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Retinal Cell Biology June 2019

Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease

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Matthew J. Hayes; Thomas Burgoyne; Silene T. Wavre-Shapton; Tanya Tolmachova; Miguel C. Seabra; Clare E. Futter
TAGS: epithelium, inner ear, mice, osmosis, pigment, retinal pigment cell, tissue membrane, eye, face, mitochondria
Invest. Ophthalmol. Vis. Sci.. 2019; 60(7):2515-2524. https://doi.org/10.1167/iovs.19-26784

Includes: Multimedia, Supplemental Content

ARVO Annual Meeting Abstract June 2017

Remodelling of the basal labyrinth of Retinal Pigment Epithelial cells with osmotic challenge, age and disease.

Miguel C Seabra; Matthew Hayes; Thomas Burgoyne; Silene T. Wavre-Shapton; Tanya Tolmachova; Clare Futter

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1039.

ARVO Annual Meeting Abstract June 2015

Enhancement of non-viral gene delivery to primary mouse retinal pigment epithelium cells using paramagnetic nanoparticles

Oleg E Tolmachov; Tanya Tolmachova; Diogo A. Feleciano; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5890.

ARVO Annual Meeting Abstract June 2015

Middle age-associated lysosomal upregulation in the healthy mouse retinal pigment epithelium

Tanya Tolmachova; Diogo A. Feleciano; Clare E. Futter; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2321.

ARVO Annual Meeting Abstract April 2014

Analysis of REP1 protein expression in blood leukocytes in typical choroideremia patients without an identifiable REP1 gene mutation

Camiel J F Boon; Tanya Tolmachova; Alun R Barnard; Susan M Downes; Markus Groppe; Andrew Webster; Robert E MacLaren

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3298.

ARVO Annual Meeting Abstract April 2014

AMD-compatible lysosomal changes in Rab38-deficient mouse model

Tanya Tolmachova; Diogo A Feleciano; Silene Wavre-Shapton; Martin J Evans; Clare Futter; Miguel C Seabra

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3459.

ARVO Annual Meeting Abstract April 2014

Mechanisms of photoreceptor degeneration in choroideremia

Ingrid Porpino Meschede; Tanya Tolmachova; Miguel C Seabra; Clare Futter

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):4367.

ARVO Annual Meeting Abstract April 2014

Improved visual function in patients with choroideremia undergoing subretinal gene therapy

Robert E MacLaren; Markus Groppe; Alun R Barnard; Tanya Tolmachova; Frans P Cremers; Graeme C Black; Andrew Lotery; Susan M Downes; Andrew Webster; Miguel C Seabra; Choroideremia Gene Therapy Study Group

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):832.

ARVO Annual Meeting Abstract March 2012

Phagosome Maturation And Interactions With The Endocytic Pathway In Retinal Pigment Epithelial Cells

Clare Futter; Ingrid P. Meschede; Silene T. Wavre; Mafalda Lopes Da Silva; Tanya Tolmachova; Miguel C. Seabra

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3701.

ARVO Annual Meeting Abstract March 2012

The Development of Non-Viral Vectors for Choroideremia

Richard P. Harbottle; Elham Ostad-Saffari; Mariya Moosajee; Suet Ping Wong; Dhani Tracey-White; Tanya Tolmachova; Miguel Seabra

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1922.

ARVO Annual Meeting Abstract March 2012

Pre-clinical Gene Therapy Studies In Choroideremia Mouse Models Using AAV Vectors

Miguel C. Seabra; Oleg Tolmachov; Robert E. MacLaren; Tanya Tolmachova

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1926.

ARVO Annual Meeting Abstract March 2012

Assessment of Visual Function by Electroretinography following rAAV2-CHM/REP1 Gene Therapy in a Mouse Model of Choroideremia

Alun R. Barnard; Tanya Tolmachova; Miguel C. Seabra; Robert E. MacLaren

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1933.

ARVO Annual Meeting Abstract March 2012

Gene Therapy For Choroideremia - Initial Report On A New Clinical Trial

Robert E. MacLaren; Markus Groppe; Alun R. Barnard; Tanya Tolmachova; Matthew J. During; Susan M. Downes; Andrew J. Lotery; Graeme C. Black; Andrew R. Webster; Miguel C. Seabra

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):5577.

ARVO Annual Meeting Abstract March 2012

Rab38 Deficiency Leads To Loss Of Cathepsin D And a Defect In Rhodopsin Degradation In Mouse Retinal Pigment Epithelium

Tanya Tolmachova; Miguel C. Seabra

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1132.

Biochemistry and Molecular Biology October 2010

Retinal Pigment Epithelium Defects Accelerate Photoreceptor Degeneration in Cell Type–Specific Knockout Mouse Models of Choroideremia

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Tanya Tolmachova; Silene T. Wavre-Shapton; Alun R. Barnard; Robert E. MacLaren; Clare E. Futter; Miguel C. Seabra
TAGS: choroideremia, mice, mice, knockout, photoreceptors, retinal pigment epithelium, tissue degeneration, electroretinography
Invest. Ophthalmol. Vis. Sci.. 2010; 51(10):4913-4920. https://doi.org/10.1167/iovs.09-4892

ARVO Annual Meeting Abstract April 2010

Persistent Expression of Non-Viral S/MAR Vectors in the RPE for Choroideremia Gene Therapy

E. Ostad-Saffari; M. Moosajee; S. P. Wong; D. C. Tracey-White; T. Tolmachova; R. P. Harbottle; M. C. Seabra

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):3122.

ARVO Annual Meeting Abstract April 2009

Development of Persistently Expressing Vectors for the Non-Viral Gene Therapy of Choroideremia

E. Ostad-Saffari; S. P. Wong; D. C. Tracey-White; O. Argyros; C. Coutelle; R. P. Harbottle; T. Tolmachova; M. C. Seabra

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):1731.

ARVO Annual Meeting Abstract April 2009

Prenylation Defect in the RPE Exacerbates Photoreceptor Degeneration in Choroideremia Mice

T. Tolmachova; S. T. M. M. Wavre; D. C. Tracey-White; C. E. Futter; M. C. Seabra

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):1937.

ARVO Annual Meeting Abstract April 2009

Correction of the Prenylation Defect in Choroideremia by Viral Delivery of the Choroideremia Gene

M. C. Seabra; D. C. Tracey-White; O. Tolmachov; H. J. Graham; T. Tolmachova

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):4300.

ARVO Annual Meeting Abstract May 2005

Choroideremia Mouse Model Generated by Conditional Rep1 Knock–Out

M.C. Seabra; T. Tolmachova; R. Anders; M. Abrink; J.S. Ramalho; C. Futter; F. Tonagel; N. Tanimoto; M. Seeliger; C. Huxley

Invest. Ophthalmol. Vis. Sci.. 2005; 46(13):3556.

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Remodeling of the Basal Labyrinth of Retinal Pigment Epithelial Cells With Osmotic Challenge, Age, and Disease

Remodelling of the basal labyrinth of Retinal Pigment Epithelial cells with osmotic challenge, age and disease.

Enhancement of non-viral gene delivery to primary mouse retinal pigment epithelium cells using paramagnetic nanoparticles

Middle age-associated lysosomal upregulation in the healthy mouse retinal pigment epithelium

Analysis of REP1 protein expression in blood leukocytes in typical choroideremia patients without an identifiable REP1 gene mutation

AMD-compatible lysosomal changes in Rab38-deficient mouse model

Mechanisms of photoreceptor degeneration in choroideremia

Improved visual function in patients with choroideremia undergoing subretinal gene therapy

Phagosome Maturation And Interactions With The Endocytic Pathway In Retinal Pigment Epithelial Cells

The Development of Non-Viral Vectors for Choroideremia

Pre-clinical Gene Therapy Studies In Choroideremia Mouse Models Using AAV Vectors

Assessment of Visual Function by Electroretinography following rAAV2-CHM/REP1 Gene Therapy in a Mouse Model of Choroideremia

Gene Therapy For Choroideremia - Initial Report On A New Clinical Trial

Rab38 Deficiency Leads To Loss Of Cathepsin D And a Defect In Rhodopsin Degradation In Mouse Retinal Pigment Epithelium

Retinal Pigment Epithelium Defects Accelerate Photoreceptor Degeneration in Cell Type–Specific Knockout Mouse Models of Choroideremia

Persistent Expression of Non-Viral S/MAR Vectors in the RPE for Choroideremia Gene Therapy

Development of Persistently Expressing Vectors for the Non-Viral Gene Therapy of Choroideremia

Prenylation Defect in the RPE Exacerbates Photoreceptor Degeneration in Choroideremia Mice

Correction of the Prenylation Defect in Choroideremia by Viral Delivery of the Choroideremia Gene

Choroideremia Mouse Model Generated by Conditional Rep1 Knock–Out

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