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ARVO Annual Meeting Abstract June 2020

Alu RNA exacerbates experimental choroidal neovascularization via an inflammasome-dependent pathway

Felipe Pereira; Ivana Apicella; Ryan Makin; Younghee Kim; Charles Wright; Tetsuhiro Yasuma; Reo Yasuma; Shuichiro Hirahara; Shinichi Fukuda; Siddharth Narendran; Romulo Albuquerque; Benjamin Fowler; Nagaraj Kerur; Jayakrishna Ambati; Bradley Gelfand

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5394. doi:

ARVO Annual Meeting Abstract July 2018

Long-term analysis of intravitreal anti-VEGF drugs

Tetsuhiro Yasuma; Keiko Kataoka; Yasuki Ito; Hiroko Terasaki

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):823. doi:

ARVO Annual Meeting Abstract July 2018

Non-integrated, reverse transcribed Alu complementary DNAs in Geographic Atrophy cause RPE toxicity

Shinichi Fukuda; Benjamin J Fowler; Tetsuhiro Yasuma; Akhil Varshney; Kameshwari Ambati; Nagaraj Kerur; Bradley Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2456. doi:

ARVO Annual Meeting Abstract July 2018

Nucleoside reverse transcriptase inhibitors are broad-spectrum RPE protectants

Shuichiro Hirahara; Shinichi Fukuda; Younghee Kim; Reo Yasuma; Kameshwari Ambati; Junichi Fukuhara; Dongxu Fu; DAIPAYAN BANERJEE; Benjamin J Fowler; Tetsuhiro Yasuma; Nagaraj Kerur; Bradley Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2459. doi:

ARVO Annual Meeting Abstract July 2018

Nucleoside reverse transcriptase inhibitors (NRTI) prevent inflammasome activation in retinal pigmented epithelium cells.

DAIPAYAN BANERJEE; Junichi Fukuhara; Dongxu Fu; Shinichi Fukuda; Shuichiro Hirahara; Younghee Kim; Benjamin J Fowler; Tetsuhiro Yasuma; Reo Yasuma; Kameshwari Ambati; Nagaraj Kerur; Bradley Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2475. doi:

ARVO Annual Meeting Abstract June 2017

Endogenous complementary DNA in age-related macular degeneration

Shinichi Fukuda; Tetsuhiro Yasuma; Benjamin J Fowler; Bradley D Gelfand; Nagaraj Kerur; Reo Yasuma; Brian Werner; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5262. doi:

ARVO Annual Meeting Abstract September 2016

Non-canonical NLRP3 Inflammasome activation in Geographic Atrophy

Nagaraj Kerur; Younghee Kim; Shinichi Fukuda; Reo Yasuma; Ana Bastos-Carvalho; Daipayan Banerjee; Benjamin Fowler; Tetsuhiro Yasuma; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):486. doi:

ARVO Annual Meeting Abstract September 2016

Role of interferon signaling in Alu RNA-induced AMD

Daipayan Banerjee; Younghee Kim; Shinichi Fukuda; Reo Yasuma; Ana Bastos-Carvalho; Benjamin Fowler; Tetsuhiro Yasuma; Bradley D Gelfand; Nagaraj Kerur; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):487. doi:

ARVO Annual Meeting Abstract September 2016

Local administration of IL-18 from multiple sources does not suppress experimental CNV.

Reo Yasuma; Tetsuhiro Yasuma; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4517. doi:

ARVO Annual Meeting Abstract September 2016

Subcutaneous IL-18 administration does not inhibit laser CNV in mice

Tetsuhiro Yasuma; Reo Yasuma; Bradley D Gelfand; Nagaraj Kerur; Ana Bastos-Carvalho; Younghee Kim; Charles B Wright; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4518. doi:

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors are anti-inflammatory and inhibit poly I:C-induced retinal pigment epithelium degeneration

Shinichi Fukuda; Junichi Fukuhara; Younghee Kim; Benjamin Fowler; Tetsuhiro Yasuma; Reo Yasuma; Takako Fukuhara; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6551. doi:

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors attenuate amyloid-beta-induced retinal pigment epithelium degeneration

Takako Fukuhara; Junichi Fukuhara; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Benjamin Fowler; Shinichi Fukuda; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6552. doi:

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors prevent iron-induced retinal pigment epithelium cell death

Junichi Fukuhara; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Benjamin Fowler; Shinichi Fukuda; Takako Fukuhara; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5005. doi:

ARVO Annual Meeting Abstract June 2015

Nucleoside reverse transcriptase inhibitor (NRTI) protection against iron cytotoxicity

Charles B Wright; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Shengjian Li; Benjamin J Fowler; Ana Bastos-Carvalho; Mark Ellsworth Kleinman; Jayakrishna Ambati; Bradley D Gelfand

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4211. doi:

ARVO Annual Meeting Abstract April 2014

Intravenous immunoglobulin treatment inhibits choroidal and corneal neovascularization via FcyR1

Reo Yasuma; Sasha Bogdanovich; Younghee Kim; Tetsuhiro Yasuma; Takeshi Mizutani; Ana Bastos-Carvalho; Benjamin Fowler; shengjian li; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1190. doi:

ARVO Annual Meeting Abstract April 2014

Enhanced Alu RNA stability due to iron-mediated DICER1 impairment causes NLRP3 inflammasome priming

Charles B Wright; Younghee Kim; Tetsuhiro Yasuma; Shengjian Li; Benjamin J Fowler; Mark Ellsworth Kleinman; Jayakrishna Ambati; Bradley D Gelfand

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2187. doi:

ARVO Annual Meeting Abstract April 2014

Myd88 as a therapeutic target for choroidal neovascularization

Nagaraj Kerur; Younghee Kim; Yoshio Hirano; Valeria Tarallo; Ana Bastos-Carvalho; Benjamin Fowler; Tetsuhiro Yasuma; Reo Yasuma; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2195. doi:

ARVO Annual Meeting Abstract April 2014

IL18 is not therapeutic for neovascular age-related macular degeneration

Bradley D Gelfand; Yoshio Hirano; Tetsuhiro Yasuma; Takeshi Mizutani; Benjamin J Fowler; Miho Nozaki; Hiroki Kaneko; Balamurali Ambati; David R Hinton; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3553. doi:

ARVO Annual Meeting Abstract April 2014

Human therapeutic monoclonal antibodies inhibit corneal neovascularization via FcγRI in a target-independent manner

Ana Bastos-Carvalho; Sasha Bogdanovich; Younghee Kim; Reo Yasuma; Takeshi Mizutani; Nagaraj Kerur; Tetsuhiro Yasuma; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5049. doi:

ARVO Annual Meeting Abstract April 2014

Dual anti-angiogenic activity of Bevacizumab from its IgG1-Fc domain and VEGF neutralization

Takeshi Mizutani; Nagaraj Kerur; Shengjian Li; Younghee Kim; Reo Yasuma; Tetsuhiro Yasuma; Ana Bastos-Carvalho; Benjamin Fowler; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1936. doi:

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Alu RNA exacerbates experimental choroidal neovascularization via an inflammasome-dependent pathway

Long-term analysis of intravitreal anti-VEGF drugs

Non-integrated, reverse transcribed Alu complementary DNAs in Geographic Atrophy cause RPE toxicity

Nucleoside reverse transcriptase inhibitors are broad-spectrum RPE protectants

Nucleoside reverse transcriptase inhibitors (NRTI) prevent inflammasome activation in retinal pigmented epithelium cells.

Endogenous complementary DNA in age-related macular degeneration

Non-canonical NLRP3 Inflammasome activation in Geographic Atrophy

Role of interferon signaling in Alu RNA-induced AMD

Local administration of IL-18 from multiple sources does not suppress experimental CNV.

Subcutaneous IL-18 administration does not inhibit laser CNV in mice

Nucleoside reverse transcriptase inhibitors are anti-inflammatory and inhibit poly I:C-induced retinal pigment epithelium degeneration

Nucleoside reverse transcriptase inhibitors attenuate amyloid-beta-induced retinal pigment epithelium degeneration

Nucleoside reverse transcriptase inhibitors prevent iron-induced retinal pigment epithelium cell death

Nucleoside reverse transcriptase inhibitor (NRTI) protection against iron cytotoxicity

Intravenous immunoglobulin treatment inhibits choroidal and corneal neovascularization via FcyR1

Enhanced Alu RNA stability due to iron-mediated DICER1 impairment causes NLRP3 inflammasome priming

Myd88 as a therapeutic target for choroidal neovascularization

IL18 is not therapeutic for neovascular age-related macular degeneration

Human therapeutic monoclonal antibodies inhibit corneal neovascularization via FcγRI in a target-independent manner

Dual anti-angiogenic activity of Bevacizumab from its IgG1-Fc domain and VEGF neutralization

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