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ARVO Annual Meeting Abstract July 2018

New insights into the mechanisms of retinal degeneration due to Phosphodiesterase 6 (PDE6) deficiency

Regine Lotte Muehlfriedel; Vithiyanjali Sothilingam; Marina Garcia Garrido; Naoyuki Tanimoto; Susanne Beck; Stylianos Michalakis; Martin Biel; Francois Paquet-Durand; Mathias W Seeliger

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):998. doi:

ARVO Annual Meeting Abstract July 2018

First Gene Supplementation Therapy for CNGA3-linked Achromatopsia

M Dominik Fischer; Stylianos Michalakis; Barbara Wilhelm; Nadine Kahle; Tobias Peters; Karl Ulrich Bartz-Schmidt; Susanne Kohl; Mathias W Seeliger; Nicole Weisschuh; Ditta Zobor; Eberhart Zrenner; Marius Ueffing; Martin Biel; Bernd Wissinger

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2982. doi:

ARVO Annual Meeting Abstract July 2018

Safety study in cynomolgus monkeys after subretinal injection of rAAV.hPDE6A

Tobias Peters; Barbara Wilhelm; Birgit Korbmacher; Sven Korte; Karl Ulrich Bartz-Schmidt; Stylianos Michalakis; Guy Alex Ochakovski; M Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2658. doi:

ARVO Annual Meeting Abstract July 2018

cGMP/PKG Signaling Regulation of Endoplasmic Reticulum Calcium Channels in Cyclic Nucleotide-gated Channel-deficient Cones

Fan Yang; Hongwei Ma; Michael Butler; Wolfgang Baehr; Martin Biel; Stylianos Michalakis; Xi-Qin Ding

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4966. doi:

ARVO Annual Meeting Abstract July 2018

Evaluation of reconstitution efficiencies of rAAV-dCas9-VPR split-intein protein trans-splicing vectors in retinal cells

Victoria Splith; Sybille Boehm; Johanna Wagner; Martin Biel; Elvir Becirovic; Stylianos Michalakis

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5663. doi:

ARVO Annual Meeting Abstract July 2018

Preclinical evaluation of rAAV.CNGB1 in the Cngb1 knockout mouse model of retinitis pigmentosa.

Johanna Wagner; Christian Schön; Catherine O'Riordan; Abraham Scaria; Seng Cheng; Martin Biel; Stylianos Michalakis

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5664. doi:

Retina April 2018

Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients

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Felix F. Reichel; Tobias Peters; Barbara Wilhelm; Martin Biel; Marius Ueffing; Bernd Wissinger; Karl U. Bartz-Schmidt; Reinhild Klein; Stylianos Michalakis; M. Dominik Fischer; for the RD-CURE Consortium

Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1910-1915. doi: 10.1167/iovs.17-22494

Includes: Supplemental Content

Retina November 2017

Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates

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Immanuel P. Seitz; Stylianos Michalakis; Barbara Wilhelm; Felix F. Reichel; G. Alex Ochakovski; Eberhart Zrenner; Marius Ueffing; Martin Biel; Bernd Wissinger; Karl U. Bartz-Schmidt; Tobias Peters; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: gene transfer techniques, cohort studies, disease vectors, dna, genome, injection of therapeutic agent, lymphoid tissue, primates, surgical procedures, operative, body tissue, nose, urine, visual system, spatial vectors, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5792-5801. doi: 10.1167/iovs.17-22473

Includes: Supplemental Content

Retina August 2017

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae

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G. Alex Ochakovski; Tobias Peters; Stylianos Michalakis; Barbara Wilhelm; Bernd Wissinger; Martin Biel; K. Ulrich Bartz-Schmidt; M. Dominik Fischer; for the RD-CURE Consortium
TAGS: gene therapy, injection of therapeutic agent, primates, safety, serotonin uptake inhibitors, surgical procedures, operative, eye, retina
Invest. Ophthalmol. Vis. Sci.. 2017; 58(10):4155-4160. doi: 10.1167/iovs.17-22402

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Peripherin-2 and Rom-1 Have Opposing Effects on Rod Outer Segment Targeting of Two Misfolded Peripherin-2 Mutants in Rods

Elvir Becirovic; Sybille Böhm; Lisa Maria Riedmayr; Andreas Gießl; Christian Schön; Stylianos Michalakis; Martin Biel

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3564. doi:

ARVO Annual Meeting Abstract June 2017

Evaluation of electroretinography in cynomolgus monkeys after subretinal injection of rAAV.hPDE6A

Tobias Peters; Barbara Wilhelm; birgit niggemann; Sven Korte; Karl Ulrich Bartz-Schmidt; Stylianos Michalakis; Guy Alex Ochakovski; Dominik M Fischer

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4096. doi:

ARVO Annual Meeting Abstract June 2017

Non-inferiority of subretinal versus intravitreal injection regarding photoreceptor layer thickness

Guy Alex Ochakovski; Tobias Peters; Stylianos Michalakis; Barbara Wilhelm; K. Ulrich Bartz-Schmidt; M Dominik Fischer

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4100. doi:

ARVO Annual Meeting Abstract June 2017

Preclinical evaluation of rAAV8.CNGA3 in the Cnga3 knockout mouse model of ACHM2

Stylianos Michalakis; Christian Schön; Regine Mühlfriedel; Vithiyanjali Sothilingam; Bernd Wissinger; Mathias W Seeliger; Martin Biel

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4499. doi:

ARVO Annual Meeting Abstract June 2017

Preclinical evaluation of rAAV8.PDE6A in the Pde6a D670G mutant mouse model of RP43

Christian Schön; Regine Mühlfriedel; Vithiyanjali Sothilingam; Francois Paquet-Durand; Bernd Wissinger; Mathias W Seeliger; Martin Biel; Stylianos Michalakis

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4500. doi:

ARVO Annual Meeting Abstract June 2017

How do patients rate their subjective symptoms after CNGA3 gene therapy: First application of the instrument A3-PRO

Barbara Wilhelm; Andreas Koegel; Nadine Kahle; Tobias Peters; Stylianos Michalakis; Martin Biel; Mathias Seeliger; Eberhart Zrenner; Bernd Wissinger; Susanne Kohl; Marius Ueffing; Karl Ulrich Bartz-Schmidt; Dominik M Fischer; Ditta Zobor

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4678. doi:

Letters to the Editor October 2016

Author Response: Possibility of Cytoplasmic Transportation Between Donor–Host Cell Following Photoreceptor Transplantation

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Tiago Santos-Ferreira; Manuela Völkner; Oliver Borsch; Jochen Haas; Peter Cimalla; Praveen Vasudevan; Peter Carmeliet; Denis Corbeil; Stylianos Michalakis; Edmund Koch; Mike O Karl; Marius Ader
TAGS: cytoplasm, photoreceptors, transplantation, transportation, donors
Invest. Ophthalmol. Vis. Sci.. 2016; 57(13):5336-5337. doi: 10.1167/iovs.16-20687

ARVO Annual Meeting Abstract September 2016

Inactivation of Hif1a rescues rods and cones from degeneration induced by a chronic hypoxia-like response: HIF1A as therapeutic target in AMD?

Christian Grimm; Maya Barben; Divya Ail; Brigitt Kast; Christian Schori; Christina Giger-Lange; Stylianos Michalakis; Marijana Samardzija

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

rAAV8 biodistribution and shedding after subretinal injection in non-human primates

Immanuel Philipp Seitz; M. Dominik Fischer; Stylianos Michalakis; Barbara Wilhelm; Nadine Kahle; Eberhart Zrenner; Marius Ueffing; Karl Ulrich Bartz-Schmidt; Martin Biel; Bernd Wissinger; Tobias Peters

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4025. doi:

ARVO Annual Meeting Abstract September 2016

Humoral immune response to subretinal AAV8 in non-human primates

Felix Friedrich Reichel; Tobias Peters; Regine Muehlfriedel; Martin Biel; Francois Paquet-Durand; Marius Ueffing; Bernd Wissinger; Karl Ulrich Bartz-Schmidt; M. Dominik Fischer; Stylianos Michalakis

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):778. doi:

ARVO Annual Meeting Abstract September 2016

Differential rescue of protein expression and localization of two adRP-linked PRPH2 mutants in rods is mediated by their specific binding characteristics

Elvir Becirovic; Sybille Böhm; Ong Nam Phuong Nguyen; Lisa Maria Riedmayr; Nadja Schroeder; Andreas Giessl; Stylianos Michalakis; Martin Biel

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1170. doi:

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New insights into the mechanisms of retinal degeneration due to Phosphodiesterase 6 (PDE6) deficiency

First Gene Supplementation Therapy for CNGA3-linked Achromatopsia

Safety study in cynomolgus monkeys after subretinal injection of rAAV.hPDE6A

cGMP/PKG Signaling Regulation of Endoplasmic Reticulum Calcium Channels in Cyclic Nucleotide-gated Channel-deficient Cones

Evaluation of reconstitution efficiencies of rAAV-dCas9-VPR split-intein protein trans-splicing vectors in retinal cells

Preclinical evaluation of rAAV.CNGB1 in the Cngb1 knockout mouse model of retinitis pigmentosa.

Humoral Immune Response After Intravitreal But Not After Subretinal AAV8 in Primates and Patients

Superior Retinal Gene Transfer and Biodistribution Profile of Subretinal Versus Intravitreal Delivery of AAV8 in Nonhuman Primates

Subretinal Injection for Gene Therapy Does Not Cause Clinically Significant Outer Nuclear Layer Thinning in Normal Primate Foveae

Peripherin-2 and Rom-1 Have Opposing Effects on Rod Outer Segment Targeting of Two Misfolded Peripherin-2 Mutants in Rods

Evaluation of electroretinography in cynomolgus monkeys after subretinal injection of rAAV.hPDE6A

Non-inferiority of subretinal versus intravitreal injection regarding photoreceptor layer thickness

Preclinical evaluation of rAAV8.CNGA3 in the Cnga3 knockout mouse model of ACHM2

Preclinical evaluation of rAAV8.PDE6A in the Pde6a D670G mutant mouse model of RP43

How do patients rate their subjective symptoms after CNGA3 gene therapy: First application of the instrument A3-PRO

Author Response: Possibility of Cytoplasmic Transportation Between Donor–Host Cell Following Photoreceptor Transplantation

Inactivation of Hif1a rescues rods and cones from degeneration induced by a chronic hypoxia-like response: HIF1A as therapeutic target in AMD?

rAAV8 biodistribution and shedding after subretinal injection in non-human primates

Humoral immune response to subretinal AAV8 in non-human primates

Differential rescue of protein expression and localization of two adRP-linked PRPH2 mutants in rods is mediated by their specific binding characteristics

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