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Retina July 2023

AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model

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Daniel Grigsby; Mikael Klingeborn; Una Kelly; Lindsey A. Chew; Aravind Asokan; Garth Devlin; Sharon Smith; Lisa Keyes; Adrian Timmers; Abraham Scaria; Catherine Bowes Rickman
TAGS: complement factor h, complement system proteins, follicular bronchiolitis, foreign bodies, genes, mice, liver, eye, injections, plasma
Invest. Ophthalmol. Vis. Sci.. 2023; 64(10):25. https://doi.org/10.1167/iovs.64.10.25

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Chronic Oxidative Stress in Primary Retinal Pigmented Epithelium Monolayers Increases Basolateral Exosome Release and Changes Both Exosome and Extracellular Matrix Proteomes

Belinda Hernandez; Mikael Klingeborn; Nikolai Skiba; Daniel Grigsby; Una Kelly; Martha Caday; Arvydas Maminishkis; TeddiJo Watkins; Sheldon S Miller; W. Daniel Stamer; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):256.

ARVO Annual Meeting Abstract July 2019

Systemic AAV delivery of complement regulator, Factor H Like-1 (FHL-1) impacts visual function.

Daniel Grigsby; Michael Landowski; Una Kelly; Mikael Klingeborn; Marybeth Groelle; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5197.

ARVO Annual Meeting Abstract July 2018

Dietary Cholesterol Contributes to Vision Loss in a Complement-Dysregulated AMD Mouse Model

Michael Landowski; Una L Kelly; Daniel Grigsby; Marybeth Groelle; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):348.

ARVO Annual Meeting Abstract July 2018

sGC Stimulators and Trabecular Meshwork Biology

Iris Navarro; Marco Kessler; Una L Kelly; Megan Parker; Gerhard Hannig; Pei Ge; W Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1649.

Retinal Cell Biology February 2018

Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration

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Christopher B. Toomey; Michael Landowski; Mikael Klingeborn; Una Kelly; John Deans; Holly Dong; Ons Harrabi; Thomas Van Blarcom; Yik Andy Yeung; Ruslan Grishanin; John C. Lin; Daniel R. Saban; Catherine Bowes Rickman
TAGS: mice, antibodies, choroidal neovascularization, age-related macular degeneration, choroid
Invest. Ophthalmol. Vis. Sci.. 2018; 59(2):662-673. https://doi.org/10.1167/iovs.17-23134

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Lipoprotein synthesis and deposition in the eye is regulated by the complement system and glycosaminoglycans (GAGs).

Una L Kelly; Michael Landowski; Nikolai Skiba; Jian Liu; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5249.

ARVO Annual Meeting Abstract September 2016

Effect of Complement Factor H Variants in Regulating AMD-like Pathologies In Vivo .

Michael Landowski; Jindong Ding; Mikael Klingeborn; Una Kelly; Marybeth Groelle; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):6526.

ARVO Annual Meeting Abstract June 2015

Complement dysregulation exacerbates AMD-like phenotype in APOE4 transgenic mouse model of AMD

John R Deans; Christopher B Toomey; Una Kelly; Mikael Klingeborn; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):831.

ARVO Annual Meeting Abstract April 2014

Exogenous CFH Contributes to Complement Regulation in the Eyes of Cfh-Deficient Animals.

Michael J Landowski; Una L Kelly; Marybeth Groelle; Jindong Ding; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1321.

ARVO Annual Meeting Abstract June 2013

Human Complement Factor H (CFH) Transgene Expression Rescues the Visual Function and Retina Abnormalities in Aged cfh-/- Mice

Jindong Ding; Una Kelly; Marybeth Groelle; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):5015.

ARVO Annual Meeting Abstract June 2013

Oxidative Stress Significantly Increases Expression of Inflammatory and Antioxidant Markers in Complement Factor H Deficient Mice Compared to Wild-Type Mice

Terry Singhapricha; Una Kelly; Michael Landowski; Marybeth Groelle; Peter Saloupis; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):364.

ARVO Annual Meeting Abstract March 2012

Effect of Excess Complement Activation on AMD-like Pathology in the APOE4/cfh Knockout Transgenic Murine Model: Does Loss-of-function Exacerbate Retinal Disease?

Joseph G. Christenbury; Jin-Dong Ding; Una Kelly; Marybeth Groelle; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):1641.

ARVO Annual Meeting Abstract March 2012

Properdin and Malondialdehyde (MDA) effects on the APOE4 mouse model of Age-Related Macula Degeneration (AMD)

Una L. Kelly; Marybeth Groelle; Jindong Ding; Wen-Chao Song; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6466.

ARVO Annual Meeting Abstract April 2011

Development and Characterization of Humanized Complement Factor H (CFH) Transgenic Mice

Jindong Ding; Una Kelly; Stephanie G. Smith; Marybeth Groelle; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):958.

ARVO Annual Meeting Abstract April 2011

Effect Of Excess Complement Inhibition On AMD-like Pathology Using The APOE4/sCrry Transgenic Murine Model: Does Gain-of-function Worsen Retinal Disease?

Wenlan Zhang; Jin-Dong Ding; Una Kelly; Stephanie Smith; Michael Frank; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2294.

ARVO Annual Meeting Abstract April 2011

Age-dependent Distribution of Glycosaminoglycans in Mouse Bruch’s Membrane

Kent Y. Feng; Jindong Ding; Una Kelly; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2327.

ARVO Annual Meeting Abstract April 2011

Concentration and Composition Changes in Heparan Sulfate Increase Complement Activation Through Modulation of C3bBb Convertase Formation and This Effect is Modified by Factor H

Una L. Kelly; Jin-Dong Ding; Kent Y. Feng; Haixiang Jiang; Michael Frank; Catherine Bowes Rickman

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):2301.

Biochemistry and Molecular Biology April 2009

Rapid and Sensitive Method for Detection of Y402, H402, I62, and V62 Variants of Complement Factor H in Human Plasma Samples Using Mass Spectrometry

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Una Kelly; Catherine Bowes Rickman; Eric A. Postel; Michael A. Hauser; Gregory S. Hageman; Vadim Y. Arshavsky; Nikolai P. Skiba

Invest. Ophthalmol. Vis. Sci.. 2009; 50(4):1540-1545. https://doi.org/10.1167/iovs.08-2782

Retinal Cell Biology October 2003

Expression of the Blue-Light Receptor Cryptochrome in the Human Retina

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Carol L. Thompson; Catherine Bowes Rickman; Steven J. Shaw; Jessica N. Ebright; Una Kelly; Aziz Sancar; Dennis W. Rickman
TAGS: blue light, retina, antibodies, proteins, immunoblotting, peptides, lysate
Invest. Ophthalmol. Vis. Sci.. 2003; 44(10):4515-4521. https://doi.org/10.1167/iovs.03-0303

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AAV Gene Augmentation of Truncated Complement Factor H Differentially Rescues Ocular Complement Dysregulation in a Mouse Model

Chronic Oxidative Stress in Primary Retinal Pigmented Epithelium Monolayers Increases Basolateral Exosome Release and Changes Both Exosome and Extracellular Matrix Proteomes

Systemic AAV delivery of complement regulator, Factor H Like-1 (FHL-1) impacts visual function.

Dietary Cholesterol Contributes to Vision Loss in a Complement-Dysregulated AMD Mouse Model

sGC Stimulators and Trabecular Meshwork Biology

Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration

Lipoprotein synthesis and deposition in the eye is regulated by the complement system and glycosaminoglycans (GAGs).

Effect of Complement Factor H Variants in Regulating AMD-like Pathologies In Vivo .

Complement dysregulation exacerbates AMD-like phenotype in APOE4 transgenic mouse model of AMD

Exogenous CFH Contributes to Complement Regulation in the Eyes of Cfh-Deficient Animals.

Human Complement Factor H (CFH) Transgene Expression Rescues the Visual Function and Retina Abnormalities in Aged cfh-/- Mice

Oxidative Stress Significantly Increases Expression of Inflammatory and Antioxidant Markers in Complement Factor H Deficient Mice Compared to Wild-Type Mice

Effect of Excess Complement Activation on AMD-like Pathology in the APOE4/cfh Knockout Transgenic Murine Model: Does Loss-of-function Exacerbate Retinal Disease?

Properdin and Malondialdehyde (MDA) effects on the APOE4 mouse model of Age-Related Macula Degeneration (AMD)

Development and Characterization of Humanized Complement Factor H (CFH) Transgenic Mice

Effect Of Excess Complement Inhibition On AMD-like Pathology Using The APOE4/sCrry Transgenic Murine Model: Does Gain-of-function Worsen Retinal Disease?

Age-dependent Distribution of Glycosaminoglycans in Mouse Bruch’s Membrane

Concentration and Composition Changes in Heparan Sulfate Increase Complement Activation Through Modulation of C3bBb Convertase Formation and This Effect is Modified by Factor H

Rapid and Sensitive Method for Detection of Y402, H402, I62, and V62 Variants of Complement Factor H in Human Plasma Samples Using Mass Spectrometry

Expression of the Blue-Light Receptor Cryptochrome in the Human Retina

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