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ARVO Annual Meeting Abstract July 2018

Understanding the onset of Leber's Hereditary Optic Neuropathy

Rustum Karanjia; Henry Liu; Chiara La Morgia; Samir Nazarali; Milton Moraes Filho; Michele Carbonelli; Adriana Berezovsky; Lidia Di Vito; Anna Maria De Negri; Carolina Ramos; Alexander Liam; Rubens Belfort Jr; Solange Salomao; Patrick Yu-Wai-Man; Alfredo A Sadun; Valerio Carelli

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3356. doi:

ARVO Annual Meeting Abstract July 2018

Cardiovascular comorbidity in Leber’s hereditary optic neuropathy mtDNA 11778

Starleen Frousiakis; Jeffrey Tran; Rustum Karanjia; Samuel Asanad; Jesse Gale; Jack Tian; Andrew E Pouw; Gary Conrad; Milton Moraes Filho; Solange Salomao; Rubens Belfort Jr; Peter A Quiros; Stratos Christianakis; Valerio Carelli; Alfredo A Sadun

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):3366. doi:

Special Issue October 2017

The Photopic Negative Response: An Objective Measure of Retinal Ganglion Cell Function in Patients With Leber's Hereditary Optic Neuropathy

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Rustum Karanjia; Adriana Berezovsky; Paula Yuri Sacai; Nivea Nunes Cavascan; Henry Yuheng Liu; Samir Nazarali; Milton Nunes Moraes-Filho; Kirsten Anderson; Jeffrey Show Tran; Sung EunSong Watanabe; Milton Nunes Moraes; Federico Sadun; Anna Maria DeNegri; Piero Barboni; Carolina do Val Ferreira Ramos; Chiara La Morgia; Valerio Carelli; Rubens Belfort, Jr; Stuart Glenn Coupland; Solange Rios Salomao; Alfredo A. Sadun
TAGS: optic atrophy, hereditary, leber, retinal ganglion cells
Invest. Ophthalmol. Vis. Sci.. 2017; 58(6):BIO300-BIO306. doi: 10.1167/iovs.17-21773

ARVO Annual Meeting Abstract June 2017

Visual function changes in patients with Leber’s hereditary optic neuropathy during one year of follow-up.

Vincenzo Parisi; Lucia Ziccardi; federico sadun; Anna Maria De Negri; chiara la morgia; Piero Barboni; Valerio Carelli

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3863. doi:

ARVO Annual Meeting Abstract June 2017

Preliminary Baseline Characteristics of Patients with Leber Hereditary Optic Neuropathy (LHON) Enrolled in the RESCUE and REVERSE Clinical Gene Therapy Trials

Patrick Yu-Wai-Man; Nancy J Newman; Robert Sergott; Molly Scannell Bryan; Valerio Carelli; Thomas Klopstock; Mark Moster; Alfredo A. Sadun; Jose Alain Sahel; Catherine Vignal; Scott Uretsky

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3865. doi:

ARVO Annual Meeting Abstract June 2017

Indications of mitochondrial dysfunction in Wolfram syndrome.

Chiara La Morgia; Michele Carbonelli; Leonardo Caporali; Francesca Tagliavini; Giulia Amore; federico sadun; Caterina Tonon; Ludovica Gramegna; Raffaele Lodi; Piero Barboni; Rocco Liguori; Valerio Carelli

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5132. doi:

ARVO Annual Meeting Abstract June 2015

Clinically-Significant Cardiac Pathology in Leber’s Hereditary Optic Neuropathy

Starleen E Frousiakis; Rustum Karanjia; Jeffrey S Tran; Andrew E Pouw; Chiara La Morgia; Milton Moraes; Solange Rios Salomao; Peter Quiros; Valerio Carelli; Alfredo A Sadun

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):3856. doi:

ARVO Annual Meeting Abstract June 2015

Electron microscopy of human melanopsin retinal ganglion cells

Jesse Gale; Fred N Ross-Cisneros; Chiara La Morgia; Ernesto Barron; Jens Hannibal; Carla Giordano; Valerio Carelli; Alfredo A Sadun

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):834. doi:

ARVO Annual Meeting Abstract April 2014

Melanopsin Retinal Ganglion Cells are Spared in Wolfram Syndrome

Fred N Ross-Cisneros; Chiara La Morgia; Billy Xiaoyi Pan; Jens Hannibal; Neil Miller; Valerio Carelli; Alfredo A Sadun

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):1236. doi:

ARVO Annual Meeting Abstract April 2014

Although smoking and alcohol are known to increase incidence of Leber's Hereditary Optic Neuropathy (LHON) only smoking increases severity of LHON.

Rustum Karanjia; Jeffery Tran; Edward Rickie Chu; Jesse Gale; Starleen Elizabeth Frousiakis; Andrew Pouw; Christianne A Wa; Milton Moraes; Solange Rios Salomao; Valerio Carelli

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6203. doi:

ARVO Annual Meeting Abstract April 2014

Multifocal bioelectrical cortical responses in Leber Hereditary Optic Neuropathy

Vincenzo Parisi; Lucia Ziccardi; Daniela Giannini; Federico Sadun; Anna Maria De Negri; Giacomo Savini; Piero Barboni; Chiara La Morgia; Valerio Carelli

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6204. doi:

ARVO Annual Meeting Abstract April 2014

The mt11778/ND4 mutation, in Leber’s hereditary optic neuropathy, is associated with less degeneration in the peripheral nerve compared to the mt3460/ND1 mutation

Edward Rickie Chu; Fred N Ross-Cisneros; Anh Hoang Pham; Jesse Gale; Milton Moraes; Solange Rios Salomao; Adriana Berezovsky; Valerio Carelli; Rubens Belfort, Jr.; Alfredo A Sadun

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6208. doi:

ARVO Annual Meeting Abstract April 2014

Characterization of a Novel OPA1 Mouse Model by Light and Transmission Electron Microscopy

Anh Hoang Pham; Fred N Ross-Cisneros; Billy Xiaoyi Pan; Marta Zaninello; Luca Scorrano; Valerio Carelli; Alfredo A Sadun

Invest. Ophthalmol. Vis. Sci.. 2014; 55(13):6437. doi:

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology October 2013

Retinal Function and Neural Conduction Along the Visual Pathways in Affected and Unaffected Carriers With Leber's Hereditary Optic Neuropathy

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Lucia Ziccardi; Federico Sadun; Anna Maria De Negri; Piero Barboni; Giacomo Savini; Enrico Borrelli; Chiara La Morgia; Valerio Carelli; Vincenzo Parisi
TAGS: evoked potentials, visual, nerve conduction function, optic atrophy, hereditary, leber, visual pathways, eye
Invest. Ophthalmol. Vis. Sci.. 2013; 54(10):6893-6901. doi: 10.1167/iovs.13-12894

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology July 2013

The Pupil Light Reflex in Leber's Hereditary Optic Neuropathy: Evidence for Preservation of Melanopsin-Expressing Retinal Ganglion Cells

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Ana Laura A. Moura; Balázs V. Nagy; Chiara La Morgia; Piero Barboni; André Gustavo Fernandes Oliveira; Solange R. Salomão; Adriana Berezovsky; Milton Nunes de Moraes-Filho; Carlos Filipe Chicani; Rubens Belfort, Jr; Valerio Carelli; Alfredo A. Sadun; Donald C. Hood; Dora Fix Ventura
TAGS: optic atrophy, hereditary, leber, retinal ganglion cells, pupil light reflex, melanopsin
Invest. Ophthalmol. Vis. Sci.. 2013; 54(7):4471-4477. doi: 10.1167/iovs.12-11137

ARVO Annual Meeting Abstract June 2013

Optic nerve involvement in relation to rest-activity circadian rhythm in Alzheimer's disease

Chiara La Morgia; Roberto Gallassi; Luisa Sambati; Federica Provini; Piero Barboni; Valerio Carelli

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):3426. doi:

ARVO Annual Meeting Abstract June 2013

Linkage analysis in Leber’s hereditary optic neuropathy (LHON): failure to locate significant loci in a very large family indicates a polygenic/environmental complex contribution to penetrance

Valerio Carelli; Leonardo Caporali; Alessandra Maresca; Maria Valentino; Solange Salomao; Alfredo Sadun; Pio d'Adamo

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):1208. doi:

ARVO Annual Meeting Abstract June 2013

A Histopathologic and Morphometric Analysis of Degenerating Melanopsin Retinal Ganglion Cells in Alzheimer’s Disease

Fred Ross-Cisneros; Chiara La Morgia; Billy Pan; Jens Hannibal; Valerio Carelli; Alfredo Sadun

Invest. Ophthalmol. Vis. Sci.. 2013; 54(15):299. doi:

Anatomy and Pathology/Oncology November 2012

Mathematically Modeling the Involvement of Axons in Leber's Hereditary Optic Neuropathy

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Billy X. Pan; Fred N. Ross-Cisneros; Valerio Carelli; Kelly S. Rue; Solange R. Salomao; Milton N. Moraes-Filho; Milton N. Moraes; Adriana Berezovsky; Rubens Belfort, Jr; Alfredo A. Sadun
TAGS: axon, optic atrophy, hereditary, leber, optic nerve, optic nerve disorders, stress
Invest. Ophthalmol. Vis. Sci.. 2012; 53(12):7608-7617. doi: 10.1167/iovs.12-10452

Biochemistry and Molecular Biology September 2012

Neuron-Specific Enolase Is Elevated in Asymptomatic Carriers of Leber's Hereditary Optic Neuropathy

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Kenneth M. Yee; Fred N. Ross-Cisneros; Jeong Goo Lee; Arlon Bastos Da Rosa; Solange R. Salomao; Adriana Berezovsky; Rubens Belfort, Jr; Filipe Chicani; Milton Moraes-Filho; Jerry Sebag; Valerio Carelli; Alfredo A. Sadun
TAGS: carrier state, optic atrophy, hereditary, leber, neuron-specific enolase
Invest. Ophthalmol. Vis. Sci.. 2012; 53(10):6389-6392. doi: 10.1167/iovs.12-9677

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Understanding the onset of Leber's Hereditary Optic Neuropathy

Cardiovascular comorbidity in Leber’s hereditary optic neuropathy mtDNA 11778

The Photopic Negative Response: An Objective Measure of Retinal Ganglion Cell Function in Patients With Leber's Hereditary Optic Neuropathy

Visual function changes in patients with Leber’s hereditary optic neuropathy during one year of follow-up.

Preliminary Baseline Characteristics of Patients with Leber Hereditary Optic Neuropathy (LHON) Enrolled in the RESCUE and REVERSE Clinical Gene Therapy Trials

Indications of mitochondrial dysfunction in Wolfram syndrome.

Clinically-Significant Cardiac Pathology in Leber’s Hereditary Optic Neuropathy

Electron microscopy of human melanopsin retinal ganglion cells

Melanopsin Retinal Ganglion Cells are Spared in Wolfram Syndrome

Although smoking and alcohol are known to increase incidence of Leber's Hereditary Optic Neuropathy (LHON) only smoking increases severity of LHON.

Multifocal bioelectrical cortical responses in Leber Hereditary Optic Neuropathy

The mt11778/ND4 mutation, in Leber’s hereditary optic neuropathy, is associated with less degeneration in the peripheral nerve compared to the mt3460/ND1 mutation

Characterization of a Novel OPA1 Mouse Model by Light and Transmission Electron Microscopy

Retinal Function and Neural Conduction Along the Visual Pathways in Affected and Unaffected Carriers With Leber's Hereditary Optic Neuropathy

The Pupil Light Reflex in Leber's Hereditary Optic Neuropathy: Evidence for Preservation of Melanopsin-Expressing Retinal Ganglion Cells

Optic nerve involvement in relation to rest-activity circadian rhythm in Alzheimer's disease

Linkage analysis in Leber’s hereditary optic neuropathy (LHON): failure to locate significant loci in a very large family indicates a polygenic/environmental complex contribution to penetrance

A Histopathologic and Morphometric Analysis of Degenerating Melanopsin Retinal Ganglion Cells in Alzheimer’s Disease

Mathematically Modeling the Involvement of Axons in Leber's Hereditary Optic Neuropathy

Neuron-Specific Enolase Is Elevated in Asymptomatic Carriers of Leber's Hereditary Optic Neuropathy

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