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Immunology and Microbiology June 2025

Adrenomedullin-RAMP2 System Modulates Inflammation and Tissue Repair in Experimental Autoimmune Uveitis Via T-Cell and M2 Macrophage Regulation

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Yorishige Matsuda; Megumu Tanaka; Yunlu Zhao; Shinji Kakihara; Ken Hoshiyama; Takayuki Sakurai; Akiko Kamiyoshi; Yuka Ichikawa-Shindo; Hisaka Kawate; Yan Zhang; Qianqian Guo; Peixuan Li; Jiake Li; Jun Duan; Marina Hayashi; Hideki Sanjo; Toshinori Murata; Takayuki Shindo
TAGS: adrenomedullin, autoimmunity, inflammation, macrophages, mice, t-lymphocytes, uveitis, wound healing, regulation, cytokine
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):12. https://doi.org/10.1167/iovs.66.6.12

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Optical coherence tomography angiography-based artificial intelligence-inferred fluorescein angiography for the detection of microaneurysms in patients with diabetic retinopathy

Takao Hirano; Toshinori Murata; Hideaki Mizobe; Shuhei Toba

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4855.

ARVO Annual Meeting Abstract June 2024

Pathophysiological roles of adrenomedullin in experimental autoimmune uveitis

Yorishige Matsuda; Shinji Kakihara; Kazutaka Hirabayashi; Akira Imai; Yasuhiro Iesato; Takayuki Sakurai; Akiko Kamiyoshi; Yuka Ichikawa-Shindo; Megumu Tanaka; Hisaka Kawate; Yunlu Zhao; Toshinori Murata; Takayuki Shindo

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2994.

ARVO Imaging in the Eye Conference Abstract June 2023

Novel artificial intelligence-assisted optical coherence tomography-angiography delineation of retinal vessels and leakage by deep learning with fluorescein angiography video training data

Toshinori Murata; Takao Hirano; Hideaki Mizobe; Shuhei Toba

Invest. Ophthalmol. Vis. Sci.. 2023; 64(9):PP0013.

ARVO Annual Meeting Abstract June 2023

Retinal volume assessment using wide-field swept-source optical coherence tomography in eyes without retinal disease

Yoshiaki Chiku; Takao Hirano; Shun Ito; Yoshiaki Takahashi; Ken Hoshiyama; Yasuhiro Iesato; Toshinori Murata

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3700.

ARVO Annual Meeting Abstract June 2023

Investigation of the therapeutic effect of adrenomedullin on experimental autoimmune uveitis

Yorishige Matsuda; Shinji Kakihara; Kazutaka Hirabayashi; Akira Imai; Yasuhiro Iesato; Takayuki Sakurai; Akiko Kamiyoshi; Yuka Ichikawa-Shindo; Megumu Tanaka; Hisaka Kawate; Zhao Yunlu; Toshinori Murata; Takayuki Shindo

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3543.

ARVO Annual Meeting Abstract June 2022

Transcriptome analysis of the pathophysiological significance of adrenomedullin 2 in the mouse choroidal neovascularization model

Shinji Kakihara; Takayuki Sakurai; Akiko Kamiyoshi; Megumu Tanaka; Hisaka Kawate; Yuka Ichikawa-Shindo; Yunlu Zhao; Yorishige Matsuda; Kazutaka Hirabayashi; Akira Imai; Yasuhiro Iesato; Toshinori Murata; Takayuki Shindo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3875 – A0077.

ARVO Annual Meeting Abstract June 2022

Investigation of the therapeutic effect of adrenomedullin on experimental autoimmune uveitis

Yorishige Matsuda; Shinji Kakihara; Kazutaka Hirabayashi; Akira Imai; Yasuhiro Iesato; Takayuki Sakurai; Akiko Kamiyoshi; Yuka Ichikawa-Shindo; Megumu Tanaka; Hisaka Kawate; Yunlu Zhao; Toshinori Murata; Takayuki Shindo

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3571 – A0458.

ARVO Annual Meeting Abstract June 2021

Pathophysiological roles of adrenomedullin-2 in mouse model of ocular neovascularization

Shinji Kakihara; Masaaki Tanaka; Kazutaka Hirabayashi; Akira Imai; Yuichi Toriyama; Yasuhiro Iesato; Takayuki Sakurai; Akiko Kamiyoshi; Hisaka Kawate; Yuka Ichikawa-Shindo; Megumu Tanaka; Toshinori Murata; Takayuki Shindo

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2946.

ARVO Annual Meeting Abstract June 2021

Changes in retinal sensitivity, thickness, and perfusion density following treatment for branch retinal vein occlusion (BRVO)

Kazutaka Hirabayashi; Srinivas R Sadda; Akira Imai; Yasuhiro Iesato; Toshinori Murata

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):3177.

ARVO Annual Meeting Abstract June 2021

Evaluation of the vitreoretinal interface in eyes with diabetic retinopathy using a 23 mm wide-field OCT

Takao Hirano; Yoshiaki Chiku; Ken Hoshiyama; Toshinori Murata

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1912.

ARVO Annual Meeting Abstract June 2020

Comparison of ranibizumab with or without focal/grid laser for macular edema secondary to branch retinal vein occlusion: 12-month results from the ZIPANGU study

Toshinori Murata; Mineo Kondo; Makoto Inoue; Shintaro Nakao; Rie Osaka; Chieko Shiragami; Kenji Sogawa; Akikazu Mochizuki; Rumiko Shiraga; Yohei Ohashi; Takeumi Kaneko; Akitaka Tsujikawa; Motohiro Kamei

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3522.

ARVO Annual Meeting Abstract June 2020

The therapeutic potency of exogenous administration of adrenomedullin-2 in ocular neovascular diseases

Shinji Kakihara; Masaaki Tanaka; Kazutaka Hirabayashi; Akira Imai; Yuichi Toriyama; Yasuhiro Iesato; Takayuki Sakurai; Akiko Kamiyoshi; Hisaka Kawate; Yuka Ichikawa-Shindo; Megumu Tanaka; Kun Dai; Nanqi Cui; Yangxuan Wei; Toshinori Murata; Takayuki Shindo

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4937.

ARVO Annual Meeting Abstract June 2020

Evaluation of wide-field OCT angiography using Xephilio OCT-S1 for detecting retinal neovascularization in eyes with proliferative diabetic retinopathy

Takao Hirano; Ken Hoshiyama; Yuichi Toriyama; Toshinori Murata

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5300.

ARVO Annual Meeting Abstract July 2019

Change of baseline visual acuity in eyes with age-related macular degeneration from 2006-201 5

Tomoko Sawada; Tsutomu Yasukawa; Hiroko Imaizumi; Hisashi Mastubara; Kazuhiro Kimura; Hiroto Terasaki; Hiroto Ishikawa; Tomoya Murakami; Masaru Takeuchi; Yoshinori Mitamura; Mariko Yamashita; Yoshihiro Takamura; Toshinori Murata; Jiro Kogo; Taiji Sakamoto; Masahito Ohji

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1160.

ARVO Annual Meeting Abstract July 2019

One year follow-up data on changes in aqueous VEGF levels in eyes with diabetic macula edema treated with ranibizumab using the pro re nata regimen

Takao Hirano; Yuichi Toriyama; Kazutaka Hirabayashi; Toshinori Murata

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3660.

ARVO Annual Meeting Abstract July 2019

Correlation between initial visit binocular intraocular pressure difference and mean pulse pressure, and the number of ranibizumab administrations in branch retinal vein occlusion

Kazutaka Hirabayashi; Akira Imai; Yasuhiro Iesato; Toshinori Murata

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4069.

ARVO Annual Meeting Abstract July 2019

Pathophysiological significance of adrenomedullin-RAMP2 system in age-related macular degeneration

Masaaki Tanaka; Kazutaka Hirabayashi; Akira Imai; Yuichi Toriyama; Yasuhiro Iesato; Akihiro Yamauchi; Megumu Tanaka; Takayuki Sakurai; Akiko Kamiyoshi; Yuka Ichikawa-Shindo; Hisaka Kawate; Toshinori Murata; Takayuki Shindo

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5382.

ARVO Annual Meeting Abstract July 2019

Change in 1-year visual acuity gain with age-related macular degeneration from 2006 and 2015

Sachi Nishino; Tsutomu Yasukawa; Hiroko Imaizumi; Hisashi Mastubara; Hiroto Ishikawa; Kazuhiro Kimura; Hiroto Terasaki; Yoshinori Mitamura; Toshinori Murata; Mariko Yamashita; Jiro Kogo; Masaru Takeuchi; Yoshihiro Takamura; Tomoya Murakami; Taiji Sakamoto; Masahito Ohji

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):92.

ARVO Annual Meeting Abstract July 2018

Investigation of the therapeutic effect of adrenomedullin on central retinal vein occlusion

Kazutaka Hirabayashi; Toshinori Murata; Yasuhiro Iesato; Akira Imai; Yuichi Toriyama; Masaaki Tanaka; Takayuki Sakurai; Akiko Kamiyoshi; Yuka Ichikawa-Shindo; Hisaka Kawate; Megumu Tanaka; Akihiro Yamauchi; Takayuki Shindo

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4257.

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Adrenomedullin-RAMP2 System Modulates Inflammation and Tissue Repair in Experimental Autoimmune Uveitis Via T-Cell and M2 Macrophage Regulation

Optical coherence tomography angiography-based artificial intelligence-inferred fluorescein angiography for the detection of microaneurysms in patients with diabetic retinopathy

Pathophysiological roles of adrenomedullin in experimental autoimmune uveitis

Novel artificial intelligence-assisted optical coherence tomography-angiography delineation of retinal vessels and leakage by deep learning with fluorescein angiography video training data

Retinal volume assessment using wide-field swept-source optical coherence tomography in eyes without retinal disease

Investigation of the therapeutic effect of adrenomedullin on experimental autoimmune uveitis

Transcriptome analysis of the pathophysiological significance of adrenomedullin 2 in the mouse choroidal neovascularization model

Investigation of the therapeutic effect of adrenomedullin on experimental autoimmune uveitis

Pathophysiological roles of adrenomedullin-2 in mouse model of ocular neovascularization

Changes in retinal sensitivity, thickness, and perfusion density following treatment for branch retinal vein occlusion (BRVO)

Evaluation of the vitreoretinal interface in eyes with diabetic retinopathy using a 23 mm wide-field OCT

Comparison of ranibizumab with or without focal/grid laser for macular edema secondary to branch retinal vein occlusion: 12-month results from the ZIPANGU study

The therapeutic potency of exogenous administration of adrenomedullin-2 in ocular neovascular diseases

Evaluation of wide-field OCT angiography using Xephilio OCT-S1 for detecting retinal neovascularization in eyes with proliferative diabetic retinopathy

Change of baseline visual acuity in eyes with age-related macular degeneration from 2006-201 5

One year follow-up data on changes in aqueous VEGF levels in eyes with diabetic macula edema treated with ranibizumab using the pro re nata regimen

Correlation between initial visit binocular intraocular pressure difference and mean pulse pressure, and the number of ranibizumab administrations in branch retinal vein occlusion

Pathophysiological significance of adrenomedullin-RAMP2 system in age-related macular degeneration

Change in 1-year visual acuity gain with age-related macular degeneration from 2006 and 2015

Investigation of the therapeutic effect of adrenomedullin on central retinal vein occlusion

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