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Glaucoma June 2018

YAP/TAZ Are Essential for TGF-β2–Mediated Conjunctival Fibrosis

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Akiko Futakuchi; Toshihiro Inoue; Fan-Yan Wei; Miyuki Inoue-Mochita; Tomokazu Fujimoto; Kazuhito Tomizawa; Hidenobu Tanihara
TAGS: conjunctiva, fibroblasts, fibrosis, proteins, signal transduction, verteporfin
Invest. Ophthalmol. Vis. Sci.. 2018; 59(7):3069-3078. doi: https://doi.org/10.1167/iovs.18-24258

Includes: Supplemental Content

Glaucoma April 2018

Interaction Between Pilocarpine and Ripasudil on Intraocular Pressure, Pupil Diameter, and the Aqueous-Outflow Pathway

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Reiko Yamagishi-Kimura; Megumi Honjo; Takashi Komizo; Takashi Ono; Akiko Yagi; Jinhee Lee; Kazunori Miyata; Tomokazu Fujimoto; Toshihiro Inoue; Hidenobu Tanihara; Junko Nishida; Takatoshi Uchida; Yuka Araki; Makoto Aihara
TAGS: pilocarpine, intraocular pressure, pupil
Invest. Ophthalmol. Vis. Sci.. 2018; 59(5):1844-1854. doi: https://doi.org/10.1167/iovs.18-23900

Glaucoma April 2017

Molecular Mechanisms Underlying the Filtration Bleb-Maintaining Effects of Suberoylanilide Hydroxamic Acid (SAHA)

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Akiko Futakuchi; Toshihiro Inoue; Tomokazu Fujimoto; Utako Kuroda; Miyuki Inoue-Mochita; Eri Takahashi; Saori Ohira; Hidenobu Tanihara
TAGS: vorinostat, blister, filtration
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2421-2429. doi: https://doi.org/10.1167/iovs.16-21403

Glaucoma November 2016

Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity

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Takayuki Tsutsumi; Keiichiro Iwao; Hideki Hayashi; Tomoko Kirihara; Takahiro Kawaji; Toshihiro Inoue; Shinjiro Hino; Mitsuyoshi Nakao; Hidenobu Tanihara
TAGS: neuroprotective effect, tranylcypromine, mitogen-activated protein kinase p38, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2016; 57(14):6461-6473. doi: https://doi.org/10.1167/iovs.16-19494

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Effects of ripasudil (K-115), a Rho kinase inhibitor, on the activation of human conjunctival fibroblasts

Akiko Futakuchi; Toshihiro Inoue; Tomokazu Fujimoto; Miyuki Mochita Inoue; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2929. doi:

ARVO Annual Meeting Abstract September 2016

Specific clinical features of intraocular pressure-lowering effect in ripasudil (K-115): insights from 52-week phase 3 study

Hidenobu Tanihara; Toshihiro Inoue; Tetsuya Yamamoto; Yasuaki Kuwayama; Haruki Abe; Atsuki Fukushima; Hideki Suganami; Makoto Araie

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3033. doi:

ARVO Annual Meeting Abstract September 2016

Vascular Endothelial Growth Factor-A Increases Aqueous humor Outflow Fcility

Tomokazu Fujimoto; Toshihiro Inoue; KEI MAKI; Miyuki Mochita Inoue; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4689. doi:

ARVO Annual Meeting Abstract September 2016

Effects of interleukin-6 signaling activity on fibrogenic activity of human trabecular meshwork cells

Toshihiro Inoue; Miyuki Mochita Inoue; Tomokazu Fujimoto; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):4693. doi:

ARVO Annual Meeting Abstract September 2016

Four-dimensional imaging revealed influences of monocyte chemoattractant protein-1 on immune cell dynamics in the subconjunctival tissue.

Sachi Kojima; Toshihiro Inoue; Tomokazu Fujimoto; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5148. doi:

Multidisciplinary Ophthalmic Imaging March 2016

Visualization of Intravital Immune Cell Dynamics After Conjunctival Surgery Using Multiphoton Microscopy

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Sachi Kojima; Toshihiro Inoue; Junichi Kikuta; Masayuki Furuya; Ayaka Koga; Tomokazu Fujimoto; Mayumi Ueta; Shigeru Kinoshita; Masaru Ishii; Hidenobu, Tanihara
TAGS: conjunctiva, diagnostic imaging, surgical procedures, operative, wounds and injuries, mice, body tissue
Invest. Ophthalmol. Vis. Sci.. 2016; 57(3):1207-1212. doi: https://doi.org/10.1167/iovs.15-18507

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2015

Totally organized mitochondrial axonal transport patterns in retinal ganglion cells of old mice in vivo

Yuji Takihara; Masaru Inatani; Toshihiro Inoue; Keiichiro Iwao; Yoshihiro Takamura; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3661. doi:

ARVO Annual Meeting Abstract June 2015

Histone deacetylase inhibitor attenuates TGF-β2 induced human conjunctival fibroblast activation

Akiko Futakuchi; Toshihiro Inoue; Tomokazu Fujimoto; Utako Kuroda; Miyuki Mochita Inoue; Eri Takahashi; Kohei Shobayashi; Saori Ohira; Sachi Kojima; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2678. doi:

ARVO Annual Meeting Abstract June 2015

The Effect of VEGF-A on Trabecular Meshwork and Schlemm’s Canal Endothelial Cells Permeability

Tomokazu Fujimoto; Toshihiro Inoue; Kei Maki; Sachi Kojima; Miyuki Inoue-Mochita; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2008. doi:

Glaucoma June 2015

Simultaneous Increase in Multiple Proinflammatory Cytokines in the Aqueous Humor in Neovascular Glaucoma With and Without Intravitreal Bevacizumab Injection

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Saori Ohira; Toshihiro Inoue; Kohei Shobayashi; Keiichiro Iwao; Mikiko Fukushima; Hidenobu Tanihara
TAGS: aqueous humor, bevacizumab, cytokine, glaucoma, neovascular, vascular endothelial growth factor a, interleukin-8
Invest. Ophthalmol. Vis. Sci.. 2015; 56(6):3541-3548. doi: https://doi.org/10.1167/iovs.14-15918

ARVO Annual Meeting Abstract April 2014

Age-related changes in mitochondrial axonal transport in the mammalian CNS in vivo

Yuji Takihara; Masaru Inatani; Toshihiro Inoue; Keiichiro Iwao; Yoshihiro Takamura; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2408. doi:

ARVO Annual Meeting Abstract April 2014

Live cell imaging of F-actin in dexamethasone treated trabecular meshwork cells

Tomokazu Fujimoto; Toshihiro Inoue; Miyuki Mochita Inoue; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5679. doi:

ARVO Annual Meeting Abstract April 2014

Effects of p38 inhibitor on TGF-β2 signal in trabecular meshwork cells

Miyuki Mochita Inoue; Toshihiro Inoue; Tomokazu Fujimoto; Nanako Awai-Kasaoka; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5691. doi:

ARVO Annual Meeting Abstract April 2014

Investigation of Multiple Proinflammatory Cytokines in the Aqueous Humor in Eyes with Neovascular Glaucoma

Saori Ohira; Toshihiro Inoue; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):5698. doi:

ARVO Annual Meeting Abstract April 2014

Prospective investigation of filtering bleb by three-dimensional anterior-segment optical coherence tomography

Toshihiro Inoue; Sachi Kojima; Ayako Fukushima; Nakashima Kei-Ichi; Hidenobu Tanihara

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):944. doi:

Glaucoma August 2013

Elevated Levels of Multiple Biomarkers of Alzheimer's Disease in the Aqueous Humor of Eyes With Open-Angle Glaucoma

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Toshihiro Inoue; Takahiro Kawaji; Hidenobu Tanihara
TAGS: alzheimer's disease, aqueous humor, biological markers, eye, open-angle glaucoma, proteins, apolipoprotein e, apolipoprotein a-i, complement factor h, glaucoma
Invest. Ophthalmol. Vis. Sci.. 2013; 54(8):5353-5358. doi: https://doi.org/10.1167/iovs.13-12245

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YAP/TAZ Are Essential for TGF-β2–Mediated Conjunctival Fibrosis

Interaction Between Pilocarpine and Ripasudil on Intraocular Pressure, Pupil Diameter, and the Aqueous-Outflow Pathway

Molecular Mechanisms Underlying the Filtration Bleb-Maintaining Effects of Suberoylanilide Hydroxamic Acid (SAHA)

Potential Neuroprotective Effects of an LSD1 Inhibitor in Retinal Ganglion Cells via p38 MAPK Activity

Effects of ripasudil (K-115), a Rho kinase inhibitor, on the activation of human conjunctival fibroblasts

Specific clinical features of intraocular pressure-lowering effect in ripasudil (K-115): insights from 52-week phase 3 study

Vascular Endothelial Growth Factor-A Increases Aqueous humor Outflow Fcility

Effects of interleukin-6 signaling activity on fibrogenic activity of human trabecular meshwork cells

Four-dimensional imaging revealed influences of monocyte chemoattractant protein-1 on immune cell dynamics in the subconjunctival tissue.

Visualization of Intravital Immune Cell Dynamics After Conjunctival Surgery Using Multiphoton Microscopy

Totally organized mitochondrial axonal transport patterns in retinal ganglion cells of old mice in vivo

Histone deacetylase inhibitor attenuates TGF-β2 induced human conjunctival fibroblast activation

The Effect of VEGF-A on Trabecular Meshwork and Schlemm’s Canal Endothelial Cells Permeability

Simultaneous Increase in Multiple Proinflammatory Cytokines in the Aqueous Humor in Neovascular Glaucoma With and Without Intravitreal Bevacizumab Injection

Age-related changes in mitochondrial axonal transport in the mammalian CNS in vivo

Live cell imaging of F-actin in dexamethasone treated trabecular meshwork cells

Effects of p38 inhibitor on TGF-β2 signal in trabecular meshwork cells

Investigation of Multiple Proinflammatory Cytokines in the Aqueous Humor in Eyes with Neovascular Glaucoma

Prospective investigation of filtering bleb by three-dimensional anterior-segment optical coherence tomography

Elevated Levels of Multiple Biomarkers of Alzheimer's Disease in the Aqueous Humor of Eyes With Open-Angle Glaucoma

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