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Physiology and Pharmacology December 2020

A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

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Guorong Li; Astrid F. Nottebaum; Mitchell Brigell; Iris D. Navarro; Ute Ipe; Sarthak Mishra; Maria Gomez-Caraballo; Heather Schmitt; Brandi Soldo; Steve Pakola; Barbara Withers; Kevin G. Peters; Dietmar Vestweber; W. Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2020; 61(14):12. doi: https://doi.org/10.1167/iovs.61.14.12

Includes: Supplemental Content

Glaucoma November 2020

Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells

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Khalid Kamel; Colm J. O'Brien; Alexander V. Zhdanov; Dmitri B. Papkovsky; Abbot F. Clark; W. Daniel Stamer; Mustapha Irnaten

Invest. Ophthalmol. Vis. Sci.. 2020; 61(13):4. doi: https://doi.org/10.1167/iovs.61.13.4

Physiology and Pharmacology September 2020

Physiologic Consequences of Caveolin-1 Ablation in Conventional Outflow Endothelia

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Michael L. De Ieso; Jami M. Gurley; Mark E. McClellan; Xiaowu Gu; Iris Navarro; Guorong Li; Maria Gomez-Caraballo; Eric Enyong; W. Daniel Stamer; Michael H. Elliott
TAGS: ablation, caveolins, endothelium, intraocular pressure, mice, nitric oxide synthase, body tissue, eye
Invest. Ophthalmol. Vis. Sci.. 2020; 61(11):32. doi: https://doi.org/10.1167/iovs.61.11.32

Includes: Supplemental Content

Articles June 2020

An In Vitro Bovine Cellular Model for Human Schlemm's Canal Endothelial Cells and Their Response to TGFβ Treatment

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Jingwen Cai; Kristin Perkumas; W. Daniel Stamer; Yutao Liu
TAGS: cattle, endothelial cells, genes, glaucoma, schlemm's canal, puromycin
Trans. Vis. Sci. Tech.. 2020; 9(7):32. doi: https://doi.org/10.1167/tvst.9.7.32

Glaucoma May 2020

Expression of mRNAs, miRNAs, and lncRNAs in Human Trabecular Meshwork Cells Upon Mechanical Stretch

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Hannah Youngblood; Jingwen Cai; Michelle D. Drewry; Inas Helwa; Eric Hu; Sabrina Liu; Hongfang Yu; Hongmei Mu; Yanzhong Hu; Kristin Perkumas; Inas F. Aboobakar; William M. Johnson; W. Daniel Stamer; Yutao Liu
TAGS: micrornas, rna, messenger, genes
Invest. Ophthalmol. Vis. Sci.. 2020; 61(5):2. doi: https://doi.org/10.1167/iovs.61.5.2

Includes: Supplemental Content

Glaucoma March 2020

The β 4 -Subunit of the Large-Conductance Potassium Ion Channel K Ca 1.1 Regulates Outflow Facility in Mice

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Jacques A. Bertrand; Martin Schicht; W. Daniel Stamer; David Baker; Joseph M. Sherwood; Elke Lütjen-Drecoll; David L. Selwood; Darryl R. Overby
TAGS: mice, potassium channel, eye
Invest. Ophthalmol. Vis. Sci.. 2020; 61(3):41. doi: https://doi.org/10.1167/iovs.61.3.41

Includes: Supplemental Content

ARVO Annual Meeting Abstract July 2019

The Role of Yes-Associated Protein (YAP) in Mechanotransduction at the Lamina Cribrosa and its Potential as a Novel Therapeutic Target In Glaucoma.

Rory Murphy; Alan Hopkins; Mustapha Irnaten; W Daniel Stamer; Abbot F Clark; Deirdre Brennan; Deborah Wallace; Colm J O'Brien

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):1786. doi:

ARVO Annual Meeting Abstract July 2019

By targeting Tie2/VE-PTP in Schlemm’s canal, AKB-9778 lowers intraocular pressure via increasing outflow facility in mice

W Daniel Stamer; Guorong Li; Iris D Navarro; Astrid Nottebaum; Dietmar Vestweber; Kevin G Peters

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2186. doi:

ARVO Annual Meeting Abstract July 2019

ENDOTHELIAL CAVEOLIN-1 DEFICIENCY RESULTS IN ENLARGED DISTAL VESSELS

Michael H Elliott; Mark E McClellan; Iris D Navarro; Jami Gurley; W Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):2188. doi:

ARVO Annual Meeting Abstract July 2019

Elevated IOP increases Shear Stress in Schlemm’s Canal

Fiona McDonnell; Kristin Marie Perkumas; Nicole E. Ashpole; Joan Kalnitsky; Joseph M Sherwood; Darryl R Overby; W Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3181. doi:

ARVO Annual Meeting Abstract July 2019

Caveolin-mediated mechanosensation in Schlemm’s canal endothelia

Maria Gomez-Caraballo; Kristin Marie Perkumas; Joan Kalnitsky; Michael H Elliott; William D Stamer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3183. doi:

ARVO Annual Meeting Abstract July 2019

The PEXpress lncRNA/hnRNPL complex regulates signaling and morphology of human Schlemm’s canal cells

Heather Schmitt; William Johnson; Shelby Strickland; Michael A Hauser; William D Stamer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3185. doi:

ARVO Annual Meeting Abstract July 2019

Abnormal Extracellular Matrix Homeostasis of Trabecular Meshwork Cells Isolated from Human Donor Eyes with Pseudoexfoliation Syndrome

Katy C Liu; Raghunathan VijayKrishna; Iris D Navarro; Michael A Hauser; W Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3186. doi:

ARVO Annual Meeting Abstract July 2019

Role of LOXL1 in conventional outflow function and behavior

Guorong Li; William M Johnson; Heather Schmitt; Iris D Navarro; Jenny Jingyi Cui; Marybeth Groelle; Haven Roberts; Michael A Hauser; William D Stamer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):3190. doi:

ARVO Annual Meeting Abstract July 2019

The role of TGFβ2 on mechano-responsive genes of bovine angular aqueous plexus cells

Jingwen Cai; Kristin Marie Perkumas; William D Stamer; Yutao Liu

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5134. doi:

ARVO Annual Meeting Abstract July 2019

The effects of a Rho-associated protein kinase (ROCK) inhibitor (Y39983) on human trabecular meshwork cells – a morphological and proteomic study

Sze Wan Shan; Thomas Cheun Lam; William D Stamer; Hoi Lam Li; Chi-wai Do; Chi Ho To

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5138. doi:

ARVO Annual Meeting Abstract July 2019

Evidence of Increased Glycolysis and Glutaminolysis in Glaucoma Lamina Cribrosa Cells

Mustapha Irnaten; Diarmaid Hickey; Deirdre Brennan; William D Stamer; Abbot F Clark; Colm J O'Brien

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5650. doi:

ARVO Annual Meeting Abstract July 2019

microRNA21 mimics reduce intraocular pressure by PTEN/Akt/eNOS pathway

Yuan Lei; Chen Tan; Junyi Chen; Xing-Huai Sun; W Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):6475. doi:

ARVO Annual Meeting Abstract July 2019

In vivo measurement of TM stiffness: proof-of-principle in mice

C Ross Ethier; Guorong Li; Chanyoung Lee; Ke Wang; Iris D Navarro; Joseph M Sherwood; Karen Crews; Sina Farsiu; Cheng-Wen Lin; W Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5213. doi:

ARVO Annual Meeting Abstract July 2019

Blockade of the BK- a / β 4 potassium ion channel reduces outflow facility in mice

Jacques Alexander Bertrand; Joseph M Sherwood; Martin Schicht; Elke Lütjen-Drecoll; David Selwood; William D Stamer; Darryl R Overby

Invest. Ophthalmol. Vis. Sci.. 2019; 60(9):5214. doi:

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A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure

Reduced Oxidative Phosphorylation and Increased Glycolysis in Human Glaucoma Lamina Cribrosa Cells

Physiologic Consequences of Caveolin-1 Ablation in Conventional Outflow Endothelia

An In Vitro Bovine Cellular Model for Human Schlemm's Canal Endothelial Cells and Their Response to TGFβ Treatment

Expression of mRNAs, miRNAs, and lncRNAs in Human Trabecular Meshwork Cells Upon Mechanical Stretch

The β 4 -Subunit of the Large-Conductance Potassium Ion Channel K Ca 1.1 Regulates Outflow Facility in Mice

The Role of Yes-Associated Protein (YAP) in Mechanotransduction at the Lamina Cribrosa and its Potential as a Novel Therapeutic Target In Glaucoma.

By targeting Tie2/VE-PTP in Schlemm’s canal, AKB-9778 lowers intraocular pressure via increasing outflow facility in mice

ENDOTHELIAL CAVEOLIN-1 DEFICIENCY RESULTS IN ENLARGED DISTAL VESSELS

Elevated IOP increases Shear Stress in Schlemm’s Canal

Caveolin-mediated mechanosensation in Schlemm’s canal endothelia

The PEXpress lncRNA/hnRNPL complex regulates signaling and morphology of human Schlemm’s canal cells

Abnormal Extracellular Matrix Homeostasis of Trabecular Meshwork Cells Isolated from Human Donor Eyes with Pseudoexfoliation Syndrome

Role of LOXL1 in conventional outflow function and behavior

The role of TGFβ2 on mechano-responsive genes of bovine angular aqueous plexus cells

The effects of a Rho-associated protein kinase (ROCK) inhibitor (Y39983) on human trabecular meshwork cells – a morphological and proteomic study

Evidence of Increased Glycolysis and Glutaminolysis in Glaucoma Lamina Cribrosa Cells

microRNA21 mimics reduce intraocular pressure by PTEN/Akt/eNOS pathway

In vivo measurement of TM stiffness: proof-of-principle in mice

Blockade of the BK- a / β 4 potassium ion channel reduces outflow facility in mice

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