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Articles April 2020

Implantation and Extraction of Penetrating Electrode Arrays in Minipig Retinas

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Jinghua Chen; Vasiliki Poulaki; Seong-Joon Kim; William D. Eldred; Sheryl Kane; Marcus Gingerich; Douglas B. Shire; Ralph Jensen; Gloria DeWalt; Henry J. Kaplan; Joseph F. Rizzo, III
TAGS: implantation procedure, retina, surgical procedures, operative, swine, miniature, surgery specialty
Trans. Vis. Sci. Tech.. 2020; 9(5):19. https://doi.org/10.1167/tvst.9.5.19

Anatomy and Pathology/Oncology January 2018

ICG-001 Exerts Potent Anticancer Activity Against Uveal Melanoma Cells

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Salma Kaochar; Jianrong Dong; Marie Torres; Kimal Rajapakshe; Fotis Nikolos; Christel M. Davis; Erik A. Ehli; Cristian Coarfa; Nicholas Mitsiades; Vasiliki Poulaki
TAGS: genes, intraocular melanoma, neoplasm metastasis, cell lines, cell cycle, transplantation, heterologous, gene expression profiling, mtor serine-threonine kinases, transcription, genetic
Invest. Ophthalmol. Vis. Sci.. 2018; 59(1):132-143. https://doi.org/10.1167/iovs.17-22454

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2017

Loss of ABCB5 leads to progressive visual loss due to sphingolipid accumulation in Retinal Pigment Epithelium

Yuzuru Sasamoto; Gabriel Gonzalez; Pallavi Banerjee; James D Akula; Vassiliki Poulaki; Gretchen Berg; Markus Hermann Frank; Bruce Ksander; Natasha Frank

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):1048.

ARVO Annual Meeting Abstract June 2015

Bromodomain (BRD) inhibition as a novel strategy to inhibit the Microphthalmia-associated transcription factor (MITF) axis in uveal melanoma (UM)

Vassiliki Poulaki; Nicholas Mitsiades; Warren Fiskus

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5337.

ARVO Annual Meeting Abstract April 2014

Sensitivity and Resistance of Uveal Melanoma (UM) cells to PKC inhibition: Role of the Steroid Receptor Coactivator (SRC)-3

Vassiliki Poulaki; Sue Anne Chew; Bert W O'Malley; Nicholas Mitsiades

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):847.

Translational Research April 2014

Protein Kinase C Inhibitors Sensitize GNAQ Mutant Uveal Melanoma Cells to Ionizing Radiation

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Jasmina Ziva Cerne; Sean Michael Hartig; Mark Patrick Hamilton; Sue Anne Chew; Nicholas Mitsiades; Vassiliki Poulaki; Sean Eric McGuire
TAGS: cell cycle, intraocular melanoma, protein kinase c, protein kinase c inhibitor, proteins, radiation, ionizing, sotrastaurin, cell survival, combined modality therapy, dna damage
Invest. Ophthalmol. Vis. Sci.. 2014; 55(4):2130-2139. https://doi.org/10.1167/iovs.13-13468

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2013

Microphthalmia-associated transcription factor (MITF) and Steroid Receptor Coactivator (SRC)-3 cooperate to promote proliferation, survival and metabolism in Gα-mutant uveal melanoma (UM) cells

Vassiliki Poulaki; Sue Anne Chew; Bin He; Vijay Kumar Eedunuri; Martine Jager; Bert O'Malley; Nicholas Mitsiades

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):4524.

ARVO Annual Meeting Abstract March 2012

The Protein Kinase C (PKC)/Protein Kinase D (PKD)/Steroid Receptor Coactivator (SRC)-3 pathway is an important therapeutic target in Gα-mutant Uveal Melanomas

Vassiliki Poulaki; Sue Anne Chew; Bin He; Vijay Kumar Eedunuri; Diego Jacinto Bedoya; Martine J. Jager; Bert W. O'Malley; Nicholas Mitsiades

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):6871.

Retinal Cell Biology September 2011

Genotype-Dependent Sensitivity of Uveal Melanoma Cell Lines to Inhibition of B-Raf, MEK, and Akt Kinases: Rationale for Personalized Therapy

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Nicholas Mitsiades; Sue Anne Chew; Bin He; Aline I. Riechardt; Theano Karadedou; Vassiliki Kotoula; Vassiliki Poulaki
TAGS: braf gene, cell lines, genotype, intraocular melanoma, phosphotransferases, proto-oncogene proteins c-akt, rationale, selumetinib, immunoblotting, braf inhibitors
Invest. Ophthalmol. Vis. Sci.. 2011; 52(10):7248-7255. https://doi.org/10.1167/iovs.11-7398

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2011

Genotype-Dependent Sensitivity Of Ocular Melanoma Cell Lines To Inhibitors Of Kinases, Including BRAF, MEK And Akt: Rationale For Personalized Therapy

Vassiliki Poulaki; Sue Anne Chew; Bin He; Nicholas Mitsiades

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):4758.

Retina October 2009

Role of α4 Integrin (CD49d) in the Pathogenesis of Diabetic Retinopathy

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Eirini Iliaki; Vassiliki Poulaki; Nicholas Mitsiades; Constantine S. Mitsiades; Joan W. Miller; Evangelos S. Gragoudas
TAGS: antibodies, diabetes mellitus, diabetic retinopathy, integrins, pathogenesis, streptozocin, adhesions, diabetes mellitus, type 2, intraperitoneal injections, up-regulation (physiology)
Invest. Ophthalmol. Vis. Sci.. 2009; 50(10):4898-4904. https://doi.org/10.1167/iovs.08-2013

Biochemistry and Molecular Biology September 2009

Molecular Sequelae of Histone Deacetylase Inhibition in Human Retinoblastoma Cell Lines: Clinical Implications

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Vassiliki Poulaki; Constantine S. Mitsiades; Vassiliki Kotoula; Joseph Negri; Ciaran McMullan; Joan W. Miller; Paul A. Marks; Nicholas Mitsiades
TAGS: retinoblastoma, vorinostat, apoptosis, cell lines, caspases, histone deacetylase
Invest. Ophthalmol. Vis. Sci.. 2009; 50(9):4072-4079. https://doi.org/10.1167/iovs.09-3517

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2009

The Antidiabetic Biguanide Metformin Induces Growth Arrest in Retinoblastoma Cells in vitro

V. Poulaki; M. Ooi; C. S. Mitsiades; J. W. Miller; N. Mitsiades

Invest. Ophthalmol. Vis. Sci.. 2009; 50(13):1699.

ARVO Annual Meeting Abstract May 2008

Antitumor Effects of the Histone Deacetylase Inhibitor Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) in Human Retinoblastoma Cell Lines: Therapeutic Implications

V. Poulaki; V. Kotoula; C. S. Mitsiades; J. Negri; J. W. Miller; S. Mukai; N. Mitsiades

Invest. Ophthalmol. Vis. Sci.. 2008; 49(13):26.

Retina October 2007

The Proteasome Inhibitor Bortezomib Induces Apoptosis in Human Retinoblastoma Cell Lines In Vitro

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Vassiliki Poulaki; Constantine S. Mitsiades; Vassiliki Kotoula; Joseph Negri; Douglas McMillin; Joan W. Miller; Nicholas Mitsiades
TAGS: bortezomib, retinoblastoma, apoptosis, proteasome inhibitors
Invest. Ophthalmol. Vis. Sci.. 2007; 48(10):4706-4719. https://doi.org/10.1167/iovs.06-1147

ARVO Annual Meeting Abstract May 2007

TIMP3 Inhibits Vascular Leakage and Leukostasis in an Animal Model of Streptozotocin-Induced Diabetes

V. Poulaki; N. Mitsiades; E. Iliaki; C. S. Mitsiades; E. S. Gragoudas; J. W. Miller

Invest. Ophthalmol. Vis. Sci.. 2007; 48(13):1383.

ARVO Annual Meeting Abstract May 2006

The Proteasome Inhibitor Bortezomib (Velcade, PS–341) Induces Apoptosis in Human Retinoblastoma Cells: Therapeutic Implications

N. Mitsiades; V. Poulaki; V. Kotoula; J. Negri; J.W. Miller; C.S. Mitsiades

Invest. Ophthalmol. Vis. Sci.. 2006; 47(13):2810.

ARVO Annual Meeting Abstract May 2006

Geldanamycin Treatment Reduces Choroidal Neovascularization In A Murine Model

V. Poulaki; N. Mitsiades; E. Iliaki; C.S. Mitsiades; E.S. Gragoudas; J.W. Miller

Invest. Ophthalmol. Vis. Sci.. 2006; 47(13):371.

ARVO Annual Meeting Abstract May 2005

Anti–FasL Neutralizing Antibody Increases the Efficacy of PDT and Reduces the Apoptotic Damage in a Rat Laser Model

V. Poulaki; N. Mitsiades; E. Iliaki; C. Mitsiades; E.S. Gragoudas; J.W. Miller

Invest. Ophthalmol. Vis. Sci.. 2005; 46(13):185.

ARVO Annual Meeting Abstract May 2005

Geldanamycin Treatment Reduces Neovascularization in a Mouse Model of Retinopathy of Prematurity

N. Kociok; V. Poulaki; C. Gavranic; B. Kirchhof; A.M. Joussen

Invest. Ophthalmol. Vis. Sci.. 2005; 46(13):4105.

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Implantation and Extraction of Penetrating Electrode Arrays in Minipig Retinas

ICG-001 Exerts Potent Anticancer Activity Against Uveal Melanoma Cells

Loss of ABCB5 leads to progressive visual loss due to sphingolipid accumulation in Retinal Pigment Epithelium

Bromodomain (BRD) inhibition as a novel strategy to inhibit the Microphthalmia-associated transcription factor (MITF) axis in uveal melanoma (UM)

Sensitivity and Resistance of Uveal Melanoma (UM) cells to PKC inhibition: Role of the Steroid Receptor Coactivator (SRC)-3

Protein Kinase C Inhibitors Sensitize GNAQ Mutant Uveal Melanoma Cells to Ionizing Radiation

Microphthalmia-associated transcription factor (MITF) and Steroid Receptor Coactivator (SRC)-3 cooperate to promote proliferation, survival and metabolism in Gα-mutant uveal melanoma (UM) cells

The Protein Kinase C (PKC)/Protein Kinase D (PKD)/Steroid Receptor Coactivator (SRC)-3 pathway is an important therapeutic target in Gα-mutant Uveal Melanomas

Genotype-Dependent Sensitivity of Uveal Melanoma Cell Lines to Inhibition of B-Raf, MEK, and Akt Kinases: Rationale for Personalized Therapy

Genotype-Dependent Sensitivity Of Ocular Melanoma Cell Lines To Inhibitors Of Kinases, Including BRAF, MEK And Akt: Rationale For Personalized Therapy

Role of α4 Integrin (CD49d) in the Pathogenesis of Diabetic Retinopathy

Molecular Sequelae of Histone Deacetylase Inhibition in Human Retinoblastoma Cell Lines: Clinical Implications

The Antidiabetic Biguanide Metformin Induces Growth Arrest in Retinoblastoma Cells in vitro

Antitumor Effects of the Histone Deacetylase Inhibitor Vorinostat (Suberoylanilide Hydroxamic Acid, SAHA) in Human Retinoblastoma Cell Lines: Therapeutic Implications

The Proteasome Inhibitor Bortezomib Induces Apoptosis in Human Retinoblastoma Cell Lines In Vitro

TIMP3 Inhibits Vascular Leakage and Leukostasis in an Animal Model of Streptozotocin-Induced Diabetes

The Proteasome Inhibitor Bortezomib (Velcade, PS–341) Induces Apoptosis in Human Retinoblastoma Cells: Therapeutic Implications

Geldanamycin Treatment Reduces Choroidal Neovascularization In A Murine Model

Anti–FasL Neutralizing Antibody Increases the Efficacy of PDT and Reduces the Apoptotic Damage in a Rat Laser Model

Geldanamycin Treatment Reduces Neovascularization in a Mouse Model of Retinopathy of Prematurity

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