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ARVO Annual Meeting Abstract July 2019

Effects of a multi-kinase inhibitor compared with mitomycin-C on conjunctival scarring in a canine filtration surgery model.

EMIKA Nemoto; Shota Kojima; Tetsuya Sugiyama; Denan Jin; Shinji Takai; Michiko Maeda; Ryohsuke Kohmoto; Mari Ueki; Hidehiro Oku; Tsunehiko Ikeda

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3751. doi:

ARVO Annual Meeting Abstract September 2016

Effects of gelatin hydrogel containing transforming growth factor-β antibody in a canine filtration surgery model

Michiko Miki; Shota Kojima; Tetsuya Sugiyama; Denan Jin; Shinji Takai; Ryohsuke Kohmoto; Mari Ueki; Tsunehiko Ikeda

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2933. doi:

Glaucoma April 2015

Effects of Gelatin Hydrogel Loading Mitomycin C on Conjunctival Scarring in a Canine Filtration Surgery Model

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Shota Kojima; Tetsuya Sugiyama; Shinji Takai; Denan Jin; Mari Ueki; Hidehiro Oku; Yasuhiko Tabata; Tsunehiko Ikeda
TAGS: blister, cicatrix, conjunctiva, dog, domestic, eye, filtering surgery, gelatin, glaucoma surgery, hydrogel, mitomycin
Invest. Ophthalmol. Vis. Sci.. 2015; 56(4):2601-2605. doi: https://doi.org/10.1167/iovs.15-16486

Multidisciplinary Ophthalmic Imaging December 2014

Laser Speckle and Hydrogen Gas Clearance Measurements of Optic Nerve Circulation in Albino and Pigmented Rabbits With or Without Optic Disc Atrophy

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Naoko Aizawa; Fumihiko Nitta; Hiroshi Kunikata; Tetsuya Sugiyama; Tsunehiko Ikeda; Makoto Araie; Toru Nakazawa
TAGS: albinism, endothelin-1, hydrogen, lasers, optic disk, oryctolagus cuniculus, drug clearance, optic atrophy, optic nerve
Invest. Ophthalmol. Vis. Sci.. 2014; 55(12):7991-7996. doi: https://doi.org/10.1167/iovs.14-15373

Physiology and Pharmacology March 2014

Changes in the Blood Flow of the Optic Nerve Head Induced by Different Concentrations of Epinephrine in Intravitreal Infusion During Vitreous Surgery

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Makoto Ubuka; Tetsuya Sugiyama; Yasutaka Onoda; Tomoaki Shiba; Yuichi Hori; Takatoshi Maeno
TAGS: epinephrine, infusion procedures, optic disk, vascular flow, vitreous surgery
Invest. Ophthalmol. Vis. Sci.. 2014; 55(3):1625-1629. doi: https://doi.org/10.1167/iovs.13-13801

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Physiology and Pharmacology June 2012

Involvement of Glial Cells in the Autoregulation of Optic Nerve Head Blood Flow in Rabbits

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Maho Shibata; Tetsuya Sugiyama; Takuji Kurimoto; Hidehiro Oku; Takashi Okuno; Takatoshi Kobayashi; Tsunehiko Ikeda
TAGS: homeostasis, intraocular pressure, neuroglia, optic disk, oryctolagus cuniculus, vascular flow, eye, intravitreal injections
Invest. Ophthalmol. Vis. Sci.. 2012; 53(7):3726-3732. doi: https://doi.org/10.1167/iovs.11-9316

Physiology and Pharmacology June 2012

Blocking Endothelin-B Receptors Rescues Retinal Ganglion Cells from Optic Nerve Injury through Suppression of Neuroinflammation

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Masahiro Tonari; Takuji Kurimoto; Taeko Horie; Tetsuya Sugiyama; Tsunehiko Ikeda; Hidehiro Oku
TAGS: cd68 antigen, human, endothelins, glial fibrillary acidic protein, optic nerve, optic nerve injuries, retinal ganglion cells, endothelin-1, tumor necrosis factors, nitric oxide synthase, passive smoking
Invest. Ophthalmol. Vis. Sci.. 2012; 53(7):3490-3500. doi: https://doi.org/10.1167/iovs.11-9415

Glaucoma September 2011

Effects of Gelatin Hydrogel Containing Chymase Inhibitor on Scarring in a Canine Filtration Surgery Model

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Shota Kojima; Tetsuya Sugiyama; Shinji Takai; Denan Jin; Maho Shibata; Hidehiro Oku; Yasuhiko Tabata; Tsunehiko Ikeda
TAGS: blister, cicatrix, dog, domestic, eye, filtering surgery, gelatin, hydrogel, intraocular pressure, adhesions, conjunctiva
Invest. Ophthalmol. Vis. Sci.. 2011; 52(10):7672-7680. doi: https://doi.org/10.1167/iovs.11-7573

Physiology and Pharmacology April 2011

Disruption of Gap Junctions May Be Involved in Impairment of Autoregulation in Optic Nerve Head Blood Flow of Diabetic Rabbits

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Maho Shibata; Hidehiro Oku; Tetsuya Sugiyama; Takatoshi Kobayashi; Mami Tsujimoto; Takashi Okuno; Tsunehiko Ikeda
TAGS: diabetes mellitus, gap junction protein, octanols, optic disk, oryctolagus cuniculus, vascular flow, homeostasis, impairment, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2011; 52(5):2153-2159. doi: https://doi.org/10.1167/iovs.10-6605

Physiology and Pharmacology January 2011

Effects of Fasudil, a Rho-Associated Protein Kinase Inhibitor, on Optic Nerve Head Blood Flow in Rabbits

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Tetsuya Sugiyama; Maho Shibata; Sumiko Kajiura; Takashi Okuno; Masahiro Tonari; Hidehiro Oku; Tsunehiko Ikeda
TAGS: optic disk, oryctolagus cuniculus, protein kinase inhibitor, vascular flow
Invest. Ophthalmol. Vis. Sci.. 2011; 52(1):64-69. doi: https://doi.org/10.1167/iovs.10-5265

Retinal Cell Biology June 2010

Involvement of P2X 7 Receptors in the Hypoxia-Induced Death of Rat Retinal Neurons

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Tetsuya Sugiyama; Hidehiro Oku; Maho Shibata; Masayuki Fukuhara; Hideyo Yoshida; Tsunehiko Ikeda
TAGS: hypoxia, neurons, antagonists
Invest. Ophthalmol. Vis. Sci.. 2010; 51(6):3236-3243. doi: https://doi.org/10.1167/iovs.09-4192

Physiology and Pharmacology May 2010

Effect of Hypoxia on Susceptibility of RGC-5 Cells to Nitric Oxide

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Takaki Sato; Hidehiro Oku; Kazuhiro Tsuruma; Kozo Katsumura; Masamitsu Shimazawa; Hideaki Hara; Tetsuya Sugiyama; Tsunehiko Ikeda
TAGS: glucose, hypoxia, sensory potential, snap-associated protein, human, nitric oxide, disease susceptibility, caspases, superoxides
Invest. Ophthalmol. Vis. Sci.. 2010; 51(5):2575-2586. doi: https://doi.org/10.1167/iovs.09-4303

Physiology and Pharmacology December 2005

Endothelin-1 Enhances Glutamate-Induced Retinal Cell Death, Possibly through ET A Receptors

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Takatoshi Kobayashi; Hidehiro Oku; Masayuki Fukuhara; Shota Kojima; Asako Komori; Masaki Ichikawa; Kozo Katsumura; Masato Kobayashi; Tetsuya Sugiyama; Tsunehiko Ikeda
TAGS: endothelin-1, glutamate, glutamates, cell death, neurons
Invest. Ophthalmol. Vis. Sci.. 2005; 46(12):4684-4690. doi: https://doi.org/10.1167/iovs.05-0785

Retinal Cell Biology March 2004

Enhancement of P2X 7 -Induced Pore Formation and Apoptosis: An Early Effect of Diabetes on the Retinal Microvasculature

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Tetsuya Sugiyama; Masato Kobayashi; Hajime Kawamura; Qing Li; Donald G. Puro
TAGS: apoptosis, diabetes mellitus, microvessels, retinal vasculature, cell death, diabetes mellitus, type 2, agonists
Invest. Ophthalmol. Vis. Sci.. 2004; 45(3):1026-1032. doi: https://doi.org/10.1167/iovs.03-1062

Physiology and Pharmacology March 2002

Evidence that Nitric Oxide Is Involved in Autoregulation in Optic Nerve Head of Rabbits

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Takashi Okuno; Hidehiro Oku; Tetsuya Sugiyama; Ying Yang; Tsunehiko Ikeda
TAGS: evoked potentials, visual, homeostasis, intraocular pressure, nitric oxide, optic disk, oryctolagus cuniculus, vascular flow, eye
Invest. Ophthalmol. Vis. Sci.. 2002; 43(3):784-789. doi:

Glaucoma November 2001

Optic Cup Enlargement Followed by Reduced Optic Nerve Head Circulation after Optic Nerve Stimulation

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Tetsuya Sugiyama; Hideaki Hara; Hidehiro Oku; Shunji Nakatsuji; Takashi Okuno; Masaaki Sasaoka; Takashi Ota; Tsunehiko Ikeda
TAGS: hypertrophy, optic cup, optic disk, optic nerve, electric stimulation, vascular flow, evoked potentials, visual, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2001; 42(12):2843-2848. doi:

Physiology and Pharmacology April 2000

Effect of Nitric Oxide Synthase Inhibitor on Optic Nerve Head Circulation in Conscious Rabbits

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Tetsuya Sugiyama; Hidehiro Oku; Shoichiro Ikari; Tsunehiko Ikeda
TAGS: acetylcholine, nitric oxide synthase inhibitors, optic disk, oryctolagus cuniculus, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2000; 41(5):1149-1152. doi:

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Effects of a multi-kinase inhibitor compared with mitomycin-C on conjunctival scarring in a canine filtration surgery model.

Effects of gelatin hydrogel containing transforming growth factor-β antibody in a canine filtration surgery model

Effects of Gelatin Hydrogel Loading Mitomycin C on Conjunctival Scarring in a Canine Filtration Surgery Model

Laser Speckle and Hydrogen Gas Clearance Measurements of Optic Nerve Circulation in Albino and Pigmented Rabbits With or Without Optic Disc Atrophy

Changes in the Blood Flow of the Optic Nerve Head Induced by Different Concentrations of Epinephrine in Intravitreal Infusion During Vitreous Surgery

Involvement of Glial Cells in the Autoregulation of Optic Nerve Head Blood Flow in Rabbits

Blocking Endothelin-B Receptors Rescues Retinal Ganglion Cells from Optic Nerve Injury through Suppression of Neuroinflammation

Effects of Gelatin Hydrogel Containing Chymase Inhibitor on Scarring in a Canine Filtration Surgery Model

Disruption of Gap Junctions May Be Involved in Impairment of Autoregulation in Optic Nerve Head Blood Flow of Diabetic Rabbits

Effects of Fasudil, a Rho-Associated Protein Kinase Inhibitor, on Optic Nerve Head Blood Flow in Rabbits

Involvement of P2X 7 Receptors in the Hypoxia-Induced Death of Rat Retinal Neurons

Effect of Hypoxia on Susceptibility of RGC-5 Cells to Nitric Oxide

Endothelin-1 Enhances Glutamate-Induced Retinal Cell Death, Possibly through ET A Receptors

Enhancement of P2X 7 -Induced Pore Formation and Apoptosis: An Early Effect of Diabetes on the Retinal Microvasculature

Evidence that Nitric Oxide Is Involved in Autoregulation in Optic Nerve Head of Rabbits

Optic Cup Enlargement Followed by Reduced Optic Nerve Head Circulation after Optic Nerve Stimulation

Effect of Nitric Oxide Synthase Inhibitor on Optic Nerve Head Circulation in Conscious Rabbits

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