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ARVO Annual Meeting Abstract June 2024

Identification of keratoconus-related phenotypes in three Ppip5k2 mouse models

Yutao Liu; Theresa Akoto; Skyler Jones; Jingwen Cai; Hongfang Yu; Hayden McCord; Amy Estes; Lin Gan; Anthony N Kuo; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3861.

ARVO Annual Meeting Abstract June 2024

Activation of Sigma 1 Receptor prevents pathological angiogenesis and subretinal fibrosis in an experimental model of choroidal neovascularization (CNV)

Jing Wang; Qiuhua Yang; Yuqing Huo; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4315.

Cornea June 2024

Identification of Keratoconus-Related Phenotypes in Three Ppip5k2 Mouse Models

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Theresa Akoto; Rachel Hadvina; Skyler Jones; Jingwen Cai; Hongfang Yu; Hayden McCord; Charles X. J. Jin; Amy J. Estes; Lin Gan; Anthony Kuo; Sylvia B. Smith; Yutao Liu
TAGS: cornea, mice, phenotype, keratoconus, animal model
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):22. https://doi.org/10.1167/iovs.65.6.22

ARVO Annual Meeting Abstract June 2023

Microvascular abnormalities and angiogenesis in NF1 mice

abdelhakim M. morsy; Valerie Harris; Yusra Zaidi; Amina Aly; jing Wang; Xiaoxiao Mao; Barbara Maysona; August Beisel; Qiuhua Yang; Kathryn E Bollinger; Sylvia B Smith; Brian Stansfield

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4868.

ARVO Annual Meeting Abstract June 2023

Estrogen signaling, trabecular meshwork, and intraocular pressure regulation

Yutao Liu; Hannah Youngblood; Jingwen Cai; Jason Sun; Hongfang Yu; Patricia Schoenlein; Hongyan Xu; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):64.

ARVO Annual Meeting Abstract June 2022

Sigma 1 Receptor (Sig1R) activation attenuates vasculopathy associated with Retinopathy of Prematurity (ROP)

Jing Wang; Haiyan Xiao; zhimin Xu; Ruth B Caldwell; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):784 – F0343.

ARVO Annual Meeting Abstract June 2022

Sigma 1 receptor (SIG1R) modulates Cullin3 (CUL3) in retinal cone photoreceptor cells.

Sylvia B Smith; Jing Wang; Shannon Barwick; Haiyan Xiao

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2582 – F0465.

Retinal Cell Biology February 2022

Sigma 1 Receptor Contributes to Astrocyte-Mediated Retinal Ganglion Cell Protection

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Jing Zhao; Graydon B. Gonsalvez; Barbara A. Mysona; Sylvia B. Smith; Kathryn E. Bollinger
TAGS: astrocytes, coculture techniques, mice, retinal ganglion cells, patient isolation, in situ nick-end labeling, neurites, limb, apoptosis, social isolation
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):1. https://doi.org/10.1167/iovs.63.2.1

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

The Role of PCSK1 in Keratoconus Pathogenesis in Two Mouse Models

Yutao Liu; Hongfang Yu; Anthony N Kuo; Amy Estes; Sylvia B Smith; Jingwen Cai

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):782.

Retinal Cell Biology June 2021

Sigma 1 Receptor Modulates Optic Nerve Head Astrocyte Reactivity

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Jing Zhao; Graydon Gonsalvez; Manuela Bartoli; Barbara A. Mysona; Sylvia B. Smith; Kathryn E. Bollinger
TAGS: astrocytes, glial fibrillary acidic protein, optic disk, receptors, sigma, mice, stress, ischemia, cell culture techniques
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):5. https://doi.org/10.1167/iovs.62.7.5

Retinal Cell Biology November 2020

Comparison of Sigma 1 Receptor Ligands SA4503 and PRE084 to (+)-Pentazocine in the rd10 Mouse Model of RP

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Jing Wang; Haiyan Xiao; Shannon R. Barwick; Sylvia B. Smith

Invest. Ophthalmol. Vis. Sci.. 2020; 61(13):3. https://doi.org/10.1167/iovs.61.13.3

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Sigma 1 Receptor Activation Enhances Optic Neve Head Astrocyte Reactivity Under Conditions of Cellular Stress

Kathryn E Bollinger; Barbara A Mysona; graydon gonsalvez; Manuela Bartoli; Sylvia B Smith; Jing Zhao

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):691.

ARVO Annual Meeting Abstract June 2020

Comparison of Sigma 1 Receptor (Sig1R) ligands SA4503, PRE084 and (+)-pentazocine ((+)-PTZ) for their cone photoreceptor (PRC) rescue effects in the Pde6b rd10 /J (rd10) mouse model of retinitis pigmentosa

Haiyan Xiao; Jing Wang; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1288.

ARVO Annual Meeting Abstract June 2020

Activation of Sigma1 Receptor (Sig1R) improves retinal architecture & visual acuity in the Rho P23H/+ mouse model of autosomal dominant retinitis pigmentosa (adRP)

Shannon Barwick; Haiyan Xiao; Jing Wang; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1289.

ARVO Annual Meeting Abstract June 2020

Sigma 1 Receptor (Sig1R) activation: a novel therapy for neurovascular injury in Retinopathy of Prematurity (ROP)

Jing Wang; Haiyan Xiao; Zhimin Xu; Ruth B Caldwell; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5411.

ARVO Annual Meeting Abstract June 2020

Advanced age-related macular degeneration like pathology in aged BALB/c mice following systemic neonatal murine cytomegalovirus (MCMV) infection

Jinxian Xu; Xinyan Zhang; Brendan Marshall; Sylvia B Smith; Diego Gabriel Espinosa-Heidmann; Ming Zhang

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1118.

Retinal Cell Biology March 2020

Comparison of Neuroprotective Effects of Monomethylfumarate to the Sigma 1 Receptor Ligand (+)-Pentazocine in a Murine Model of Retinitis Pigmentosa

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Haiyan Xiao; Jing Wang; Alan Saul; Sylvia B. Smith
TAGS: ligands, mice, neuroprotective effect, pentazocine, retinal cone, retinitis pigmentosa, retina, electroretinography, antioxidants, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2020; 61(3):5. https://doi.org/10.1167/iovs.61.3.5

Retinal Cell Biology October 2019

Activation of Sigma 1 Receptor Extends Survival of Cones and Improves Visual Acuity in a Murine Model of Retinitis Pigmentosa

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Jing Wang; Alan Saul; Sylvia B. Smith
TAGS: ligands, mice, retinal cone, visual acuity, retinitis pigmentosa, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4397-4407. https://doi.org/10.1167/iovs.19-27709

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

PPIP5K2 mutations & Keratoconus in Human Patients and Mouse Models

Yutao Liu; Mariam Khaled; Yelena Bykhovskaya; Khaled Abu-Amero; Sylvia B Smith; Mitchell A Watsky; Amy Estes; Stephen B. Shears; Anthony N Kuo; Yaron S Rabinowitz

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4784.

ARVO Annual Meeting Abstract July 2019

Investigation of the interaction of Sigma1 Receptor (S1R) and NRF2 in cone photoreceptor cells

Shannon Renee Barwick; Mevish Siddiq; Brendan Marshall; Elizabeth Perry; Jing Wang; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4867.

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Identification of keratoconus-related phenotypes in three Ppip5k2 mouse models

Activation of Sigma 1 Receptor prevents pathological angiogenesis and subretinal fibrosis in an experimental model of choroidal neovascularization (CNV)

Identification of Keratoconus-Related Phenotypes in Three Ppip5k2 Mouse Models

Microvascular abnormalities and angiogenesis in NF1 mice

Estrogen signaling, trabecular meshwork, and intraocular pressure regulation

Sigma 1 Receptor (Sig1R) activation attenuates vasculopathy associated with Retinopathy of Prematurity (ROP)

Sigma 1 receptor (SIG1R) modulates Cullin3 (CUL3) in retinal cone photoreceptor cells.

Sigma 1 Receptor Contributes to Astrocyte-Mediated Retinal Ganglion Cell Protection

The Role of PCSK1 in Keratoconus Pathogenesis in Two Mouse Models

Sigma 1 Receptor Modulates Optic Nerve Head Astrocyte Reactivity

Comparison of Sigma 1 Receptor Ligands SA4503 and PRE084 to (+)-Pentazocine in the rd10 Mouse Model of RP

Sigma 1 Receptor Activation Enhances Optic Neve Head Astrocyte Reactivity Under Conditions of Cellular Stress

Comparison of Sigma 1 Receptor (Sig1R) ligands SA4503, PRE084 and (+)-pentazocine ((+)-PTZ) for their cone photoreceptor (PRC) rescue effects in the Pde6b rd10 /J (rd10) mouse model of retinitis pigmentosa

Activation of Sigma1 Receptor (Sig1R) improves retinal architecture & visual acuity in the Rho P23H/+ mouse model of autosomal dominant retinitis pigmentosa (adRP)

Sigma 1 Receptor (Sig1R) activation: a novel therapy for neurovascular injury in Retinopathy of Prematurity (ROP)

Advanced age-related macular degeneration like pathology in aged BALB/c mice following systemic neonatal murine cytomegalovirus (MCMV) infection

Comparison of Neuroprotective Effects of Monomethylfumarate to the Sigma 1 Receptor Ligand (+)-Pentazocine in a Murine Model of Retinitis Pigmentosa

Activation of Sigma 1 Receptor Extends Survival of Cones and Improves Visual Acuity in a Murine Model of Retinitis Pigmentosa

PPIP5K2 mutations & Keratoconus in Human Patients and Mouse Models

Investigation of the interaction of Sigma1 Receptor (S1R) and NRF2 in cone photoreceptor cells

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