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ARVO Annual Meeting Abstract June 2022

Viral delivery approaches for CRISPR/Cas9-based knockdown of the Myocilin gene in Trabecular Meshwork

Shruti V Patil; Sam Yacoub; Bindu Kodati; Bhavani Nagarajan; J Cameron Millar; Ramesh B Kasetti; Stacy Curry; Charles Kiehlbauch; Charles C. Searby; Qihong Zhang; Abbot F Clark; Val C. Sheffield; Gulab Zode

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):87 – A0060.

Perspective February 2022

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

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Colleen M. McDowell; Krishnakumar Kizhatil; Michael H. Elliott; Darryl R. Overby; Joseph van Batenburg-Sherwood; J. Cameron Millar; Markus H. Kuehn; Gulab Zode; Ted S. Acott; Michael G. Anderson; Sanjoy K. Bhattacharya; Jacques A. Bertrand; Terete Borras; Diane E. Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A. Faralli; Rudolf Fuchshofer; Preethi S. Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W. M. John; Paul L. Kaufman; Kate E. Keller; Mary J. Kelley; Ruth A. Kelly; David Krizaj; Ajay Kumar; Brian C. Leonard; Raquel L. Lieberman; Paloma Liton; Yutao Liu; Katy C. Liu; Navita N. Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J. McLellan; Philip Mzyk; Andrews Nartey; Louis R. Pasquale; Gaurang C. Patel; Padmanabhan P. Pattabiraman; Donna M. Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R. Samples; E. Griffen Samples; Najam Sharif; Joel S. Schuman; Val C. Sheffield; Cooper H. Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B. Toris; Karen Y. Torrejon; Amir Vahabikashi; Janice A. Vranka; Ting Wang; Colin E. Willoughby; Chen Xin; Hongmin Yun; Hao F. Zhang; Michael P. Fautsch; Ernst R. Tamm; Abbot F. Clark; C. Ross Ethier; W. Daniel Stamer
TAGS: eye, mice, ocular hypertension, intraocular pressure, perfusion
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):12. https://doi.org/10.1167/iovs.63.2.12

ARVO Annual Meeting Abstract June 2020

Increased expression of the chronic ER stress-induced transcriptional factor, ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

Ramesh Kasetti; Pinkal Patel; Prabhavathi Maddineni; Shruti Patil; Charles Kiehlbauch; J Cameron Millar; Charles Searby; Val C Sheffield; Gulab Zode

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1236.

ARVO Annual Meeting Abstract June 2020

Retinal degeneration in BBS10 mice is ameliorated by subretinal gene replacement

Arlene V Drack; Sajag Bhattarai; Jacintha Thomas; Elliot Stalter; Poppy Datta; ying Hsu; Janelle Garrison; Charles Searby; Luk H Vandenberghe; Elise Heon; Seongjin Seo; Val C Sheffield

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1914.

ARVO Annual Meeting Abstract June 2020

Positively Charged TPGS-Chiotsan Nanocapsules as a Non-Viral Vector for Glaucoma Gene Therapy

Kesavan Karthikeyan; Ankur Jain; Matthew Cring; Charles Searby; Val C Sheffield

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2896.

ARVO Annual Meeting Abstract July 2018

Determination of the optimal time window for gene replacement therapies for blindness using an inducible rescue mouse model of Bardet-Biedl Syndrome

Ying Hsu; Janelle Garrison; Gunhee Kim; Arlene V Drack; Darryl Nishimura; Seongjin Seo; Val C. Sheffield

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3962.

ARVO Annual Meeting Abstract July 2018

Primary Cilia and Extracellular Matrix Interactions in Trabecular Meshwork Cells

Ankur Jain; Wei Zhu; Qihong Zhang; Markus H Kuehn; Abbot F. Clark; Val C. Sheffield

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4721.

Glaucoma April 2017

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma

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Wei Zhu; Ankur Jain; Oliver W. Gramlich; Budd A. Tucker; Val C. Sheffield; Markus H. Kuehn
TAGS: aqueous humor, glaucoma, intraocular pressure, mice, mice, transgenic, myoc gene, trabecular meshwork, transplantation, eye, painful bladder syndrome
Invest. Ophthalmol. Vis. Sci.. 2017; 58(4):2054-2062. https://doi.org/10.1167/iovs.16-20672

ARVO Annual Meeting Abstract June 2015

CRISPR-Cas9 Mediated Genome Editing of Myocilin in Trabecular Meshwork Cells

Ankur Jain; Gulab Zode; Charles Searby; Abbot F Clark; Val C Sheffield

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3187.

ARVO Annual Meeting Abstract June 2015

Resolving genotype-phenotype mismatches in whole-exome based genetic testing.

Adam P DeLuca; Matthew Thurtell; Robert A Madumba; Todd E Scheetz; Val C Sheffield; Edwin M Stone

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):1255.

ARVO Annual Meeting Abstract June 2015

Functional Characterization of the Bardet-Biedl Syndrome1 M390R Mutation in Zebrafish

Diane C Slusarski; Lisa Baye; Trudi Westfall; Gunhee Kim; Val C Sheffield

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):2598.

Glaucoma May 2015

Rat, Mouse, and Primate Models of Chronic Glaucoma Show Sustained Elevation of Extracellular ATP and Altered Purinergic Signaling in the Posterior Eye

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Wennan Lu; HuiLing Hu; Jean Sévigny; B'Ann T. Gabelt; Paul L. Kaufman; Elaine C. Johnson; John C. Morrison; Gulab S. Zode; Val C. Sheffield; Xiulan Zhang; Alan M. Laties; Claire H. Mitchell
TAGS: eye, glaucoma, intraocular pressure, mice, primates, entpd1 gene, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2015; 56(5):3075-3083. https://doi.org/10.1167/iovs.14-15891

Includes: Supplemental Content

ARVO Annual Meeting Abstract March 2012

Topical Ocular Sodium 4-phenylbutyrate Rescues Glaucoma In A Myocilin Mouse Model Of Primary Open Angle Glaucoma

Gulab S. Zode; Kevin E. Bugge; Sinisa D. Grozdanic; Randy H. Kardon; Michael G. Anderson; Edwin M. Stone; Val C. Sheffield

Invest. Ophthalmol. Vis. Sci.. 2012; 53(14):4678.

Glaucoma March 2012

Topical Ocular Sodium 4-Phenylbutyrate Rescues Glaucoma in a Myocilin Mouse Model of Primary Open-Angle Glaucoma

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Gulab S. Zode; Kevin E. Bugge; Kabhilan Mohan; Sinisa D. Grozdanic; Joseph C. Peters; Demelza R. Koehn; Michael G. Anderson; Randy H. Kardon; Edwin M. Stone; Val C. Sheffield
TAGS: mice, myoc gene, glaucoma, open-angle glaucoma, sodium, phenylbutyrates
Invest. Ophthalmol. Vis. Sci.. 2012; 53(3):1557-1565. https://doi.org/10.1167/iovs.11-8837

Translational Research January 2012

TUDCA Slows Retinal Degeneration in Two Different Mouse Models of Retinitis Pigmentosa and Prevents Obesity in Bardet-Biedl Syndrome Type 1 Mice

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Arlene V. Drack; Alina V. Dumitrescu; Sajag Bhattarai; Daniel Gratie; Edwin M. Stone; Robert Mullins; Val C. Sheffield
TAGS: bardet-biedl syndrome, electroretinography, mice, obesity, retinal degeneration, retinitis pigmentosa, histology
Invest. Ophthalmol. Vis. Sci.. 2012; 53(1):100-106. https://doi.org/10.1167/iovs.11-8544

Glaucoma September 2011

Copy Number Variations and Primary Open-Angle Glaucoma

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Lea K. Davis; Kacie J. Meyer; Emily I. Schindler; John S. Beck; Danielle S. Rudd; A. Jason Grundstad; Todd E. Scheetz; Terry A. Braun; John H. Fingert; Wallace L. M. Alward; Young H. Kwon; James C. Folk; Stephen R. Russell; Thomas H. Wassink; Val C. Sheffield; Edwin M. Stone
TAGS: copy number polymorphism, glaucoma, open-angle glaucoma, single nucleotide polymorphism
Invest. Ophthalmol. Vis. Sci.. 2011; 52(10):7122-7133. https://doi.org/10.1167/iovs.10-5606

Includes: Supplemental Content

ARVO Annual Meeting Abstract April 2011

Analysis of 200 Human Exomes for Improved Mutation Detection Specificity

Edwin M. Stone; Adam DeLuca; Todd E. Scheetz; Terry A. Braun; Louisa M. Affatigato; Heather T. Daggett; Rebecca M. Johnston; Megan R. Streb; Val C. Sheffield

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):3314.

ARVO Annual Meeting Abstract April 2011

A Chemical Chaperone Rescues Glaucoma By Reducing ER Stress In A Novel Murine Model Of Primary Open Angle Glaucoma

Gulab S. Zode; Darryl Y. Nishimura; Qiong Ding; Charles C. Searby; Kabhilan Mohan; Sinisa D. Grozdanic; Edvin M. Stone; Val C. Sheffield; Markus H. Kuehn

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):5917.

ARVO Annual Meeting Abstract April 2011

Genetic Analysis and Phenotypic Staging of Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy

Vinit B. Mahajan; James C. Folk; John H. Fingert; Jessica M. Skeie; Tyson R. Kinnick; Todd C. Scheetz; Alexander G. Bassuk; J. Robert Manak; Val C. Sheffield; Edwin M. Stone

Invest. Ophthalmol. Vis. Sci.. 2011; 52(14):62.

ARVO Annual Meeting Abstract April 2010

Different Bipolar Cell Input Pathways for Negative Masking and the Pupil Light Reflex in Mice

S. Thompson; E. L. Nylen; J. S. East; R. H. Kardon; L. H. Pinto; V. C. Sheffield; S. F. Stasheff; R. F. Mullins; E. M. Stone

Invest. Ophthalmol. Vis. Sci.. 2010; 51(13):669.

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Viral delivery approaches for CRISPR/Cas9-based knockdown of the Myocilin gene in Trabecular Meshwork

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

Increased expression of the chronic ER stress-induced transcriptional factor, ATF4 leads to glaucoma by promoting protein synthesis and ER client protein load

Retinal degeneration in BBS10 mice is ameliorated by subretinal gene replacement

Positively Charged TPGS-Chiotsan Nanocapsules as a Non-Viral Vector for Glaucoma Gene Therapy

Determination of the optimal time window for gene replacement therapies for blindness using an inducible rescue mouse model of Bardet-Biedl Syndrome

Primary Cilia and Extracellular Matrix Interactions in Trabecular Meshwork Cells

Restoration of Aqueous Humor Outflow Following Transplantation of iPSC-Derived Trabecular Meshwork Cells in a Transgenic Mouse Model of Glaucoma

CRISPR-Cas9 Mediated Genome Editing of Myocilin in Trabecular Meshwork Cells

Resolving genotype-phenotype mismatches in whole-exome based genetic testing.

Functional Characterization of the Bardet-Biedl Syndrome1 M390R Mutation in Zebrafish

Rat, Mouse, and Primate Models of Chronic Glaucoma Show Sustained Elevation of Extracellular ATP and Altered Purinergic Signaling in the Posterior Eye

Topical Ocular Sodium 4-phenylbutyrate Rescues Glaucoma In A Myocilin Mouse Model Of Primary Open Angle Glaucoma

Topical Ocular Sodium 4-Phenylbutyrate Rescues Glaucoma in a Myocilin Mouse Model of Primary Open-Angle Glaucoma

TUDCA Slows Retinal Degeneration in Two Different Mouse Models of Retinitis Pigmentosa and Prevents Obesity in Bardet-Biedl Syndrome Type 1 Mice

Copy Number Variations and Primary Open-Angle Glaucoma

Analysis of 200 Human Exomes for Improved Mutation Detection Specificity

A Chemical Chaperone Rescues Glaucoma By Reducing ER Stress In A Novel Murine Model Of Primary Open Angle Glaucoma

Genetic Analysis and Phenotypic Staging of Autosomal Dominant Neovascular Inflammatory Vitreoretinopathy

Different Bipolar Cell Input Pathways for Negative Masking and the Pupil Light Reflex in Mice

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