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Glaucoma January 2025

In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics

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Daniel Kim; Raymond Fang; Pengpeng Zhang; Zihang Yan; Cheng Sun; Guorong Li; Christa Montgomery; Simon W. M. John; W. Daniel Stamer; Hao F. Zhang; C. Ross Ethier
TAGS: anterior chamber of eye, aqueous humor, diagnostic imaging, eye, mice, vaccine information sheets, volume, x-ray microtomography
Invest. Ophthalmol. Vis. Sci.. 2025; 66(1):18. https://doi.org/10.1167/iovs.66.1.18

Includes: Supplemental Content

Perspective December 2024

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

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Ted S. Acott; Michael P. Fautsch; Weiming Mao; C. Ross Ethier; Alex S. Huang; Mary J. Kelley; Mini Aga; Sanjoy K. Bhattacharya; Terete Borras; Diane Bovenkamp; Uttio Roy Chowdhury; Abbot F. Clark; Mohammed I. Dibas; Yiqin Du; Michael H. Elliott; Jennifer A. Faralli; Haiyan Gong; Samuel Herberg; Murray A. Johnstone; Paul L. Kaufman; Kate E. Keller; Ruth A. Kelly; David Krizaj; Markus H. Kuehn; Hoi Lam Li; Raquel Lieberman; Shan C. Lin; Yutao Liu; Fiona S. McDonnell; Colleen M. McDowell; Gillian J. McLellan; Philip Mzyk; Kayarat Saidas Nair; Darryl R. Overby; Donna M. Peters; VijayKrishna Raghunathan; Ponugoti Vasantha Rao; Gavin W. Roddy; Najam A. Sharif; Myoung Sup Shim; Yang Sun; Benjamin R. Thomson; Carol B. Toris; Colin E. Willoughby; Hao F. Zhang; Thomas F. Freddo; Rudolf Fuchshofer; Kamisha R. Hill; Alireza Karimi; Krishnakumar Kizhatil; Casey C. Kopcyznski; Paloma Liton; Gaurang Patel; Michael Peng; Padmanabhan P. Pattabiraman; Ganesh Prasanna; Ester Reina-Torres; E. Griffen Samples; John R. Samples; Cynthia L. Steel; Clemens A. Strohmaier; Preeti Subramanian; Chenna Kesavulu Sugali; Joseph van Batenburg-Sherwood; Cydney Wong; Hannah Youngblood; Gulab S. Zode; Elizabeth White; W. Daniel Stamer
TAGS: body tissue, eye, fluid flow, intraocular pressure, perfusion, regulation, organ culture techniques
Invest. Ophthalmol. Vis. Sci.. 2024; 65(14):32. https://doi.org/10.1167/iovs.65.14.32

Retinal Cell Biology November 2024

Small Extracellular Vesicle-Associated MiRNAs in Polarized Retinal Pigmented Epithelium

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Belinda J. Hernandez; Madison Strain; Maria Fernanda Suarez; W. Daniel Stamer; Allison Ashley-Koch; Yutao Liu; Mikael Klingeborn; Catherine Bowes Rickman
TAGS: micrornas, patient isolation, social isolation
Invest. Ophthalmol. Vis. Sci.. 2024; 65(13):57. https://doi.org/10.1167/iovs.65.13.57

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2024

Extracellular Calcium Entry via Mechanosensitive Ion Channels is Necessary for Transcellular Pore Formation in Schlemm’s Canal Endothelial Cells

Jacques A Bertrand; C Ross Ethier; W Daniel Stamer; Darryl R Overby

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5155.

ARVO Annual Meeting Abstract June 2024

Mouse Trabecular Meshwork Stiffness in High and Low Flow Regions

Cydney A Wong; A. Thomas Read; Guorong Li; Amia Loveless; Todd Sulchek; W Daniel Stamer; C Ross Ethier

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2489.

ARVO Annual Meeting Abstract June 2024

Profiling of Macrophage Populations in the Conventional Outflow Tract

Aleksander Grimsrud; Joan Kalnitsky; Rose Mathew; W Daniel Stamer; Daniel R Saban; Katy Liu

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):578.

ARVO Annual Meeting Abstract June 2024

Proteomic analysis of conventional outflow tissues reveals upregulation of the immune system and metabolism with age

Guorong Li; Andrea Wilson; Nikolai Skiba; W Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):1261.

ARVO Annual Meeting Abstract June 2024

Postnatal deletion of Nos3 prevents IOP dysregulation observed in global null mice

Ruth A Kelly; Megan Kuhn; Michael H Elliott; Ester Reina-Torres; Darryl R Overby; W Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2817.

ARVO Annual Meeting Abstract June 2024

Characterization of Short-Lived Macrophages Reveals Lineage Specific Macrophage Function in the Conventional Outflow Tract

Katy Liu; Aleksander Grimsrud; Megan Kuhn; W Daniel Stamer; Daniel R Saban

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):3886.

ARVO Annual Meeting Abstract June 2024

Magnetically-steered Human Mesenchymal Stem Cells Lower Intraocular Pressure (IOP) for 9 Months in Mice

C Ross Ethier; M. Reza Bahrani Fard; Jessica T. Chan; A. Thomas Read; Guorong Li; Lin Cheng; Anamik Jhunjhunwala; Babak N. Safa; Seyed Mohammad Siadat; Hans E Grossniklaus; Stanislav Y. Emelianov; W Daniel Stamer; Markus H Kuehn

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):6460.

ARVO Annual Meeting Abstract June 2024

Investigating the Dynamic Behavior of Murine Pectinate Ligaments in Response to Intraocular Pressure Changes

babak safa; Nina Sara Fraticelli-Guzman; W Daniel Stamer; Andrew J. Feola; C Ross Ethier

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):2490.

ARVO Annual Meeting Abstract June 2024

The Nitric Oxide Concentration within Schlemm’s Canal Depends on IOP

Darryl R Overby; W Daniel Stamer; C Ross Ethier

Invest. Ophthalmol. Vis. Sci.. 2024; 65(7):5162.

Physiology and Pharmacology June 2024

The Factors Affecting the Stability of IOP Homeostasis

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Darryl R. Overby; C. Ross Ethier; Changxu Miao; Ruth A. Kelly; Ester Reina-Torres; W. Daniel Stamer
TAGS: fluid flow, homeostasis, intraocular pressure, perfusion, perturbations, shear stress
Invest. Ophthalmol. Vis. Sci.. 2024; 65(6):4. https://doi.org/10.1167/iovs.65.6.4

Includes: Supplemental Content

Glaucoma March 2024

ANGPTL7 and Its Role in IOP and Glaucoma

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Suzette Farber-Katz Brown; Hien Nguyen; Philip Mzyk; Michael L. De Ieso; Andrea M. Unser; Ian Brown; Pujhitha Ramesh; Hira Afzaal; Feryan Ahmed; Karen Y. Torrejon; Alan Nhan; Dalton Markrush; Tom Daly; Ellie Knecht; William McConaughy; Sara Halmos; Zhiquan Lucy Liu; Rachel Rennard; Andrew Peterson; W. Daniel Stamer
TAGS: antibodies, eye, glaucoma, intraocular pressure, mice, aqueous humor, oryctolagus cuniculus
Invest. Ophthalmol. Vis. Sci.. 2024; 65(3):22. https://doi.org/10.1167/iovs.65.3.22

Includes: Supplemental Content

Physiology and Pharmacology June 2023

Pressure Clamping During Ocular Perfusions Drives Nitric Oxide-Mediated Washout

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Ruth A. Kelly; Fiona S. McDonnell; Michael L. De Ieso; Darryl R. Overby; W. Daniel Stamer
TAGS: eye, ng-nitroarginine methyl ester, perfusion, deet, nitric oxide, oxides
Invest. Ophthalmol. Vis. Sci.. 2023; 64(7):36. https://doi.org/10.1167/iovs.64.7.36

Includes: Supplemental Content

ARVO Annual Meeting Abstract June 2023

Mechanoregulation of IOP by Nitric Oxide Predicts the “Washout” Phenomenon

Darryl R Overby; Ruth A Kelly; Changxu Miao; Ester Reina-Torres; W Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):3460.

ARVO Annual Meeting Abstract June 2023

Aging modifies conventional outflow tissue morphology, response to pressure challenge and proteomic signature of C57BL/6 mice

Guorong Li; Andrea Wilson; Michael Lucio De Ieso; Nikolai P Skiba; Sina Farsiu; C Ross Ethier; W Daniel Stamer

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):4740.

ARVO Annual Meeting Abstract June 2023

Development of a Schlemm’s Canal “Inner Wall on a Chip” for High Content Screening

Seyed Mohammad Siadat; Jacques A Bertrand; Darryl R Overby; W Daniel Stamer; C Ross Ethier

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):50.

ARVO Annual Meeting Abstract June 2023

Mapping the Stretch Dependence of Pore Formation in Normal versus Glaucomatous Schlemm’s Canal Cells

Jacques A Bertrand; W Daniel Stamer; Darryl R Overby

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5079.

ARVO Annual Meeting Abstract June 2023

Glaucomatous trabecular meshwork cells induce Schlemm’s canal cell pathobiology in a biomimetic 3D ECM hydrogel co-culture model

Ayushi Singh; Suhani Patel; Alekhya Rajasekaran; Ana Nicolle Strat; Kristin Marie Perkumas; W Daniel Stamer; Kate E Keller; Preethi S Ganapathy; Samuel Herberg

Invest. Ophthalmol. Vis. Sci.. 2023; 64(8):5077.

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In Vivo Quantification of Anterior and Posterior Chamber Volumes in Mice: Implications for Aqueous Humor Dynamics

Consensus Recommendations for Studies of Outflow Facility and Intraocular Pressure Regulation Using Ex Vivo Perfusion Approaches

Small Extracellular Vesicle-Associated MiRNAs in Polarized Retinal Pigmented Epithelium

Extracellular Calcium Entry via Mechanosensitive Ion Channels is Necessary for Transcellular Pore Formation in Schlemm’s Canal Endothelial Cells

Mouse Trabecular Meshwork Stiffness in High and Low Flow Regions

Profiling of Macrophage Populations in the Conventional Outflow Tract

Proteomic analysis of conventional outflow tissues reveals upregulation of the immune system and metabolism with age

Postnatal deletion of Nos3 prevents IOP dysregulation observed in global null mice

Characterization of Short-Lived Macrophages Reveals Lineage Specific Macrophage Function in the Conventional Outflow Tract

Magnetically-steered Human Mesenchymal Stem Cells Lower Intraocular Pressure (IOP) for 9 Months in Mice

Investigating the Dynamic Behavior of Murine Pectinate Ligaments in Response to Intraocular Pressure Changes

The Nitric Oxide Concentration within Schlemm’s Canal Depends on IOP

The Factors Affecting the Stability of IOP Homeostasis

ANGPTL7 and Its Role in IOP and Glaucoma

Pressure Clamping During Ocular Perfusions Drives Nitric Oxide-Mediated Washout

Mechanoregulation of IOP by Nitric Oxide Predicts the “Washout” Phenomenon

Aging modifies conventional outflow tissue morphology, response to pressure challenge and proteomic signature of C57BL/6 mice

Development of a Schlemm’s Canal “Inner Wall on a Chip” for High Content Screening

Mapping the Stretch Dependence of Pore Formation in Normal versus Glaucomatous Schlemm’s Canal Cells

Glaucomatous trabecular meshwork cells induce Schlemm’s canal cell pathobiology in a biomimetic 3D ECM hydrogel co-culture model

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