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ARVO Annual Meeting Abstract June 2022

The phase III REFLECT trial: efficacy of bilateral gene therapy for Leber hereditary optic neuropathy (LHON) is maintained 2 years post administration

Patrick Yu-Wai-Man; Nancy Newman; Prem S Subramanian; Mark Moster; An-Guor Wang; Sean Donahue; Bart Leroy; Valerio Carelli; Valerie Biousse; Catherine Vignal-Clermont; Alfredo A Sadun; Gema Fernandez; Elizabeth Fortin; Rudrani Banik; Magali Taiel; Jose Alain Sahel

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):434. doi:

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology January 2022

Longitudinal Study of Optic Disk Perfusion and Retinal Structure in Leber's Hereditary Optic Neuropathy

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Giacomo Calzetti; Chiara La Morgia; Marco Cattaneo; Arturo Carta; Francesca Bosello; Giulia Amore; Michele Carbonelli; Maria Lucia Cascavilla; Stefano Gandolfi; Valerio Carelli; Leopold Schmetterer; Hendrik P. N. Scholl; Piero Barboni
TAGS: longitudinal studies, optic atrophy, hereditary, leber, optic disk, perfusion, retina, vascular flow
Invest. Ophthalmol. Vis. Sci.. 2022; 63(1):43. doi: https://doi.org/10.1167/iovs.63.1.43

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2021

Evaluation of the efficacy of rAAV2/2- ND4 gene therapy for Leber hereditary optic neuropathy compared with the natural history

Patrick Yu-Wai-Man; Nancy J Newman; Valerio Carelli; Mark Moster; Catherine Vignal-Clermont; Alfredo A Sadun; Chiara La Morgia; Francesco Bandello; Lorena Castillo Campillo; Stephanie Leruez; Dean Cestari; Robert Foroozan; Rustum Karanjia; Laure Blouin; Magali Taiel; Jose Alain Sahel

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2676. doi:

ARVO Annual Meeting Abstract June 2020

Longitudinal Analysis of Photopic Negative Response in Carriers and Affected Members of the 11778 SOA-BR Leber’s Hereditary Optic Neuropathy Pedigree

Adriana Berezovsky; Rustum Karanjia; Paula Y Sacai; Milton Nunes Moraes Filho; Arthur Fernandes; Gabriel Izan Santos Botelho; Rubens Belfort Jr.; Valerio Carelli; Alfredo A. Sadun; Solange Rios Salomao

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5050. doi:

ARVO Annual Meeting Abstract June 2020

Bilateral Visual Improvement with Unilateral Gene Therapy for Leber Hereditary Optic Neuropathy (LHON)

Patrick Yu-Wai-Man; Nancy J Newman; Valerio Carelli; Valerie Biousse; Alfredo A. Sadun; Mark L Moster; Catherine Vignal-Clermont; Robert C Sergott; Thomas Klopstock klopstock; Laure Blouin; Magali Taiel; Pierre Burguière; Caroline Chevalier; Barrett Katz; Jose Alain Sahel

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):5181. doi:

ARVO Annual Meeting Abstract July 2019

Idebenone treatment increases chances of stabilization-recovery of visual acuity in patients affected by dominant optic atrophy (DOA)

Martina Romagnoli; Chiara La Morgia; Michele Carbonelli; Lidia Di Vito; Piero Barboni; Valerio Carelli

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2271. doi:

ARVO Annual Meeting Abstract July 2019

Blue light stimulation of melanopsin retinal ganglion cells reveals visual cortex activation and modulates cognition in LHON patients

Chiara La Morgia; Stefania Evangelisti; Claudia Testa; Gilles Vandewalle; Claudio Bianchini; David Neil Manners; Paola Fantazzini; Michele Carbonelli; Alfredo A Sadun; Caterina Tonon; Raffaele Lodi; Valerio Carelli

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2272. doi:

ARVO Annual Meeting Abstract July 2019

The landscape of mitogenomes from LHON patients carrying the m.14484T>C/MT-ND6 mutation

Valerio Carelli; Leonardo Caporali; Francesca Tagliavini; Chiara La Morgia; Alessandro Achilli; Anna Olivieri; Antonio Torroni

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3601. doi:

ARVO Annual Meeting Abstract July 2019

rAAV2/2- ND4 for the Treatment of Leber Hereditary Optic Neuropathy (LHON): 72-Week Data from the REVERSE Phase III Clinical Trial

Patrick Yu-Wai-Man; Mark Moster; Alfredo A Sadun; Thomas Klopstock; Catherine Vignal-Clermont; Nancy J Newman; Robert C Sergott; Valerio Carelli; Caroline Chevalier; Laure Blouin; Magali Taiel; Barrett Katz; Jose Alain Sahel

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):4806. doi:

ARVO Annual Meeting Abstract July 2018

Understanding the onset of Leber's Hereditary Optic Neuropathy

Rustum Karanjia; Henry Liu; Chiara La Morgia; Samir Nazarali; Milton Moraes Filho; Michele Carbonelli; Adriana Berezovsky; Lidia Di Vito; Anna Maria De Negri; Carolina Ramos; Alexander Liam; Rubens Belfort Jr; Solange Salomao; Patrick Yu-Wai-Man; Alfredo A Sadun; Valerio Carelli

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3356. doi:

ARVO Annual Meeting Abstract July 2018

Cardiovascular comorbidity in Leber’s hereditary optic neuropathy mtDNA 11778

Starleen Frousiakis; Jeffrey Tran; Rustum Karanjia; Samuel Asanad; Jesse Gale; Jack Tian; Andrew E Pouw; Gary Conrad; Milton Moraes Filho; Solange Salomao; Rubens Belfort Jr; Peter A Quiros; Stratos Christianakis; Valerio Carelli; Alfredo A Sadun

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3366. doi:

Special Issue October 2017

The Photopic Negative Response: An Objective Measure of Retinal Ganglion Cell Function in Patients With Leber's Hereditary Optic Neuropathy

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Rustum Karanjia; Adriana Berezovsky; Paula Yuri Sacai; Nivea Nunes Cavascan; Henry Yuheng Liu; Samir Nazarali; Milton Nunes Moraes-Filho; Kirsten Anderson; Jeffrey Show Tran; Sung EunSong Watanabe; Milton Nunes Moraes; Federico Sadun; Anna Maria DeNegri; Piero Barboni; Carolina do Val Ferreira Ramos; Chiara La Morgia; Valerio Carelli; Rubens Belfort, Jr; Stuart Glenn Coupland; Solange Rios Salomao; Alfredo A. Sadun
TAGS: optic atrophy, hereditary, leber, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO300-BIO306. doi: https://doi.org/10.1167/iovs.17-21773

ARVO Annual Meeting Abstract June 2017

Indications of mitochondrial dysfunction in Wolfram syndrome.

Chiara La Morgia; Michele Carbonelli; Leonardo Caporali; Francesca Tagliavini; Giulia Amore; federico sadun; Caterina Tonon; Ludovica Gramegna; Raffaele Lodi; Piero Barboni; Rocco Liguori; Valerio Carelli

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5132. doi:

ARVO Annual Meeting Abstract June 2017

Visual function changes in patients with Leber’s hereditary optic neuropathy during one year of follow-up.

Vincenzo Parisi; Lucia Ziccardi; federico sadun; Anna Maria De Negri; chiara la morgia; Piero Barboni; Valerio Carelli

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3863. doi:

ARVO Annual Meeting Abstract June 2017

Preliminary Baseline Characteristics of Patients with Leber Hereditary Optic Neuropathy (LHON) Enrolled in the RESCUE and REVERSE Clinical Gene Therapy Trials

Patrick Yu-Wai-Man; Nancy J Newman; Robert Sergott; Molly Scannell Bryan; Valerio Carelli; Thomas Klopstock; Mark Moster; Alfredo A. Sadun; Jose Alain Sahel; Catherine Vignal; Scott Uretsky

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3865. doi:

ARVO Annual Meeting Abstract June 2015

Electron microscopy of human melanopsin retinal ganglion cells

Jesse Gale; Fred N Ross-Cisneros; Chiara La Morgia; Ernesto Barron; Jens Hannibal; Carla Giordano; Valerio Carelli; Alfredo A Sadun

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):834. doi:

ARVO Annual Meeting Abstract June 2015

Clinically-Significant Cardiac Pathology in Leber’s Hereditary Optic Neuropathy

Starleen E Frousiakis; Rustum Karanjia; Jeffrey S Tran; Andrew E Pouw; Chiara La Morgia; Milton Moraes; Solange Rios Salomao; Peter Quiros; Valerio Carelli; Alfredo A Sadun

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3856. doi:

ARVO Annual Meeting Abstract April 2014

Melanopsin Retinal Ganglion Cells are Spared in Wolfram Syndrome

Fred N Ross-Cisneros; Chiara La Morgia; Billy Xiaoyi Pan; Jens Hannibal; Neil Miller; Valerio Carelli; Alfredo A Sadun

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1236. doi:

ARVO Annual Meeting Abstract April 2014

Although smoking and alcohol are known to increase incidence of Leber's Hereditary Optic Neuropathy (LHON) only smoking increases severity of LHON.

Rustum Karanjia; Jeffery Tran; Edward Rickie Chu; Jesse Gale; Starleen Elizabeth Frousiakis; Andrew Pouw; Christianne A Wa; Milton Moraes; Solange Rios Salomao; Valerio Carelli

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6203. doi:

ARVO Annual Meeting Abstract April 2014

Multifocal bioelectrical cortical responses in Leber Hereditary Optic Neuropathy

Vincenzo Parisi; Lucia Ziccardi; Daniela Giannini; Federico Sadun; Anna Maria De Negri; Giacomo Savini; Piero Barboni; Chiara La Morgia; Valerio Carelli

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6204. doi:

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The phase III REFLECT trial: efficacy of bilateral gene therapy for Leber hereditary optic neuropathy (LHON) is maintained 2 years post administration

Longitudinal Study of Optic Disk Perfusion and Retinal Structure in Leber's Hereditary Optic Neuropathy

Evaluation of the efficacy of rAAV2/2- ND4 gene therapy for Leber hereditary optic neuropathy compared with the natural history

Longitudinal Analysis of Photopic Negative Response in Carriers and Affected Members of the 11778 SOA-BR Leber’s Hereditary Optic Neuropathy Pedigree

Bilateral Visual Improvement with Unilateral Gene Therapy for Leber Hereditary Optic Neuropathy (LHON)

Idebenone treatment increases chances of stabilization-recovery of visual acuity in patients affected by dominant optic atrophy (DOA)

Blue light stimulation of melanopsin retinal ganglion cells reveals visual cortex activation and modulates cognition in LHON patients

The landscape of mitogenomes from LHON patients carrying the m.14484T>C/MT-ND6 mutation

rAAV2/2- ND4 for the Treatment of Leber Hereditary Optic Neuropathy (LHON): 72-Week Data from the REVERSE Phase III Clinical Trial

Understanding the onset of Leber's Hereditary Optic Neuropathy

Cardiovascular comorbidity in Leber’s hereditary optic neuropathy mtDNA 11778

The Photopic Negative Response: An Objective Measure of Retinal Ganglion Cell Function in Patients With Leber's Hereditary Optic Neuropathy

Indications of mitochondrial dysfunction in Wolfram syndrome.

Visual function changes in patients with Leber’s hereditary optic neuropathy during one year of follow-up.

Preliminary Baseline Characteristics of Patients with Leber Hereditary Optic Neuropathy (LHON) Enrolled in the RESCUE and REVERSE Clinical Gene Therapy Trials

Electron microscopy of human melanopsin retinal ganglion cells

Clinically-Significant Cardiac Pathology in Leber’s Hereditary Optic Neuropathy

Melanopsin Retinal Ganglion Cells are Spared in Wolfram Syndrome

Although smoking and alcohol are known to increase incidence of Leber's Hereditary Optic Neuropathy (LHON) only smoking increases severity of LHON.

Multifocal bioelectrical cortical responses in Leber Hereditary Optic Neuropathy

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