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ARVO Annual Meeting Abstract June 2025

The Role of the Melanocortin System in Limbal Niche Homeostasis

Shen Li; Matthias Zenkel; Friedrich E Kruse; Andreas Gießl; Ursula Schlötzer-Schrehardt

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):4412.

ARVO Annual Meeting Abstract June 2025

Molecular Interplay in the Limbal Stem Cell Niche: Roles of Laminin and Small Extracellular Vesicles

Naresh Polisetti; Tabea Herzig; Moritz Vincent Braunsperger; Ursula Schlötzer-Schrehardt; Gunther R Schlunck; Thomas Reinhard

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):485.

ARVO Annual Meeting Abstract June 2025

Graft failure of more than 5 years after primary Descemet membrane endothelial keratoplasty (DMEK): ultramorphology of the explanted grafts

Theofilos Tourtas; Thessalia Voulgari; Julia Marina Weller; Friedrich E Kruse; Ursula Schlötzer-Schrehardt

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):124.

ARVO Annual Meeting Abstract June 2025

Limbal niche cells orchestrate immune regulation and protection in the corneal epithelial stem cell niche

Andreas Gießl; Yiqun Fan; Matthias Zenkel; Nina Eisenhauer; Simon Völkl; Friedrich E Kruse; Ursula Schlötzer-Schrehardt

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):5014.

ARVO Annual Meeting Abstract June 2025

Elucidating transcriptome-wide effects of TGF-beta signaling in an in vitro model for pseudoexfoliation syndrome

Ursula Schlötzer-Schrehardt; Matthias Zenkel; Robert Lämmer; Anja-Maria Ladek; Friedrich E Kruse; Francesca Pasutto; Sai Pulasani

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1304.

ARVO Annual Meeting Abstract June 2025

Development of immortalized cell lines derived from iris fibroblasts of pseudoexfoliation patients

Matthias Zenkel; Ursula Schlötzer-Schrehardt; Andreas Gießl; Francesca Pasutto; Friedrich E Kruse; Sai Pulasani

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):1224.

ARVO Annual Meeting Abstract June 2025

Distinct Mitochondrial DNA Mutation Patterns in Fuchs Endothelial Corneal Dystrophy

Koji Kitazawa; Hideto Deguchi; Matthias Zenkel; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Kohsaku Numa; Chie Sotozono; Friedrich E Kruse; Pierre-Yves Desprez

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):3330.

ARVO Annual Meeting Abstract June 2025

A novel self-assembly inducing compound suppresses endoplasmic reticulum stress-mediated apoptosis in Fuchs endothelial corneal dystrophy

Shunsuke Noda; Naoki Okumura; Kanna Hasegawa; Kazuma Harada; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E Kruse; Masahiro Abo; Motonari Uesugi; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2957.

ARVO Annual Meeting Abstract June 2025

Identification of Differentially Expressed Novel Isoforms in Fuchs Endothelial Corneal Dystrophy with and without trinucleotide repeat expansion in TCF4

Yata Yuma; Naoki Okumura; Taisuke Numao; Yuichi Tokuda; Masakazu Nakano; Kei Tashiro; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E Kruse; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2955.

ARVO Annual Meeting Abstract June 2025

Estrogen suppresses TGF-β-mediated extracellular matrix production in corneal endothelial cells derived from patients with Fuchs Endothelial Corneal Dystrophy

Kota Mayumi; Naoki Okumura; Itsuki Oka; Soichiro Inagaki; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E Kruse; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2954.

ARVO Annual Meeting Abstract June 2025

Investigation of Splicing Abnormalities in Fuchs Endothelial Corneal Dystrophy and Comparative Analysis with Myotonic Dystrophy Type 1

Taichi Yuasa; Naoki Okumura; Kurumi Yoshinaga; Yuichi Tokuda; Masakazu Nakano; Kei Tashiro; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich E Kruse; Noriko Koizumi

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2953.

ARVO Annual Meeting Abstract June 2025

Cultured human endothelial cells preferentially attach to the spaces between guttae in an in vitro model using Descemet membranes from patients with Fuchs dystrophy

Friedrich E Kruse; Andreas Gießl; Julia Marina Weller; Theofilos Tourtas; Shigeru Kinoshita; Ursula Schlötzer-Schrehardt

Invest. Ophthalmol. Vis. Sci.. 2025; 66(8):2939.

Cornea March 2025

The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy

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Tatsuya Nakagawa; Tetsuro Honda; Taichi Yuasa; Go Nishiuchi; Masakazu Sato; Ayumi Tokunaga; Makiko Nakahara; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Prema Padmanabhan; Amit Chatterjee; Gajanan Sathe; Vivek Ghose; Narayanan Janakiraman; Derek J. Blake; Noriko Koizumi; Sailaja Elchuri; Naoki Okumura
TAGS: apoptosis, cornea, endothelial cells, endothelium, genes, hereditary corneal dystrophy, pathogenesis, proteins, western blotting, liquid chromatography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):16. https://doi.org/10.1167/iovs.66.3.16

Includes: Supplemental Content

Cornea June 2024

Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy

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Tetsuro Honda; Tatsuya Nakagawa; Taichi Yuasa; Yuichi Tokuda; Masakazu Nakano; Kei Tashiro; Theofilos Tourtas; Ursula Schlötzer-Schrehardt; Friedrich Kruse; Koji Yamamoto; Noriko Koizumi; Naoki Okumura
TAGS: hereditary corneal dystrophy, protein isoforms, rna-seq, exons, cornea, endothelial cells, endothelium, datasets
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):27. https://doi.org/10.1167/iovs.65.6.27

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Functional Characterization of Rare Genetic Variants in the LOXL1 Gene Associated with Pseudoexfoliation Syndrome/Glaucoma

Iris Kerker; Ursula Hoja; Valentin Nelea; Matthias Zenkel; Andreas Gießl; Friedrich E Kruse; Dieter Reinhardt; Francesca Pasutto; Ursula Schlötzer-Schrehardt

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):665.

ARVO Annual Meeting Abstract June 2024

Transcriptomic analysis of anterior segment tissues derived from patients with pseudoexfoliation syndrome and glaucoma

Sai Pulasani; Matthias Zenkel; Arif Ekici; Ursula Schlötzer-Schrehardt; Francesca Pasutto

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):646.

ARVO Annual Meeting Abstract June 2024

Elucidating the asymmetric manifestation of pseudoexfoliation syndrome by RNA-sequencing and pathway analysis

Matthias Zenkel; Sai Pulasani; Steffen Uebe; Arif Ekici; Friedrich E Kruse; Francesca Pasutto; Ursula Schlötzer-Schrehardt

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):633.

ARVO Annual Meeting Abstract June 2024

Insulin for treatment of neurotrophic ulcers: Clinical evidence and potential mechanism

Victoria Elisabeth Birgit Zeisberg; Matthias Zenkel; Andreas Gießl; Ursula Schlötzer-Schrehardt; Theofilos Tourtas; Julia M Weller; Victor A. Augustin; Friedrich E Kruse

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):56.

ARVO Annual Meeting Abstract June 2024

Effects of limbal niche cells-derived melanosomes and exosomes on human limbal epithelial stem/progenitor cells

Andreas Gießl; Julia Khorolskaya; Günter Lochnit; Thomas Timm; Jan Van Deun; Matthias Zenkel; Andreas Baur; Friedrich E Kruse; Ursula Schlötzer-Schrehardt

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1997.

ARVO Annual Meeting Abstract June 2024

Late graft failure after Descemet membrane endothelial keratoplasty (DMEK): clinical characteristics and ultrastructural findings of failed grafts

Julia M Weller; Ursula Schlötzer-Schrehardt; Friedrich E Kruse; Theofilos Tourtas

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1081.

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The Role of the Melanocortin System in Limbal Niche Homeostasis

Molecular Interplay in the Limbal Stem Cell Niche: Roles of Laminin and Small Extracellular Vesicles

Graft failure of more than 5 years after primary Descemet membrane endothelial keratoplasty (DMEK): ultramorphology of the explanted grafts

Limbal niche cells orchestrate immune regulation and protection in the corneal epithelial stem cell niche

Elucidating transcriptome-wide effects of TGF-beta signaling in an in vitro model for pseudoexfoliation syndrome

Development of immortalized cell lines derived from iris fibroblasts of pseudoexfoliation patients

Distinct Mitochondrial DNA Mutation Patterns in Fuchs Endothelial Corneal Dystrophy

A novel self-assembly inducing compound suppresses endoplasmic reticulum stress-mediated apoptosis in Fuchs endothelial corneal dystrophy

Identification of Differentially Expressed Novel Isoforms in Fuchs Endothelial Corneal Dystrophy with and without trinucleotide repeat expansion in TCF4

Estrogen suppresses TGF-β-mediated extracellular matrix production in corneal endothelial cells derived from patients with Fuchs Endothelial Corneal Dystrophy

Investigation of Splicing Abnormalities in Fuchs Endothelial Corneal Dystrophy and Comparative Analysis with Myotonic Dystrophy Type 1

Cultured human endothelial cells preferentially attach to the spaces between guttae in an in vitro model using Descemet membranes from patients with Fuchs dystrophy

The TCF4 Gene Regulates Apoptosis of Corneal Endothelial Cells in Fuchs Endothelial Corneal Dystrophy

Dysregulation of the TCF4 Isoform in Corneal Endothelial Cells of Patients With Fuchs Endothelial Corneal Dystrophy

Functional Characterization of Rare Genetic Variants in the LOXL1 Gene Associated with Pseudoexfoliation Syndrome/Glaucoma

Transcriptomic analysis of anterior segment tissues derived from patients with pseudoexfoliation syndrome and glaucoma

Elucidating the asymmetric manifestation of pseudoexfoliation syndrome by RNA-sequencing and pathway analysis

Insulin for treatment of neurotrophic ulcers: Clinical evidence and potential mechanism

Effects of limbal niche cells-derived melanosomes and exosomes on human limbal epithelial stem/progenitor cells

Late graft failure after Descemet membrane endothelial keratoplasty (DMEK): clinical characteristics and ultrastructural findings of failed grafts

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