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ARVO Annual Meeting Abstract June 2024

Actin remodeling governs neutrophil activation: Implications for retinal capillary degeneration in diabetic retinopathy.

Mahesh Agarwal; Sathishkumar Chandrakumar; Irene Santiago Tierno; Emma M Lessieur; Timothy S Kern; Kaustabh Ghosh

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):881.

ARVO Annual Meeting Abstract June 2024

Role of Lysyl Oxidase in the Mechanoregulation of Retinal Vascular Inflammation and Degeneration in diabetes

Kaustabh Ghosh; Sathishkumar Chandrakumar; Irene Santiago Tierno; Mahesh Agarwal; Emma S Lessieur; Timothy S Kern

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):879.

ARVO Annual Meeting Abstract June 2024

Activation of mechanosensitive TRPV4 channel inhibits retinal vascular inflammation in diabetes

Sathishkumar Chandrakumar; Xiao Yang; Mahesh Agarwal; Irene Santiago Tierno; Timothy S Kern; Kaustabh Ghosh

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):830.

ARVO Annual Meeting Abstract June 2023

Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition

Jennings Luu; Aicha Saadane; Henri Leinonen; Elliot Choi; Fangyuan Gao; Dominik Lewandowski; Maximilian Halabi; Arum Wu; Zhiqian Dong; Grazyna Palczewska; Robert Mullins; Neal S Peachey; Philip David Kiser; Marcin Tabaka; Timothy S Kern; Krzysztof Palczewski

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2417.

ARVO Annual Meeting Abstract June 2023

Lysyl oxidase promotes neutrophil cytotoxicity towards retinal endothelial cells in diabetes

Mahesh Agarwal; Sathishkumar Chandrakumar; Irene Santiago Tierno; Adrita Chandra; Emma M Lessieur; Timothy S Kern; Kaustabh Ghosh

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):499.

ARVO Annual Meeting Abstract June 2023

Neutrophil-derived extracellular vesicles from diabetic mice promote retinal endothelial cell cytotoxicity

Emma M Lessieur; Fangyuan Gao; Yunpeng Du; Jirote Jiyacharoen; Jianying Kiser; Timothy S Kern

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1844.

ARVO Annual Meeting Abstract June 2022

Deficiency in classical monocytes prevents superoxide, inflammation and retinal vascular lesions in diabetic mice

Aicha Saadane; Alexander A Veenstra; Martine Minns; Yunpeng Du; Emma Lessieur; Timothy S Kern

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):949 – A0418.

ARVO Annual Meeting Abstract June 2022

Retinal vascular stiffening contributes to leukocyte-mediated endothelial apoptosis in diabetes

Sathishkumar Chandrakumar; Irene Santiago Tierno; Mahesh Agarwal; Emma Lessieur; Haitao Liu; Timothy S Kern; Kaustabh Ghosh

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3595 – A0050.

ARVO Annual Meeting Abstract June 2022

Partial deletion of Lrat inhibits prodromal characteristics of diabetic retinopathy

Emma M Lessieur; Yunpeng Du; Aicha Saadane; Haitao Liu; Jianying Kiser; Timothy S Kern

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3590 – A0045.

Retinal Cell Biology October 2021

Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy

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Emma M. Lessieur; Haitao Liu; Aicha Saadane; Yunpeng Du; Jie Tang; Jianying Kiser; Timothy S. Kern
TAGS: cytotoxicity, diabetes mellitus, endopeptidases, endothelial cells, leukocytes, mice, neutrophils, peptide hydrolases, superoxides, pathogenesis
Invest. Ophthalmol. Vis. Sci.. 2021; 62(13):7. https://doi.org/10.1167/iovs.62.13.7

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Lysyl oxidase inhibition prevents inflammation-dependent retinal vascular atrophy in early diabetic retinopathy

Irene Santiago Tierno; Sathishkumar Chandrakumar; Haitao Liu; Emma M Lessieur; yunpeng Du; Timothy S Kern; Kaustabh Ghosh

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1880.

Retina June 2020

All- trans -Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion

PDF

Alyssa Dreffs; Cheng-Mao Lin; Xuwen Liu; Sumathi Shanmugam; Steven F. Abcouwer; Timothy S. Kern; David A. Antonetti
TAGS: endothelial cells, ischemia, mice, permeability, physiologic reperfusion, reperfusion therapy, retinaldehyde, vascular permeability, wounds and injuries, retina
Invest. Ophthalmol. Vis. Sci.. 2020; 61(6):8. https://doi.org/10.1167/iovs.61.6.8

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

Identification of Photoreceptor Protein, Retinol Binding Protein 3 (RBP3), as a Protective Factor for Diabetic Retinopathy

Ward Fickweiler; Hisashi Yokomizo; Kyoungmin Park; Allen C Clermont; Yasutaka Maeda; Samantha M Paniagua; I-Hsien Wu; David Pober; Vanessa Bahnam; Robert L Avery; Timothy S Kern; Edward Feener; Lloyd P Aiello; Jennifer K Sun; George Liang King

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6427.

ARVO Annual Meeting Abstract July 2019

Diabetic rats with endogenously high levels of retinal dopamine do not display retinal vascular hallmarks of diabetic retinopathy

Rachael S Allen; Cara Motz; Andrew Feola; Kyle Chesler; Susov Dhakal; Peter M Thule; P. Michael Iuvone; Timothy S Kern; Machelle T Pardue

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6439.

Retina April 2019

Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy

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Haitao Liu; Jie Tang; Yunpeng Du; Aicha Saadane; Ivy Samuels; Alex Veenstra; Jianying Z. Kiser; Krzysztof Palczewski; Timothy S. Kern
TAGS: diabetes mellitus, diabetes mellitus, type 2, diabetic retinopathy, mice, phototransduction, photoreceptors, retina, vision, rod photoreceptors, tissue degeneration
Invest. Ophthalmol. Vis. Sci.. 2019; 60(5):1538-1546. https://doi.org/10.1167/iovs.18-26433

ARVO Annual Meeting Abstract July 2018

Assessment of macular thickening in spontaneously diabetic rhesus monkeys

Timothy S Kern; Jie Tang; lingzhen Pan; Zhiqiang Li; Yubo Shen; Wen Zeng; Li Gong

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3581.

ARVO Annual Meeting Abstract July 2018

Trapping all trans retinal is protective to vascular damage in ischemia reperfusion

David A Antonetti; Chengmao Lin; Timothy S Kern; Steven F Abcouwer

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3582.

Retinal Cell Biology June 2018

D- cis -Diltiazem Can Produce Oxidative Stress in Healthy Depolarized Rods In Vivo

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Bruce A. Berkowitz; Robert H. Podolsky; Benjamin Farrell; Hojun Lee; Christopher Trepanier; Ali M. Berri; Kristin Dernay; Emma Graffice; Fatema Shafie-Khorassani; Timothy S. Kern; Robin Roberts
TAGS: diltiazem, magnetic resonance imaging, mice, oxidative stress, rod photoreceptors, retina
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):2999-3010. https://doi.org/10.1167/iovs.18-23829

Retina April 2018

The Absence of Indoleamine 2,3-Dioxygenase Inhibits Retinal Capillary Degeneration in Diabetic Mice

PDF

Rooban B. Nahomi; Sruthi Sampathkumar; Angela M. Myers; Lynda Elghazi; Dawn G. Smith; Jie Tang; C. Allen Lee; Timothy S. Kern; Ram H. Nagaraj; Patrice E. Fort
TAGS: blood capillaries, diabetes mellitus, mice, tissue degeneration, tryptophan oxygenase, diabetic retinopathy
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):2042-2053. https://doi.org/10.1167/iovs.17-22702

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Development of mouse anti-mouse CD6 monoclonal antibodies (mAbs) for treating experimental autoimmune uveitis in mice

Lingjun Zhang; Wen Qiu; Brent A Bell; Li Yan; Timothy S Kern; Rachel R Caspi; Feng Lin

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1235.

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Actin remodeling governs neutrophil activation: Implications for retinal capillary degeneration in diabetic retinopathy.

Role of Lysyl Oxidase in the Mechanoregulation of Retinal Vascular Inflammation and Degeneration in diabetes

Activation of mechanosensitive TRPV4 channel inhibits retinal vascular inflammation in diabetes

Stress resilience-enhancing drugs preserve tissue structure and function in degenerating retina via phosphodiesterase inhibition

Lysyl oxidase promotes neutrophil cytotoxicity towards retinal endothelial cells in diabetes

Neutrophil-derived extracellular vesicles from diabetic mice promote retinal endothelial cell cytotoxicity

Deficiency in classical monocytes prevents superoxide, inflammation and retinal vascular lesions in diabetic mice

Retinal vascular stiffening contributes to leukocyte-mediated endothelial apoptosis in diabetes

Partial deletion of Lrat inhibits prodromal characteristics of diabetic retinopathy

Neutrophil-Derived Proteases Contribute to the Pathogenesis of Early Diabetic Retinopathy

Lysyl oxidase inhibition prevents inflammation-dependent retinal vascular atrophy in early diabetic retinopathy

All- trans -Retinaldehyde Contributes to Retinal Vascular Permeability in Ischemia Reperfusion

Identification of Photoreceptor Protein, Retinol Binding Protein 3 (RBP3), as a Protective Factor for Diabetic Retinopathy

Diabetic rats with endogenously high levels of retinal dopamine do not display retinal vascular hallmarks of diabetic retinopathy

Transducin1, Phototransduction and the Development of Early Diabetic Retinopathy

Assessment of macular thickening in spontaneously diabetic rhesus monkeys

Trapping all trans retinal is protective to vascular damage in ischemia reperfusion

D- cis -Diltiazem Can Produce Oxidative Stress in Healthy Depolarized Rods In Vivo

The Absence of Indoleamine 2,3-Dioxygenase Inhibits Retinal Capillary Degeneration in Diabetic Mice

Development of mouse anti-mouse CD6 monoclonal antibodies (mAbs) for treating experimental autoimmune uveitis in mice

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