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Retinal Cell Biology March 2020

Comparison of Neuroprotective Effects of Monomethylfumarate to the Sigma 1 Receptor Ligand (+)-Pentazocine in a Murine Model of Retinitis Pigmentosa

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Haiyan Xiao; Jing Wang; Alan Saul; Sylvia B. Smith
TAGS: ligands, mice, neuroprotective effect, pentazocine, retinal cone, retinitis pigmentosa, retina, electroretinography, antioxidants, visual acuity
Invest. Ophthalmol. Vis. Sci.. 2020; 61(3):5. doi: https://doi.org/10.1167/iovs.61.3.5

Retinal Cell Biology October 2019

Activation of Sigma 1 Receptor Extends Survival of Cones and Improves Visual Acuity in a Murine Model of Retinitis Pigmentosa

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Jing Wang; Alan Saul; Sylvia B. Smith
TAGS: ligands, mice, retinal cone, visual acuity, retinitis pigmentosa, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2019; 60(13):4397-4407. doi: https://doi.org/10.1167/iovs.19-27709

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

PPIP5K2 mutations & Keratoconus in Human Patients and Mouse Models

Yutao Liu; Mariam Khaled; Yelena Bykhovskaya; Khaled Abu-Amero; Sylvia B Smith; Mitchell A Watsky; Amy Estes; Stephen B. Shears; Anthony N Kuo; Yaron S Rabinowitz

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4784. doi: https://doi.org/

ARVO Annual Meeting Abstract July 2019

Investigation of the interaction of Sigma1 Receptor (S1R) and NRF2 in cone photoreceptor cells

Shannon Renee Barwick; Mevish Siddiq; Brendan Marshall; Elizabeth Perry; Jing Wang; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4867. doi: https://doi.org/

Retinal Cell Biology September 2017

Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa

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Jing Wang; Alan Saul; Xuezhi Cui; Penny Roon; Sylvia B. Smith
TAGS: photoreceptors, retinitis pigmentosa, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2017; 58(11):4545-4558. doi: https://doi.org/10.1167/iovs.17-21947

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Sigma 1 receptor mediated neuroprotection in a rat model of glaucoma

Kathryn E Bollinger; Barbara A Mysona; Jing Zhao; graydon gonsalvez; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2574. doi: https://doi.org/

ARVO Annual Meeting Abstract June 2017

Photoreceptor cell death following choroidal murine cytomegalovirus (MCMV) infections of deeply immunosuppressed mice

Ming Zhang; Brendan Marshall; Juan Mo; Sylvia B Smith; Zheng Dong

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3627. doi: https://doi.org/

ARVO Annual Meeting Abstract June 2017

Sigma 1 Receptor (Sig1R) regulates retinal ER & Oxidative (OX) Stress

Jing Wang; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5369. doi: https://doi.org/

ARVO Annual Meeting Abstract June 2017

Elevated homocysteine (Hcy) upregulates the NRF2 antioxidant pathway in retinal Müller cells

Soumya Navneet; Jing Wang; Xuezhi Cui; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5391. doi: https://doi.org/

Retinal Cell Biology April 2017

Analysis of MTHFR, CBS, Glutathione, Taurine, and Hydrogen Sulfide Levels in Retinas of Hyperhomocysteinemic Mice

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Xuezhi Cui; Soumya Navneet; Jing Wang; Penny Roon; Wei Chen; Ming Xian; Sylvia B. Smith
TAGS: hyperhomocysteinemia, glutathione, taurine, hydrogen sulfide, mice, proteins, retina, methylenetetrahydrofolate reductase (nadph2)
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):1954-1963. doi: https://doi.org/10.1167/iovs.16-21247

ARVO Annual Meeting Abstract September 2016

Sigma-1 receptor mediated secretion of BDNF by optic nerve head astrocytes

Barbara Ann Mysona; Jing Zhao; Sylvia B Smith; Kathryn E Bollinger

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4212. doi: https://doi.org/

ARVO Annual Meeting Abstract September 2016

Loss of GPR109A results in RPE dysfunction, neurodegeneration and increased oxidative stress with age: Potential relevance to AMD

Folami Lamoke; Pachiappan Arjunan; Shaquanna Young; Sylvia B Smith; Alan Saul; Pamela M Martin

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi: https://doi.org/

ARVO Annual Meeting Abstract September 2016

Retinal Iron Overload during Diabetic Retinopathy Accelerates Ganglion Cell Death

Jaya P Gnana-Prakasam; Kapil Chaudhary; Wanwisa Promsote; Sylvia B Smith; Vadivel Ganapathy; Pamela M Martin; Alan Saul

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):751. doi: https://doi.org/

ARVO Annual Meeting Abstract September 2016

Hyperhomocysteinemia Disrupts Retinal Pigment Epithelial Structure and Function with Features of Age-Related Macular Degeneration

Amany M Tawfik; Ahmed S Ibrahim; Nehal Elsherbini; Sylvia B Smith; Mohamed Al-Sayed Al-Shabrawey

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12) doi: https://doi.org/

ARVO Annual Meeting Abstract September 2016

Absence of Sigma 1 Receptor (σ1R) accelerates photoreceptor cell (PRC) loss in Pde6b rd10 /J ( rd10) mice.

Sylvia B Smith; Jing Wang; Alan Saul; Xuezhi Cui; Penny Roon

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2732. doi: https://doi.org/

Retinal Cell Biology May 2016

Role of Sigma 1 Receptor in Retinal Degeneration of the Ins2 Akita/+ Murine Model of Diabetic Retinopathy

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Jing Wang; Xuezhi Cui; Penny Roon; Sylvia B. Smith
TAGS: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, retinal degeneration, mice, retina
Invest. Ophthalmol. Vis. Sci.. 2016; 57(6):2770-2781. doi: https://doi.org/10.1167/iovs.15-18995

Retina February 2016

(+)-Pentazocine Reduces NMDA-Induced Murine Retinal Ganglion Cell Death Through a σR1-Dependent Mechanism

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Jing Zhao; Barbara A. Mysona; Azam Qureshi; Lily Kim; Taylor Fields; Graydon B. Gonsalvez; Sylvia B. Smith; Kathryn E. Bollinger
TAGS: injection of therapeutic agent, n-methylaspartate, pentazocine, retinal ganglion cells, mice, retina, toxic effect
Invest. Ophthalmol. Vis. Sci.. 2016; 57(2):453-461. doi: https://doi.org/10.1167/iovs.15-18565

ARVO Annual Meeting Abstract June 2015

Mild hyperhomocysteinemia (Hhcy) leads to modest retinal ganglion cell (RGC) dysfunction and focal vascular leakiness in rd8-free methylenetetrahydrofolate reductase ( Mthfr ) deficient mice.

Shanu Markand; Alan Saul; Rima Rozen; Arul Shanmugam; Vadivel Ganapathy; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4262. doi: https://doi.org/

ARVO Annual Meeting Abstract June 2015

Neuroprotective effects of growth hormone releasing hormone (GHRH) in traumatic optic neuropathy

Manuela Bartoli; Amany M Tawfik; Alan Saul; Sagar Y Patel; David Gay; Gregory Ing Liou; Sylvia B Smith; Julian J Nussbaum; Folami Lamoke

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4363. doi: https://doi.org/

ARVO Annual Meeting Abstract June 2015

(+)-Pentazocine ((+)-PTZ), a high affinity sigma 1 receptor (σ 1 R) ligand preserves cone function in the Pde6 rd10 (Rd10) mouse model of retinitis pigmentosa

Jing Wang; Alan Saul; Vadivel Ganapathy; Sylvia B Smith

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5475. doi: https://doi.org/

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Comparison of Neuroprotective Effects of Monomethylfumarate to the Sigma 1 Receptor Ligand (+)-Pentazocine in a Murine Model of Retinitis Pigmentosa

Activation of Sigma 1 Receptor Extends Survival of Cones and Improves Visual Acuity in a Murine Model of Retinitis Pigmentosa

PPIP5K2 mutations & Keratoconus in Human Patients and Mouse Models

Investigation of the interaction of Sigma1 Receptor (S1R) and NRF2 in cone photoreceptor cells

Absence of Sigma 1 Receptor Accelerates Photoreceptor Cell Death in a Murine Model of Retinitis Pigmentosa

Sigma 1 receptor mediated neuroprotection in a rat model of glaucoma

Photoreceptor cell death following choroidal murine cytomegalovirus (MCMV) infections of deeply immunosuppressed mice

Sigma 1 Receptor (Sig1R) regulates retinal ER & Oxidative (OX) Stress

Elevated homocysteine (Hcy) upregulates the NRF2 antioxidant pathway in retinal Müller cells

Analysis of MTHFR, CBS, Glutathione, Taurine, and Hydrogen Sulfide Levels in Retinas of Hyperhomocysteinemic Mice

Sigma-1 receptor mediated secretion of BDNF by optic nerve head astrocytes

Loss of GPR109A results in RPE dysfunction, neurodegeneration and increased oxidative stress with age: Potential relevance to AMD

Retinal Iron Overload during Diabetic Retinopathy Accelerates Ganglion Cell Death

Hyperhomocysteinemia Disrupts Retinal Pigment Epithelial Structure and Function with Features of Age-Related Macular Degeneration

Absence of Sigma 1 Receptor (σ1R) accelerates photoreceptor cell (PRC) loss in Pde6b rd10 /J ( rd10) mice.

Role of Sigma 1 Receptor in Retinal Degeneration of the Ins2 Akita/+ Murine Model of Diabetic Retinopathy

(+)-Pentazocine Reduces NMDA-Induced Murine Retinal Ganglion Cell Death Through a σR1-Dependent Mechanism

Mild hyperhomocysteinemia (Hhcy) leads to modest retinal ganglion cell (RGC) dysfunction and focal vascular leakiness in rd8-free methylenetetrahydrofolate reductase ( Mthfr ) deficient mice.

Neuroprotective effects of growth hormone releasing hormone (GHRH) in traumatic optic neuropathy

(+)-Pentazocine ((+)-PTZ), a high affinity sigma 1 receptor (σ 1 R) ligand preserves cone function in the Pde6 rd10 (Rd10) mouse model of retinitis pigmentosa

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