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ARVO Annual Meeting Abstract June 2022

SPVN06, a novel mutation-independent AAV-based gene therapy, dramatically reduces vision loss in the rd10 mouse model of rod-cone dystrophy

Florence Lorget; Melanie Marie; Hanen Khabou; Cardillia Simon; Didier Nuno; Phillip Vanlandingham; Alain Quiambao; Rafal Farjo; Deniz Dalkara; Jose Alain Sahel; Thierry D Leveillard

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):56 – A0029.

ARVO Annual Meeting Abstract June 2022

The potential role of rod-derived cone viability factor long (RdCVFL) in treating retinitis pigmentosa as a thioredoxin-like protein

Xiaoyuan Ren; Arne Holmgren; Elias S.J. Arnér; Thierry D Leveillard

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3900 – A0102.

ARVO Annual Meeting Abstract June 2022

Metabolic defects and circadian clock alterations in Prpf31 -mutant mice.

Elora Vanoni; Abdallah Hamieh; Géraldine Puel; Thierry D Leveillard; Emeline F Nandrot

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3819.

ARVO Annual Meeting Abstract June 2022

Retrospective natural history of retinitis pigmentosa due to RHO , PDE6A, or PDE6B mutations: the PHENOROD1 study

Alice Le Meur; Daniel C Chung; Léa Thiebault; Pierre-Axel Vinot; Berthe Pom; Thierry D Leveillard; Saddek Mohand-Said; Jose Alain Sahel; Isabelle S Audo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):4497 – F0284.

ARVO Annual Meeting Abstract June 2021

A 1-Month Toxicology and Biodistribution NHP Pilot Study Evaluating a Single Subretinal Bilateral Administration of SPVN06 - A Novel AAV-Based Gene Therapy for the Treatment of Rod-Cone Dystrophies Agnostic of the Causative Mutation

Melanie MARIE; Myriam Marussig; Pierre-Axel VINOT; Thomas VIHTELIC; Ryan F. Boyd; Lauren KNUPP; Jennifer LAMOUREUX; Thierry D Leveillard; Jose Alain Sahel; Florence LORGET

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):194.

ARVO Annual Meeting Abstract June 2021

SPVN06, a Novel Mutation-Independent AAV-based Gene Therapy, Protects Cone Degeneration in a Pig Model of Retinitis Pigmentosa

Jennifer Noel; archana jalligampala; Myriam Marussig; Pierre-Axel VINOT; Melanie MARIE; Melanie Butler; Florence LORGET; Stephane Boissel; Thierry D Leveillard; Jose Alain Sahel; Maureen A McCall

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1189.

ARVO Annual Meeting Abstract June 2021

A mouse model with specific inactivation of the thioredoxin-like protein encoded by the nucleoredoxin-like1 reveals its role in the prevention of secondary cone death in retinitis pigmentosa

Emmanuelle Clerin; Emanuele Procopio; Stephanie M Hauck; Jose-Alain Sahel; Erika Tatiana Camacho; Thierry D Leveillard

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2256.

ARVO Annual Meeting Abstract June 2021

Correlations between progression markers in rod-cone dystrophy due to mutations in RHO, PDE6A, or PDE6B .

Daniel C Chung; Pierre-Axel VINOT; Myriam Marussig; Léa Thiébault; Berthe Pom; Camille Andrieu; Christina Zeitz; Thierry D Leveillard; Stephane Boissel; Saddek Mohand-Said; Isabelle Audo; Jose-Alain Sahel

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3539.

ARVO Annual Meeting Abstract June 2020

Natural history of retinitis pigmentosa due to RHO , PDE6A OR PDE6B mutations

Myriam Marussig; Léa Thiebault; Pierre-Axel Vinot; Berthe Pom; Camille Andrieu; Christina Zeitz; Thierry D Leveillard; Florence Allouche; Saddek Mohand-Said; Isabelle S Audo; Jose Alain Sahel

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3035.

ARVO Annual Meeting Abstract July 2019

Modeling Cone Aerobic Glycolysis

Erika Tatiana Camacho; Danielle Brager; Ghizlane Elachouri; Tatyana Korneyeva; Geraldine Millet-Puel; Jose Alain Sahel; Thierry D Leveillard

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):567.

ARVO Annual Meeting Abstract July 2019

Mathematically Assessing the Contributions of Key Processes in Cone Aerobic Glycolysis

Danielle Brager; Erika Tatiana Camacho; Ghizlane Elachouri; Tatyana Korneyeva; Geraldine Millet-Puel; Jose Alain Sahel; Thierry D Leveillard

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):569.

ARVO Annual Meeting Abstract July 2019

Mutations in WDR34 is a rare cause of non-syndromic autosomal recessive rod-cone dystrophy

Isabelle S Audo; Maria Solaguren-Beascoa; Kinga Bujakowska; Cécile Méjécase; Lisa Emmengger; Saddek Mohand-Said; Thierry D Leveillard; Eric A Pierce; Helene Dollfus; Jose Alain Sahel; Shomi Bhattacharya; Christina Zeitz

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):381.

ARVO Annual Meeting Abstract July 2019

A CCDC51 frameshift variant as a candidate gene defect for autosomal recessive rod-cone dystrophy

Christina Zeitz; Cécile Méjécase; Saddek Mohand-Saïd; Lisa Emmengger; Audrey Schalk; Marion Neuillé; Elise Orhan; Frédéric Blond; Camille Prévot; Sandra Sandra Chantot-Bastaraud; Thierry D Leveillard; Jose Alain Sahel; Isabelle S Audo

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):415.

ARVO Annual Meeting Abstract July 2019

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 governs the metabolic flux between rod and cone photoreceptors

Géraldine Millet Puel; Marie Cordonnier; Alexandra Saint-charles; Emmanuelle Clerin; Frédéric Blond; Seiki Achiedo; Najate Ait-Ali; Orna Corchia; Laurence Klipfel; Ying Yang; Raju V S Rajala; Erika Tatiana Camacho; Thierry D Leveillard

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6404.

ARVO Annual Meeting Abstract July 2019

Characterization of mitochondrial respiratory chain dysfunction, oxidative attacks and lipids accumulation in Prpf31 -mutant mice

Abdallah Hamieh; Geraldine Millet-Puel; Thierry D Leveillard; Emeline F Nandrot

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1678.

ARVO Annual Meeting Abstract July 2019

HTRA1 inactivates Thrombospondin-1 mediated subretinal immune-suppression

Florian Sennlaub; Fanny Beguier; Michael Housset; Sebastien Augustin; Christophe Roubeix; Thibaud Mathis; Chiara M Eandi; Sara Touhami; Jean-Baptiste Conart; Yvrick Zagar; Mustapha Benchaboune; Jean-François Girmens; Thierry D Leveillard; Jose Alain Sahel; Przemyslaw Mike Sapieha; Xavier Guilonneau

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1723.

ARVO Annual Meeting Abstract July 2019

NCL is implicated in the NXNL1 gene splicing and leads to RdCVF expression in retinoblastoma cell lines

Najate Ait-Ali; Frédéric Blond; Sunhye Lee; Sijia Wang; David Cobrinik; Thierry D Leveillard

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4940.

ARVO Annual Meeting Abstract July 2018

Photoreceptor metabolic and redox signaling in health & disease

Thierry D. Leveillard

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):5999.

ARVO Annual Meeting Abstract July 2018

Implication of various oxidative stress pathways in the aging phenotype of Prpf31 -mutant mice

Abdallah Hamieh; Nawel Hadjout; Géraldine Millet-puel; Thierry D. Leveillard; Emeline F Nandrot

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6074.

ARVO Annual Meeting Abstract July 2018

Impact of lactate transport deficit in age-related macular degeneration

Laurence Klipfel; Mélanie Var; Marie Cordonnier; Saddek Mohand-Saïd; Olivier Goureau; Thierry D. Leveillard

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):793.

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SPVN06, a novel mutation-independent AAV-based gene therapy, dramatically reduces vision loss in the rd10 mouse model of rod-cone dystrophy

The potential role of rod-derived cone viability factor long (RdCVFL) in treating retinitis pigmentosa as a thioredoxin-like protein

Metabolic defects and circadian clock alterations in Prpf31 -mutant mice.

Retrospective natural history of retinitis pigmentosa due to RHO , PDE6A, or PDE6B mutations: the PHENOROD1 study

A 1-Month Toxicology and Biodistribution NHP Pilot Study Evaluating a Single Subretinal Bilateral Administration of SPVN06 - A Novel AAV-Based Gene Therapy for the Treatment of Rod-Cone Dystrophies Agnostic of the Causative Mutation

SPVN06, a Novel Mutation-Independent AAV-based Gene Therapy, Protects Cone Degeneration in a Pig Model of Retinitis Pigmentosa

A mouse model with specific inactivation of the thioredoxin-like protein encoded by the nucleoredoxin-like1 reveals its role in the prevention of secondary cone death in retinitis pigmentosa

Correlations between progression markers in rod-cone dystrophy due to mutations in RHO, PDE6A, or PDE6B .

Natural history of retinitis pigmentosa due to RHO , PDE6A OR PDE6B mutations

Modeling Cone Aerobic Glycolysis

Mathematically Assessing the Contributions of Key Processes in Cone Aerobic Glycolysis

Mutations in WDR34 is a rare cause of non-syndromic autosomal recessive rod-cone dystrophy

A CCDC51 frameshift variant as a candidate gene defect for autosomal recessive rod-cone dystrophy

6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 governs the metabolic flux between rod and cone photoreceptors

Characterization of mitochondrial respiratory chain dysfunction, oxidative attacks and lipids accumulation in Prpf31 -mutant mice

HTRA1 inactivates Thrombospondin-1 mediated subretinal immune-suppression

NCL is implicated in the NXNL1 gene splicing and leads to RdCVF expression in retinoblastoma cell lines

Photoreceptor metabolic and redox signaling in health & disease

Implication of various oxidative stress pathways in the aging phenotype of Prpf31 -mutant mice

Impact of lactate transport deficit in age-related macular degeneration

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