis Pigmentosa results in functional and structural rescue for at least 2.5 years.

Laurence Mireille Occelli; Stylianos Michalakis; Martin Biel; consortium RD-Cure; Simon M Petersen-Jones

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1913.

ARVO Annual Meeting Abstract July 2019

The Role of Endoplasmic Reticulum (ER) Calcium Channels in ER Stress and Cone Death in CNG Channel Deficiency

Michael Robert Butler; Hongwei Ma; Fan Yang; Jacob Rapp; Yun-Zheng Le; Katsuhiko Mikoshiba; Martin Biel; Stylianos Michalakis; Xi-Qin Ding

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4864.

ARVO Annual Meeting Abstract July 2019

Effects of Subretinal AAV8 Gene Therapy on Microperimetry in CNGA3 Achromatopsia Patients

G. Alex Ochakovski; Ahmad Zhour; Laura Kuehlewein; Susanne Kohl; Andrea Rindtorff; Karl Ulrich Bartz-Schmidt; Marius Ueffing; Eberhart Zrenner; Stylianos Michalakis; Martin Biel; Bernd Wissinger; Tobias Peters; Barbara Wilhelm; M. Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2921.

ARVO Annual Meeting Abstract July 2019

The Contribution of Endoplasmic Reticulum Calcium Deficiency to Mistrafficking of Cone Outer Segment Proteins in CNG Channel Deficiency

Hongwei Ma; Fan Yang; Michael Robert Butler; Jacob Rapp; Yun-Zheng Le; Katsuhiko Mikoshiba; Martin Biel; Stylianos Michalakis; Xi-Qin Ding

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4207.

ARVO Annual Meeting Abstract July 2019

Digenic triallelic inheritance in cone photoreceptor cyclic nucleotide gated channel associated retinopathies

Susanne Kohl; Markus Burkard; Timm Kraetzig; Naoyuki Tanimoto; Britta Baumann; Martin Biel; Robert Lukowski; Mathias W Seeliger; Stylianos Michalakis; Bernd Wissinger; Peter Ruth

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):419.

ARVO Annual Meeting Abstract July 2018

New insights into the mechanisms of retinal degeneration due to Phosphodiesterase 6 (PDE6) deficiency

Regine Lotte Muehlfriedel; Vithiyanjali Sothilingam; Marina Garcia Garrido; Naoyuki Tanimoto; Susanne Beck; Stylianos Michalakis; Martin Biel; Francois Paquet-Durand; Mathias W Seeliger

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):998.

ARVO Annual Meeting Abstract July 2018

Safety study in cynomolgus monkeys after subretinal injection of rAAV.hPDE6A

Tobias Peters; Barbara Wilhelm; Birgit Korbmacher; Sven Korte; Karl Ulrich Bartz-Schmidt; Stylianos Michalakis; Guy Alex Ochakovski; M Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2658.

ARVO Annual Meeting Abstract July 2018

cGMP/PKG Signaling Regulation of Endoplasmic Reticulum Calcium Channels in Cyclic Nucleotide-gated Channel-deficient Cones

Fan Yang; Hongwei Ma; Michael Butler; Wolfgang Baehr; Martin Biel; Stylianos Michalakis; Xi-Qin Ding

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4966.

ARVO Annual Meeting Abstract July 2018

Evaluation of reconstitution efficiencies of rAAV-dCas9-VPR split-intein protein trans-splicing vectors in retinal cells

Victoria Splith; Sybille Boehm; Johanna Wagner; Martin Biel; Elvir Becirovic; Stylianos Michalakis

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5663.

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Engineered AAV capsid variants allow efficient in vivo and ex vivo gene transfer into the porcine retina

The impact of photoreceptor-specific miRNAs in health and disease

Host cell protein impurities are not a relevant driver of gene therapy-associated immune response

Safety and Vision Outcomes of subretinal gene supplementation therapy in PDE6A -associated Retinitis pigmentosa

Applying photoreceptor-specific miRNAs to prevent cone photoreceptor degeneration

Evidence of potential early-stage ocular tertiary lymphoid tissue formation following high dose retinal AAV8 gene therapy

Preclinical human model for retinal cell therapy: Pathology dependent integration of photoreceptor transplants into human retina organoid hosts

The role of Tet3 in retinal development and function

Multimodal retina examination of patients with CNGA1 retinitis pigmentosa

Gene Therapy Successfully Restores Retinal Function and Delays Degeneration in a Mouse Model of CNGB1-linked Retinitis Pigmentosa

Testing of a therapeutic vector for CNGB1 retinitis pigmentosa

Gene augmentation therapy in a large animal model of PDE6A -Retinitis Pigmentosa results in functional and structural rescue for at least 2.5 years.

The Role of Endoplasmic Reticulum (ER) Calcium Channels in ER Stress and Cone Death in CNG Channel Deficiency

Effects of Subretinal AAV8 Gene Therapy on Microperimetry in CNGA3 Achromatopsia Patients

The Contribution of Endoplasmic Reticulum Calcium Deficiency to Mistrafficking of Cone Outer Segment Proteins in CNG Channel Deficiency

Digenic triallelic inheritance in cone photoreceptor cyclic nucleotide gated channel associated retinopathies

New insights into the mechanisms of retinal degeneration due to Phosphodiesterase 6 (PDE6) deficiency

Safety study in cynomolgus monkeys after subretinal injection of rAAV.hPDE6A

cGMP/PKG Signaling Regulation of Endoplasmic Reticulum Calcium Channels in Cyclic Nucleotide-gated Channel-deficient Cones

Evaluation of reconstitution efficiencies of rAAV-dCas9-VPR split-intein protein trans-splicing vectors in retinal cells

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