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ARVO Annual Meeting Abstract June 2020

Alu RNA exacerbates experimental choroidal neovascularization via an inflammasome-dependent pathway

Felipe Pereira; Ivana Apicella; Ryan Makin; Younghee Kim; Charles Wright; Tetsuhiro Yasuma; Reo Yasuma; Shuichiro Hirahara; Shinichi Fukuda; Siddharth Narendran; Romulo Albuquerque; Benjamin Fowler; Nagaraj Kerur; Jayakrishna Ambati; Bradley Gelfand

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5394. doi:

ARVO Annual Meeting Abstract July 2018

Long-term analysis of intravitreal anti-VEGF drugs

Tetsuhiro Yasuma; Keiko Kataoka; Yasuki Ito; Hiroko Terasaki

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):823. doi:

ARVO Annual Meeting Abstract July 2018

Non-integrated, reverse transcribed Alu complementary DNAs in Geographic Atrophy cause RPE toxicity

Shinichi Fukuda; Benjamin J Fowler; Tetsuhiro Yasuma; Akhil Varshney; Kameshwari Ambati; Nagaraj Kerur; Bradley Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2456. doi:

ARVO Annual Meeting Abstract July 2018

Nucleoside reverse transcriptase inhibitors are broad-spectrum RPE protectants

Shuichiro Hirahara; Shinichi Fukuda; Younghee Kim; Reo Yasuma; Kameshwari Ambati; Junichi Fukuhara; Dongxu Fu; DAIPAYAN BANERJEE; Benjamin J Fowler; Tetsuhiro Yasuma; Nagaraj Kerur; Bradley Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2459. doi:

ARVO Annual Meeting Abstract July 2018

Nucleoside reverse transcriptase inhibitors (NRTI) prevent inflammasome activation in retinal pigmented epithelium cells.

DAIPAYAN BANERJEE; Junichi Fukuhara; Dongxu Fu; Shinichi Fukuda; Shuichiro Hirahara; Younghee Kim; Benjamin J Fowler; Tetsuhiro Yasuma; Reo Yasuma; Kameshwari Ambati; Nagaraj Kerur; Bradley Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):2475. doi:

ARVO Annual Meeting Abstract June 2017

Endogenous complementary DNA in age-related macular degeneration

Shinichi Fukuda; Tetsuhiro Yasuma; Benjamin J Fowler; Bradley D Gelfand; Nagaraj Kerur; Reo Yasuma; Brian Werner; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5262. doi:

ARVO Annual Meeting Abstract September 2016

Non-canonical NLRP3 Inflammasome activation in Geographic Atrophy

Nagaraj Kerur; Younghee Kim; Shinichi Fukuda; Reo Yasuma; Ana Bastos-Carvalho; Daipayan Banerjee; Benjamin Fowler; Tetsuhiro Yasuma; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):486. doi:

ARVO Annual Meeting Abstract September 2016

Role of interferon signaling in Alu RNA-induced AMD

Daipayan Banerjee; Younghee Kim; Shinichi Fukuda; Reo Yasuma; Ana Bastos-Carvalho; Benjamin Fowler; Tetsuhiro Yasuma; Bradley D Gelfand; Nagaraj Kerur; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):487. doi:

ARVO Annual Meeting Abstract September 2016

Local administration of IL-18 from multiple sources does not suppress experimental CNV.

Reo Yasuma; Tetsuhiro Yasuma; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4517. doi:

ARVO Annual Meeting Abstract September 2016

Subcutaneous IL-18 administration does not inhibit laser CNV in mice

Tetsuhiro Yasuma; Reo Yasuma; Bradley D Gelfand; Nagaraj Kerur; Ana Bastos-Carvalho; Younghee Kim; Charles B Wright; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4518. doi:

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors prevent iron-induced retinal pigment epithelium cell death

Junichi Fukuhara; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Benjamin Fowler; Shinichi Fukuda; Takako Fukuhara; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5005. doi:

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors are anti-inflammatory and inhibit poly I:C-induced retinal pigment epithelium degeneration

Shinichi Fukuda; Junichi Fukuhara; Younghee Kim; Benjamin Fowler; Tetsuhiro Yasuma; Reo Yasuma; Takako Fukuhara; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6551. doi:

ARVO Annual Meeting Abstract September 2016

Nucleoside reverse transcriptase inhibitors attenuate amyloid-beta-induced retinal pigment epithelium degeneration

Takako Fukuhara; Junichi Fukuhara; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Benjamin Fowler; Shinichi Fukuda; Nagaraj Kerur; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6552. doi:

ARVO Annual Meeting Abstract June 2015

Nucleoside reverse transcriptase inhibitor (NRTI) protection against iron cytotoxicity

Charles B Wright; Younghee Kim; Tetsuhiro Yasuma; Reo Yasuma; Shengjian Li; Benjamin J Fowler; Ana Bastos-Carvalho; Mark Ellsworth Kleinman; Jayakrishna Ambati; Bradley D Gelfand

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4211. doi:

ARVO Annual Meeting Abstract April 2014

Intravenous immunoglobulin treatment inhibits choroidal and corneal neovascularization via FcyR1

Reo Yasuma; Sasha Bogdanovich; Younghee Kim; Tetsuhiro Yasuma; Takeshi Mizutani; Ana Bastos-Carvalho; Benjamin Fowler; shengjian li; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1190. doi:

ARVO Annual Meeting Abstract April 2014

Dual anti-angiogenic activity of Bevacizumab from its IgG1-Fc domain and VEGF neutralization

Takeshi Mizutani; Nagaraj Kerur; Shengjian Li; Younghee Kim; Reo Yasuma; Tetsuhiro Yasuma; Ana Bastos-Carvalho; Benjamin Fowler; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1936. doi:

ARVO Annual Meeting Abstract April 2014

Generic, target-independent suppression of choroidal neovascularization by human IgG1 antibodies via Fc gamma receptor I

Tetsuhiro Yasuma; Reo Yasuma; Younghee Kim; Takeshi Mizutani; Nagaraj Kerur; Ana Bastos-Carvalho; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1937. doi:

ARVO Annual Meeting Abstract April 2014

Enhanced Alu RNA stability due to iron-mediated DICER1 impairment causes NLRP3 inflammasome priming

Charles B Wright; Younghee Kim; Tetsuhiro Yasuma; Shengjian Li; Benjamin J Fowler; Mark Ellsworth Kleinman; Jayakrishna Ambati; Bradley D Gelfand

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2187. doi:

ARVO Annual Meeting Abstract April 2014

Myd88 as a therapeutic target for choroidal neovascularization

Nagaraj Kerur; Younghee Kim; Yoshio Hirano; Valeria Tarallo; Ana Bastos-Carvalho; Benjamin Fowler; Tetsuhiro Yasuma; Reo Yasuma; Bradley D Gelfand; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2195. doi:

ARVO Annual Meeting Abstract April 2014

IL18 is not therapeutic for neovascular age-related macular degeneration

Bradley D Gelfand; Yoshio Hirano; Tetsuhiro Yasuma; Takeshi Mizutani; Benjamin J Fowler; Miho Nozaki; Hiroki Kaneko; Balamurali Ambati; David R Hinton; Jayakrishna Ambati

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3553. doi:

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Alu RNA exacerbates experimental choroidal neovascularization via an inflammasome-dependent pathway

Long-term analysis of intravitreal anti-VEGF drugs

Non-integrated, reverse transcribed Alu complementary DNAs in Geographic Atrophy cause RPE toxicity

Nucleoside reverse transcriptase inhibitors are broad-spectrum RPE protectants

Nucleoside reverse transcriptase inhibitors (NRTI) prevent inflammasome activation in retinal pigmented epithelium cells.

Endogenous complementary DNA in age-related macular degeneration

Non-canonical NLRP3 Inflammasome activation in Geographic Atrophy

Role of interferon signaling in Alu RNA-induced AMD

Local administration of IL-18 from multiple sources does not suppress experimental CNV.

Subcutaneous IL-18 administration does not inhibit laser CNV in mice

Nucleoside reverse transcriptase inhibitors prevent iron-induced retinal pigment epithelium cell death

Nucleoside reverse transcriptase inhibitors are anti-inflammatory and inhibit poly I:C-induced retinal pigment epithelium degeneration

Nucleoside reverse transcriptase inhibitors attenuate amyloid-beta-induced retinal pigment epithelium degeneration

Nucleoside reverse transcriptase inhibitor (NRTI) protection against iron cytotoxicity

Intravenous immunoglobulin treatment inhibits choroidal and corneal neovascularization via FcyR1

Dual anti-angiogenic activity of Bevacizumab from its IgG1-Fc domain and VEGF neutralization

Generic, target-independent suppression of choroidal neovascularization by human IgG1 antibodies via Fc gamma receptor I

Enhanced Alu RNA stability due to iron-mediated DICER1 impairment causes NLRP3 inflammasome priming

Myd88 as a therapeutic target for choroidal neovascularization

IL18 is not therapeutic for neovascular age-related macular degeneration

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