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ARVO Annual Meeting Abstract June 2022

Investigation of fibrillin-1 and LOXL1 in ocular health and disease

Rachel W Kuchtey; Lauren wareham; Hangjing Wu; Evan Krystofiak; Yusheng Wu; Cynthia Reinhart-King; Vijaykrishna Raghunathan; Elena Pokidysheva; Sergei Budko; John Kuchtey

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):1923 – A0069. doi:

ARVO Annual Meeting Abstract June 2022

Effects of long-term application of topical ROCK inhibitor on corneal endothelium and Descemet’s membrane of TAZ deficient mice

Sara M Thomasy; Sangwan Park; Krista Cosert; Michelle Mccorkell; Nayeli Echeverria; Sophie M Le; Christopher J Murphy; Vijaykrishna Raghunathan; Brian C Leonard

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2280. doi:

ARVO Annual Meeting Abstract June 2022

Single cell-RNA sequencing analysis of corneal endothelial cells in TAZ deficient mice

Sangwan Park; Brian C Leonard; Michelle Ferneding; Sophie M Le; Monica Ardon; Christopher J Murphy; Vijaykrishna Raghunathan; Sara M Thomasy

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):2746 – A0235. doi:

ARVO Annual Meeting Abstract June 2022

A novel ex vivo human anterior segment perfusion culture model using dornor corneal rims

Weiming Mao; Michael Peng; Tyler J Margetts; Chenna Kesavulu Sugali; Naga pradeep Rayana; Jiannong Dai; Tasneem Putliwala Sharma; Vijaykrishna Raghunathan

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):3287 – A0387. doi:

Perspective February 2022

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

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Colleen M. McDowell; Krishnakumar Kizhatil; Michael H. Elliott; Darryl R. Overby; Joseph van Batenburg-Sherwood; J. Cameron Millar; Markus H. Kuehn; Gulab Zode; Ted S. Acott; Michael G. Anderson; Sanjoy K. Bhattacharya; Jacques A. Bertrand; Terete Borras; Diane E. Bovenkamp; Lin Cheng; John Danias; Michael Lucio De Ieso; Yiqin Du; Jennifer A. Faralli; Rudolf Fuchshofer; Preethi S. Ganapathy; Haiyan Gong; Samuel Herberg; Humberto Hernandez; Peter Humphries; Simon W. M. John; Paul L. Kaufman; Kate E. Keller; Mary J. Kelley; Ruth A. Kelly; David Krizaj; Ajay Kumar; Brian C. Leonard; Raquel L. Lieberman; Paloma Liton; Yutao Liu; Katy C. Liu; Navita N. Lopez; Weiming Mao; Timur Mavlyutov; Fiona McDonnell; Gillian J. McLellan; Philip Mzyk; Andrews Nartey; Louis R. Pasquale; Gaurang C. Patel; Padmanabhan P. Pattabiraman; Donna M. Peters; Vijaykrishna Raghunathan; Ponugoti Vasantha Rao; Naga Rayana; Urmimala Raychaudhuri; Ester Reina-Torres; Ruiyi Ren; Douglas Rhee; Uttio Roy Chowdhury; John R. Samples; E. Griffen Samples; Najam Sharif; Joel S. Schuman; Val C. Sheffield; Cooper H. Stevenson; Avinash Soundararajan; Preeti Subramanian; Chenna Kesavulu Sugali; Yang Sun; Carol B. Toris; Karen Y. Torrejon; Amir Vahabikashi; Janice A. Vranka; Ting Wang; Colin E. Willoughby; Chen Xin; Hongmin Yun; Hao F. Zhang; Michael P. Fautsch; Ernst R. Tamm; Abbot F. Clark; C. Ross Ethier; W. Daniel Stamer
TAGS: eye, mice, ocular hypertension, intraocular pressure, perfusion
Invest. Ophthalmol. Vis. Sci.. 2022; 63(2):12. doi: https://doi.org/10.1167/iovs.63.2.12

ARVO Annual Meeting Abstract June 2021

TGM2 inhibition with cysteamine hydrochloride does not impact corneal epithelial and stromal wound healing in vitro and in vivo

Andrea Minella; Tanvi J Chokshi; Jennifer Kang; Krista Cosert; M. Isabel Casanova; Megan M Gragg; Morgan A. W. Bowman; Michelle E Mccorkell; Nicole L Daley; Vijaykrishna Raghunathan; Brian Leonard; Christopher J Murphy; Sara M Thomasy

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):724. doi:

ARVO Annual Meeting Abstract June 2021

Knockout of the mechanotransducer, Integrin-α7, in trabecular meshwork cells affects signaling through Akt and mTOR

Julia Staverosky; VijayKrishna Raghunathan; Janice A Vranka

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):490. doi:

ARVO Annual Meeting Abstract June 2021

Activation of canonical Wnt signaling pathway inhibits dexamethasone-induced glucocorticoid receptor signaling in the trabecular meshwork

Chenna Kesavulu Sugali; Naga Pradeep Rayana; jiannong dai; Michael Peng; Sherri L Harris; Hannah Christine Webber; Shaohui Liu; Stephan Dixon; Priyanka Parekh; Elizabeth Martin; Louis B Cantor; Abbot F Clark; VijayKrishna Raghunathan; Weiming Mao

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):485. doi:

ARVO Annual Meeting Abstract June 2021

Decreased levels of Notch signaling in human trabecular meshwork cells cultured on rigid substrate

Kamesh Dhamodaran; Julia Staverosky; Janice A Vranka; VijayKrishna Raghunathan

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):481. doi:

ARVO Annual Meeting Abstract June 2021

Dose dependent induction and kinetics of human beta-defensin 3 peptide expression after treatment with herbal compounds

Brian Leonard; Theint Aung; Melinda Quan; Allison Shannon; VijayKrishna Raghunathan; Sara M Thomasy; Christopher J Murphy

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):916. doi:

ARVO Annual Meeting Abstract June 2021

Evaluation of function-related corneal endothelial markers in TAZ deficient mice over time

Sangwan Park; Brian Leonard; Soohyun Kim; Michelle E Mccorkell; Christopher J Murphy; Vijaykrishna Raghunathan; Sara M Thomasy

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):840. doi:

ARVO Annual Meeting Abstract June 2021

Substrate stiffness modulates gene expression and phagocytosis in segmental human trabecular meshwork cells

Andrews Nartey; Kamesh Dhamodaran; Julia Staverosky; Janice A Vranka; VijayKrishna Raghunathan

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):1632. doi:

Glaucoma November 2020

Lysophosphatidic Acid and IL-6 Trans-signaling Interact via YAP/TAZ and STAT3 Signaling Pathways in Human Trabecular Meshwork Cells

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Felix Yemanyi; VijayKrishna Raghunathan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(13):29. doi: https://doi.org/10.1167/iovs.61.13.29

Includes: Supplemental Content

Glaucoma November 2020

Dexamethasone and Glucocorticoid-Induced Matrix Temporally Modulate Key Integrins, Caveolins, Contractility, and Stiffness in Human Trabecular Meshwork Cells

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Felix Yemanyi; Hasna Baidouri; Alan R. Burns; VijayKrishna Raghunathan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(13):16. doi: https://doi.org/10.1167/iovs.61.13.16

Includes: Supplemental Content

Glaucoma June 2020

Wnt Activation After Inhibition Restores Trabecular Meshwork Cells Toward a Normal Phenotype

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Kamesh Dhamodaran; Hasna Baidouri; Lyndsey Sandoval; VijayKrishna Raghunathan
TAGS: actins, cytoskeleton, donors, genes, pathology, phenotype, proteins, trabecular meshwork, western blotting, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2020; 61(6):30. doi: https://doi.org/10.1167/iovs.61.6.30

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2020

Treatment of corneal epithelial cells with herbal compounds results in upregulation of the antimicrobial peptide, human beta-defensin 3 (DEFB103)

Brian Leonard; Sanskruti Potnis; Vijaykrishna Raghunathan; Sara M Thomasy; Christopher Murphy

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):408. doi:

ARVO Annual Meeting Abstract June 2020

Cell shape and attachment dictate actin reorganization and mechanics

Vijaykrishna Raghunathan; Hasna Baidouri; Alec Entringer

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):999. doi:

ARVO Annual Meeting Abstract June 2020

Crosslinked ECM modulates β-Catenin and YAP/TAZ pathways in human trabecular meshwork cells

Felix Yemanyi; Janice A Vranka; Vijaykrishna Raghunathan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1434. doi:

ARVO Annual Meeting Abstract June 2020

A new model for endothelial injury in TAZ deficient mice using phototherapeutic keratectomy

Sangwan Park; Brian Leonard; Soohyun Kim; Michelle Emily Mccorkell; Christopher Murphy; Vijaykrishna Raghunathan; Sara M Thomasy

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):1475. doi:

ARVO Annual Meeting Abstract June 2020

Expression of Notch signal in primary human trabecular meshwork segmental flow cells

Kamesh Dhamodaran; Janice A Vranka; Vijaykrishna Raghunathan

Invest. Ophthalmol. Vis. Sci.. 2020; 61(7):3443. doi:

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Investigation of fibrillin-1 and LOXL1 in ocular health and disease

Effects of long-term application of topical ROCK inhibitor on corneal endothelium and Descemet’s membrane of TAZ deficient mice

Single cell-RNA sequencing analysis of corneal endothelial cells in TAZ deficient mice

A novel ex vivo human anterior segment perfusion culture model using dornor corneal rims

Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms

TGM2 inhibition with cysteamine hydrochloride does not impact corneal epithelial and stromal wound healing in vitro and in vivo

Knockout of the mechanotransducer, Integrin-α7, in trabecular meshwork cells affects signaling through Akt and mTOR

Activation of canonical Wnt signaling pathway inhibits dexamethasone-induced glucocorticoid receptor signaling in the trabecular meshwork

Decreased levels of Notch signaling in human trabecular meshwork cells cultured on rigid substrate

Dose dependent induction and kinetics of human beta-defensin 3 peptide expression after treatment with herbal compounds

Evaluation of function-related corneal endothelial markers in TAZ deficient mice over time

Substrate stiffness modulates gene expression and phagocytosis in segmental human trabecular meshwork cells

Lysophosphatidic Acid and IL-6 Trans-signaling Interact via YAP/TAZ and STAT3 Signaling Pathways in Human Trabecular Meshwork Cells

Dexamethasone and Glucocorticoid-Induced Matrix Temporally Modulate Key Integrins, Caveolins, Contractility, and Stiffness in Human Trabecular Meshwork Cells

Wnt Activation After Inhibition Restores Trabecular Meshwork Cells Toward a Normal Phenotype

Treatment of corneal epithelial cells with herbal compounds results in upregulation of the antimicrobial peptide, human beta-defensin 3 (DEFB103)

Cell shape and attachment dictate actin reorganization and mechanics

Crosslinked ECM modulates β-Catenin and YAP/TAZ pathways in human trabecular meshwork cells

A new model for endothelial injury in TAZ deficient mice using phototherapeutic keratectomy

Expression of Notch signal in primary human trabecular meshwork segmental flow cells

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