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ARVO Annual Meeting Abstract July 2019

Pharmacologic and safety profile of the ocular hypotensive agent cromakalim prodrug 1 (CKLP1), a novel ATP-sensitive potassium channel opener

Michael P Fautsch; Rachel Kudgus; Tommy Rinkoski; Cheryl Hann; Cindy Bahler; Bradley Holman; Joel Reid; Peter Dosa; Uttio Roy Chowdhury

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3772. doi:

Glaucoma November 2017

Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents

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Uttio Roy Chowdhury; Tommy A. Rinkoski; Cindy K. Bahler; J. Cameron Millar; Jacques A. Bertrand; Bradley H. Holman; Joseph M. Sherwood; Darryl R. Overby; Kristen L. Stoltz; Peter I. Dosa; Michael P. Fautsch
TAGS: antihypertensive agents, aqueous humor, combined modality therapy, cromakalim, eye, intraocular pressure, mice, oryctolagus cuniculus, prodrugs, perfusion
Invest. Ophthalmol. Vis. Sci.. 2017; 58(13):5731-5742. doi: https://doi.org/10.1167/iovs.17-22538

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Pharmacologic profile and distribution of CKLP1, a novel prodrug of the ATP sensitive potassium channel opener levcromakalim, following various modes of administration

Uttio Roy Chowdhury; Rachel A Kudgus; Tommy A. Rinkoski; Joel M Reid; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4595. doi:

Glaucoma May 2017

Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure–Lowering Effects of Latanoprost

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Gavin W. Roddy; Kimberly B. Viker; Nelson S. Winkler; Cindy K. Bahler; Bradley H. Holman; David Sheikh-Hamad; Uttio Roy Chowdhury; W. Daniel Stamer; Michael P. Fautsch
TAGS: intraocular pressure, latanoprost, molecule, antihypertensive agents, schlemm's canal
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2715-2724. doi: https://doi.org/10.1167/iovs.16-21004

ARVO Annual Meeting Abstract September 2016

Ocular hypotensive properties of water soluble prodrugs of the ATP sensitive potassium channel opener cromakalim

Uttio Roy Chowdhury; Kimberly B Viker; Peter I Dosa; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):3018. doi:

ARVO Annual Meeting Abstract September 2016

Characterization of mis-splicing events in primary Fuchs corneal endothelial cell cultures harboring TCF4 repeat expansion

Thomas Rinkoski; Keith H Baratz; Uttio Roy Chowdhury; Ross A Aleff; Michael P Fautsch; Eric Wieben

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):5288. doi:

ARVO Annual Meeting Abstract June 2015

Effect of low intracranial pressure on optic neuronal health in an experimental rat model

Uttio Roy Chowdhury; Bradley H Holman; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):4131. doi:

Research Opportunities May 2015

Aqueous Humor Outflow: Dynamics and Disease

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Uttio Roy Chowdhury; Cheryl R. Hann; W. Daniel Stamer; Michael P. Fautsch
TAGS: aqueous humor, extracellular matrix, glaucoma, intraocular pressure, mice, signal transduction, eye, hypertension, raised intraocular pressure, body tissue
Invest. Ophthalmol. Vis. Sci.. 2015; 56(5):2993-3003. doi: https://doi.org/10.1167/iovs.15-16744

ARVO Annual Meeting Abstract April 2014

Mutants in NBCe1A isoform have elevated Intraocular Pressure

Michael F Romero; Heather L Holmes; Uttio Roy Chowdhury; Cheryl R Hann; Minhwang Chang; Michael P Fautsch; An-Ping Chen

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):2415. doi:

ARVO Annual Meeting Abstract April 2014

Ocular hypotensive effects of the K ATP channel opener cromakalim in murine and human experimental model systems

Uttio Roy Chowdhury; Cindy K Bahler; Bradley H Holman; Michael P Fautsch

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):3547. doi:

Glaucoma July 2013

ATP-Sensitive Potassium (K ATP ) Channel Openers Diazoxide and Nicorandil Lower Intraocular Pressure In Vivo

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Uttio Roy Chowdhury; Bradley H. Holman; Michael P. Fautsch
TAGS: diazoxide, eye, intraocular pressure, mice, nicorandil, potassium
Invest. Ophthalmol. Vis. Sci.. 2013; 54(7):4892-4899. doi: https://doi.org/10.1167/iovs.13-11872

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2013

A Novel Rat Model to Study the Role of Intracranial Hypotension in Optic Neuropathy

Uttio Roy Chowdhury; Bradley Holman; Cheryl Hann; Cindy Bahler; Michael Fautsch

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):2292. doi:

ARVO Annual Meeting Abstract June 2013

Transcriptional Profiling of Human Schlemm’s Canal Cells Following Latanoprost, Bimatoprost and Prostaglandin F2alpha (PGF2α) Treatment

Nelson Winkler; Uttio Roy Chowdhury; Michael Fautsch

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):3539. doi:

ARVO Annual Meeting Abstract June 2013

Ocular Indications of Partial Penetrance in Mice Heterozygous for NBCe1 (Slc4a4)

Michael Romero; Heather Holmes; Uttio Roy Chowdhury; Cheryl Hann; Min-Hwang Chang; Michael Fautsch; An-Ping Chen

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):5646. doi:

ARVO Annual Meeting Abstract March 2012

The ATP-sensitive Potassium (KATP) Channel Opener Diazoxide Increases Outflow Facility by Activating the Erk1/2 Signaling Pathway

Uttio Roy Chowdhury; Cindy K. Bahler; Cheryl R. Hann; Bradley H. Holman; Michael P. Fautsch

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):3260. doi:

Glaucoma August 2011

ATP-Sensitive Potassium (K ATP ) Channel Activation Decreases Intraocular Pressure in the Anterior Chamber of the Eye

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Uttio Roy Chowdhury; Cindy K. Bahler; Cheryl R. Hann; Minhwang Chang; Zachary T. Resch; Michael F. Romero; Michael P. Fautsch
TAGS: anterior chamber of eye, diazoxide, intraocular pressure, potassium, eye, glyburide
Invest. Ophthalmol. Vis. Sci.. 2011; 52(9):6435-6442. doi: https://doi.org/10.1167/iovs.11-7523

Glaucoma August 2011

Expression Profile of the Matricellular Protein Osteopontin in Primary Open-Angle Glaucoma and the Normal Human Eye

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Uttio Roy Chowdhury; Seung-Youn Jea; Dong-Jin Oh; Douglas J. Rhee; Michael P. Fautsch
TAGS: body tissue, eye, hypertension, open-angle glaucoma, osteopontin, proteins, intraocular pressure
Invest. Ophthalmol. Vis. Sci.. 2011; 52(9):6443-6451. doi: https://doi.org/10.1167/iovs.11-7409

ARVO Annual Meeting Abstract April 2011

Additive Effect of Latanoprost-Free Acid and Diazoxide, an ATP-Sensitive Potassium (KATP) Channel Opener, on Outflow Facility in Human Anterior Segment Culture

Uttio Roy Chowdhury; Cindy K. Bahler; Cheryl R. Hann; Minhwang Chang; Michael F. Romero; Michael P. Fautsch

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4642. doi:

Biochemistry and Molecular Biology October 2010

Proteome Analysis of Human Aqueous Humor

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Uttio Roy Chowdhury; Benjamin J. Madden; Mary Christine Charlesworth; Michael P. Fautsch
TAGS: aqueous humor, cytokine, proteins, proteome, growth factor, antibodies
Invest. Ophthalmol. Vis. Sci.. 2010; 51(10):4921-4931. doi: https://doi.org/10.1167/iovs.10-5531

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Pharmacologic and safety profile of the ocular hypotensive agent cromakalim prodrug 1 (CKLP1), a novel ATP-sensitive potassium channel opener

Effect of Cromakalim Prodrug 1 (CKLP1) on Aqueous Humor Dynamics and Feasibility of Combination Therapy With Existing Ocular Hypotensive Agents

Pharmacologic profile and distribution of CKLP1, a novel prodrug of the ATP sensitive potassium channel opener levcromakalim, following various modes of administration

Stanniocalcin-1 Is an Ocular Hypotensive Agent and a Downstream Effector Molecule That Is Necessary for the Intraocular Pressure–Lowering Effects of Latanoprost

Ocular hypotensive properties of water soluble prodrugs of the ATP sensitive potassium channel opener cromakalim

Characterization of mis-splicing events in primary Fuchs corneal endothelial cell cultures harboring TCF4 repeat expansion

Effect of low intracranial pressure on optic neuronal health in an experimental rat model

Aqueous Humor Outflow: Dynamics and Disease

Mutants in NBCe1A isoform have elevated Intraocular Pressure

Ocular hypotensive effects of the K ATP channel opener cromakalim in murine and human experimental model systems

ATP-Sensitive Potassium (K ATP ) Channel Openers Diazoxide and Nicorandil Lower Intraocular Pressure In Vivo

A Novel Rat Model to Study the Role of Intracranial Hypotension in Optic Neuropathy

Transcriptional Profiling of Human Schlemm’s Canal Cells Following Latanoprost, Bimatoprost and Prostaglandin F2alpha (PGF2α) Treatment

Ocular Indications of Partial Penetrance in Mice Heterozygous for NBCe1 (Slc4a4)

The ATP-sensitive Potassium (KATP) Channel Opener Diazoxide Increases Outflow Facility by Activating the Erk1/2 Signaling Pathway

ATP-Sensitive Potassium (K ATP ) Channel Activation Decreases Intraocular Pressure in the Anterior Chamber of the Eye

Expression Profile of the Matricellular Protein Osteopontin in Primary Open-Angle Glaucoma and the Normal Human Eye

Additive Effect of Latanoprost-Free Acid and Diazoxide, an ATP-Sensitive Potassium (KATP) Channel Opener, on Outflow Facility in Human Anterior Segment Culture

Proteome Analysis of Human Aqueous Humor

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