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Retinal Cell Biology November 2020

Comparison of Sigma 1 Receptor Ligands SA4503 and PRE084 to (+)-Pentazocine in the rd10 Mouse Model of RP

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Jing Wang; Haiyan Xiao; Shannon R. Barwick; Sylvia B. Smith

Invest. Ophthalmol. Vis. Sci.. 2020; 61(13):3. doi: https://doi.org/10.1167/iovs.61.13.3

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Sigma 1 Receptor Activation Enhances Optic Neve Head Astrocyte Reactivity Under Conditions of Cellular Stress

Kathryn E Bollinger; Barbara A Mysona; graydon gonsalvez; Manuela Bartoli; Sylvia B Smith; Jing Zhao

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):691. doi:

ARVO Annual Meeting Abstract June 2020

Comparison of Sigma 1 Receptor (Sig1R) ligands SA4503, PRE084 and (+)-pentazocine ((+)-PTZ) for their cone photoreceptor (PRC) rescue effects in the Pde6b rd10 /J (rd10) mouse model of retinitis pigmentosa

Haiyan Xiao; Jing Wang; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1288. doi:

ARVO Annual Meeting Abstract June 2020

Activation of Sigma1 Receptor (Sig1R) improves retinal architecture & visual acuity in the Rho P23H/+ mouse model of autosomal dominant retinitis pigmentosa (adRP)

Shannon Barwick; Haiyan Xiao; Jing Wang; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1289. doi:

ARVO Annual Meeting Abstract June 2020

Sigma 1 Receptor (Sig1R) activation: a novel therapy for neurovascular injury in Retinopathy of Prematurity (ROP)

Jing Wang; Haiyan Xiao; Zhimin Xu; Ruth B Caldwell; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5411. doi:

ARVO Annual Meeting Abstract June 2020

Advanced age-related macular degeneration like pathology in aged BALB/c mice following systemic neonatal murine cytomegalovirus (MCMV) infection

Jinxian Xu; Xinyan Zhang; Brendan Marshall; Sylvia B Smith; Diego Gabriel Espinosa-Heidmann; Ming Zhang

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1118. doi:

Retinal Cell Biology March 2020

Comparison of Neuroprotective Effects of Monomethylfumarate to the Sigma 1 Receptor Ligand (+)-Pentazocine in a Murine Model of Retinitis Pigmentosa

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Haiyan Xiao; Jing Wang; Alan Saul; Sylvia B. Smith
TAGS: ligands, mice, neuroprotective effect, pentazocine, retinal cone, retinitis pigmentosa, retina, electroretinography, antioxidants, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2020; 61(3):5. doi: https://doi.org/10.1167/iovs.61.3.5

Retinal Cell Biology October 2019

Activation of Sigma 1 Receptor Extends Survival of Cones and Improves Visual Acuity in a Murine Model of Retinitis Pigmentosa

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Jing Wang; Alan Saul; Sylvia B. Smith
TAGS: ligands, mice, retinal cone, visual acuity, retinitis pigmentosa, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4397-4407. doi: https://doi.org/10.1167/iovs.19-27709

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

PPIP5K2 mutations & Keratoconus in Human Patients and Mouse Models

Yutao Liu; Mariam Khaled; Yelena Bykhovskaya; Khaled Abu-Amero; Sylvia B Smith; Mitchell A Watsky; Amy Estes; Stephen B. Shears; Anthony N Kuo; Yaron S Rabinowitz

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4784. doi:

ARVO Annual Meeting Abstract July 2019

Investigation of the interaction of Sigma1 Receptor (S1R) and NRF2 in cone photoreceptor cells

Shannon Renee Barwick; Mevish Siddiq; Brendan Marshall; Elizabeth Perry; Jing Wang; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4867. doi:

Retinal Cell Biology September 2017

Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa

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Jing Wang; Alan Saul; Xuezhi Cui; Penny Roon; Sylvia B. Smith
TAGS: mice, retina, photoreceptors, retinitis pigmentosa
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4545-4558. doi: https://doi.org/10.1167/iovs.17-21947

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Sigma 1 receptor mediated neuroprotection in a rat model of glaucoma

Kathryn E Bollinger; Barbara A Mysona; Jing Zhao; graydon gonsalvez; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2574. doi:

ARVO Annual Meeting Abstract June 2017

Photoreceptor cell death following choroidal murine cytomegalovirus (MCMV) infections of deeply immunosuppressed mice

Ming Zhang; Brendan Marshall; Juan Mo; Sylvia B Smith; Zheng Dong

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3627. doi:

ARVO Annual Meeting Abstract June 2017

Sigma 1 Receptor (Sig1R) regulates retinal ER & Oxidative (OX) Stress

Jing Wang; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5369. doi:

ARVO Annual Meeting Abstract June 2017

Elevated homocysteine (Hcy) upregulates the NRF2 antioxidant pathway in retinal Müller cells

Soumya Navneet; Jing Wang; Xuezhi Cui; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5391. doi:

Retinal Cell Biology April 2017

Analysis of MTHFR, CBS, Glutathione, Taurine, and Hydrogen Sulfide Levels in Retinas of Hyperhomocysteinemic Mice

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Xuezhi Cui; Soumya Navneet; Jing Wang; Penny Roon; Wei Chen; Ming Xian; Sylvia B. Smith
TAGS: glutathione, hydrogen sulfide, hyperhomocysteinemia, methylenetetrahydrofolate reductase (nadph2), mice, proteins, retina, taurine
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):1954-1963. doi: https://doi.org/10.1167/iovs.16-21247

ARVO Annual Meeting Abstract September 2016

Sigma-1 receptor mediated secretion of BDNF by optic nerve head astrocytes

Barbara Ann Mysona; Jing Zhao; Sylvia B Smith; Kathryn E Bollinger

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4212. doi:

ARVO Annual Meeting Abstract September 2016

Loss of GPR109A results in RPE dysfunction, neurodegeneration and increased oxidative stress with age: Potential relevance to AMD

Folami Lamoke; Pachiappan Arjunan; Shaquanna Young; Sylvia B Smith; Alan Saul; Pamela M Martin

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

ARVO Annual Meeting Abstract September 2016

Retinal Iron Overload during Diabetic Retinopathy Accelerates Ganglion Cell Death

Jaya P Gnana-Prakasam; Kapil Chaudhary; Wanwisa Promsote; Sylvia B Smith; Vadivel Ganapathy; Pamela M Martin; Alan Saul

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):751. doi:

ARVO Annual Meeting Abstract September 2016

Hyperhomocysteinemia Disrupts Retinal Pigment Epithelial Structure and Function with Features of Age-Related Macular Degeneration

Amany M Tawfik; Ahmed S Ibrahim; Nehal Elsherbini; Sylvia B Smith; Mohamed Al-Sayed Al-Shabrawey

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi:

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Comparison of Sigma 1 Receptor Ligands SA4503 and PRE084 to (+)-Pentazocine in the rd10 Mouse Model of RP

Sigma 1 Receptor Activation Enhances Optic Neve Head Astrocyte Reactivity Under Conditions of Cellular Stress

Comparison of Sigma 1 Receptor (Sig1R) ligands SA4503, PRE084 and (+)-pentazocine ((+)-PTZ) for their cone photoreceptor (PRC) rescue effects in the Pde6b rd10 /J (rd10) mouse model of retinitis pigmentosa

Activation of Sigma1 Receptor (Sig1R) improves retinal architecture & visual acuity in the Rho P23H/+ mouse model of autosomal dominant retinitis pigmentosa (adRP)

Sigma 1 Receptor (Sig1R) activation: a novel therapy for neurovascular injury in Retinopathy of Prematurity (ROP)

Advanced age-related macular degeneration like pathology in aged BALB/c mice following systemic neonatal murine cytomegalovirus (MCMV) infection

Comparison of Neuroprotective Effects of Monomethylfumarate to the Sigma 1 Receptor Ligand (+)-Pentazocine in a Murine Model of Retinitis Pigmentosa

Activation of Sigma 1 Receptor Extends Survival of Cones and Improves Visual Acuity in a Murine Model of Retinitis Pigmentosa

PPIP5K2 mutations & Keratoconus in Human Patients and Mouse Models

Investigation of the interaction of Sigma1 Receptor (S1R) and NRF2 in cone photoreceptor cells

Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa

Sigma 1 receptor mediated neuroprotection in a rat model of glaucoma

Photoreceptor cell death following choroidal murine cytomegalovirus (MCMV) infections of deeply immunosuppressed mice

Sigma 1 Receptor (Sig1R) regulates retinal ER & Oxidative (OX) Stress

Elevated homocysteine (Hcy) upregulates the NRF2 antioxidant pathway in retinal Müller cells

Analysis of MTHFR, CBS, Glutathione, Taurine, and Hydrogen Sulfide Levels in Retinas of Hyperhomocysteinemic Mice

Sigma-1 receptor mediated secretion of BDNF by optic nerve head astrocytes

Loss of GPR109A results in RPE dysfunction, neurodegeneration and increased oxidative stress with age: Potential relevance to AMD

Retinal Iron Overload during Diabetic Retinopathy Accelerates Ganglion Cell Death

Hyperhomocysteinemia Disrupts Retinal Pigment Epithelial Structure and Function with Features of Age-Related Macular Degeneration

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