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Physiology and Pharmacology June 2021

Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration

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John T. Demirs; Junzheng Yang; Maura A. Crowley; Michael Twarog; Omar Delgado; Yubin Qiu; Stephen Poor; Dennis S. Rice; Thaddeus P. Dryja; Karen Anderson; Sha-Mei Liao
TAGS: complement system proteins, eye, rna, messenger, age-related macular degeneration, choroid, neural retina, donors
Invest. Ophthalmol. Vis. Sci.. 2021; 62(7):26. https://doi.org/10.1167/iovs.62.7.26

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2018

Anti-TNF-α treatment in skin burns

Vassiliki Kapoulea; Chengxin Zhou; Fengyang Lei; Natalie Wolkow; Lina Ma; Thaddeus P Dryja; James Chodosh; Claes H Dohlman; Eleftherios I Paschalis

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2664.

ARVO Annual Meeting Abstract July 2018

Evidence of complement involvement in cancer-associated retinopathy (CAR)

John Demirs; Vivian Lee; Thaddeus P Dryja

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3148.

Physiology and Pharmacology February 2018

Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

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Maura A. Crowley; Omar Delgado; Adrian Will-Orrego; Natasha M. Buchanan; Karen Anderson; Bruce D. Jaffee; Thaddeus P. Dryja; Sha-Mei Liao
TAGS: animal model, complement activation, complement factor d, complement system proteins, eye, mice, proteins, plasma, body tissue
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):940-951. https://doi.org/10.1167/iovs.17-22605

ARVO Annual Meeting Abstract June 2017

Deletion of complement factor H is associated with accumulation of subretinal Iba-1-positive cells and retinal degeneration in aged mice

Sha-Mei Liao; Natasha Buchanan; John Demirs; Barrett Leehy; Casey Lewis; Junzheng Yang; Vanessa Davis; Nalini V Rangaswamy; Maura Crowley; Karen Anderson; Chad E Bigelow; Thaddeus P Dryja; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1625.

ARVO Annual Meeting Abstract June 2017

A protective association of selective serotonin reuptake inhibitors and a harmful association of calcium channel blockers for primary open-angle glaucoma identified in a healthcare database analysis

Anthony P Khawaja; Thaddeus P Dryja; Zhongyuan Wei; Dongying Song; Haijun Tian; Kristijan Kahler; Wei Zheng

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3710.

Physiology and Pharmacology June 2017

A Compact Whole-Eye Perfusion System to Evaluate Pharmacologic Responses of Outflow Facility

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Enhua H. Zhou; Michael Paolucci; Thaddeus P. Dryja; Ted Manley; Chuanxi Xiang; Dennis S. Rice; Ganesh Prasanna; Amy Chen
TAGS: endothelin-1, eye, perfusion
Invest. Ophthalmol. Vis. Sci.. 2017; 58(7):2991-3003. https://doi.org/10.1167/iovs.16-20974

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Generation and characterization of CLG561: a fully-human, anti-properdin Fab for the treatment of age-related macular degeneration

Leslie Johnson; Igor Splawski; Lisa Baker; Ana Carrion; Anh Nguyen; Michael Twarog; Yiqin Wang; Ute Jager; Mark Keating; Thaddeus P Dryja; Michael Roguska

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):1116.

ARVO Annual Meeting Abstract September 2016

AMD-associated SNPs in the ARMS2/HTRA1 locus influence local gene expression in multiple human tissues

Sha-Mei Liao; casey lewis; Omar Delgado; Maura Crowley; Natasha Buchanan; Wei Zheng; Thaddeus P Dryja; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2629.

ARVO Annual Meeting Abstract September 2016

Microbiome Characterization in Retina and Choroid of Patients with Age-related Macular Degeneration

Wei Zheng; Sokhom S. Pin; Shubh Dhillon; Zachary Zwirko; Pavan Lingala; Peter Skewes-Cox; Oleg Iartchouk; Bruce D Jaffee; Thaddeus P Dryja; Kathryn McAllister

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4788.

Retina October 2014

Reliability of the Mouse Model of Choroidal Neovascularization Induced by Laser Photocoagulation

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Stephen H. Poor; Yubin Qiu; Elizabeth S. Fassbender; Siyuan Shen; Amber Woolfenden; Andrea Delpero; Yong Kim; Natasha Buchanan; Thomas C. Gebuhr; Shawn M. Hanks; Erik L. Meredith; Bruce D. Jaffee; Thaddeus P. Dryja
TAGS: choroidal neovascularization, lasers, light coagulation, mice, reliability
Invest. Ophthalmol. Vis. Sci.. 2014; 55(10):6525-6534. https://doi.org/10.1167/iovs.14-15067

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2014

A mouse model to assess gene therapy for RLBP1-associated retinal dystrophy

Chad E Bigelow; Shawn M Hanks; Joanna Vrouvlianis; Oliver Turner; Gregory Argentieri; George Bounoutas; Vivian W Choi; Thaddeus P Dryja; Seshidhar Reddy Police; Bruce D Jaffee

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1640.

ARVO Annual Meeting Abstract April 2014

Recombinant adeno-associated viral vector (rAAV)-mediated expression of RLBP1 (CRALBP) rescues the dark adaptation defect in a mouse model of RLBP1-associated retinal degeneration

Vivian W Choi; Chad E Bigelow; Terri L McGee; Akshata N Gujar; Hui Li; Shawn Hanks; Joanna Vrouvlianis; Thaddeus P Dryja; Bruce D Jaffee; Seshidhar Reddy Police

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):835.

ARVO Annual Meeting Abstract April 2010

An Open-Label Proof-Of Concept Study to Assess the Efficacy of AIN457 in Patients With Noninfectious Uveitis

C. M. Samson; C. S. Foster; R. Kim; N. Falk; D. S. Chu; D. Callanan; Q. Nguyen; T. P. Dryja

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):2917.

ARVO Annual Meeting Abstract April 2009

Clinical Pharmacogenetic Analysis of Patients With Neovascular AMD Treated With Ranibizumab in the EXCITE Trial

M. Neuner-Jehle; B. Scassellati-Sforzolini; T. P. Dryja; C. Paulding; S. Lewitzky; Y. He; L. Farrer; J. Meyer

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):722.

Retina April 2009

A Homozygous Missense Mutation in the IRBP Gene ( RBP3 ) Associated with Autosomal Recessive Retinitis Pigmentosa

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Anneke I. den Hollander; Terri L. McGee; Carmela Ziviello; Sandro Banfi; Thaddeus P. Dryja; Federico Gonzalez-Fernandez; Debashis Ghosh; Eliot L. Berson
TAGS: autosomal recessive inheritance, e2f1 gene, family, genes, homozygote, missense mutation, retinitis pigmentosa, dietary sodium chloride, salts, sodium chloride
Invest. Ophthalmol. Vis. Sci.. 2009; 50(4):1864-1872. https://doi.org/10.1167/iovs.08-2497

Retina December 2008

Disease Course in Patients with Autosomal Recessive Retinitis Pigmentosa due to the USH2A Gene

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Michael A. Sandberg; Bernard Rosner; Carol Weigel-DiFranco; Terri L. McGee; Thaddeus P. Dryja; Eliot L. Berson
TAGS: autosomal recessive inheritance, disease progression, genes, mutation, retinitis pigmentosa, visual fields, visual acuity, blindness, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2008; 49(12):5532-5539. https://doi.org/10.1167/iovs.08-2009

ARVO Annual Meeting Abstract May 2008

Disease Course of Patients With Autosomal Recessive Retinitis Pigmentosa Due to USH2A Gene Mutations

M. A. Sandberg; B. Rosner; C. Weigel-DiFranco; T. L. McGee; T. P. Dryja; E. L. Berson

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):2175.

ARVO Annual Meeting Abstract May 2008

A Defect in the Krebs Cycle in Retinitis Pigmentosa

D. T. Hartong; M. Dange; T. L. McGee; E. L. Berson; R. F. Colman; T. P. Dryja

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):3284.

ARVO Annual Meeting Abstract May 2007

Analysis of the 1q24-q41 Region and the Candidate Gene RGS13 in Sibling Pairs Extremely Discordant for Neovascular Age-Related Macular Degeneration

I. K. Kim; F. Ji; M. A. Morrison; L. E. Patty; S. A. Adams; A. Capone; J. W. Miller; T. P. Dryja; J. Ott; M. M. DeAngelis

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):4621.

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Differential and Altered Spatial Distribution of Complement Expression in Age-Related Macular Degeneration

Anti-TNF-α treatment in skin burns

Evidence of complement involvement in cancer-associated retinopathy (CAR)

Induction of Ocular Complement Activation by Inflammatory Stimuli and Intraocular Inhibition of Complement Factor D in Animal Models

Deletion of complement factor H is associated with accumulation of subretinal Iba-1-positive cells and retinal degeneration in aged mice

A protective association of selective serotonin reuptake inhibitors and a harmful association of calcium channel blockers for primary open-angle glaucoma identified in a healthcare database analysis

A Compact Whole-Eye Perfusion System to Evaluate Pharmacologic Responses of Outflow Facility

Generation and characterization of CLG561: a fully-human, anti-properdin Fab for the treatment of age-related macular degeneration

AMD-associated SNPs in the ARMS2/HTRA1 locus influence local gene expression in multiple human tissues

Microbiome Characterization in Retina and Choroid of Patients with Age-related Macular Degeneration

Reliability of the Mouse Model of Choroidal Neovascularization Induced by Laser Photocoagulation

A mouse model to assess gene therapy for RLBP1-associated retinal dystrophy

Recombinant adeno-associated viral vector (rAAV)-mediated expression of RLBP1 (CRALBP) rescues the dark adaptation defect in a mouse model of RLBP1-associated retinal degeneration

An Open-Label Proof-Of Concept Study to Assess the Efficacy of AIN457 in Patients With Noninfectious Uveitis

Clinical Pharmacogenetic Analysis of Patients With Neovascular AMD Treated With Ranibizumab in the EXCITE Trial

A Homozygous Missense Mutation in the IRBP Gene ( RBP3 ) Associated with Autosomal Recessive Retinitis Pigmentosa

Disease Course in Patients with Autosomal Recessive Retinitis Pigmentosa due to the USH2A Gene

Disease Course of Patients With Autosomal Recessive Retinitis Pigmentosa Due to USH2A Gene Mutations

A Defect in the Krebs Cycle in Retinitis Pigmentosa

Analysis of the 1q24-q41 Region and the Candidate Gene RGS13 in Sibling Pairs Extremely Discordant for Neovascular Age-Related Macular Degeneration

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