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ARVO Annual Meeting Abstract June 2024

Glutathione Deficiency Alters Urea Efflux from the Lens

Elizabeth Rubeira; Billy Hayden; Alejandra Soto; David Sell; Zongbo WEI; Xingjun Fan; Vincent M Monnier; Jeremy A Whitson

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5046.

ARVO Annual Meeting Abstract June 2024

Effects of γ-crystallin aggregation inhibitors Closantel and Gambogic Acid on cataract progression in the OPJ mouse

Vincent M Monnier; Victoria Simmons; Sidra Islam; David Sell

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5034.

ARVO Annual Meeting Abstract June 2023

Mouse deficiency with both gamma glutamate-cysteine ligase catalytic subunit (Gclc) and modifier subunit (Gclm) develops an early nuclear cataract

Zongbo WEI; Caili Hao; Vincent M Monnier; Xingjun Fan

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):1945.

ARVO Annual Meeting Abstract June 2023

Melatonin suppresses the long-term risk of cataract surgery in diabetic individuals: An AI based study with clinical corroboration

Vincent M Monnier; Zhengxiang Gao; Maria Gorenflo; David C Kaelber; Rong Xu

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):2465.

ARVO Annual Meeting Abstract June 2022

α-Crystallin chaperone mimetic small molecules as a paradigm for cataract prevention by inhibition of lens γ-crystallin aggregation

Vincent M Monnier; Sidra Islam; Michael Do; Brett Frank; Samuel G Wheeler; Xingjun Fan; Kirsten J Lampi; David R Sell

Invest. Ophthalmol. Vis. Sci.. 2022; 63(7):17.

ARVO Annual Meeting Abstract June 2021

Lens crystallin destabilization by ascorbylation: Mapping of glycation sites associated with protein insolubilization

Vincent M Monnier; Keith Zientek; Grant Hom; Shiyuan Dong; Larry L David; David R Sell

Invest. Ophthalmol. Vis. Sci.. 2021; 62(8):2091.

ARVO Annual Meeting Abstract July 2019

Screening for alpha-crystallin mimetic drugs with chaperone-like activity toward gamma crystallins exposed to oxidative and/or heat shock stress

Vincent M Monnier; Brett Frank; Pranesh Ravichandran; Srinivasagan Ramkumar

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1126.

ARVO Annual Meeting Abstract July 2018

Screening of FDA approved drugs for their ability to inhibit or worsen hydrogen peroxide mediated aggregation of calf lens crystallins

Vincent M Monnier; Sean Wong; Huasheng Zhou; Xingjun Fan

Invest. Ophthalmol. Vis. Sci.. 2018; 59(9):4972.

ARVO Annual Meeting Abstract June 2017

Transcriptome analysis of the cataract-prone GSH-depleted LEGSKO mouse lens reveals adaptations and EMT-like response

Jeremy Whitson; Zongbo WEI; Xiang Zhang; Mario Medvedovic; Vincent M Monnier; Xingjun Fan

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):2039.

ARVO Annual Meeting Abstract June 2017

The Comparative Lens non-crystallin Disulfidome of LEGSKO Mouse and Human Cataract

Vincent M Monnier; Benlian Wang; Xingjun Fan

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):3184.

ARVO Annual Meeting Abstract June 2017

THE RELATIONSHIP BETWEEN OXIDATION, DISULFIDE FORMATION AND AGGREGATION OF HUMAN GAMMA D CRYSTALLIN

Ramkumar Srinivasagan; Benlian Wang; Xingjun Fan; Vincent M Monnier

Invest. Ophthalmol. Vis. Sci.. 2017; 58(8):5309.

Lens May 2017

Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid Homeostasis

PDF

Jeremy A. Whitson; Xiang Zhang; Mario Medvedovic; Jenny Chen; Zongbo Wei; Vincent M. Monnier; Xingjun Fan
TAGS: genes, lens (device), lens, crystalline, epithelial to mesenchymal transition, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2017; 58(5):2666-2684. https://doi.org/10.1167/iovs.16-21398

Includes: Supplemental Content

ARVO Annual Meeting Abstract September 2016

Lens GSH deficiency mouse Promote Alpha-smooth muscle actin expression

Zongbo WEI; Vincent M Monnier; Xingjun Fan

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):2022.

ARVO Annual Meeting Abstract September 2016

IDENTIFICATION OF CRITICAL CYSTEINE RESIDUES INVOLVED IN CRYSTALLIN AGGREGATION IN AGING AND CATARACT FORMATION

Ramkumar Srinivasagan; Xingjun Fan; Vincent M Monnier

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12):733.

ARVO Annual Meeting Abstract September 2016

Ascorbic acid oxidation contributes to methylglyoxal-derived hydroimidazolone formation in aged lens

Xingjun Fan; Benlian Wang; David Sell; Daniel Wesson; Vincent M Monnier

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12)

ARVO Annual Meeting Abstract September 2016

The Source of Mouse Lens Glutathione in the Absence of De Novo Synthesis

Jeremy Whitson; Catherine Doller; David Sell; Vincent M Monnier; Xingjun Fan

Invest. Ophthalmol. Vis. Sci.. 2016; 57(12)

Lens July 2016

Evidence of Dual Mechanisms of Glutathione Uptake in the Rodent Lens: A Novel Role for Vitreous Humor in Lens Glutathione Homeostasis

PDF

Jeremy A. Whitson; David R. Sell; Michael C. Goodman; Vincent M. Monnier; Xingjun Fan
TAGS: lens (device), lens, crystalline, vitreous body, glutathione
Invest. Ophthalmol. Vis. Sci.. 2016; 57(8):3914-3925. https://doi.org/10.1167/iovs.16-19592

ARVO Annual Meeting Abstract June 2015

The Comparative Lens Crystallin Disulfidome in LEGSKO Mouse and Human Cataract

Xingjun Fan; Sheng Zhou; Mingfei Guo; Bingbing Li; Benlian Wang; Grant Hom; Jing Yang; Vincent M Monnier

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5881.

ARVO Annual Meeting Abstract June 2015

The Mouse Lens Glutathione Redox Transcriptome

Jeremy Whitson; Vincent M Monnier; Xingjun Fan

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5599.

ARVO Annual Meeting Abstract June 2015

Molecular Basis for Lens Crystallin Precipitation by Vitamin C Glycation and Oxidation Products in Age-Related Cataracts

Grant Hom; Xingjun Fan; Benlian Wang; Vincent M Monnier

Invest. Ophthalmol. Vis. Sci.. 2015; 56(7 ):5882.

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Glutathione Deficiency Alters Urea Efflux from the Lens

Effects of γ-crystallin aggregation inhibitors Closantel and Gambogic Acid on cataract progression in the OPJ mouse

Mouse deficiency with both gamma glutamate-cysteine ligase catalytic subunit (Gclc) and modifier subunit (Gclm) develops an early nuclear cataract

Melatonin suppresses the long-term risk of cataract surgery in diabetic individuals: An AI based study with clinical corroboration

α-Crystallin chaperone mimetic small molecules as a paradigm for cataract prevention by inhibition of lens γ-crystallin aggregation

Lens crystallin destabilization by ascorbylation: Mapping of glycation sites associated with protein insolubilization

Screening for alpha-crystallin mimetic drugs with chaperone-like activity toward gamma crystallins exposed to oxidative and/or heat shock stress

Screening of FDA approved drugs for their ability to inhibit or worsen hydrogen peroxide mediated aggregation of calf lens crystallins

Transcriptome analysis of the cataract-prone GSH-depleted LEGSKO mouse lens reveals adaptations and EMT-like response

The Comparative Lens non-crystallin Disulfidome of LEGSKO Mouse and Human Cataract

THE RELATIONSHIP BETWEEN OXIDATION, DISULFIDE FORMATION AND AGGREGATION OF HUMAN GAMMA D CRYSTALLIN

Transcriptome of the GSH-Depleted Lens Reveals Changes in Detoxification and EMT Signaling Genes, Transport Systems, and Lipid Homeostasis

Lens GSH deficiency mouse Promote Alpha-smooth muscle actin expression

IDENTIFICATION OF CRITICAL CYSTEINE RESIDUES INVOLVED IN CRYSTALLIN AGGREGATION IN AGING AND CATARACT FORMATION

Ascorbic acid oxidation contributes to methylglyoxal-derived hydroimidazolone formation in aged lens

The Source of Mouse Lens Glutathione in the Absence of De Novo Synthesis

Evidence of Dual Mechanisms of Glutathione Uptake in the Rodent Lens: A Novel Role for Vitreous Humor in Lens Glutathione Homeostasis

The Comparative Lens Crystallin Disulfidome in LEGSKO Mouse and Human Cataract

The Mouse Lens Glutathione Redox Transcriptome

Molecular Basis for Lens Crystallin Precipitation by Vitamin C Glycation and Oxidation Products in Age-Related Cataracts

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