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ARVO Annual Meeting Abstract June 2024

A canine model for ABCA4 Stargardt disease: in-vivo phenotypic characterization and natural disease history

Valerie L. Dufour; Artur V Cideciyan; Jennifer Kwork; Alexa Gray; Yu Sato; Kyle Quigley; William A Beltran; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4739.

ARVO Annual Meeting Abstract June 2024

Clinical characterization of canine cone-rod dystrophy with early foveo-macular degeneration

Gustavo D Aguirre; Valerie L. Dufour; Leonardo Murgiano; Jennifer Caroline Kwok; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):4734.

ARVO Annual Meeting Abstract June 2022

Long-term follow up of gene therapy for NPHP5 -LCA in a canine model shows restoration of photoreceptor function and vision for > 5 years

William A Beltran; Artur V Cideciyan; Ana Ripolles-Garcia; Valerie L Dufour; Yu Sato; Alexa Gray; Malgorzata Swider; Sanford L Boye; William W Hauswirth; Samuel G. Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):454.

ARVO Annual Meeting Abstract June 2020

Subretinal transplantation and survival of hESC-derived photoreceptor precursor cells in normal canine eyes

Ana Ripolles Garcia; Valerie Dufour; Joe Phillips; Natalia Dolgova; Allison Ludwig; Sara Stuedemann; Svetlana Savina; John H Wolfe; Karina E Guziewicz; Oliver Garden; David M Gamm; Gustavo D Aguirre; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):796.

ARVO Annual Meeting Abstract June 2020

A newly recognized canine phenotype of early-onset retinal degeneration

Karina E Guziewicz; Valerie Dufour; Lauren Lew; Brian Thomas Kendrick; Ana Ripolles Garcia; William A Beltran; Artur V Cideciyan; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):2792.

ARVO Annual Meeting Abstract June 2020

AAV capsid variants target canine and primate bipolar cells after subretinal and intravitreal delivery

William A Beltran; Natalia Dolgova; Valerie L Dufour; Iwabe Simone; Ryan F. Boyd; Joshua T Bartoe; Gustavo D Aguirre; David L schaffer; John Gerard Flannery; Leah Byrne

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):4489.

ARVO Annual Meeting Abstract July 2019

Long-term longitudinal assessment of functional rescue in mutant XLRP dogs after RPGR gene augmentation therapy

William A Beltran; Valerie L Dufour; Sommer M Ainsworth; Karolina Roszak; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4031.

ARVO Annual Meeting Abstract July 2019

Safety and long-term efficacy of AAV2- BEST1 gene augmentation therapy in canine model of Best vitelliform macular dystrophies

Karina E Guziewicz; Artur V Cideciyan; Brian T. Kendrick; Valerie L Dufour; Gordon Ruthel; Andras M Komaromy; Simone Iwabe; William Hauswirth; William A Beltran; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5200.

ARVO Annual Meeting Abstract July 2018

Isolated population helps tease out a third locus underlying a multigenic form of canine RPGRIP1 cone-rod dystrophy

Keiko Miyadera; Leonardo Murgiano; Courtney Spector; Felipe Pompeo Marinho; Valerie Dufour; Rueben G Das; Matthew Brooks; Anand Swaroop; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):1438.

ARVO Annual Meeting Abstract July 2018

BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments

Karina E Guziewicz; Artur V Cideciyan; William A Beltran; Andras M Komaromy; Valerie Dufour; Malgorzata Swider; Simone Iwabe; Alexander Sumaroka; Brian T Kendrick; Gordon Ruthel; Vince A Chiodo; Elise Heon; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4522.

ARVO Annual Meeting Abstract July 2018

AAV-mediated expression of X-linked Inhibitor of Apoptosis protects photoreceptors in two canine models of early onset RP

William A Beltran; Artur V Cideciyan; Simone Iwabe; Valerie Dufour; Jason Charng; Brianna Lisi; Jose-Manuel Guzman; Alireza Badiei; Catherine Tsilfidis; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4527.

ARVO Annual Meeting Abstract July 2018

Long-term preservation of photoreceptor function and structure following early-stage treatment by AAV-mediated gene augmentation in canine model of NPHP5 Leber congenital amaurosis

Gustavo D Aguirre; Artur V Cideciyan; Sanford L Boye; Simone Iwabe; Valerie Dufour; Malgorzata Swider; Karolina Roszak; William W Hauswirth; Samuel G Jacobson; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):6006.

ARVO Annual Meeting Abstract June 2017

Variable cone dysfunction and progressive ophthalmoscopic changes in a canine model of RPGRIP1 and MAP9 multigenic cone-rod dystrophy

Keiko Miyadera; Felipe Pompeo Marinho; Kendra McDaid; Valerie Liliane Dufour; Simone Iwabe; Gautami Das; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):269.

ARVO Annual Meeting Abstract June 2017

Influence of Ambient Illumination on the Course of Retinal Degeneration in a Canine model of RHO-ADRP

Valerie Liliane Dufour; Simone Iwabe; Gustavo D Aguirre; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):278.

ARVO Annual Meeting Abstract June 2017

Outcome measures for BEST1 gene augmentation therapy: restoration of RPE-photoreceptor interface homeostasis

Karina E Guziewicz; William A Beltran; Artur V Cideciyan; Valerie Liliane Dufour; Andras M Komaromy; Emily McTish; Alfred S Lewin; William W Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2273.

ARVO Annual Meeting Abstract June 2017

AAV-mediated Knockdown and Replacement of Rhodopsin Protects Rods in a Canine Model of RHO -ADRP

William A Beltran; Artur V Cideciyan; Raghavi Sudharsan; Michael Massengill; Brian Rossmiller; Valerie Liliane Dufour; felipe Pompeo Marinho; Tatyana Appelbaum; Malgorzata Swider; Mychajlo S. Kosyk; Simone Iwabe; William W Hauswirth; Samuel G Jacobson; Alfred S Lewin; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4483.

ARVO Annual Meeting Abstract June 2017

Evaluation of AAV2tYF-GRK1-RPGR vectors in a canine model of RPGR -XLRP

Guo-jie Ye; William A Beltran; Valerie Liliane Dufour; Felipe Pompeo Marinho; Inna Martynyuk; Chuanjian Song; David Knop; Gustavo D Aguirre; Jeffrey D Chulay; Mark S Shearman

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):4486.

ARVO Annual Meeting Abstract September 2016

Directed evolution identifies novel AAV capsid variants for targeting the canine outer retina following intravitreal delivery

Leah C Byrne; Meike Visel; Valerie Dufour; Felipe Pompeo Marinho; Gustavo D Aguirre; William A Beltran; David Schaffer; John Gerard Flannery

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):776.

ARVO Annual Meeting Abstract September 2016

Two AAV2/5-mediated RPGR gene augmentation constructs driven by the GRK1 promoter rescue photoreceptor structure and function in a canine model o f RPGR X-linked retinitis pigmentosa

William A Beltran; Artur V Cideciyan; Simone Iwabe; Valerie Dufour; Felipe Pompeo Marinho; Guo-jie Ye; Mark Shearman; Jeffrey D Chulay; William Hauswirth; Samuel G Jacobson; Gustavo D Aguirre

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):785.

ARVO Annual Meeting Abstract September 2016

AAV-mediated gene augmentation restores retinal function and vision in the canine model of NPHP5 Leber congenital amaurosis

Gustavo D Aguirre; Artur V Cideciyan; Sanford L. Boye; Simone Iwabe; Valerie Dufour; Felipe Pompeo Marinho; Louise M Downs; William Hauswirth; Samuel G Jacobson; William A Beltran

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12)

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A canine model for ABCA4 Stargardt disease: in-vivo phenotypic characterization and natural disease history

Clinical characterization of canine cone-rod dystrophy with early foveo-macular degeneration

Long-term follow up of gene therapy for NPHP5 -LCA in a canine model shows restoration of photoreceptor function and vision for > 5 years

Subretinal transplantation and survival of hESC-derived photoreceptor precursor cells in normal canine eyes

A newly recognized canine phenotype of early-onset retinal degeneration

AAV capsid variants target canine and primate bipolar cells after subretinal and intravitreal delivery

Long-term longitudinal assessment of functional rescue in mutant XLRP dogs after RPGR gene augmentation therapy

Safety and long-term efficacy of AAV2- BEST1 gene augmentation therapy in canine model of Best vitelliform macular dystrophies

Isolated population helps tease out a third locus underlying a multigenic form of canine RPGRIP1 cone-rod dystrophy

BEST1 gene augmentation therapy corrects light-modulated retinal micro-detachments

AAV-mediated expression of X-linked Inhibitor of Apoptosis protects photoreceptors in two canine models of early onset RP

Long-term preservation of photoreceptor function and structure following early-stage treatment by AAV-mediated gene augmentation in canine model of NPHP5 Leber congenital amaurosis

Variable cone dysfunction and progressive ophthalmoscopic changes in a canine model of RPGRIP1 and MAP9 multigenic cone-rod dystrophy

Influence of Ambient Illumination on the Course of Retinal Degeneration in a Canine model of RHO-ADRP

Outcome measures for BEST1 gene augmentation therapy: restoration of RPE-photoreceptor interface homeostasis

AAV-mediated Knockdown and Replacement of Rhodopsin Protects Rods in a Canine Model of RHO -ADRP

Evaluation of AAV2tYF-GRK1-RPGR vectors in a canine model of RPGR -XLRP

Directed evolution identifies novel AAV capsid variants for targeting the canine outer retina following intravitreal delivery

Two AAV2/5-mediated RPGR gene augmentation constructs driven by the GRK1 promoter rescue photoreceptor structure and function in a canine model o f RPGR X-linked retinitis pigmentosa

AAV-mediated gene augmentation restores retinal function and vision in the canine model of NPHP5 Leber congenital amaurosis

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