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Clinical Trials September 2021

Integrating Clinical Data and Tear Proteomics to Assess Efficacy, Ocular Surface Status, and Biomarker Response After Orthokeratology Lens Wear

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Jimmy S.H. Tse; Jimmy K.W. Cheung; Gigi T.K. Wong; Thomas C. Lam; Kai Yip Choi; Katherine H.Y. So; Christie D.M. Lam; Andes Y.H. Sze; Angel C.K. Wong; Gigi M.C. Yee; Henry H.L. Chan
TAGS: biological markers, lens (device), lens, crystalline, orthokeratology, proteins, proteome, proteomics, safety, cornea
Trans. Vis. Sci. Tech.. 2021; 10(11):18. doi: https://doi.org/10.1167/tvst.10.11.18

Includes: Supplemental Content

Articles September 2021

AAV-Mediated Expression of Human VEGF, TNF-α, and IL-6 Induces Retinal Pathology in Mice

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Carina M. Weigelt; Holger Fuchs; Tanja Schönberger; Birgit Stierstorfer; Benjamin Strobel; Thorsten Lamla; Thomas Ciossek; Remko A. Bakker; Norbert H. Redemann
TAGS: eye, interleukin-6, mice, retinal diseases, tumor necrosis factors, vascular endothelial growth factor a, injections, pathology, inflammation, retina
Trans. Vis. Sci. Tech.. 2021; 10(11):15. doi: https://doi.org/10.1167/tvst.10.11.15

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

A Minipump Continuous Drug Infusion Dog Model System to Identify Candidate Drugs and Drug Delivery Rates for Intracameral IOP-lowering Implants

Jie Shen; Michael R Robinson; James Burke; Tim T Lam; Mayssa Attar

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2753. doi:

ARVO Annual Meeting Abstract June 2021

Efficacy of elastic Breath-O Correct orthokeratology on myopia control in a 1-year study period

Tsz King Wong; Kai Yip Choi; Henry Ho-lung Chan; Chuen Thomas Lam

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):666. doi:

ARVO Annual Meeting Abstract June 2021

The Role of Thrombospondin-1 in Rho-kinase Inhibitor Mediated Changes in Outflow Facility

Sze Wan Shan; Chi-wai Do; Chuen Thomas Lam; Hoi Lam Li; Daniel W Stamer; Chi Ho To

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1631. doi:

ARVO Annual Meeting Abstract June 2021

Quantitative proteomic analysis reveals temporal regulation of aldehyde dehydrogenase 1A1 in the rat retina after partial optic nerve transection

Jacky Man Kwong Kwong; Joseph Caprioli; Chi Ho To; Chuen Thomas Lam

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2366. doi:

ARVO Annual Meeting Abstract June 2021

Handheld chromatic pupillometry detects functional retinal loss in patients with retinal dystrophies

Walter Sze Tung Walter Lam; Ranjana Mathur; Choi Mun Chan; Pratik Chougule; Dan Milea; Raymond Najjar

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2414. doi:

ARVO Annual Meeting Abstract June 2021

Association between initial mfERG responses and myopic progression in children with and without prescription of Breath-O Correct orthokeratology lenses.

Kai Yip Choi; Tsz King Wong; Thomas Chuen Lam; Henry Ho-lung Chan

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):602. doi:

ARVO Annual Meeting Abstract June 2021

Ultra-widefield fundus autofluorescence derived atrophy expansion rate in ABCA4 -associated retinopathy is dependent on mutation severity

Rachael C Heath Jeffery; Jennifer A. Thompson; Johnny Lo; Tina M. Lamey; Terri L. McLaren; Ian L McAllister; David A Mackey; Ian Constable; John N. De Roach; Fred Kuanfu Chen

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1552. doi:

ARVO Annual Meeting Abstract June 2021

Using induced pluripotent stem cell-derived retinal pigment epithelial cells to model splicing defects of ABCA4 c.5461-10T>C detected in an Australian Stargardt disease cohort

Di Huang; Jennifer A. Thompson; Samuel McLenachan; Shang-Chih Chen; Dan Zhang; Rachael C Heath Jeffery; Mary Attia; Terri L. McLaren; Tina M. Lamey; John N. De Roach; May Thandar Aung-Htut; Abbie Adams; Sue Fletcher; Steve Wilton; Fred Kuanfu Chen

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3294. doi:

ARVO Annual Meeting Abstract June 2021

Natural history of PRPF31 -associated retinopathy: multimodal imaging findings

Danial Roshandel; Jennifer A. Thompson; Rachael C Heath Jeffery; Dan Zhang; Tina M. Lamey; Terri L. McLaren; John N. De Roach; Samuel McLenachan; David A Mackey; Fred Kuanfu Chen

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3207. doi:

Articles February 2021

Multimodal Retinal Imaging and Microperimetry Reveal a Novel Phenotype and Potential Trial End Points in CRB1 -Associated Retinopathies

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Danial Roshandel; Jennifer A. Thompson; Rachael C. Heath Jeffery; Danuta M. Sampson; Enid Chelva; Terri L. McLaren; Tina M. Lamey; John N. De Roach; Shane R. Durkin; Fred K. Chen
TAGS: macular disorders, phenotype, retinal diseases, retinal imaging, surrogate endpoints, volume, spectral domain-optical coherence tomography, fenestration
Trans. Vis. Sci. Tech.. 2021; 10(2):38. doi: https://doi.org/10.1167/tvst.10.2.38

Includes: Supplemental Content

Articles September 2020

Edge of Scotoma Sensitivity as a Microperimetry Clinical Trial End Point in USH2A Retinopathy

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Jason Charng; Tina M. Lamey; Jennifer A. Thompson; Terri L. McLaren; Mary S. Attia; Ian L. McAllister; Ian J. Constable; David A. Mackey; John N. De Roach; Fred K. Chen
TAGS: eye, retinal diseases, scotoma
Trans. Vis. Sci. Tech.. 2020; 9(10):9. doi: https://doi.org/10.1167/tvst.9.10.9

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Reprogramming human induced pluripotent stem cell (hiPSC)-derived RPE into neural retina progenitors (NRPs)

Anil Upreti; Phuong T. Lam; Jared Austin Tangeman; Brad Wagner; Davide Ortolan; Ruchi Sharma; Kapil Bharti; Katia Del Rio-Tsonis; Michael L Robinson

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2503. doi:

ARVO Annual Meeting Abstract June 2020

Cross-sectional and longitudinal analyses of microperimetry in USH2A -related retinitis pigmentosa

Jason Charng; Tina Lamey; Jen Thompson; Terri Mclaren; Mary Attia; John De Roach; David A Mackey; Fred Kuanfu Chen

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3384. doi:

Articles February 2020

Generation of a Retina Reporter hiPSC Line to Label Progenitor, Ganglion, and Photoreceptor Cell Types

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Phuong T. Lam; Christian Gutierrez; Katia Del Rio-Tsonis; Michael L. Robinson
TAGS: ganglia, organoids, photoreceptors, retina
Trans. Vis. Sci. Tech.. 2020; 9(3):21. doi: https://doi.org/10.1167/tvst.9.3.21

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract July 2019

Screening for RPE to Neural Retina Reprogramming using CRISPR Edited VSX2 -specific fluorescent reporter hiPSC

Phuong T. Lam; Christian Gutierrez; Nathan G. Burns; Bryan J. Smucker; Kapil Bharti; Katia Del Rio-Tsonis; Michael L. Robinson

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3327. doi:

ARVO Annual Meeting Abstract July 2019

An Injectable Formulation of a Beta-Adrenergic Antagonist Prodrug for Sustained Reduction of Intraocular Pressure (IOP)

Bryan Hoang; Jane Chisholm; Ting-Wei Young; Mark Holland; Qingyun Lu; Weiling Yu; Tim T Lam; Lichun Zhong; Shivakumar Vasanth; John Bauman; Charles Semba; Rajendra Mohabir; Ming Yang; Jin-Zhong Zhang

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3368. doi:

ARVO Annual Meeting Abstract July 2019

Optical coherence tomography derived macular volume loss over 5 years in Stargardt disease

Fred Kuanfu Chen; Sukanya Arunachalam; Natasha Vallis; Di Huang; Yi Chen; Jennifer A. Thompson; Terri McLaren; Tina Lamey; John De Roach; Samuel McLenachan

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4521. doi:

ARVO Annual Meeting Abstract July 2019

Phenotype characterization and transcript analysis in RCBTB1 -associated retinopathy

Zhiqin Huang; Samuel McLenachan; Dan Zhang; Jennifer A Thompson; Saumya Shekhar Jamuar; Terri McLaren; Tina Lamey; Enid Chelva; John De Roach; Choi Mun Chan; Fred Kuanfu Chen

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6059. doi:

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Integrating Clinical Data and Tear Proteomics to Assess Efficacy, Ocular Surface Status, and Biomarker Response After Orthokeratology Lens Wear

AAV-Mediated Expression of Human VEGF, TNF-α, and IL-6 Induces Retinal Pathology in Mice

A Minipump Continuous Drug Infusion Dog Model System to Identify Candidate Drugs and Drug Delivery Rates for Intracameral IOP-lowering Implants

Efficacy of elastic Breath-O Correct orthokeratology on myopia control in a 1-year study period

The Role of Thrombospondin-1 in Rho-kinase Inhibitor Mediated Changes in Outflow Facility

Quantitative proteomic analysis reveals temporal regulation of aldehyde dehydrogenase 1A1 in the rat retina after partial optic nerve transection

Handheld chromatic pupillometry detects functional retinal loss in patients with retinal dystrophies

Association between initial mfERG responses and myopic progression in children with and without prescription of Breath-O Correct orthokeratology lenses.

Ultra-widefield fundus autofluorescence derived atrophy expansion rate in ABCA4 -associated retinopathy is dependent on mutation severity

Using induced pluripotent stem cell-derived retinal pigment epithelial cells to model splicing defects of ABCA4 c.5461-10T>C detected in an Australian Stargardt disease cohort

Natural history of PRPF31 -associated retinopathy: multimodal imaging findings

Multimodal Retinal Imaging and Microperimetry Reveal a Novel Phenotype and Potential Trial End Points in CRB1 -Associated Retinopathies

Edge of Scotoma Sensitivity as a Microperimetry Clinical Trial End Point in USH2A Retinopathy

Reprogramming human induced pluripotent stem cell (hiPSC)-derived RPE into neural retina progenitors (NRPs)

Cross-sectional and longitudinal analyses of microperimetry in USH2A -related retinitis pigmentosa

Generation of a Retina Reporter hiPSC Line to Label Progenitor, Ganglion, and Photoreceptor Cell Types

Screening for RPE to Neural Retina Reprogramming using CRISPR Edited VSX2 -specific fluorescent reporter hiPSC

An Injectable Formulation of a Beta-Adrenergic Antagonist Prodrug for Sustained Reduction of Intraocular Pressure (IOP)

Optical coherence tomography derived macular volume loss over 5 years in Stargardt disease

Phenotype characterization and transcript analysis in RCBTB1 -associated retinopathy

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