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Cornea June 2025

Activation of Sympathetic Nervous System Drives Dry Eye Onset Via Norepinephrine-β2-Adrenergic Receptor Signaling in Mice

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Mingli Qu; Xiaofei Bai; Mengyao Zhang; Jingyi Wu; Lei Wan; Xiaoyu Li; Qun Wang; Lin Cong; Benxiang Qi; Qingjun Zhou
TAGS: cornea, dry eye syndromes, mice, norepinephrine, sympathetic nervous system, signal transduction
Invest. Ophthalmol. Vis. Sci.. 2025; 66(6):13. https://doi.org/10.1167/iovs.66.6.13

Includes: Supplemental Content

Anatomy and Pathology/Oncology May 2025

SOX4 as a Key Oncogene Driving Tumor Invasion in Retinoblastoma

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Jiahe Nie; Junjie Tang; Zhihui Zhang; Hetian Sun; Xinyue Wang; Longxiang Wang; Meng Wang; Weifeng Huang; Yang Gao; Jinmiao Li; Chao Cheng; Shicai Su; Shuxia Chen; Siming Ai; Yuxiang Mao; Ping Zhang; Yaoming Liu; Rong Lu
TAGS: oncogenes, retinoblastoma, tumor cell invasion, genes, cell lines, transplantation, heterologous
Invest. Ophthalmol. Vis. Sci.. 2025; 66(5):24. https://doi.org/10.1167/iovs.66.5.24

Includes: Supplemental Content

Cornea April 2025

Prox1 Protein in Corneal Limbal Lymphatic Vessels Maintains Limbal Stem Cell Stemness and Regulates Corneal Injury Repair

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An Wang; Zongyuan Li; Yilin Jiang; Mingxiong Chen; Hanrui Yu; Zhao Li; Shengshu Sun; Ge Bai; Qun Wang; Yifei Huang; Liqiang Wang
TAGS: alkalies, burns, cornea, corneal injuries, limbal stem cells, lymphatic vessels, prospero-related homeobox 1 protein, recovery of function, epithelium, rna, messenger
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):81. https://doi.org/10.1167/iovs.66.4.81

Includes: Supplemental Content

Clinical and Epidemiologic Research April 2025

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

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Wenxu Wang; Rui Ren; Yue Liu; Xingyue Ye; Ru Zhang; Linze Xi; Liying Wang; Yao Zhang; Yi Zhang; Difei Wang
TAGS: age-related macular degeneration, genetic predisposition to disease, genetics, health, polygenic risk score, prospective studies
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):54. https://doi.org/10.1167/iovs.66.4.54

Includes: Supplemental Content

Cornea April 2025

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

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Xiaoqi Li; Anqi Liu; Yannan Zhou; Haolan Qi; Junyi Wang; Mingxiong Chen; Tunan Sun; Jie Wu; Yifei Huang; Liqiang Wang
TAGS: cornea, endothelium, mice, ppar alpha, chronic exertional compartment syndrome, fenofibrate, hereditary corneal dystrophy
Invest. Ophthalmol. Vis. Sci.. 2025; 66(4):36. https://doi.org/10.1167/iovs.66.4.36

Includes: Supplemental Content

Genetics March 2025

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

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Qiu-Yi Huo; Rui-Zheng Zhang; Wan-Nan Jia; Ya-Lei Wang; Xin Shen; Xin-Yao Chen; Tian-Hui Chen; Yan Liu; Ling-Hao Song; Xinyue Wang; Yong Lv; Ze-Xu Chen; Yong-Xiang Jiang
TAGS: biomechanics, cornea, ectopia lentis, fibrillin-1, marfan syndrome, mutation, genotype
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):23. https://doi.org/10.1167/iovs.66.3.23

Includes: Supplemental Content

Biochemistry and Molecular Biology March 2025

Butyrate Ameliorates Graves’ Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota

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Pingbo Ouyang; Jia Qi; Boding Tong; Yunping Li; Jiamin Cao; Lujue Wang; Tongxin Niu; Xin Qi
TAGS: butyrates, fibroblasts, gastrointestinal microbiome, mice
Invest. Ophthalmol. Vis. Sci.. 2025; 66(3):5. https://doi.org/10.1167/iovs.66.3.5

Includes: Supplemental Content

Glaucoma February 2025

Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma

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Jonathan B. Lin; Hani El Helwe; Henisk Falah; Bruno L. Hammerschlag; Stephanie A. Schultz; George Baldwin; Yixi Xue; Ryan A. Vasan; Christian Song; Kristine Lo; Austin Meeker; Silas L. Wang; Pia Kivisäkk; David Solá-Del Valle; Milica A. Margeta
TAGS: aqueous humor, glaucoma, nerve degeneration, neurofilament protein l, hypertension
Trans. Vis. Sci. Tech.. 2025; 14(2):24. https://doi.org/10.1167/tvst.14.2.24

Includes: Supplemental Content

Cornea February 2025

Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways

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Fang Han; Leyi Wang; Jiayin Wu; Lin Shen; Yangyang Li; Hui Guo; Jianqiao Li
TAGS: keratitis, leucine-rich repeat serine/threonine-protein kinase 2, lrrk2 gene, signal pathway, signal transduction pathways, inflammatory response
Invest. Ophthalmol. Vis. Sci.. 2025; 66(2):13. https://doi.org/10.1167/iovs.66.2.13

Includes: Supplemental Content

Eye Movements, Strabismus, Amblyopia and Neuro-ophthalmology January 2025

Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves’ Ophthalmopathy

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Lujue Wang; Yuan Li; Tongxin Niu; Jing Deng; Yuxian Shi; Yating Liu; Boding Tong; Xin Qi; Dan Cao; Yongguang Tao; Yunping Li
TAGS: ferroptosis, graves' ophthalmopathy, simvastatin, fibroblasts
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):56. https://doi.org/10.1167/iovs.66.1.56

Cornea & External Disease January 2025

Clinical Characteristics and In Vivo Confocal Microscopic Study in Candida Keratitis

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Yan Peng; Qiankun Chen; Yuan Wei; Leying Wang; Zijun Zhang; Zhenyu Wei; Jinding Pang; Bo Peng; Qingquan Shi; Zhiqun Wang; Yang Zhang; Kexin Chen; Xizhan Xu; Qingfeng Liang
TAGS: candida, keratitis, hyphae, plant spores, reproduction spores
Trans. Vis. Sci. Tech.. 2025; 14(1):23. https://doi.org/10.1167/tvst.14.1.23

Includes: Supplemental Content

Retina January 2025

Relationship Between Axial Length and Retinal Oxygen Dynamics in Adults With Myopia

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Guocheng Xiao; Mei Ge; Guoqing Qiao; Shuyu Liu; Na Li; Feng Liu; Yanye Lu; Qiushi Ren; Liqiang Wang
TAGS: adult, myopia, oxygen
Trans. Vis. Sci. Tech.. 2025; 14(1):18. https://doi.org/10.1167/tvst.14.1.18

Cornea January 2025

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

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Ling Wang; Ye Tian; Hui Zhang; Yongxiao Dong; Xia Hua; Xiaoyong Yuan
TAGS: caspase-3, cornea, dry eye syndromes, epithelium, mice, proteins, pyroptosis, apoptosis, genes, western blotting
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):24. https://doi.org/10.1167/iovs.66.1.24

Includes: Supplemental Content

Retina January 2025

Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment

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Lisong Wang; Gaocheng Zou; Yuanye Yan; Ronghua Shi; Yue Guo; Mei Zhang; Li Lu; Kai Dong
TAGS: idebenone, mice, oxidative phosphorylation defect, photoreceptors, retinal detachment, body tissue, mitochondria, retina, pathophysiology
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):17. https://doi.org/10.1167/iovs.66.1.17

Includes: Supplemental Content

Genetics December 2024

Linking Iris Cis -Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics

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Jiaying Li; Yun Chen; Wenbin Wang; Ye Zhang; Guangsong Su; Sean K. Wang; Yuanyuan Zhang; Yilong Yao; Shen Wu; Wange Lu; Kunlin Zhang; Chunyan Qiao; Shuning Li; Hengtong Li; Ching-Yu Cheng; Yuwen Liu; Ningli Wang
TAGS: angle closure glaucoma, iris, pathogenesis, enhancer of transcription, diagnostic imaging, chromatin, alleles, multiomics
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):18. https://doi.org/10.1167/iovs.65.14.18

Includes: Supplemental Content

Cornea November 2024

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

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Yang Huang; Lijun Wang; Haiying Jin
TAGS: bilirubin, cornea, dry eye syndromes, mice, mitophagy, nadph oxidase 4, nanoparticles, ocular surfaces, pink1 gene, nitric oxide synthase
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):55. https://doi.org/10.1167/iovs.65.13.55

Includes: Supplemental Content

Cornea October 2024

PAX6–WNK2 Axis Governs Corneal Epithelial Homeostasis

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Liqiong Zhu; Chaoqun Chen; Siqi Wu; Huizhen Guo; Lingyu Li; Li Wang; Dongmei Liu; Yu Zhan; Xinyue Du; Jiafeng Liu; Jieying Tan; Ying Huang; Kunlun Mo; Xihong Lan; Hong Ouyang; Jin Yuan; Xiangjun Chen; Jianping Ji
TAGS: cornea, homeostasis, pax6 transcription factor, scirrhous adenocarcinoma, epithelium, chronic exertional compartment syndrome, genes
Invest. Ophthalmol. Vis. Sci.. 2024; 65(12):40. https://doi.org/10.1167/iovs.65.12.40

Includes: Supplemental Content

Cornea September 2024

Single-Cell Transcriptomic Analysis Reveals Dynamic Cellular Processes in Corneal Epithelium During Wound Healing in Cynomolgus Monkeys

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Ming Zhou; Zhuo-Xing Shi; Zhong Liu; Shu-Rui Ke; Chao-Yang Wang; Xiao-Lin Liang; Qiu-Ling Hu; Qi-Kai Zhang; Dong-Liang Wang; Li Sun; Yu-Heng Lin; Qi Dai; Ying-Feng Zheng
TAGS: cornea, corneal epithelium, genes, macaca fascicularis, wound healing, epithelium, transcription, genetic, wounds and injuries
Invest. Ophthalmol. Vis. Sci.. 2024; 65(11):43. https://doi.org/10.1167/iovs.65.11.43

Includes: Supplemental Content

Vision Sciences Society Annual Meeting Abstract September 2024

The Neural Basis of Visual Working Memory of Real-World Object

Wanru Li; Jia Yang; PingLei Bao

Journal of Vision. 2024; 24(10):786. https://doi.org/10.1167/jov.24.10.786

Vision Sciences Society Annual Meeting Abstract September 2024

Cross-Species and Cross-Modality Studies of Food-Specific Brain Regions

Baoqi GONG; Haoxuan YAO; Yipeng LI; Wanru LI; Shiming TANG; Pinglei BAO

Journal of Vision. 2024; 24(10):489. https://doi.org/10.1167/jov.24.10.489

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Activation of Sympathetic Nervous System Drives Dry Eye Onset Via Norepinephrine-β2-Adrenergic Receptor Signaling in Mice

SOX4 as a Key Oncogene Driving Tumor Invasion in Retinoblastoma

Prox1 Protein in Corneal Limbal Lymphatic Vessels Maintains Limbal Stem Cell Stemness and Regulates Corneal Injury Repair

Life's Essential 8, Genetic Susceptibility, and the Risk of Age-Related Macular Degeneration: A Prospective Cohort Study

Proliferator–Activated Receptor Alpha Inhibits Abnormal Extracellular Matrix Accumulation and Maintains Energy Metabolism in Late-Onset Fuchs Endothelial Corneal Dystrophy

Corneal Biomechanics Are Associated With FBN1 Mutations in Patients With Marfan Syndrome and Ectopia Lentis

Butyrate Ameliorates Graves’ Orbitopathy Through Regulating Orbital Fibroblast Phenotypes and Gut Microbiota

Evaluation of Serum and Aqueous Humor Neurofilament Light Chain as Markers of Neurodegeneration in Glaucoma

Inhibition of LRRK2 Ameliorates Aspergillus fumigatus Keratitis by Regulating STING Signaling Pathways

Simvastatin-Induced Ferroptosis in Orbital Fibroblasts in Graves’ Ophthalmopathy

Clinical Characteristics and In Vivo Confocal Microscopic Study in Candida Keratitis

Relationship Between Axial Length and Retinal Oxygen Dynamics in Adults With Myopia

Caspase 3/GSDME-Mediated Corneal Epithelial Pyroptosis Promotes Dry Eye Disease

Idebenone Protects Photoreceptors Impaired by Oxidative Phosphorylation Disorder in Retinal Detachment

Linking Iris Cis -Regulatory Variants to Primary Angle-Closure Glaucoma Via Clinical Imaging and Multiomics

cRGD-Conjugated Bilirubin Nanoparticles Alleviate Dry Eye Disease Via Activating the PINK1-Mediated Mitophagy

PAX6–WNK2 Axis Governs Corneal Epithelial Homeostasis

Single-Cell Transcriptomic Analysis Reveals Dynamic Cellular Processes in Corneal Epithelium During Wound Healing in Cynomolgus Monkeys

The Neural Basis of Visual Working Memory of Real-World Object

Cross-Species and Cross-Modality Studies of Food-Specific Brain Regions

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